Details for: PSME2

Gene ID: 5721

Symbol: PSME2

Ensembl ID: ENSG00000100911

Description: proteasome activator subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 331.4792
    Cell Significance Index: -51.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 160.9671
    Cell Significance Index: -66.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 157.0680
    Cell Significance Index: -63.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.7862
    Cell Significance Index: -37.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 136.7335
    Cell Significance Index: -64.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 134.7239
    Cell Significance Index: -69.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 96.2263
    Cell Significance Index: -64.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 68.5473
    Cell Significance Index: -65.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.8306
    Cell Significance Index: -57.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.9664
    Cell Significance Index: -49.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.5168
    Cell Significance Index: -61.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.6509
    Cell Significance Index: 165.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.5286
    Cell Significance Index: 83.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.1043
    Cell Significance Index: 145.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.4413
    Cell Significance Index: 127.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3882
    Cell Significance Index: 68.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3767
    Cell Significance Index: 153.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.1997
    Cell Significance Index: 50.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1995
    Cell Significance Index: 239.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.9040
    Cell Significance Index: 21.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6494
    Cell Significance Index: 194.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6006
    Cell Significance Index: 874.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4774
    Cell Significance Index: 181.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4402
    Cell Significance Index: 67.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4242
    Cell Significance Index: 256.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3718
    Cell Significance Index: 175.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3689
    Cell Significance Index: 135.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3583
    Cell Significance Index: 600.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2786
    Cell Significance Index: 165.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2396
    Cell Significance Index: 92.3900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.2347
    Cell Significance Index: 10.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1847
    Cell Significance Index: 162.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1791
    Cell Significance Index: 83.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1569
    Cell Significance Index: 31.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1166
    Cell Significance Index: 29.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0207
    Cell Significance Index: 53.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8452
    Cell Significance Index: 18.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7314
    Cell Significance Index: 6.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6912
    Cell Significance Index: 12.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6256
    Cell Significance Index: 101.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6002
    Cell Significance Index: 541.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3725
    Cell Significance Index: 63.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3104
    Cell Significance Index: 59.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3097
    Cell Significance Index: 8.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2627
    Cell Significance Index: 3.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2281
    Cell Significance Index: 10.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2118
    Cell Significance Index: 160.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1744
    Cell Significance Index: 4.6600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1598
    Cell Significance Index: 1.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1446
    Cell Significance Index: 7.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0721
    Cell Significance Index: 1.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0282
    Cell Significance Index: 0.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0237
    Cell Significance Index: 0.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0151
    Cell Significance Index: 0.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0133
    Cell Significance Index: 9.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0116
    Cell Significance Index: 0.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0058
    Cell Significance Index: 0.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0225
    Cell Significance Index: -16.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0228
    Cell Significance Index: -43.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0332
    Cell Significance Index: -11.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0384
    Cell Significance Index: -70.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0460
    Cell Significance Index: -25.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0471
    Cell Significance Index: -72.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0522
    Cell Significance Index: -32.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0548
    Cell Significance Index: -74.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0673
    Cell Significance Index: -1.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0752
    Cell Significance Index: -14.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0868
    Cell Significance Index: -55.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1308
    Cell Significance Index: -5.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1412
    Cell Significance Index: -29.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1435
    Cell Significance Index: -16.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1496
    Cell Significance Index: -67.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1601
    Cell Significance Index: -4.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1738
    Cell Significance Index: -20.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1866
    Cell Significance Index: -37.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1891
    Cell Significance Index: -54.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2374
    Cell Significance Index: -5.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3244
    Cell Significance Index: -6.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3316
    Cell Significance Index: -8.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3777
    Cell Significance Index: -54.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4509
    Cell Significance Index: -51.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4663
    Cell Significance Index: -2.8200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5694
    Cell Significance Index: -6.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5864
    Cell Significance Index: -61.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6006
    Cell Significance Index: -47.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6358
    Cell Significance Index: -22.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6536
    Cell Significance Index: -45.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7042
    Cell Significance Index: -42.2800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7125
    Cell Significance Index: -4.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7153
    Cell Significance Index: -9.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7204
    Cell Significance Index: -20.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7367
    Cell Significance Index: -46.4300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7565
    Cell Significance Index: -10.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8164
    Cell Significance Index: -62.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8858
    Cell Significance Index: -9.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9206
    Cell Significance Index: -56.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9467
    Cell Significance Index: -16.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9530
    Cell Significance Index: -25.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9547
    Cell Significance Index: -53.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0428
    Cell Significance Index: -13.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PSME2 is a highly conserved gene that is expressed in a wide range of tissues and cell types, including immune cells, cancer cells, and embryonic development. The gene encodes a regulatory subunit of the 11S proteasome, which is composed of two alpha subunits and seven beta subunits. The PSME2 protein is a key component of the UPS, which is responsible for the degradation of proteins that are marked by ubiquitin chains. The PSME2 protein plays a crucial role in the activation of the proteasome and the subsequent degradation of proteins. **Pathways and Functions** PSME2 is involved in various cellular processes, including: 1. **Antigen processing and presentation**: PSME2 is essential for the activation of the proteasome and the subsequent degradation of antigens, which are then presented to T cells and other immune cells. 2. **Apoptosis**: PSME2 plays a role in regulating apoptosis, or programmed cell death, by controlling the degradation of pro-apoptotic proteins. 3. **Cell cycle regulation**: PSME2 is involved in regulating the cell cycle by controlling the degradation of proteins that are essential for cell cycle progression. 4. **Immune system regulation**: PSME2 is essential for the regulation of the immune system, including the activation of T cells and natural killer cells. 5. **Cancer development**: Abnormal expression or dysfunction of PSME2 has been linked to cancer development and progression. **Clinical Significance** Dysregulation of PSME2 has been implicated in various diseases, including: 1. **Cancer**: Abnormal expression or dysfunction of PSME2 has been linked to cancer development and progression, including breast cancer, lung cancer, and colon cancer. 2. **Autoimmune disorders**: PSME2 is involved in the regulation of the immune system, and dysregulation of PSME2 has been implicated in autoimmune disorders, including rheumatoid arthritis and lupus. 3. **Infectious diseases**: PSME2 is essential for the regulation of the immune system, and dysregulation of PSME2 has been implicated in infectious diseases, including HIV and tuberculosis. 4. **Neurodegenerative diseases**: PSME2 is involved in the regulation of protein degradation, and dysregulation of PSME2 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, PSME2 is a critical gene that plays a vital role in protein degradation and regulation of various cellular processes. Dysregulation of PSME2 has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. Further research is needed to fully understand the mechanisms by which PSME2 regulates cellular processes and to develop therapeutic strategies to target PSME2 in disease treatment.

Genular Protein ID: 2385010592

Symbol: PSME2_HUMAN

Name: Proteasome activator complex subunit 2

UniProtKB Accession Codes:

Q9UL46 Q15129

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 4 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 60 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10199920

Title: Organization of the genes encoding the human proteasome activators PA28alpha and beta.

PubMed ID: 10199920

DOI: 10.1007/s002510050517

PubMed ID: 7789512

Title: Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome.

PubMed ID: 7789512

DOI: 10.1016/0014-5793(95)00492-r

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 239
  • Mass: 27402
  • Checksum: 98A30D83B3F93A91
  • Sequence:
    • MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED SLNVADLTSL 
RAPLDIPIPD PPPKDDEMET DKQEKKEVHK CGFLPGNEKV LSLLALVKPE VWTLKEKCIL 
VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK 
ETHVMDYRAL VHERDEAAYG ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.