Details for: EMP3

Gene ID: 2014

Symbol: EMP3

Ensembl ID: ENSG00000142227

Description: epithelial membrane protein 3 (MAM blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 286.9262
    Cell Significance Index: -44.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 172.8805
    Cell Significance Index: -43.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 148.6111
    Cell Significance Index: -61.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 143.0621
    Cell Significance Index: -58.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 121.7376
    Cell Significance Index: -62.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 120.1489
    Cell Significance Index: -56.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 63.9649
    Cell Significance Index: -61.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.0339
    Cell Significance Index: -49.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.6148
    Cell Significance Index: -47.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.7574
    Cell Significance Index: -54.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 12.5101
    Cell Significance Index: 231.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.0306
    Cell Significance Index: -26.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 9.4239
    Cell Significance Index: 276.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3501
    Cell Significance Index: -19.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.7817
    Cell Significance Index: 137.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.6195
    Cell Significance Index: 59.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.9143
    Cell Significance Index: 252.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.8468
    Cell Significance Index: 80.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.1703
    Cell Significance Index: 26.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4229
    Cell Significance Index: 332.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2245
    Cell Significance Index: 285.1700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.5184
    Cell Significance Index: 7.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9856
    Cell Significance Index: 51.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9767
    Cell Significance Index: 96.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9315
    Cell Significance Index: 43.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7040
    Cell Significance Index: 311.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5581
    Cell Significance Index: 14.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4569
    Cell Significance Index: 74.3100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4115
    Cell Significance Index: 1.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3699
    Cell Significance Index: 7.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1555
    Cell Significance Index: 16.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1293
    Cell Significance Index: 70.5900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.1165
    Cell Significance Index: 0.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0741
    Cell Significance Index: 14.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0457
    Cell Significance Index: 0.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0431
    Cell Significance Index: 3.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0244
    Cell Significance Index: 18.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0099
    Cell Significance Index: 1.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0078
    Cell Significance Index: -14.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0271
    Cell Significance Index: -50.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0325
    Cell Significance Index: -50.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0452
    Cell Significance Index: -61.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0598
    Cell Significance Index: -7.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0670
    Cell Significance Index: -46.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0789
    Cell Significance Index: -50.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0797
    Cell Significance Index: -58.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0801
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0835
    Cell Significance Index: -61.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1016
    Cell Significance Index: -57.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1161
    Cell Significance Index: -72.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1236
    Cell Significance Index: -56.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1360
    Cell Significance Index: -48.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1395
    Cell Significance Index: -40.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1463
    Cell Significance Index: -17.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1665
    Cell Significance Index: -11.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1751
    Cell Significance Index: -34.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1949
    Cell Significance Index: -22.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1956
    Cell Significance Index: -4.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2027
    Cell Significance Index: -36.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2300
    Cell Significance Index: -46.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2522
    Cell Significance Index: -31.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2645
    Cell Significance Index: -4.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2888
    Cell Significance Index: -13.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3005
    Cell Significance Index: -8.1800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3045
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3139
    Cell Significance Index: -66.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3147
    Cell Significance Index: -45.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3388
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3473
    Cell Significance Index: -59.3000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3564
    Cell Significance Index: -2.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3676
    Cell Significance Index: -15.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3744
    Cell Significance Index: -4.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3925
    Cell Significance Index: -11.3100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4200
    Cell Significance Index: -2.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4439
    Cell Significance Index: -26.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4492
    Cell Significance Index: -51.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4583
    Cell Significance Index: -12.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5139
    Cell Significance Index: -53.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5457
    Cell Significance Index: -14.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5893
    Cell Significance Index: -41.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5970
    Cell Significance Index: -45.8200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.7716
    Cell Significance Index: -4.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7926
    Cell Significance Index: -62.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8089
    Cell Significance Index: -21.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8259
    Cell Significance Index: -50.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8369
    Cell Significance Index: -21.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8789
    Cell Significance Index: -59.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8834
    Cell Significance Index: -54.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8993
    Cell Significance Index: -56.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9051
    Cell Significance Index: -50.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9232
    Cell Significance Index: -29.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9357
    Cell Significance Index: -26.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0185
    Cell Significance Index: -52.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0984
    Cell Significance Index: -57.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1223
    Cell Significance Index: -39.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1368
    Cell Significance Index: -53.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2559
    Cell Significance Index: -55.5500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.2643
    Cell Significance Index: -10.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.3809
    Cell Significance Index: -27.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EMP3 is a transmembrane protein that is primarily expressed on the surface of immune cells, including mature T cells, monocytes, and natural killer cells. Its expression is characterized by a unique structure, with a short cytoplasmic domain and a longer extracellular domain that interacts with various ligands and receptors. EMP3 is also notable for its ability to regulate apoptosis, cell adhesion, and the assembly of blebs on the plasma membrane. Its expression is tightly regulated by various signaling pathways, including those involved in the regulation of T cell activation and proliferation. **Pathways and Functions:** EMP3 is involved in several key pathways that regulate immune responses, including: 1. **Apoptotic process:** EMP3 has been shown to play a role in the regulation of apoptosis in various immune cells, including T cells and monocytes. Its expression is induced by pro-inflammatory cytokines and is involved in the clearance of apoptotic cells. 2. **Bleb assembly:** EMP3 is involved in the assembly of blebs on the plasma membrane, which is a critical process for the regulation of immune cell functions, including cell adhesion and migration. 3. **Protein binding:** EMP3 interacts with various proteins, including integrins, cadherins, and other adhesion molecules, to regulate cell adhesion and migration. **Clinical Significance:** EMP3 has significant implications for the understanding and treatment of immune-mediated diseases, including: 1. **Autoimmune diseases:** EMP3 has been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis and lupus. Its expression is altered in patients with these diseases, and its function is disrupted, leading to impaired immune regulation. 2. **Cancer:** EMP3 has been shown to play a role in the regulation of immune cell functions in cancer, including the evasion of immune surveillance and the promotion of tumor growth. 3. **Infectious diseases:** EMP3 has been implicated in the regulation of immune responses to infectious diseases, including HIV and tuberculosis. Its expression is altered in patients with these diseases, and its function is disrupted, leading to impaired immune regulation. In conclusion, EMP3 is a multifunctional protein that plays a critical role in the regulation of immune responses. Its expression and function are closely linked to the regulation of apoptosis, cell adhesion, and the assembly of blebs on the plasma membrane. Understanding the mechanisms of EMP3 regulation and its clinical significance is essential for the development of novel therapeutic strategies for immune-mediated diseases.

Genular Protein ID: 3424179450

Symbol: EMP3_HUMAN

Name: Epithelial membrane protein 3

UniProtKB Accession Codes:

P54852 Q6FH01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8996089

Title: Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.

PubMed ID: 8996089

DOI: 10.1016/s0378-1119(96)00475-1

PubMed ID: 8917086

Title: Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family.

PubMed ID: 8917086

DOI: 10.1016/0378-1119(96)00134-5

PubMed ID: 9204931

Title: HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury.

PubMed ID: 9204931

DOI: 10.1523/jneurosci.17-14-05493.1997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 163
  • Mass: 18429
  • Checksum: 2B5DF55938825940
  • Sequence:
    • MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNNDTK TWACSNVSEN 
GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT GLCQLCTSVA VFTGALIYAI 
HAEEILEKHP RGGSFGYCFA LAWVAFPLAL VSGIIYIHLR KRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.