Details for: PSME1

Gene ID: 5720

Symbol: PSME1

Ensembl ID: ENSG00000092010

Description: proteasome activator subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 359.1881
    Cell Significance Index: -55.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 224.8466
    Cell Significance Index: -92.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 215.4793
    Cell Significance Index: -87.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 185.2908
    Cell Significance Index: -87.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 181.4885
    Cell Significance Index: -93.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.3072
    Cell Significance Index: -42.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 130.8750
    Cell Significance Index: -87.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 94.4600
    Cell Significance Index: -90.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.9129
    Cell Significance Index: -73.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.2277
    Cell Significance Index: -65.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.9501
    Cell Significance Index: -82.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 12.9981
    Cell Significance Index: 324.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.1357
    Cell Significance Index: -26.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 7.6580
    Cell Significance Index: 892.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.9943
    Cell Significance Index: 110.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.8194
    Cell Significance Index: 170.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0203
    Cell Significance Index: 259.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.3919
    Cell Significance Index: 417.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.3703
    Cell Significance Index: 175.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.2431
    Cell Significance Index: 445.3700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.1337
    Cell Significance Index: 35.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.0766
    Cell Significance Index: 500.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.7171
    Cell Significance Index: 489.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7084
    Cell Significance Index: 73.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.6823
    Cell Significance Index: 47.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6537
    Cell Significance Index: 124.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.5808
    Cell Significance Index: 304.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4430
    Cell Significance Index: 1334.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.3683
    Cell Significance Index: 1047.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.3083
    Cell Significance Index: 53.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2425
    Cell Significance Index: 167.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9938
    Cell Significance Index: 141.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9133
    Cell Significance Index: 50.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9089
    Cell Significance Index: 188.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.8296
    Cell Significance Index: 236.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8200
    Cell Significance Index: 233.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5434
    Cell Significance Index: 71.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1739
    Cell Significance Index: 10.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9080
    Cell Significance Index: 47.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7995
    Cell Significance Index: 17.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6133
    Cell Significance Index: 27.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.4666
    Cell Significance Index: -1.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3648
    Cell Significance Index: 69.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3213
    Cell Significance Index: 54.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2099
    Cell Significance Index: 158.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2056
    Cell Significance Index: 5.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1729
    Cell Significance Index: 4.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1603
    Cell Significance Index: 31.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1441
    Cell Significance Index: 1.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1205
    Cell Significance Index: 3.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0956
    Cell Significance Index: 5.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0483
    Cell Significance Index: 1.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0332
    Cell Significance Index: 0.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0069
    Cell Significance Index: 0.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0062
    Cell Significance Index: 0.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0110
    Cell Significance Index: -8.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0338
    Cell Significance Index: -25.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0350
    Cell Significance Index: -65.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0496
    Cell Significance Index: -91.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0612
    Cell Significance Index: -94.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0630
    Cell Significance Index: -39.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0735
    Cell Significance Index: -99.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0988
    Cell Significance Index: -3.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1099
    Cell Significance Index: -61.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1290
    Cell Significance Index: -81.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1416
    Cell Significance Index: -5.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1854
    Cell Significance Index: -39.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1914
    Cell Significance Index: -4.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1939
    Cell Significance Index: -88.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1940
    Cell Significance Index: -5.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1977
    Cell Significance Index: -22.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2066
    Cell Significance Index: -74.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2069
    Cell Significance Index: -59.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3510
    Cell Significance Index: -70.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3818
    Cell Significance Index: -12.2300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4258
    Cell Significance Index: -3.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4823
    Cell Significance Index: -13.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5640
    Cell Significance Index: -81.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5749
    Cell Significance Index: -65.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7929
    Cell Significance Index: -82.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8224
    Cell Significance Index: -11.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8427
    Cell Significance Index: -66.7400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8469
    Cell Significance Index: -14.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9067
    Cell Significance Index: -62.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9122
    Cell Significance Index: -57.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9187
    Cell Significance Index: -19.2300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.1332
    Cell Significance Index: -16.9800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.1352
    Cell Significance Index: -6.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1404
    Cell Significance Index: -6.8900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1722
    Cell Significance Index: -12.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1753
    Cell Significance Index: -90.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1889
    Cell Significance Index: -25.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2909
    Cell Significance Index: -72.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.3008
    Cell Significance Index: -37.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4349
    Cell Significance Index: -87.9700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -1.5268
    Cell Significance Index: -4.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5542
    Cell Significance Index: -38.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.5869
    Cell Significance Index: -13.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7424
    Cell Significance Index: -51.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.8369
    Cell Significance Index: -19.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The PSME1 gene is a highly conserved gene, with high sequence identity among different species. It is located on chromosome 11q13.1 in humans and is expressed in a wide range of cell types, including immune cells, hematopoietic stem cells, and cancer cells. The PSME1 protein is a subunit of the 11S regulatory particle, which is composed of seven identical subunits. This subunit is responsible for the assembly and maturation of the 26S proteasome. **Pathways and Functions** The PSME1 gene is involved in several key cellular pathways, including: 1. **Protein Degradation**: The PSME1 protein is essential for the proper functioning of the proteasome, which is responsible for degrading damaged or misfolded proteins. 2. **Cell Cycle Progression**: The PSME1 protein is involved in the regulation of cell cycle progression, particularly during the G2/M phase. 3. **Immune Responses**: The PSME1 protein is expressed in immune cells, such as T cells and natural killer cells, and plays a role in the regulation of immune responses. 4. **Cancer**: Abnormal expression or mutations of the PSME1 gene have been linked to various cancers, including breast, lung, and colon cancer. 5. **Autoimmune Disorders**: The PSME1 protein is also involved in the regulation of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. **Clinical Significance** Dysregulation of the PSME1 gene has been implicated in various diseases, including: 1. **Cancer**: Mutations or overexpression of the PSME1 gene have been linked to an increased risk of cancer. 2. **Autoimmune Disorders**: Abnormal expression of the PSME1 protein has been linked to autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious Diseases**: The PSME1 protein is also involved in the regulation of immune responses to infectious diseases, such as HIV and tuberculosis. 4. **Neurological Disorders**: Abnormal expression of the PSME1 gene has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the PSME1 gene plays a crucial role in the regulation of various cellular processes, including protein degradation, cell cycle progression, and immune responses. Abnormal expression or mutations of the PSME1 gene have been linked to various diseases, including cancer, autoimmune disorders, and infectious diseases. Further research is needed to fully understand the mechanisms by which the PSME1 gene regulates cellular processes and to develop effective therapeutic strategies for the treatment of related diseases.

Genular Protein ID: 4210852874

Symbol: PSME1_HUMAN

Name: Proteasome activator complex subunit 1

UniProtKB Accession Codes:

Q06323 A6NJG9 H0YNE3 Q6IBM2 Q9UEF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 EMDB 4 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 59 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8269930

Title: Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111.

PubMed ID: 8269930

DOI: 10.1111/j.1432-1033.1993.tb18392.x

PubMed ID: 8051173

Title: Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease.

PubMed ID: 8051173

DOI: 10.1016/s0021-9258(17)32052-5

PubMed ID: 10199920

Title: Organization of the genes encoding the human proteasome activators PA28alpha and beta.

PubMed ID: 10199920

DOI: 10.1007/s002510050517

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9590240

Title: Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes.

PubMed ID: 9590240

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 9385652

Title: The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer.

PubMed ID: 9385652

DOI: 10.1002/pro.5560061123

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9403698

Title: Structure of the proteasome activator REGalpha (PA28alpha).

PubMed ID: 9403698

DOI: 10.1038/37670

Sequence Information:

  • Length: 249
  • Mass: 28723
  • Checksum: 5E27727E5A0B0AAB
  • Sequence:
    • MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP 
LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP CGPVNCNEKI VVLLQRLKPE 
IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TSLHTKLEGF HTQISKYFSE 
RGDAVTKAAK QPHVGDYRQL VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP 
RGETKGMIY

Genular Protein ID: 968695209

Symbol: Q86SZ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86SZ9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 174
  • Mass: 20035
  • Checksum: 80BD30573C725191
  • Sequence:
    • RKKQQEKEDK DEKKKGEDED KGPPCGPVNC NEKIVVLLQR LKPEIKDVIE QLNLVTTWLQ 
LQIPRIEDGN NFGVAVQEKV FELMTSLHTK LEGFHTQISK YFSERGDAVT KAAKQPHVGD 
YRQLVHELDE AEYRDIRLMV MEIRNAYVRR QGQGRGGQRQ LSQATHSLTL QARG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.