Details for: BIN2

Gene ID: 51411

Symbol: BIN2

Ensembl ID: ENSG00000110934

Description: bridging integrator 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 77.1480
    Cell Significance Index: -12.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.9039
    Cell Significance Index: -17.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.1791
    Cell Significance Index: -18.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.7488
    Cell Significance Index: -18.8600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 12.3727
    Cell Significance Index: 33.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9922
    Cell Significance Index: -12.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1997
    Cell Significance Index: -11.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5614
    Cell Significance Index: -14.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3451
    Cell Significance Index: -13.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1179
    Cell Significance Index: 91.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6141
    Cell Significance Index: 69.8000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.2484
    Cell Significance Index: 6.8500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1745
    Cell Significance Index: 40.1900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.4342
    Cell Significance Index: 15.2600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.1700
    Cell Significance Index: 7.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0934
    Cell Significance Index: 208.0800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.9903
    Cell Significance Index: 9.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9159
    Cell Significance Index: 24.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 0.7097
    Cell Significance Index: -0.1800
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.6135
    Cell Significance Index: 4.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5653
    Cell Significance Index: 12.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5166
    Cell Significance Index: 466.4600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4145
    Cell Significance Index: 2.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3903
    Cell Significance Index: 42.4500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.3887
    Cell Significance Index: 3.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3819
    Cell Significance Index: 22.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3698
    Cell Significance Index: 36.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3640
    Cell Significance Index: 42.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3540
    Cell Significance Index: 57.5800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.2726
    Cell Significance Index: 1.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1398
    Cell Significance Index: 9.6700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1225
    Cell Significance Index: 1.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0708
    Cell Significance Index: 2.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0563
    Cell Significance Index: 1.9800
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.0508
    Cell Significance Index: 0.1300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0500
    Cell Significance Index: 0.4100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0320
    Cell Significance Index: 0.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0210
    Cell Significance Index: 0.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0147
    Cell Significance Index: 0.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0008
    Cell Significance Index: -0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0018
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0043
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0073
    Cell Significance Index: -9.8900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0109
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0160
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0221
    Cell Significance Index: -13.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0235
    Cell Significance Index: -2.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0235
    Cell Significance Index: -13.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0237
    Cell Significance Index: -12.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0252
    Cell Significance Index: -9.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0255
    Cell Significance Index: -18.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0263
    Cell Significance Index: -0.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0269
    Cell Significance Index: -17.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0336
    Cell Significance Index: -15.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0346
    Cell Significance Index: -15.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0414
    Cell Significance Index: -11.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0652
    Cell Significance Index: -13.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0674
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0681
    Cell Significance Index: -11.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0778
    Cell Significance Index: -14.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0905
    Cell Significance Index: -1.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0905
    Cell Significance Index: -12.4300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0916
    Cell Significance Index: -0.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0949
    Cell Significance Index: -6.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0958
    Cell Significance Index: -13.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1070
    Cell Significance Index: -2.2200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1099
    Cell Significance Index: -0.8600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1113
    Cell Significance Index: -1.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1132
    Cell Significance Index: -14.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1150
    Cell Significance Index: -7.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1183
    Cell Significance Index: -12.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1197
    Cell Significance Index: -13.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1241
    Cell Significance Index: -15.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1249
    Cell Significance Index: -5.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1295
    Cell Significance Index: -2.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1493
    Cell Significance Index: -19.1400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1494
    Cell Significance Index: -1.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1515
    Cell Significance Index: -7.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1563
    Cell Significance Index: -12.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1804
    Cell Significance Index: -9.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1820
    Cell Significance Index: -12.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2096
    Cell Significance Index: -15.6200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2206
    Cell Significance Index: -2.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2267
    Cell Significance Index: -13.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2281
    Cell Significance Index: -11.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2364
    Cell Significance Index: -18.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2410
    Cell Significance Index: -6.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2463
    Cell Significance Index: -13.8200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2524
    Cell Significance Index: -2.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2557
    Cell Significance Index: -11.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2639
    Cell Significance Index: -13.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2666
    Cell Significance Index: -14.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2887
    Cell Significance Index: -4.3500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2999
    Cell Significance Index: -3.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3078
    Cell Significance Index: -14.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BIN2 is a bridging integrator protein that belongs to the BNI2 family. It is characterized by its ability to interact with various proteins and lipids, including phospholipids, to regulate the organization of the actin cytoskeleton and cell signaling pathways. BIN2 is highly expressed in immune cells, including T cells, B cells, and myeloid cells, and is also found in non-immune cells, such as epithelial and endothelial cells. **Pathways and Functions:** BIN2 is involved in several key signaling pathways, including: 1. **Cell signaling by membrane-tethered fusions of pdgfra or pdgfrb**: BIN2 acts as a scaffold protein to regulate the interaction between membrane-tethered receptors and their downstream signaling molecules. 2. **Signaling by pdgfr in disease**: BIN2 is involved in the regulation of PDGFR signaling, which is critical for cell growth, differentiation, and survival. 3. **Innate and adaptive immune responses**: BIN2 regulates the organization of the actin cytoskeleton and cell signaling pathways in immune cells, including T cells, B cells, and myeloid cells. 4. **Phagocytosis and engulfment**: BIN2 is involved in the regulation of phagocytosis and engulfment by immune cells, including neutrophils and macrophages. **Clinical Significance:** BIN2 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: BIN2 has been shown to play a role in the regulation of immune responses and the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: BIN2 has been implicated in the regulation of cell growth, differentiation, and survival in cancer cells, including T cells and B cells. 3. **Infectious diseases**: BIN2 has been shown to play a role in the regulation of immune responses to infectious diseases, including HIV and tuberculosis. In conclusion, BIN2 is a multifunctional gene that plays a critical role in the regulation of immune cell function and signaling. Its dysregulation has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. Further research is needed to fully understand the mechanisms by which BIN2 regulates immune responses and to explore its potential as a therapeutic target. **Significantly expressed cells:** 1. Polychromatophilic erythroblast 2. Mucosal type mast cell 3. Peripheral blood mononuclear cell 4. Ciliated cell of the bronchus 5. Hepatic pit cell 6. Orthochromatic erythroblast 7. Epidermal Langerhans cell 8. CD8-positive, alpha-beta regulatory T cell 9. CD4-positive, alpha-beta memory T cell 10. Stromal cell of bone marrow 11. CD45RO-positive **Proteins:** 1. BIN2_HUMAN (Bridging integrator 2)

Genular Protein ID: 3765929024

Symbol: BIN2_HUMAN

Name: Bridging integrator 2

UniProtKB Accession Codes:

Q9UBW5 B7Z6F3 F5H0W4 Q86VV0 Q9NWK4 Q9UKN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10903846

Title: Bin2, a functionally nonredundant member of the BAR adaptor gene family.

PubMed ID: 10903846

DOI: 10.1006/geno.2000.6216

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23285027

Title: Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.

PubMed ID: 23285027

DOI: 10.1371/journal.pone.0052401

Sequence Information:

  • Length: 565
  • Mass: 61874
  • Checksum: B1D1FB89A97E9E43
  • Sequence:
    • MAEGKAGGAA GLFAKQVQKK FSRAQEKVLQ KLGKAVETKD ERFEQSASNF YQQQAEGHKL 
YKDLKNFLSA VKVMHESSKR VSETLQEIYS SEWDGHEELK AIVWNNDLLW EDYEEKLADQ 
AVRTMEIYVA QFSEIKERIA KRGRKLVDYD SARHHLEAVQ NAKKKDEAKT AKAEEEFNKA 
QTVFEDLNQE LLEELPILYN SRIGCYVTIF QNISNLRDVF YREMSKLNHN LYEVMSKLEK 
QHSNKVFVVK GLSSSSRRSL VISPPVRTAT VSSPLTSPTS PSTLSLKSES ESVSATEDLA 
PDAAQGEDNS EIKELLEEEE IEKEGSEASS SEEDEPLPAC NGPAQAQPSP TTERAKSQEE 
VLPSSTTPSP GGALSPSGQP SSSATEVVLR TRTASEGSEQ PKKRASIQRT SAPPSRPPPP 
RATASPRPSS GNIPSSPTAS GGGSPTSPRA SLGTGTASPR TSLEVSPNPE PPEKPVRTPE 
AKENENIHNQ NPEELCTSPT LMTSQVASEP GEAKKMEDKE KDNKLISANS SEGQDQLQVS 
MVPENNNLTA PEPQEEVSTS ENPQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.