Details for: IFITM1
Gene ID: 8519
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: IFITM1
Ensembl ID: ENSG00000185885
Description: interferon induced transmembrane protein 1
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 83.25rCSI 56.09%PRS 85.79
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CSI 81.03rCSI 54.01%PRS 87.68
-
CSI 76.81rCSI 57.6%PRS 92.5
-
CSI 76.75rCSI 53.9%PRS 88.11
-
CSI 68.5rCSI 55.35%PRS 82.52
-
CSI 64.35rCSI 72.43%PRS 87.14
-
CSI 51.43rCSI 38.49%PRS 86.36
-
CSI 49rCSI 28.94%PRS 88.6
-
CSI 41.27rCSI 70.61%PRS 87.46
-
CSI 40.53rCSI 55.2%PRS 92.1
-
CSI 40.45rCSI 42.25%PRS 88.82
-
CSI 39.91rCSI 50.15%PRS 91.86
-
CSI 39.52rCSI 29.69%PRS 78.53
-
CSI 39.45rCSI 46.34%PRS 91.06
-
CSI 38.93rCSI 35.46%PRS 85.63
-
CSI 38.75rCSI 27.82%PRS 85.9
-
CSI 33.49rCSI 46.01%PRS 89.63
-
CSI 31.76rCSI 63.31%PRS 86.59
-
CSI 26.53rCSI 32.15%PRS 55.39
-
CSI 24.15rCSI 18.27%PRS 85.61
-
CSI 23.8rCSI 27.89%PRS 87.18
-
CSI 23.4rCSI 53.1%PRS 74.47
-
CSI 22.74rCSI 33.27%PRS 77.58
-
CSI 21.4rCSI 18.99%PRS 70.43
-
CSI 21.37rCSI 28.59%PRS 84.1
-
CSI 19.54rCSI 18.46%PRS 71.87
-
CSI 19.19rCSI 18.85%PRS 87.1
-
CSI 18.72rCSI 33.79%PRS 90.21
-
CSI 18.2rCSI 37.77%PRS 69.5
-
CSI 18.03rCSI 14.19%PRS 79.01
-
CSI 17.73rCSI 38.7%PRS 82.18
-
CSI 17.43rCSI 13.01%PRS 86.62
-
CSI 16.67rCSI 19.32%PRS 77.51
-
CSI 15.59rCSI 24.89%PRS 76.39
-
CSI 15.36rCSI 19.55%PRS 78.17
-
CSI 14.81rCSI 48.04%PRS 71.43
-
CSI 14.79rCSI 13.01%PRS 60.9
-
CSI 14.69rCSI 12.6%PRS 79.69
-
CSI 14.38rCSI 14.2%PRS 89.04
-
CSI 14.04rCSI 11.25%PRS 88.91
-
CSI 13.39rCSI 17.14%PRS 90.04
-
CSI 13.06rCSI 12.07%PRS 88.85
-
CSI 13.02rCSI 37.69%PRS 73.03
-
CSI 12.97rCSI 11.18%PRS 75.44
-
CSI 12.33rCSI 61.86%PRS 84.9
-
CSI 12.23rCSI 21.15%PRS 63.13
-
CSI 12.14rCSI 11.93%PRS 88.73
-
CSI 11.95rCSI 14.89%PRS 82.88
-
CSI 11.72rCSI 63.41%PRS 93.14
-
CSI 11.51rCSI 27.49%PRS 78.49
-
CSI 10.97rCSI 11.36%PRS 77.88
-
CSI 10.45rCSI 8.29%PRS 91.01
-
CSI 10.38rCSI 15.2%PRS 83.01
-
CSI 9.94rCSI 15.93%PRS 87.78
-
CSI 9.74rCSI 12.05%PRS 69.85
-
CSI 9.52rCSI 43.27%PRS 92.52
-
CSI 9.45rCSI 14.73%PRS 91.71
-
CSI 9.21rCSI 11.78%PRS 87.27
-
CSI 9.08rCSI 6.32%PRS 87.02
-
CSI 8.87rCSI 9.08%PRS 83.23
-
CSI 8.58rCSI 8.99%PRS 69.68
-
CSI 8.55rCSI 11.84%PRS 71.39
-
CSI 8.45rCSI 9.68%PRS 86.57
-
CSI 8.33rCSI 16.28%PRS 93.38
-
CSI 8.28rCSI 16.04%PRS 87.92
-
CSI 8.12rCSI 8.47%PRS 72.41
-
CSI 8.06rCSI 22.67%PRS 68.28
-
CSI 8.01rCSI 20.35%PRS 66.13
-
CSI 7.94rCSI 16.4%PRS 71.36
-
CSI 7.85rCSI 20.31%PRS 92.01
-
CSI 7.82rCSI 6.36%PRS 72.6
-
CSI 7.71rCSI 12.5%PRS 68.23
-
CSI 7.7rCSI 13.49%PRS 65.28
-
CSI 7.66rCSI 6.4%PRS 77.27
-
CSI 7.65rCSI 9.13%PRS 89.1
-
CSI 7.36rCSI 10.01%PRS 82.39
-
CSI 7.18rCSI 13.58%PRS 86.5
-
CSI 7.12rCSI 6.86%PRS 72.15
-
CSI 7.1rCSI 8.75%PRS 80.69
-
CSI 6.95rCSI 9.82%PRS 74.06
-
CSI 6.92rCSI 5.39%PRS 88.3
-
CSI 6.63rCSI 6.17%PRS 73.37
-
CSI 6.53rCSI 5.5%PRS 87.19
-
CSI 6.43rCSI 11.62%PRS 81.5
-
CSI 6.27rCSI 22.25%PRS 78.62
-
CSI 6.22rCSI 4.73%PRS 85.31
-
CSI 6.2rCSI 11.95%PRS 92.61
-
CSI 6.06rCSI 4.5%PRS 84.73
-
CSI 5.99rCSI 11.34%PRS 94.14
-
CSI 5.87rCSI 4.86%PRS 72.92
-
CSI 5.86rCSI 6.88%PRS 74.65
-
CSI 5.68rCSI 4.98%PRS 78.01
-
CSI 5.59rCSI 6.49%PRS 78.27
-
CSI 5.41rCSI 33.4%PRS 84.77
-
CSI 5.39rCSI 30.15%PRS 76.45
-
CSI 5.38rCSI 7.05%PRS 84.67
-
CSI 5.37rCSI 6.43%PRS 85.8
-
CSI 5.31rCSI 16.35%PRS 78.43
-
CSI 5.16rCSI 7.06%PRS 78.01
-
CSI 5.15rCSI 5.14%PRS 66.21
-
CSI 0.4rCSI 9.4%PRS 85.5%
-
CSI 0.4rCSI 2.2%PRS 79.1%
-
CSI 0.5rCSI 3.1%PRS 78.9%
-
CSI 0.6rCSI 12.2%PRS 93.0%
-
CSI 0.8rCSI 11.7%PRS 95.4%
-
CSI 0.9rCSI 21.6%PRS 84.6%
-
CSI 1.0rCSI 5.3%PRS 84.2%
-
CSI 1.0rCSI 9.7%PRS 90.9%
-
CSI 1.0rCSI 6.6%PRS 82.0%
-
CSI 1.0rCSI 4.3%PRS 81.0%
-
CSI 1.1rCSI 2.4%PRS 67.5%
-
CSI 1.1rCSI 10.7%PRS 92.3%
-
CSI 1.1rCSI 1.0%PRS 70.0%
-
CSI 1.1rCSI 3.8%PRS 82.7%
-
CSI 1.1rCSI 3.2%PRS 80.7%
-
CSI 1.3rCSI 9.8%PRS 76.4%
-
CSI 1.4rCSI 3.8%PRS 87.2%
-
CSI 1.5rCSI 2.3%PRS 81.9%
-
CSI 1.6rCSI 5.7%PRS 89.4%
-
CSI 1.6rCSI 4.3%PRS 63.6%
-
CSI 1.8rCSI 2.8%PRS 86.0%
-
CSI 1.9rCSI 59.0%PRS 94.1%
-
CSI 1.9rCSI 2.8%PRS 74.6%
-
CSI 2.0rCSI 3.6%PRS 85.2%
-
CSI 2.0rCSI 2.2%PRS 73.2%
-
CSI 2.2rCSI 5.1%PRS 86.3%
-
CSI 2.2rCSI 1.7%PRS 76.0%
-
CSI 2.3rCSI 5.5%PRS 74.6%
-
CSI 2.5rCSI 2.3%PRS 81.5%
-
CSI 2.5rCSI 6.9%PRS 81.7%
-
CSI 2.7rCSI 3.9%PRS 86.7%
-
CSI 2.7rCSI 4.4%PRS 73.3%
-
CSI 2.8rCSI 19.6%PRS 81.3%
-
CSI 2.8rCSI 11.7%PRS 80.9%
-
CSI 2.8rCSI 4.7%PRS 77.6%
-
CSI 3.0rCSI 2.8%PRS 74.3%
-
CSI 3.1rCSI 4.8%PRS 74.5%
-
CSI 3.1rCSI 3.7%PRS 81.3%
-
CSI 3.2rCSI 5.7%PRS 83.3%
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CSI 3.2rCSI 3.9%PRS 79.6%
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CSI 3.2rCSI 11.0%PRS 88.9%
-
CSI 3.2rCSI 12.0%PRS 64.5%
-
CSI 3.3rCSI 3.9%PRS 70.7%
-
CSI 3.4rCSI 64.8%PRS 93.4%
-
CSI 3.5rCSI 18.9%PRS 70.0%
-
CSI 3.5rCSI 3.1%PRS 82.9%
-
CSI 3.6rCSI 8.6%PRS 94.9%
-
CSI 3.7rCSI 2.6%PRS 84.0%
-
CSI 3.7rCSI 8.2%PRS 76.8%
-
CSI 3.8rCSI 5.7%PRS 77.9%
-
CSI 3.9rCSI 5.0%PRS 76.6%
-
CSI 4.0rCSI 6.1%PRS 83.2%
-
CSI 4.1rCSI 11.7%PRS 90.3%
-
CSI 4.1rCSI 10.7%PRS 80.7%
-
CSI 4.1rCSI 2.7%PRS 75.4%
-
CSI 4.1rCSI 4.8%PRS 63.9%
-
CSI 4.2rCSI 3.4%PRS 74.7%
-
CSI 4.2rCSI 19.1%PRS 83.3%
-
CSI 4.3rCSI 17.6%PRS 72.4%
-
CSI 4.3rCSI 24.9%PRS 81.0%
-
CSI 4.4rCSI 25.6%PRS 81.9%
-
CSI 4.5rCSI 27.4%PRS 87.0%
-
CSI 4.7rCSI 13.5%PRS 81.6%
-
CSI 4.8rCSI 5.0%PRS 70.3%
-
CSI 4.9rCSI 13.4%PRS 84.3%
-
CSI 5.0rCSI 39.5%PRS 84.4%
-
CSI 5.0rCSI 7.6%PRS 81.2%
-
CSI 5.0rCSI 20.2%PRS 71.8%
-
CSI 5.0rCSI 8.8%PRS 79.4%
-
CSI 5.0rCSI 3.9%PRS 74.7%
-
CSI 5.1rCSI 11.4%PRS 80.6%
-
CSI 5.1rCSI 7.5%PRS 67.5%
-
CSI 5.1rCSI 23.5%PRS 79.4%
-
CSI 5.2rCSI 5.1%PRS 66.2%
-
CSI 5.2rCSI 7.1%PRS 78.0%
-
CSI 5.3rCSI 16.4%PRS 78.4%
-
CSI 5.4rCSI 6.4%PRS 85.8%
-
CSI 5.4rCSI 7.1%PRS 84.7%
-
CSI 5.4rCSI 30.2%PRS 76.5%
-
CSI 5.4rCSI 33.4%PRS 84.8%
-
CSI 5.6rCSI 6.5%PRS 78.3%
-
CSI 5.7rCSI 5.0%PRS 78.0%
-
CSI 5.9rCSI 6.9%PRS 74.7%
-
CSI 5.9rCSI 4.9%PRS 72.9%
-
CSI 6.0rCSI 11.3%PRS 94.1%
-
CSI 6.1rCSI 4.5%PRS 84.7%
-
CSI 6.2rCSI 12.0%PRS 92.6%
-
CSI 6.2rCSI 4.7%PRS 85.3%
-
CSI 6.3rCSI 22.3%PRS 78.6%
-
CSI 6.4rCSI 11.6%PRS 81.5%
-
CSI 6.5rCSI 5.5%PRS 87.2%
-
CSI 6.6rCSI 6.2%PRS 73.4%
-
CSI 6.9rCSI 5.4%PRS 88.3%
-
CSI 7.0rCSI 9.8%PRS 74.1%
-
CSI 7.1rCSI 8.8%PRS 80.7%
-
CSI 7.1rCSI 6.9%PRS 72.2%
-
CSI 7.2rCSI 13.6%PRS 86.5%
-
CSI 7.4rCSI 10.0%PRS 82.4%
-
CSI 7.7rCSI 9.1%PRS 89.1%
-
CSI 7.7rCSI 6.4%PRS 77.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4203545101
Symbol: IFM1_HUMAN
Name: Dispanin subfamily A member 2a
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2492664
Title: A single DNA response element can confer inducibility by both alpha- and gamma-interferons.
PubMed ID: 2492664
PubMed ID: 7559564
Title: Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth.
PubMed ID: 7559564
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2398277
Title: TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen.
PubMed ID: 2398277
PubMed ID: 1383329
Title: The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.
PubMed ID: 1383329
PubMed ID: 16847454
Title: IFITM1 plays an essential role in the antiproliferative action of interferon-gamma.
PubMed ID: 16847454
PubMed ID: 19499152
Title: Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation.
PubMed ID: 19499152
DOI: 10.1093/abbs/gmp034
PubMed ID: 20064371
Title: The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
PubMed ID: 20064371
PubMed ID: 21166591
Title: The small interferon-induced transmembrane genes and proteins.
PubMed ID: 21166591
PubMed ID: 20838853
Title: Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells.
PubMed ID: 20838853
PubMed ID: 21177806
PubMed ID: 21976647
Title: ISG56 and IFITM1 proteins inhibit hepatitis C virus replication.
PubMed ID: 21976647
DOI: 10.1128/jvi.05633-11
PubMed ID: 21253575
Title: Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
PubMed ID: 21253575
PubMed ID: 22634173
Title: IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells.
PubMed ID: 22634173
PubMed ID: 22479637
Title: IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.
PubMed ID: 22479637
PubMed ID: 22363774
Title: The dispanins: a novel gene family of ancient origin that contains 14 human members.
PubMed ID: 22363774
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25105503
Title: A membrane topology model for human interferon inducible transmembrane protein 1.
PubMed ID: 25105503
PubMed ID: 26354436
Title: The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.
PubMed ID: 26354436
PubMed ID: 33051876
Title: Syncytia formation by SARS-CoV-2-infected cells.
PubMed ID: 33051876
PubMed ID: 33522642
Title: Syncytia formation by SARS-CoV-2-infected cells.
PubMed ID: 33522642
PubMed ID: 33270927
Title: Opposing activities of IFITM proteins in SARS-CoV-2 infection.
PubMed ID: 33270927
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 125
- Mass: 13964
- Checksum: 10EE5B64894838ED
- Sequence:
MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF ILLLVFGSVT VYHIMLQIIQ EKRGY