Details for: IFITM1

Gene ID: 8519

Symbol: IFITM1

Ensembl ID: ENSG00000185885

Description: interferon induced transmembrane protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 243.4662
    Cell Significance Index: -37.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.8383
    Cell Significance Index: -36.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 117.0441
    Cell Significance Index: -47.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 103.6188
    Cell Significance Index: -53.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.5922
    Cell Significance Index: -40.4100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 54.2950
    Cell Significance Index: 145.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.3911
    Cell Significance Index: -50.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.7067
    Cell Significance Index: -37.8600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 11.7415
    Cell Significance Index: 35.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.7055
    Cell Significance Index: -29.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6147
    Cell Significance Index: -37.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.9741
    Cell Significance Index: 263.5600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 8.4455
    Cell Significance Index: 41.0800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 6.1166
    Cell Significance Index: 35.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.1720
    Cell Significance Index: 269.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.0186
    Cell Significance Index: 51.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.3970
    Cell Significance Index: -9.1000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 2.6617
    Cell Significance Index: 9.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3131
    Cell Significance Index: 317.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.0047
    Cell Significance Index: 256.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9815
    Cell Significance Index: 35.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.9633
    Cell Significance Index: 373.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3219
    Cell Significance Index: 130.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9817
    Cell Significance Index: 886.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9276
    Cell Significance Index: 26.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9161
    Cell Significance Index: 19.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7386
    Cell Significance Index: 120.1200
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.5986
    Cell Significance Index: 1.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4560
    Cell Significance Index: 11.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3697
    Cell Significance Index: 43.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3098
    Cell Significance Index: 18.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2843
    Cell Significance Index: 3.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2518
    Cell Significance Index: 137.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2110
    Cell Significance Index: 14.6000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.1992
    Cell Significance Index: 0.9200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1037
    Cell Significance Index: 1.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0936
    Cell Significance Index: 3.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0825
    Cell Significance Index: 9.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0130
    Cell Significance Index: 9.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0097
    Cell Significance Index: 6.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0159
    Cell Significance Index: -7.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0196
    Cell Significance Index: -36.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0206
    Cell Significance Index: -1.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0318
    Cell Significance Index: -1.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0355
    Cell Significance Index: -20.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0397
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0487
    Cell Significance Index: -10.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0668
    Cell Significance Index: -1.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0743
    Cell Significance Index: -54.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0785
    Cell Significance Index: -3.5600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0816
    Cell Significance Index: -0.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0824
    Cell Significance Index: -52.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0849
    Cell Significance Index: -1.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1088
    Cell Significance Index: -49.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1100
    Cell Significance Index: -18.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1529
    Cell Significance Index: -44.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1567
    Cell Significance Index: -3.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1903
    Cell Significance Index: -34.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1960
    Cell Significance Index: -39.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1970
    Cell Significance Index: -22.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2013
    Cell Significance Index: -5.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2217
    Cell Significance Index: -7.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2268
    Cell Significance Index: -5.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2617
    Cell Significance Index: -4.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2738
    Cell Significance Index: -4.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2804
    Cell Significance Index: -34.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2980
    Cell Significance Index: -30.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3047
    Cell Significance Index: -18.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3054
    Cell Significance Index: -22.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3087
    Cell Significance Index: -14.5100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.3149
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3169
    Cell Significance Index: -36.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3195
    Cell Significance Index: -41.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3209
    Cell Significance Index: -46.6500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3253
    Cell Significance Index: -5.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3408
    Cell Significance Index: -7.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3661
    Cell Significance Index: -38.1200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.3728
    Cell Significance Index: -4.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4025
    Cell Significance Index: -28.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4853
    Cell Significance Index: -13.2100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.5052
    Cell Significance Index: -3.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5210
    Cell Significance Index: -39.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5327
    Cell Significance Index: -32.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5464
    Cell Significance Index: -4.5900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.5578
    Cell Significance Index: -4.1500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.6131
    Cell Significance Index: -4.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6914
    Cell Significance Index: -54.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7068
    Cell Significance Index: -45.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7369
    Cell Significance Index: -41.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7665
    Cell Significance Index: -39.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7897
    Cell Significance Index: -41.4600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.8121
    Cell Significance Index: -6.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8333
    Cell Significance Index: -22.2900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8520
    Cell Significance Index: -11.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8600
    Cell Significance Index: -12.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8649
    Cell Significance Index: -12.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8661
    Cell Significance Index: -40.3800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.9218
    Cell Significance Index: -6.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.0013
    Cell Significance Index: -43.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFITM1 is a transmembrane protein that belongs to the Dispanin subfamily. It is characterized by its ability to bind to various proteins, including interferons, and to modulate immune responses. IFITM1 is highly expressed in cells of the adaptive immune system, including T cells, dendritic cells, and monocytes, and is involved in the regulation of cell migration, proliferation, and viral entry. The protein's expression is induced by interferons, which are key players in the innate immune response against viral infections. **Pathways and Functions:** IFITM1's mechanisms of action are closely linked to the interferon signaling pathway, which is critical for the defense against viral infections. The protein's functions can be broadly categorized into the following: 1. **Negative regulation of cell migration**: IFITM1 can inhibit the migration of immune cells, such as T cells and monocytes, which can prevent the spread of viral infections. 2. **Negative regulation of cell population proliferation**: IFITM1 can also inhibit the proliferation of immune cells, which can prevent the overactivation of the immune response. 3. **Negative regulation of viral entry into host cells**: IFITM1 can prevent the entry of viruses into host cells by interacting with viral proteins and inhibiting their function. 4. **Negative regulation of viral genome replication**: IFITM1 can also inhibit the replication of viral genomes by interacting with viral proteins and preventing their function. **Clinical Significance:** IFITM1's role in immune regulation has significant clinical implications. Dysregulation of IFITM1 has been implicated in various immune-related disorders, including: 1. **Viral infections**: IFITM1's ability to prevent viral entry into host cells makes it a potential target for the treatment of viral infections. 2. **Autoimmune diseases**: IFITM1's role in regulating immune cell migration and proliferation makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: IFITM1's ability to inhibit cell migration and proliferation makes it a potential target for the treatment of cancer. In conclusion, IFITM1 is a crucial protein that plays a vital role in immune regulation. Its mechanisms of action are closely linked to the interferon signaling pathway, and its dysregulation has significant clinical implications. Further research is needed to fully understand the role of IFITM1 in immune regulation and its potential applications in the treatment of immune-related disorders.

Genular Protein ID: 4203545101

Symbol: IFM1_HUMAN

Name: Dispanin subfamily A member 2a

UniProtKB Accession Codes:

P13164 Q15322 Q53XZ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2492664

Title: A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

PubMed ID: 2492664

DOI: 10.1073/pnas.86.3.840

PubMed ID: 7559564

Title: Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth.

PubMed ID: 7559564

DOI: 10.1074/jbc.270.40.23860

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2398277

Title: TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen.

PubMed ID: 2398277

PubMed ID: 1383329

Title: The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

PubMed ID: 1383329

PubMed ID: 16847454

Title: IFITM1 plays an essential role in the antiproliferative action of interferon-gamma.

PubMed ID: 16847454

DOI: 10.1038/sj.onc.1209807

PubMed ID: 19499152

Title: Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation.

PubMed ID: 19499152

DOI: 10.1093/abbs/gmp034

PubMed ID: 20064371

Title: The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

PubMed ID: 20064371

DOI: 10.1016/j.cell.2009.12.017

PubMed ID: 21166591

Title: The small interferon-induced transmembrane genes and proteins.

PubMed ID: 21166591

DOI: 10.1089/jir.2010.0112

PubMed ID: 20838853

Title: Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells.

PubMed ID: 20838853

DOI: 10.1007/s11060-010-0377-4

PubMed ID: 21177806

Title: The IFITM proteins inhibit HIV-1 infection.

PubMed ID: 21177806

DOI: 10.1128/jvi.01531-10

PubMed ID: 21976647

Title: ISG56 and IFITM1 proteins inhibit hepatitis C virus replication.

PubMed ID: 21976647

DOI: 10.1128/jvi.05633-11

PubMed ID: 21253575

Title: Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.

PubMed ID: 21253575

DOI: 10.1371/journal.ppat.1001258

PubMed ID: 22634173

Title: IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells.

PubMed ID: 22634173

DOI: 10.1016/j.bone.2012.05.012

PubMed ID: 22479637

Title: IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.

PubMed ID: 22479637

DOI: 10.1371/journal.pone.0034508

PubMed ID: 22363774

Title: The dispanins: a novel gene family of ancient origin that contains 14 human members.

PubMed ID: 22363774

DOI: 10.1371/journal.pone.0031961

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25105503

Title: A membrane topology model for human interferon inducible transmembrane protein 1.

PubMed ID: 25105503

DOI: 10.1371/journal.pone.0104341

PubMed ID: 26354436

Title: The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.

PubMed ID: 26354436

DOI: 10.1074/jbc.m115.657346

PubMed ID: 33051876

Title: Syncytia formation by SARS-CoV-2-infected cells.

PubMed ID: 33051876

DOI: 10.15252/embj.2020106267

PubMed ID: 33522642

Title: Syncytia formation by SARS-CoV-2-infected cells.

PubMed ID: 33522642

DOI: 10.15252/embj.2020107405

PubMed ID: 33270927

Title: Opposing activities of IFITM proteins in SARS-CoV-2 infection.

PubMed ID: 33270927

DOI: 10.15252/embj.2020106501

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 125
  • Mass: 13964
  • Checksum: 10EE5B64894838ED
  • Sequence:
    • MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC CLGFIAFAYS 
VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF ILLLVFGSVT VYHIMLQIIQ 
EKRGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.