CCL4 | ENSG00000275302 | NCBI 6351

Details for: CCL4

Gene ID: 6351

Symbol: CCL4

Ensembl ID: ENSG00000275302

Description: C-C motif chemokine ligand 4

Associated with

Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Cytokine signaling in immune system
(R-HSA-1280215)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Interleukin-10 signaling
(R-HSA-6783783)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Ccr1 chemokine receptor binding
(GO:0031726)
Ccr5 chemokine receptor binding
(GO:0031730)
Ccr chemokine receptor binding
(GO:0048020)
Cell-cell signaling
(GO:0007267)
Cell adhesion
(GO:0007155)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Cytokine activity
(GO:0005125)
Eosinophil chemotaxis
(GO:0048245)
Establishment or maintenance of cell polarity
(GO:0007163)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Negative regulation by host of viral transcription
(GO:0043922)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of calcium ion transport
(GO:0051928)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of natural killer cell chemotaxis
(GO:2000503)
Protein binding
(GO:0005515)
Response to toxic substance
(GO:0009636)
Response to virus
(GO:0009615)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 92.3171
Cell Significance Index: -43.5900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 91.1185
Cell Significance Index: -46.8700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 65.1767
Cell Significance Index: -43.7400
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 62.0520
Cell Significance Index: 166.2300
Cell Name: mononuclear cell (CL0000842)
Fold Change: 18.2774
Cell Significance Index: 76.0700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.6641
Cell Significance Index: -45.0400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 9.4659
Cell Significance Index: 332.6200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 4.0294
Cell Significance Index: 100.7300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.7738
Cell Significance Index: 108.7300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4209
Cell Significance Index: 64.4100
Cell Name: activated type II NK T cell (CL0000931)
Fold Change: 1.3788
Cell Significance Index: 3.5300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.0615
Cell Significance Index: 28.4000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0564
Cell Significance Index: 201.0300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8955
Cell Significance Index: 19.4000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7063
Cell Significance Index: 637.7700
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.5831
Cell Significance Index: 11.8700
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.3050
Cell Significance Index: 31.1600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2637
Cell Significance Index: 42.8900
Cell Name: mature T cell (CL0002419)
Fold Change: 0.2335
Cell Significance Index: 1.6800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.1975
Cell Significance Index: 3.6500
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.1920
Cell Significance Index: 2.9700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1515
Cell Significance Index: 19.4200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0820
Cell Significance Index: 62.0500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0139
Cell Significance Index: 1.5100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0077
Cell Significance Index: 4.8300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0024
Cell Significance Index: 0.2400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.0002
Cell Significance Index: 0.1400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0019
Cell Significance Index: -0.3900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0106
Cell Significance Index: -7.8300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0222
Cell Significance Index: -0.9100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0223
Cell Significance Index: -42.0400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0346
Cell Significance Index: -53.3400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0579
Cell Significance Index: -42.4300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0682
Cell Significance Index: -43.2900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0697
Cell Significance Index: -11.9000
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0768
Cell Significance Index: -41.9300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0808
Cell Significance Index: -9.2600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0852
Cell Significance Index: -37.6600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0894
Cell Significance Index: -4.2000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1020
Cell Significance Index: -46.3100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1045
Cell Significance Index: -2.7900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1242
Cell Significance Index: -44.5500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1243
Cell Significance Index: -22.4000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1859
Cell Significance Index: -36.9000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2132
Cell Significance Index: -42.7700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2178
Cell Significance Index: -29.9100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2273
Cell Significance Index: -27.9500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2443
Cell Significance Index: -14.9800
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.2507
Cell Significance Index: -2.6000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2854
Cell Significance Index: -19.7400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2951
Cell Significance Index: -38.1200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2968
Cell Significance Index: -43.1500
Cell Name: helper T cell (CL0000912)
Fold Change: -0.3202
Cell Significance Index: -4.5500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3311
Cell Significance Index: -37.8000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3383
Cell Significance Index: -39.9000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3464
Cell Significance Index: -16.1500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3557
Cell Significance Index: -41.4500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3918
Cell Significance Index: -10.9500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4283
Cell Significance Index: -11.0100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4586
Cell Significance Index: -5.2100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4630
Cell Significance Index: -14.8300
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.5470
Cell Significance Index: -8.0000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5496
Cell Significance Index: -43.5300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5598
Cell Significance Index: -41.7200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5843
Cell Significance Index: -35.0800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5919
Cell Significance Index: -30.7500
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.6005
Cell Significance Index: -10.1000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6125
Cell Significance Index: -47.0000
Cell Name: leukocyte (CL0000738)
Fold Change: -0.6465
Cell Significance Index: -10.9800
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.6487
Cell Significance Index: -6.1500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6558
Cell Significance Index: -41.3300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6819
Cell Significance Index: -4.1200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.6950
Cell Significance Index: -44.8400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.7003
Cell Significance Index: -30.4500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7975
Cell Significance Index: -44.7500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8220
Cell Significance Index: -43.1600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.8478
Cell Significance Index: -44.1600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.9436
Cell Significance Index: -14.2200
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.9737
Cell Significance Index: -7.9400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.0359
Cell Significance Index: -45.8200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.0629
Cell Significance Index: -39.0200
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.1512
Cell Significance Index: -40.3300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1839
Cell Significance Index: -34.8700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.2648
Cell Significance Index: -43.9500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.2967
Cell Significance Index: -42.4600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.3117
Cell Significance Index: -27.2100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.3511
Cell Significance Index: -43.0300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.3638
Cell Significance Index: -29.0500
Cell Name: natural killer cell (CL0000623)
Fold Change: -1.4067
Cell Significance Index: -15.5800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.4236
Cell Significance Index: -38.7500
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -1.4419
Cell Significance Index: -14.9500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -1.4495
Cell Significance Index: -28.3400
Cell Name: lymphocyte (CL0000542)
Fold Change: -1.4837
Cell Significance Index: -20.1900
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -1.4939
Cell Significance Index: -13.3000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.5370
Cell Significance Index: -44.0600
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.6243
Cell Significance Index: -42.7100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.6291
Cell Significance Index: -39.4600
Cell Name: decidual cell (CL2000002)
Fold Change: -1.6324
Cell Significance Index: -26.1900
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -1.6353
Cell Significance Index: -11.0800
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.6546
Cell Significance Index: -42.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** CCL4 is a small, secreted protein that belongs to the C-C chemokine family. It is structurally related to other chemokines, such as CCL3 and CCL5, and is known to interact with several chemokine receptors, including CCR1, CCR5, and CCR6. CCL4 is produced by various cell types, including immune cells, endothelial cells, and epithelial cells, and is released in response to inflammatory stimuli, such as cytokines and chemokines. The gene encoding CCL4 is highly conserved across species, suggesting its importance in the regulation of immune responses. **Pathways and Functions** CCL4 plays a crucial role in the regulation of immune responses, particularly in the recruitment of immune cells to sites of inflammation. The gene encoding CCL4 is involved in several signaling pathways, including: 1. Chemokine-mediated signaling pathway: CCL4 interacts with chemokine receptors, such as CCR1 and CCR5, to activate signaling pathways that regulate immune responses. 2. Cell-cell signaling: CCL4 is involved in the regulation of cell-cell interactions, particularly in the recruitment of immune cells to sites of inflammation. 3. Cell adhesion: CCL4 is involved in the regulation of cell adhesion, particularly in the recruitment of immune cells to endothelial cells. 4. Cytokine activity: CCL4 is involved in the regulation of cytokine production, particularly in the production of pro-inflammatory cytokines. CCL4 is also involved in the regulation of immune responses to various pathogens, including viruses, bacteria, and parasites. It is produced in response to viral infections, bacterial infections, and tissue injury, and plays a crucial role in the recruitment of immune cells to sites of infection. **Clinical Significance** CCL4 has been implicated in various diseases, including: 1. Autoimmune diseases: CCL4 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. Inflammatory diseases: CCL4 has been implicated in the pathogenesis of inflammatory diseases, such as atherosclerosis and inflammatory bowel disease. 3. Cancer: CCL4 has been implicated in the metastasis of cancer cells, particularly in the recruitment of immune suppressive cells to tumor sites. 4. Viral infections: CCL4 has been implicated in the pathogenesis of viral infections, such as HIV and hepatitis C. In conclusion, CCL4 is a chemokine that plays a crucial role in the regulation of immune responses, particularly in the recruitment of immune cells to sites of inflammation. Its dysregulation has been implicated in various diseases, including autoimmune diseases, inflammatory diseases, cancer, and viral infections. Further studies are needed to fully understand the role of CCL4 in the regulation of immune responses and its implications in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.