Details for: LY6E

Gene ID: 4061

Symbol: LY6E

Ensembl ID: ENSG00000160932

Description: lymphocyte antigen 6 family member E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 461.4735
    Cell Significance Index: -71.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 224.4096
    Cell Significance Index: -56.9200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 191.9176
    Cell Significance Index: -79.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 159.9373
    Cell Significance Index: -75.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 153.1440
    Cell Significance Index: -78.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 112.6639
    Cell Significance Index: -75.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.5950
    Cell Significance Index: -72.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.9151
    Cell Significance Index: -74.6400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 15.7207
    Cell Significance Index: 392.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.2013
    Cell Significance Index: -46.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.8762
    Cell Significance Index: 285.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.0603
    Cell Significance Index: -26.9500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 9.9534
    Cell Significance Index: 127.4700
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 8.2666
    Cell Significance Index: 40.2100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 8.1634
    Cell Significance Index: 47.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.4722
    Cell Significance Index: 219.4500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.0794
    Cell Significance Index: 52.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 5.1405
    Cell Significance Index: 363.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.6889
    Cell Significance Index: 643.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.0938
    Cell Significance Index: 75.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.0546
    Cell Significance Index: 71.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.7580
    Cell Significance Index: 78.6600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.1767
    Cell Significance Index: 8.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.1753
    Cell Significance Index: 149.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.9934
    Cell Significance Index: 383.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5658
    Cell Significance Index: 1401.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4987
    Cell Significance Index: 23.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.4939
    Cell Significance Index: 322.2000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.3916
    Cell Significance Index: 14.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3716
    Cell Significance Index: 291.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2034
    Cell Significance Index: 59.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0530
    Cell Significance Index: 55.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0316
    Cell Significance Index: 366.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9084
    Cell Significance Index: 843.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8468
    Cell Significance Index: 20.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4802
    Cell Significance Index: 77.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0724
    Cell Significance Index: 968.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0005
    Cell Significance Index: 64.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9196
    Cell Significance Index: 21.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8160
    Cell Significance Index: 42.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7824
    Cell Significance Index: 20.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7694
    Cell Significance Index: 57.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7496
    Cell Significance Index: 121.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5829
    Cell Significance Index: 116.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5337
    Cell Significance Index: 58.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4193
    Cell Significance Index: 79.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4039
    Cell Significance Index: 39.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3566
    Cell Significance Index: 7.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3304
    Cell Significance Index: 11.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3128
    Cell Significance Index: 62.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2967
    Cell Significance Index: 85.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1108
    Cell Significance Index: 83.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0956
    Cell Significance Index: 1.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0662
    Cell Significance Index: 23.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0608
    Cell Significance Index: 3.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0298
    Cell Significance Index: -56.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0459
    Cell Significance Index: -84.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0474
    Cell Significance Index: -2.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0556
    Cell Significance Index: -85.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0558
    Cell Significance Index: -3.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0633
    Cell Significance Index: -86.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0867
    Cell Significance Index: -63.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0867
    Cell Significance Index: -3.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0955
    Cell Significance Index: -70.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1105
    Cell Significance Index: -62.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1134
    Cell Significance Index: -72.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1537
    Cell Significance Index: -3.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1691
    Cell Significance Index: -76.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1702
    Cell Significance Index: -19.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2051
    Cell Significance Index: -20.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2287
    Cell Significance Index: -10.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2395
    Cell Significance Index: -6.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2540
    Cell Significance Index: -7.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2827
    Cell Significance Index: -7.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3124
    Cell Significance Index: -7.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3319
    Cell Significance Index: -39.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3345
    Cell Significance Index: -38.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3623
    Cell Significance Index: -11.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3875
    Cell Significance Index: -66.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4018
    Cell Significance Index: -84.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4357
    Cell Significance Index: -3.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5121
    Cell Significance Index: -74.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7280
    Cell Significance Index: -75.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7715
    Cell Significance Index: -35.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8026
    Cell Significance Index: -10.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8917
    Cell Significance Index: -22.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9611
    Cell Significance Index: -76.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0016
    Cell Significance Index: -76.8600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0088
    Cell Significance Index: -17.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2443
    Cell Significance Index: -76.2900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.3241
    Cell Significance Index: -7.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3329
    Cell Significance Index: -39.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3649
    Cell Significance Index: -76.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3880
    Cell Significance Index: -87.4800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.4252
    Cell Significance Index: -29.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4399
    Cell Significance Index: -24.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4456
    Cell Significance Index: -14.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4744
    Cell Significance Index: -39.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.4948
    Cell Significance Index: -16.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5175
    Cell Significance Index: -53.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LY6E is a GPI-anchored protein, which allows it to interact with cell membranes and participate in signal transduction events. Its expression is widespread across various cell types, including immune cells, endothelial cells, and cells of the ovary. This gene is also involved in the regulation of viral entry into host cells, suggesting its role in immune defense mechanisms. Furthermore, LY6E is implicated in the negative regulation of viral entry, highlighting its potential as a therapeutic target for viral infections. **Pathways and Functions:** LY6E is involved in several signaling pathways, including: 1. **Acetylcholine receptor inhibitor activity**: LY6E has been shown to inhibit the activity of acetylcholine receptors, which are involved in the regulation of muscle contraction and neurotransmission. 2. **Cell surface receptor signaling pathway**: LY6E interacts with cell surface receptors, modulating signaling events that regulate cellular responses. 3. **Extracellular region**: LY6E is localized to the extracellular region of cells, where it interacts with other proteins and lipids to regulate cellular signaling. 4. **Metabolism of proteins**: LY6E is involved in the regulation of protein synthesis and degradation, which is essential for maintaining cellular homeostasis. 5. **Negative regulation of viral entry into host cell**: LY6E has been shown to inhibit the entry of viruses into host cells, highlighting its role in immune defense mechanisms. **Clinical Significance:** The identification of LY6E as a key player in immune regulation and cellular signaling has significant implications for the treatment of various diseases, including: 1. **Viral infections**: LY6E's role in the negative regulation of viral entry into host cells makes it a potential therapeutic target for viral infections. 2. **Autoimmune diseases**: LY6E's involvement in immune regulation and signaling pathways suggests its potential role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: LY6E's expression in various cell types, including immune cells and endothelial cells, highlights its potential role in cancer development and progression. 4. **Ovarian cancer**: LY6E's expression in interstitial cells of the ovary suggests its potential role in ovarian cancer development and progression. In conclusion, LY6E is a multifunctional protein that plays a crucial role in immune regulation, cellular signaling, and protein metabolism. Its involvement in various biological processes highlights its significance as a potential therapeutic target for various diseases. Further research is needed to elucidate the molecular mechanisms underlying LY6E's functions and to explore its potential applications in human health and disease.

Genular Protein ID: 3318077381

Symbol: LY6E_HUMAN

Name: Retinoic acid-induced gene E protein

UniProtKB Accession Codes:

Q16553 B2R4X5 D3DWJ2 Q0VDE5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 15 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8650192

Title: RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell.

PubMed ID: 8650192

DOI: 10.1073/pnas.93.12.5910

PubMed ID: 8757598

Title: Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2: a new member of the human Ly-6 family.

PubMed ID: 8757598

PubMed ID: 9551972

Title: Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1.

PubMed ID: 9551972

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28130445

Title: Interferon-inducible LY6E Protein Promotes HIV-1 Infection.

PubMed ID: 28130445

DOI: 10.1074/jbc.m116.755819

PubMed ID: 29610346

Title: Flavivirus internalization is regulated by a size-dependent endocytic pathway.

PubMed ID: 29610346

DOI: 10.1073/pnas.1720032115

PubMed ID: 30190477

Title: LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step.

PubMed ID: 30190477

DOI: 10.1038/s41467-018-06000-y

PubMed ID: 32641482

Title: LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2.

PubMed ID: 32641482

DOI: 10.1128/jvi.00562-20

PubMed ID: 32704094

Title: LY6E impairs coronavirus fusion and confers immune control of viral disease.

PubMed ID: 32704094

DOI: 10.1038/s41564-020-0769-y

Sequence Information:

  • Length: 131
  • Mass: 13507
  • Checksum: 0F6D1157741AFC98
  • Sequence:
    • MKIFLPVLLA ALLGVERASS LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT VSASAGIGNL 
VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF SAADGGLRAS VTLLGAGLLL 
SLLPALLRFG P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.