Details for: LY6E

Gene ID: 4061

Symbol: LY6E

Ensembl ID: ENSG00000160932

Description: lymphocyte antigen 6 family member E

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.32
    Marker Score: 7884
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.03
    Marker Score: 11126
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.02
    Marker Score: 10230
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.95
    Marker Score: 39071
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.8
    Marker Score: 11999
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.57
    Marker Score: 2861
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.46
    Marker Score: 10104
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.41
    Marker Score: 22209.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.41
    Marker Score: 39593
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.3
    Marker Score: 4777.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.26
    Marker Score: 17122
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.2
    Marker Score: 13714
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.13
    Marker Score: 175251
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.1
    Marker Score: 2994.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.06
    Marker Score: 22803.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3
    Marker Score: 158869
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3
    Marker Score: 4119.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.99
    Marker Score: 4407.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.89
    Marker Score: 7050
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.88
    Marker Score: 18412
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.85
    Marker Score: 28697
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.83
    Marker Score: 2230
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.82
    Marker Score: 773
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.81
    Marker Score: 4605.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.79
    Marker Score: 7583.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.78
    Marker Score: 2396.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.76
    Marker Score: 885.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.72
    Marker Score: 11744.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.72
    Marker Score: 1946
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.69
    Marker Score: 5249
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.66
    Marker Score: 68139
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.65
    Marker Score: 2353
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.64
    Marker Score: 3647
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.64
    Marker Score: 29707
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.61
    Marker Score: 5115
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.6
    Marker Score: 1527
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.6
    Marker Score: 857
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.56
    Marker Score: 88603
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.55
    Marker Score: 2146
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.51
    Marker Score: 3024
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.51
    Marker Score: 1817
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.48
    Marker Score: 6496
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.46
    Marker Score: 2651
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.45
    Marker Score: 622
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.45
    Marker Score: 1208.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.45
    Marker Score: 2859
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.45
    Marker Score: 32291
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.44
    Marker Score: 1019
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.43
    Marker Score: 4863
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.43
    Marker Score: 2848
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.43
    Marker Score: 6817
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.43
    Marker Score: 1777
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.42
    Marker Score: 1045
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.41
    Marker Score: 2258
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.41
    Marker Score: 1758
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.41
    Marker Score: 2561
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.37
    Marker Score: 840
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.36
    Marker Score: 2119.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.34
    Marker Score: 677
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.34
    Marker Score: 5653
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.33
    Marker Score: 523
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.32
    Marker Score: 1400
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.32
    Marker Score: 1332
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.28
    Marker Score: 551
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.28
    Marker Score: 833
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.28
    Marker Score: 3515
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.27
    Marker Score: 8937.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.27
    Marker Score: 2802
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.26
    Marker Score: 9259.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.25
    Marker Score: 2215
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.23
    Marker Score: 1228
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.19
    Marker Score: 764
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.18
    Marker Score: 1966
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.17
    Marker Score: 1705
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.15
    Marker Score: 3816
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.13
    Marker Score: 2135
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.13
    Marker Score: 659
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.12
    Marker Score: 18293
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.12
    Marker Score: 601
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.12
    Marker Score: 1990
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.12
    Marker Score: 16525
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.1
    Marker Score: 983
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.1
    Marker Score: 1326.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.1
    Marker Score: 1289
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.09
    Marker Score: 3541.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.08
    Marker Score: 1512
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.05
    Marker Score: 1739
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.04
    Marker Score: 3645
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.02
    Marker Score: 2612
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.02
    Marker Score: 2181
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2
    Marker Score: 3494
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.99
    Marker Score: 4148
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.98
    Marker Score: 1625
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.97
    Marker Score: 631
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.97
    Marker Score: 1995
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.96
    Marker Score: 3360.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.94
    Marker Score: 670
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.93
    Marker Score: 411
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.93
    Marker Score: 2835.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.92
    Marker Score: 2089

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Other Information

**Key characteristics:** - LY6E is a transmembrane protein with a predicted molecular weight of 55 kDa. - It is expressed in high levels in secretory cell, decidual natural killer cell, human, alveolar capillary type 1 endothelial cell, mature T cell, mature gamma-delta T cell, early promyelocyte, NKp46-positive innate lymphoid cell, human, and alveolar capillary type 2 endothelial cell. - It is a ligand for the acetylcholine receptor. **Pathways and functions:** - LY6E is involved in the regulation of cell growth and differentiation. - It is a negative regulator of acetylcholine receptor activity, which is important for the survival and proliferation of secretory cell, decidual natural killer cell, human, and alveolar capillary type 1 endothelial cell. - It is also involved in the regulation of inflammation. - LY6E is a potential therapeutic target for cancer and other diseases that are characterized by abnormal cell growth and migration. **Clinical significance:** - Mutations in the LY6E gene have been linked to a number of human diseases, including cancer and autoimmune disorders. - LY6E inhibitors are currently being investigated as potential treatments for these diseases.

Genular Protein ID: 3318077381

Symbol: LY6E_HUMAN

Name: Retinoic acid-induced gene E protein

UniProtKB Accession Codes:

Q16553 B2R4X5 D3DWJ2 Q0VDE5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 15 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8650192

Title: RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell.

PubMed ID: 8650192

DOI: 10.1073/pnas.93.12.5910

PubMed ID: 8757598

Title: Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2: a new member of the human Ly-6 family.

PubMed ID: 8757598

PubMed ID: 9551972

Title: Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1.

PubMed ID: 9551972

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28130445

Title: Interferon-inducible LY6E Protein Promotes HIV-1 Infection.

PubMed ID: 28130445

DOI: 10.1074/jbc.m116.755819

PubMed ID: 29610346

Title: Flavivirus internalization is regulated by a size-dependent endocytic pathway.

PubMed ID: 29610346

DOI: 10.1073/pnas.1720032115

PubMed ID: 30190477

Title: LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step.

PubMed ID: 30190477

DOI: 10.1038/s41467-018-06000-y

PubMed ID: 32641482

Title: LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2.

PubMed ID: 32641482

DOI: 10.1128/jvi.00562-20

PubMed ID: 32704094

Title: LY6E impairs coronavirus fusion and confers immune control of viral disease.

PubMed ID: 32704094

DOI: 10.1038/s41564-020-0769-y

Sequence Information:

  • Length: 131
  • Mass: 13507
  • Checksum: 0F6D1157741AFC98
  • Sequence:
    • MKIFLPVLLA ALLGVERASS LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT VSASAGIGNL 
VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF SAADGGLRAS VTLLGAGLLL 
SLLPALLRFG P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.