Details for: EMP3

Gene ID: 2014

Symbol: EMP3

Ensembl ID: ENSG00000142227

Description: epithelial membrane protein 3 (MAM blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.29
    Marker Score: 13524
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.17
    Marker Score: 233028
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.78
    Marker Score: 43973.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.73
    Marker Score: 10895
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.72
    Marker Score: 15937
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.71
    Marker Score: 3585
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.7
    Marker Score: 36676.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.61
    Marker Score: 190690
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.57
    Marker Score: 3134
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.55
    Marker Score: 5228
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.46
    Marker Score: 3957.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.42
    Marker Score: 8331
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.39
    Marker Score: 7097
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.37
    Marker Score: 6573
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.34
    Marker Score: 1957
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.26
    Marker Score: 1550
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.26
    Marker Score: 3936
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.23
    Marker Score: 109738
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.16
    Marker Score: 7619
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.1
    Marker Score: 5315
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.03
    Marker Score: 2848
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.03
    Marker Score: 39947
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3
    Marker Score: 2559
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.97
    Marker Score: 1330
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.96
    Marker Score: 7364.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.96
    Marker Score: 1231
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.94
    Marker Score: 18780
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.94
    Marker Score: 1769
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.92
    Marker Score: 3804
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.89
    Marker Score: 1009
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.88
    Marker Score: 2456
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.88
    Marker Score: 2424
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.85
    Marker Score: 5588
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.81
    Marker Score: 2627
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.8
    Marker Score: 1206
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.79
    Marker Score: 1537
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.78
    Marker Score: 3830
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.77
    Marker Score: 2467
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.77
    Marker Score: 7766
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.76
    Marker Score: 2023
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.74
    Marker Score: 7562
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.73
    Marker Score: 2851
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.72
    Marker Score: 1175
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.71
    Marker Score: 1667
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.7
    Marker Score: 957
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.69
    Marker Score: 4813.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.69
    Marker Score: 17474
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.68
    Marker Score: 68722
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.67
    Marker Score: 1721
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.65
    Marker Score: 6730
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.63
    Marker Score: 11330
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.62
    Marker Score: 2585
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.59
    Marker Score: 1295
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.59
    Marker Score: 980
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.57
    Marker Score: 28990
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.57
    Marker Score: 3529
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.52
    Marker Score: 15305
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.5
    Marker Score: 6549
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.49
    Marker Score: 3609
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.49
    Marker Score: 1457
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.48
    Marker Score: 25085
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.45
    Marker Score: 807
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.41
    Marker Score: 1003
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.4
    Marker Score: 1370
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.39
    Marker Score: 2583
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.39
    Marker Score: 6186.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.38
    Marker Score: 739
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.36
    Marker Score: 861
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.35
    Marker Score: 586
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.35
    Marker Score: 596
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.33
    Marker Score: 586
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.3
    Marker Score: 1884
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.29
    Marker Score: 2287
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.27
    Marker Score: 1785
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.27
    Marker Score: 1653
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.26
    Marker Score: 2793
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.25
    Marker Score: 721
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.22
    Marker Score: 775
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.2
    Marker Score: 988.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.2
    Marker Score: 1593
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.19
    Marker Score: 5151
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.19
    Marker Score: 3369.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.18
    Marker Score: 942
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.17
    Marker Score: 1117
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.16
    Marker Score: 613
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.15
    Marker Score: 1184
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.13
    Marker Score: 1542
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.1
    Marker Score: 1588
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.1
    Marker Score: 2786
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.09
    Marker Score: 2453
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.07
    Marker Score: 1368
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.06
    Marker Score: 2193
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.06
    Marker Score: 3596
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.05
    Marker Score: 2184
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 2.04
    Marker Score: 654
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.01
    Marker Score: 1271
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2
    Marker Score: 566
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.98
    Marker Score: 984
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.97
    Marker Score: 444
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.97
    Marker Score: 4439

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Other Information

**Key characteristics:** * The EMP3 gene is located on chromosome 17q21.1. * It is a member of the EMP3 family of proteins, which are involved in the regulation of cell death and survival. * EMP3 is a type II transmembrane protein, which means that it is a protein that is anchored to the cell membrane and projects into the cytoplasm. * It is a highly conserved protein, with a similar sequence in humans and mice. **Pathways and functions:** * EMP3 is involved in the regulation of apoptosis. It is expressed in cells that are about to die, and it helps to trigger apoptosis when these cells are damaged. * EMP3 is also involved in the assembly of blebs. Blebs are small membrane vesicles that are responsible for cell signaling. EMP3 is a key component of the bleb assembly complex, and it is required for the formation of new blebs. * EMP3 is also involved in the regulation of inflammation. It is expressed in cells that are activated by inflammatory stimuli, and it helps to promote inflammation. **Clinical significance:** * Mutations in the EMP3 gene have been linked to a number of human diseases, including cancer and autoimmune disorders. * One common mutation in the EMP3 gene is a deletion of a portion of the protein that is involved in the regulation of apoptosis. This mutation can lead to the uncontrolled growth of cells, which can eventually lead to cancer. * Another common mutation in the EMP3 gene is a mutation that results in the production of a truncated form of the protein. This mutation can also lead to the uncontrolled growth of cells, which can eventually lead to cancer.

Genular Protein ID: 3424179450

Symbol: EMP3_HUMAN

Name: Epithelial membrane protein 3

UniProtKB Accession Codes:

P54852 Q6FH01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8996089

Title: Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.

PubMed ID: 8996089

DOI: 10.1016/s0378-1119(96)00475-1

PubMed ID: 8917086

Title: Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family.

PubMed ID: 8917086

DOI: 10.1016/0378-1119(96)00134-5

PubMed ID: 9204931

Title: HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury.

PubMed ID: 9204931

DOI: 10.1523/jneurosci.17-14-05493.1997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 163
  • Mass: 18429
  • Checksum: 2B5DF55938825940
  • Sequence:
    • MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNNDTK TWACSNVSEN 
GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT GLCQLCTSVA VFTGALIYAI 
HAEEILEKHP RGGSFGYCFA LAWVAFPLAL VSGIIYIHLR KRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.