Details for: EVL

Gene ID: 51466

Symbol: EVL

Ensembl ID: ENSG00000196405

Description: Enah/Vasp-like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 448.9691
    Cell Significance Index: -69.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 244.7925
    Cell Significance Index: -62.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 174.5385
    Cell Significance Index: -70.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 156.3153
    Cell Significance Index: -73.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 150.9569
    Cell Significance Index: -77.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 75.0359
    Cell Significance Index: -71.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.5268
    Cell Significance Index: -69.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.2207
    Cell Significance Index: -68.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.9803
    Cell Significance Index: -41.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.1929
    Cell Significance Index: -71.7900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 7.0421
    Cell Significance Index: 18.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 6.2065
    Cell Significance Index: 73.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.9233
    Cell Significance Index: 173.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4489
    Cell Significance Index: 491.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.3530
    Cell Significance Index: 144.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.3438
    Cell Significance Index: 56.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1484
    Cell Significance Index: 770.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0508
    Cell Significance Index: 115.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8891
    Cell Significance Index: 1306.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8797
    Cell Significance Index: 118.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.8713
    Cell Significance Index: 82.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7419
    Cell Significance Index: 65.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6905
    Cell Significance Index: 199.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4540
    Cell Significance Index: 288.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0062
    Cell Significance Index: 74.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9481
    Cell Significance Index: 20.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8470
    Cell Significance Index: 23.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8287
    Cell Significance Index: 113.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7150
    Cell Significance Index: 48.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6699
    Cell Significance Index: 604.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5411
    Cell Significance Index: 34.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4717
    Cell Significance Index: 46.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4520
    Cell Significance Index: 52.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3843
    Cell Significance Index: 209.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3154
    Cell Significance Index: 51.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2830
    Cell Significance Index: 4.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1274
    Cell Significance Index: 239.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1002
    Cell Significance Index: 10.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0895
    Cell Significance Index: 16.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0687
    Cell Significance Index: 30.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0432
    Cell Significance Index: 5.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0227
    Cell Significance Index: 30.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0178
    Cell Significance Index: 27.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0066
    Cell Significance Index: 3.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0063
    Cell Significance Index: 3.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0014
    Cell Significance Index: -2.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0337
    Cell Significance Index: -6.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0434
    Cell Significance Index: -1.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0556
    Cell Significance Index: -4.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0627
    Cell Significance Index: -1.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0732
    Cell Significance Index: -55.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0750
    Cell Significance Index: -55.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0817
    Cell Significance Index: -59.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1175
    Cell Significance Index: -17.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1231
    Cell Significance Index: -69.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1285
    Cell Significance Index: -80.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1505
    Cell Significance Index: -19.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1605
    Cell Significance Index: -16.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1910
    Cell Significance Index: -6.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2115
    Cell Significance Index: -36.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2242
    Cell Significance Index: -64.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2393
    Cell Significance Index: -6.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2436
    Cell Significance Index: -12.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2550
    Cell Significance Index: -15.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2977
    Cell Significance Index: -38.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3369
    Cell Significance Index: -23.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3457
    Cell Significance Index: -15.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3650
    Cell Significance Index: -76.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3770
    Cell Significance Index: -9.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4223
    Cell Significance Index: -19.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4482
    Cell Significance Index: -9.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5109
    Cell Significance Index: -26.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5265
    Cell Significance Index: -24.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5990
    Cell Significance Index: -68.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6151
    Cell Significance Index: -19.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6506
    Cell Significance Index: -67.7400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.6545
    Cell Significance Index: -10.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6871
    Cell Significance Index: -11.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7935
    Cell Significance Index: -56.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8015
    Cell Significance Index: -21.4400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.9235
    Cell Significance Index: -9.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9293
    Cell Significance Index: -73.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9556
    Cell Significance Index: -58.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9709
    Cell Significance Index: -18.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0012
    Cell Significance Index: -52.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0434
    Cell Significance Index: -33.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0614
    Cell Significance Index: -34.7500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1412
    Cell Significance Index: -22.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1746
    Cell Significance Index: -24.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2250
    Cell Significance Index: -26.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2766
    Cell Significance Index: -44.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2949
    Cell Significance Index: -22.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.3090
    Cell Significance Index: -34.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.3885
    Cell Significance Index: -19.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4986
    Cell Significance Index: -52.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.5321
    Cell Significance Index: -43.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6386
    Cell Significance Index: -40.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.6751
    Cell Significance Index: -33.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.6952
    Cell Significance Index: -42.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.7026
    Cell Significance Index: -25.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EVL is characterized by its unique expression profile, with notable presence in cells involved in immune responses, such as polychromatophilic erythroblast, mucosal type mast cell, and alpha-beta regulatory T cells. The gene's involvement in actin binding, polymerization, and depolymerization pathways is well-documented, highlighting its potential role in modulating cellular motility, morphology, and signaling. EVL's expression in smooth muscle fibers of the ileum and its association with actin filament organization also underscore its importance in tissue development and maintenance. **Pathways and Functions:** EVL's role in actin dynamics is a key aspect of its function. As an Ena/Vasp-like protein, EVL interacts with various actin-binding proteins to regulate actin filament organization, polymerization, and depolymerization. This regulatory function is essential for maintaining cellular morphology, facilitating cell migration, and modulating cell signaling pathways. Specifically, EVL's involvement in actin polymerization and depolymerization processes is critical for: 1. **Adaptive Immune System:** EVL's expression in immune cells, such as T cells and dendritic cells, suggests its role in modulating immune responses and cellular migration. 2. **Cell Surface Receptor Signaling:** EVL's interaction with actin-binding proteins can influence the organization of the cytoskeleton, thereby modulating the signaling efficiency of cell surface receptors. 3. **Axon Guidance and Nervous System Development:** EVL's expression in neurons and its role in actin filament organization may contribute to axon guidance and neuronal development. 4. **Epithelial Cell Migration and Morphogenesis:** EVL's involvement in actin polymerization and depolymerization processes can influence epithelial cell migration and tissue morphogenesis. **Clinical Significance:** The clinical significance of EVL is multifaceted, with potential implications for various diseases and disorders. For instance: 1. **Immune-related Disorders:** EVL's expression in immune cells suggests its potential role in modulating immune responses in diseases such as autoimmune disorders, allergies, and cancer. 2. **Neurological Disorders:** EVL's involvement in axon guidance and neuronal development may contribute to the pathogenesis of neurological disorders, such as stroke, neurodegenerative diseases, and developmental disorders. 3. **Cancer:** EVL's expression in cancer cells may influence tumor cell migration, invasion, and metastasis, highlighting its potential as a therapeutic target. 4. **Regenerative Medicine:** EVL's role in actin filament organization and cellular migration may make it a valuable target for regenerative medicine applications, such as tissue engineering and wound healing. In conclusion, EVL is a gene of significant interest in the realm of immunology and cellular biology, with its multifaceted expression profile and involvement in various cellular processes highlighting its potential role in modulating immune responses, cellular migration, and tissue development. Further research is necessary to fully elucidate the clinical significance of EVL and its potential applications in disease treatment and regenerative medicine.

Genular Protein ID: 2769900050

Symbol: EVL_HUMAN

Name: Ena/VASP-like protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10747096

Title: Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.

PubMed ID: 10747096

DOI: 10.1083/jcb.149.1.181

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10993894

Title: The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain.

PubMed ID: 10993894

DOI: 10.1074/jbc.m006316200

PubMed ID: 15469845

Title: Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.

PubMed ID: 15469845

DOI: 10.1016/j.devcel.2004.07.024

PubMed ID: 18158903

Title: Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding.

PubMed ID: 18158903

DOI: 10.1016/j.molcel.2007.10.033

PubMed ID: 28882895

Title: Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase.

PubMed ID: 28882895

DOI: 10.1074/jbc.m117.799650

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 416
  • Mass: 44620
  • Checksum: AD5B67458755D659
  • Sequence:
  • MSEQSICQAR ASVMVYDDTS KKWVPIKPGQ QGFSRINIYH NTASNTFRVV GVKLQDQQVV 
    INYSIVKGLK YNQATPTFHQ WRDARQVYGL NFASKEEATT FSNAMLFALN IMNSQEGGPS 
    SQRQVQNGPS PDEMDIQRRQ VMEQHQQQRQ ESLERRTSAT GPILPPGHPS SAASAPVSCS 
    GPPPPPPPPV PPPPTGATPP PPPPLPAGGA QGSSHDESSM SGLAAAIAGA KLRRVQRPED 
    ASGGSSPSGT SKSDANRASS GGGGGGLMEE MNKLLAKRRK AASQSDKPAE KKEDESQMED 
    PSTSPSPGTR AASQPPNSSE AGRKPWERSN SVEKPVSSIL SRTPSVAKSP EAKSPLQSQP 
    HSRMKPAGSV NDMALDAFDL DRMKQEILEE VVRELHKVKE EIIDAIRQEL SGISTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.