Details for: LAPTM5

Gene ID: 7805

Symbol: LAPTM5

Ensembl ID: ENSG00000162511

Description: lysosomal protein transmembrane 5

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Cytoplasmic vesicle
    (GO:0031410)
  • Cytosol
    (GO:0005829)
  • Defense response to tumor cell
    (GO:0002357)
  • Golgi to lysosome transport
    (GO:0090160)
  • Induction of programmed cell death
    (GO:0012502)
  • Intracellular protein transport
    (GO:0006886)
  • Lysosomal membrane
    (GO:0005765)
  • Lysosome
    (GO:0005764)
  • Negative regulation of autophagic cell death
    (GO:1904093)
  • Negative regulation of b cell activation
    (GO:0050869)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of t cell activation
    (GO:0050868)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cytokine production involved in immune response
    (GO:0002720)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of lysosomal membrane permeability
    (GO:0097214)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of protein ubiquitination
    (GO:0031398)
  • Positive regulation of receptor catabolic process
    (GO:2000646)
  • Positive regulation of tumor necrosis factor-mediated signaling pathway
    (GO:1903265)
  • Positive regulation of ubiquitin-dependent protein catabolic process
    (GO:2000060)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein sequestering activity
    (GO:0140311)
  • Protein targeting to lysosome
    (GO:0006622)
  • Transport vesicle
    (GO:0030133)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.8764
    Cell Significance Index: -28.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 126.3670
    Cell Significance Index: -51.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 100.4889
    Cell Significance Index: -51.6900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 93.6527
    Cell Significance Index: -38.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.4128
    Cell Significance Index: -52.9100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 41.4069
    Cell Significance Index: 96.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.7235
    Cell Significance Index: -29.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 14.4771
    Cell Significance Index: 267.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.9315
    Cell Significance Index: -3.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.7318
    Cell Significance Index: -39.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2630
    Cell Significance Index: -24.6500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 10.4409
    Cell Significance Index: 27.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5402
    Cell Significance Index: -33.7000
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 8.1216
    Cell Significance Index: 36.3200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 8.0082
    Cell Significance Index: 33.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.6466
    Cell Significance Index: 493.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.3500
    Cell Significance Index: 215.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.1555
    Cell Significance Index: 843.8500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.8920
    Cell Significance Index: 25.8200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.1450
    Cell Significance Index: 9.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.7434
    Cell Significance Index: 46.6400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.5814
    Cell Significance Index: 10.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7577
    Cell Significance Index: 684.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6365
    Cell Significance Index: 33.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5102
    Cell Significance Index: 50.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3645
    Cell Significance Index: 59.2800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2934
    Cell Significance Index: 1.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1265
    Cell Significance Index: 13.7600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1080
    Cell Significance Index: 1.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0735
    Cell Significance Index: 13.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0302
    Cell Significance Index: 3.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0132
    Cell Significance Index: 8.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0169
    Cell Significance Index: -31.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0194
    Cell Significance Index: -14.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0228
    Cell Significance Index: -16.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0228
    Cell Significance Index: -41.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0264
    Cell Significance Index: -40.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0290
    Cell Significance Index: -15.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0309
    Cell Significance Index: -41.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0314
    Cell Significance Index: -17.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0400
    Cell Significance Index: -1.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0418
    Cell Significance Index: -8.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0731
    Cell Significance Index: -53.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0731
    Cell Significance Index: -32.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0809
    Cell Significance Index: -51.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0899
    Cell Significance Index: -32.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0904
    Cell Significance Index: -26.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0958
    Cell Significance Index: -16.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0989
    Cell Significance Index: -20.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1025
    Cell Significance Index: -46.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1086
    Cell Significance Index: -3.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1088
    Cell Significance Index: -2.7800
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.1159
    Cell Significance Index: -0.7000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1223
    Cell Significance Index: -1.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1258
    Cell Significance Index: -8.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1317
    Cell Significance Index: -5.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1407
    Cell Significance Index: -7.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1498
    Cell Significance Index: -27.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1696
    Cell Significance Index: -34.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1772
    Cell Significance Index: -3.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1932
    Cell Significance Index: -7.9200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1961
    Cell Significance Index: -3.3800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2049
    Cell Significance Index: -1.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2052
    Cell Significance Index: -7.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2254
    Cell Significance Index: -30.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2573
    Cell Significance Index: -31.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2665
    Cell Significance Index: -8.5400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2732
    Cell Significance Index: -4.6400
  • Cell Name: centrocyte (CL0009111)
    Fold Change: -0.2789
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2994
    Cell Significance Index: -34.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3117
    Cell Significance Index: -36.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3143
    Cell Significance Index: -32.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3206
    Cell Significance Index: -41.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3226
    Cell Significance Index: -41.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3457
    Cell Significance Index: -39.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3482
    Cell Significance Index: -50.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3768
    Cell Significance Index: -17.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3958
    Cell Significance Index: -8.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4144
    Cell Significance Index: -24.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4674
    Cell Significance Index: -35.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5068
    Cell Significance Index: -35.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5105
    Cell Significance Index: -31.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5207
    Cell Significance Index: -22.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5493
    Cell Significance Index: -40.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5590
    Cell Significance Index: -29.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5592
    Cell Significance Index: -37.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6216
    Cell Significance Index: -39.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6412
    Cell Significance Index: -39.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7084
    Cell Significance Index: -13.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7091
    Cell Significance Index: -39.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7394
    Cell Significance Index: -34.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7523
    Cell Significance Index: -39.5000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7861
    Cell Significance Index: -6.4100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.8092
    Cell Significance Index: -7.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8489
    Cell Significance Index: -37.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8508
    Cell Significance Index: -18.1200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.8564
    Cell Significance Index: -11.3800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.8806
    Cell Significance Index: -8.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9450
    Cell Significance Index: -26.4100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.9651
    Cell Significance Index: -16.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LAPTM5 is a conserved protein across species, with high sequence similarity to its homologs in other organisms. It is characterized by its unique transmembrane domain, which is critical for its function. LAPTM5 is expressed in various cell types, including immune cells, such as naive B cells, mature T cells, and NKp46-positive innate lymphoid cells. Its expression is also observed in other cell types, including monocytes, macrophages, and B cells. **Pathways and Functions:** LAPTM5 is involved in multiple signaling pathways, including: 1. **Apoptosis**: LAPTM5 regulates the activation of cysteine-type endopeptidase activity, which is essential for the execution of apoptosis. 2. **Immune response**: LAPTM5 positively regulates cytokine production, including IL-12, and negatively regulates the activation of T cells, B cells, and macrophages. 3. **Autophagy**: LAPTM5 negatively regulates autophagic cell death, suggesting that it may play a role in maintaining cellular homeostasis. 4. **Lysosomal function**: LAPTM5 regulates the permeability of lysosomes and the targeting of proteins to lysosomes. 5. **Golgi to lysosome transport**: LAPTM5 is involved in the transport of proteins from the Golgi apparatus to lysosomes. **Clinical Significance:** Dysregulation of LAPTM5 has been implicated in various diseases, including: 1. **Autoimmune disorders**: LAPTM5 has been shown to regulate the activation of autoreactive T cells and B cells, suggesting that it may play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: LAPTM5 has been found to be overexpressed in various cancers, including breast, lung, and colon cancer, suggesting that it may contribute to tumorigenesis and metastasis. 3. **Neurological disorders**: LAPTM5 has been implicated in the regulation of neuroinflammation and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, LAPTM5 is a critical regulator of immune response, apoptosis, autophagy, and lysosomal function. Its dysregulation has been implicated in various diseases, highlighting the importance of LAPTM5 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the functions of LAPTM5 and its role in human disease.

Genular Protein ID: 708116570

Symbol: LAPM5_HUMAN

Name: Lysosomal-associated transmembrane protein 5

UniProtKB Accession Codes:

Q13571 Q13240 Q14698 Q3KP54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 32 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661146

Title: LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells.

PubMed ID: 8661146

DOI: 10.1006/geno.1996.0364

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 262
  • Mass: 29937
  • Checksum: 64A9B3F09C14FCE7
  • Sequence:
    • MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI 
ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI MDYLLCLLTL LGSYIELPAY 
LKLASRSRAS SSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP 
HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE 
EALSLPSKTP EGGPAPPPYS EV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.