Details for: EVL
Gene ID: 51466
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: EVL
Ensembl ID: ENSG00000196405
Description: Enah/Vasp-like
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 91.88rCSI 61.23%PRS 32.02
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CSI 87.09rCSI 65.88%PRS 16.97
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CSI 80.03rCSI 60.02%PRS 34.95
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CSI 76.73rCSI 45.31%PRS 16.89
-
CSI 76.14rCSI 53.48%PRS 31.73
-
CSI 71.45rCSI 56.73%PRS 21.6
-
CSI 63.05rCSI 64.26%PRS 17.51
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CSI 59.34rCSI 66.78%PRS 19.64
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CSI 49.92rCSI 62.11%PRS 6.65
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CSI 48.78rCSI 50.95%PRS 36.7
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CSI 47.64rCSI 55.96%PRS 66.1
-
CSI 43.16rCSI 33.25%PRS 11.13
-
CSI 39.59rCSI 66.45%PRS 7.18
-
CSI 39.45rCSI 50.86%PRS 7.5
-
CSI 38.46rCSI 61.86%PRS 7.9
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CSI 36.7rCSI 46.12%PRS 52.29
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CSI 36.64rCSI 66.14%PRS 32.46
-
CSI 33.69rCSI 81.87%PRS 7
-
CSI 32.72rCSI 24.49%PRS 19.87
-
CSI 32.3rCSI 44.01%PRS 10.95
-
CSI 31.54rCSI 25.49%PRS 20.26
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CSI 29.9rCSI 40.73%PRS 29.49
-
CSI 29.27rCSI 79.68%PRS 48.38
-
CSI 28.87rCSI 22.46%PRS 17.68
-
CSI 28.5rCSI 45.86%PRS 9.41
-
CSI 28.01rCSI 32.35%PRS 10.77
-
CSI 28rCSI 87.52%PRS 7.68
-
CSI 27.43rCSI 19.69%PRS 16.65
-
CSI 27.08rCSI 20.35%PRS 12.72
-
CSI 26.23rCSI 46.33%PRS 7.15
-
CSI 24.86rCSI 66.2%PRS 9.52
-
CSI 24.69rCSI 93.29%PRS 7.35
-
CSI 24.31rCSI 21.13%PRS 15.15
-
CSI 24.29rCSI 19.46%PRS 22.21
-
CSI 24.11rCSI 53.26%PRS 8.8
-
CSI 23.83rCSI 85.77%PRS 6.66
-
CSI 22.26rCSI 20.54%PRS 12.45
-
CSI 22.14rCSI 19.47%PRS 8.9
-
CSI 21.18rCSI 20.82%PRS 34.89
-
CSI 21.07rCSI 18.5%PRS 13.78
-
CSI 20.91rCSI 20.53%PRS 19.31
-
CSI 20.28rCSI 48.5%PRS 6.66
-
CSI 20.25rCSI 23.18%PRS 25.14
-
CSI 20.21rCSI 24.13%PRS 21.23
-
CSI 19.59rCSI 13.63%PRS 17.4
-
CSI 19.51rCSI 25.04%PRS 11.94
-
CSI 19.45rCSI 13.52%PRS 14.36
-
CSI 19.35rCSI 68.76%PRS 38.03
-
CSI 17.76rCSI 42.73%PRS 60.45
-
CSI 17.37rCSI 32.9%PRS 33.46
-
CSI 17.1rCSI 29.26%PRS 24.47
-
CSI 16.89rCSI 33.67%PRS 20.32
-
CSI 16.53rCSI 15.28%PRS 22.31
-
CSI 16.46rCSI 72.32%PRS 8.98
-
CSI 15.98rCSI 15.95%PRS 10.48
-
CSI 15.93rCSI 54.56%PRS 10.96
-
CSI 15.75rCSI 21.64%PRS 25.26
-
CSI 15.66rCSI 20.04%PRS 83.39
-
CSI 15.44rCSI 29.75%PRS 27.46
-
CSI 15.27rCSI 89.93%PRS 7.55
-
CSI 14.72rCSI 17.07%PRS 36.78
-
CSI 14.61rCSI 17.45%PRS 7.01
-
CSI 13.62rCSI 35.54%PRS 19.73
-
CSI 13.56rCSI 50.82%PRS 10.39
-
CSI 12.8rCSI 11.66%PRS 18.52
-
CSI 12.58rCSI 15.24%PRS 16.29
-
CSI 12.49rCSI 67.59%PRS 41.03
-
CSI 11.68rCSI 14.93%PRS 48.53
-
CSI 11.5rCSI 35.98%PRS 8.27
-
CSI 11.48rCSI 8.53%PRS 18.16
-
CSI 11.46rCSI 84.23%PRS 6.18
-
CSI 11.14rCSI 19.64%PRS 12.16
-
CSI 11.1rCSI 13.01%PRS 16.43
-
CSI 11.08rCSI 8.43%PRS 16.03
-
CSI 11.05rCSI 36.16%PRS 34.38
-
CSI 10.95rCSI 9.39%PRS 21.55
-
CSI 10.71rCSI 36.21%PRS 20.62
-
CSI 10.03rCSI 25.94%PRS 32.27
-
CSI 9.84rCSI 49.38%PRS 15.97
-
CSI 9.74rCSI 20.11%PRS 18.68
-
CSI 9.66rCSI 6.51%PRS 14.69
-
CSI 9.43rCSI 26.93%PRS 21.23
-
CSI 9.18rCSI 12.52%PRS 7.08
-
CSI 9.12rCSI 11.45%PRS 15.61
-
CSI 9.09rCSI 17.78%PRS 73.73
-
CSI 8.96rCSI 16.04%PRS 11.42
-
CSI 8.74rCSI 55.97%PRS 18.58
-
CSI 8.68rCSI 18.84%PRS 6.48
-
CSI 8.63rCSI 16.73%PRS 75
-
CSI 8.5rCSI 73.2%PRS 3.78
-
CSI 8.49rCSI 86.29%PRS 67.26
-
CSI 7.81rCSI 7.51%PRS 25.34
-
CSI 7.63rCSI 6.33%PRS 11.57
-
CSI 7.61rCSI 6.35%PRS 35.79
-
CSI 7.57rCSI 10.13%PRS 49.64
-
CSI 7.11rCSI 11.72%PRS 14.26
-
CSI 7.01rCSI 78.91%PRS 31.2
-
CSI 6.8rCSI 5.96%PRS 16.25
-
CSI 6.45rCSI 14.64%PRS 17.07
-
CSI 6.39rCSI 20.98%PRS 6.18
-
CSI -5.1rCSI -9.8%PRS 19.6%
-
CSI -4.2rCSI -6.1%PRS 16.1%
-
CSI -3.4rCSI -4.8%PRS 17.1%
-
CSI -3.3rCSI -20.9%PRS 9.7%
-
CSI -3.1rCSI -2.9%PRS 12.7%
-
CSI -2.3rCSI -5.8%PRS 12.5%
-
CSI -2.2rCSI -12.7%PRS 18.4%
-
CSI -1.7rCSI -4.2%PRS 12.2%
-
CSI -1.1rCSI -3.2%PRS 13.9%
-
CSI -0.9rCSI -1.6%PRS 9.3%
-
CSI -0.9rCSI -14.8%PRS 47.3%
-
CSI -0.8rCSI -1.3%PRS 10.6%
-
CSI -0.7rCSI -0.9%PRS 13.6%
-
CSI -0.6rCSI -3.1%PRS 4.8%
-
CSI -0.4rCSI -1.8%PRS 34.8%
-
CSI -0.2rCSI -7.4%PRS 84.6%
-
CSI 0.0rCSI -0.3%PRS 22.2%
-
CSI 0.0rCSI 0.1%PRS 16.7%
-
CSI 0.1rCSI 0.2%PRS 54.3%
-
CSI 0.1rCSI 0.7%PRS 4.8%
-
CSI 0.1rCSI 2.0%PRS 21.9%
-
CSI 0.1rCSI 0.2%PRS 11.5%
-
CSI 0.1rCSI 0.5%PRS 25.2%
-
CSI 0.2rCSI 3.6%PRS 41.5%
-
CSI 0.2rCSI 1.1%PRS 39.7%
-
CSI 0.2rCSI 2.0%PRS 12.1%
-
CSI 0.2rCSI 5.4%PRS 28.4%
-
CSI 0.2rCSI 0.4%PRS 12.5%
-
CSI 0.2rCSI 2.0%PRS 48.2%
-
CSI 0.2rCSI 1.7%PRS 24.1%
-
CSI 0.3rCSI 1.3%PRS 13.3%
-
CSI 0.3rCSI 1.6%PRS 19.0%
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CSI 0.3rCSI 0.4%PRS 13.4%
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CSI 0.3rCSI 0.8%PRS 13.9%
-
CSI 0.3rCSI 5.0%PRS 30.9%
-
CSI 0.4rCSI 1.5%PRS 31.5%
-
CSI 0.4rCSI 1.6%PRS 25.5%
-
CSI 0.4rCSI 1.9%PRS 14.2%
-
CSI 0.4rCSI 1.2%PRS 18.0%
-
CSI 0.4rCSI 2.2%PRS 30.3%
-
CSI 0.4rCSI 1.4%PRS 13.3%
-
CSI 0.4rCSI 0.7%PRS 11.4%
-
CSI 0.4rCSI 0.4%PRS 13.3%
-
CSI 0.5rCSI 1.3%PRS 23.9%
-
CSI 0.5rCSI 0.7%PRS 18.0%
-
CSI 0.5rCSI 0.5%PRS 21.8%
-
CSI 0.5rCSI 1.9%PRS 21.5%
-
CSI 0.5rCSI 1.4%PRS 17.5%
-
CSI 0.5rCSI 1.3%PRS 11.3%
-
CSI 0.5rCSI 3.2%PRS 33.7%
-
CSI 0.5rCSI 1.4%PRS 11.4%
-
CSI 0.5rCSI 3.0%PRS 38.5%
-
CSI 0.5rCSI 2.4%PRS 4.6%
-
CSI 0.6rCSI 4.6%PRS 12.3%
-
CSI 0.6rCSI 2.0%PRS 22.2%
-
CSI 0.6rCSI 0.9%PRS 12.3%
-
CSI 0.6rCSI 0.8%PRS 12.5%
-
CSI 0.6rCSI 3.3%PRS 24.1%
-
CSI 0.6rCSI 6.9%PRS 47.2%
-
CSI 0.7rCSI 0.9%PRS 20.1%
-
CSI 0.7rCSI 2.7%PRS 20.1%
-
CSI 0.7rCSI 14.8%PRS 84.8%
-
CSI 0.8rCSI 2.0%PRS 14.6%
-
CSI 0.8rCSI 4.4%PRS 17.9%
-
CSI 0.8rCSI 0.9%PRS 9.0%
-
CSI 0.8rCSI 1.3%PRS 16.4%
-
CSI 0.8rCSI 1.0%PRS 21.1%
-
CSI 0.8rCSI 1.5%PRS 15.2%
-
CSI 0.8rCSI 2.0%PRS 18.4%
-
CSI 0.8rCSI 6.2%PRS 33.4%
-
CSI 0.9rCSI 2.2%PRS 16.5%
-
CSI 0.9rCSI 1.1%PRS 14.3%
-
CSI 0.9rCSI 4.4%PRS 15.8%
-
CSI 1.0rCSI 3.9%PRS 26.3%
-
CSI 1.0rCSI 3.1%PRS 15.0%
-
CSI 1.0rCSI 0.7%PRS 12.9%
-
CSI 1.0rCSI 4.4%PRS 12.1%
-
CSI 1.0rCSI 3.7%PRS 21.0%
-
CSI 1.1rCSI 1.9%PRS 16.2%
-
CSI 1.1rCSI 1.3%PRS 10.8%
-
CSI 1.1rCSI 1.2%PRS 12.9%
-
CSI 1.1rCSI 2.1%PRS 18.8%
-
CSI 1.2rCSI 2.7%PRS 19.1%
-
CSI 1.2rCSI 5.6%PRS 8.1%
-
CSI 1.2rCSI 2.4%PRS 13.0%
-
CSI 1.2rCSI 11.4%PRS 36.2%
-
CSI 1.3rCSI 1.6%PRS 14.2%
-
CSI 1.3rCSI 9.8%PRS 10.9%
-
CSI 1.3rCSI 6.2%PRS 11.9%
-
CSI 1.4rCSI 3.4%PRS 19.4%
-
CSI 1.4rCSI 3.0%PRS 21.5%
-
CSI 1.5rCSI 1.6%PRS 11.3%
-
CSI 1.5rCSI 3.4%PRS 11.4%
-
CSI 1.5rCSI 1.4%PRS 10.8%
-
CSI 1.5rCSI 10.9%PRS 11.6%
-
CSI 1.5rCSI 32.7%PRS 59.2%
-
CSI 1.6rCSI 40.0%PRS 55.9%
-
CSI 1.6rCSI 2.4%PRS 14.3%
-
CSI 1.6rCSI 3.3%PRS 5.2%
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CSI 1.7rCSI 5.5%PRS 8.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2769900050
Symbol: EVL_HUMAN
Name: Ena/VASP-like protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10931946
Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
PubMed ID: 10931946
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 10747096
Title: Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.
PubMed ID: 10747096
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 10993894
Title: The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain.
PubMed ID: 10993894
PubMed ID: 15469845
Title: Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.
PubMed ID: 15469845
PubMed ID: 18158903
Title: Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding.
PubMed ID: 18158903
PubMed ID: 28882895
Title: Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase.
PubMed ID: 28882895
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 416
- Mass: 44620
- Checksum: AD5B67458755D659
- Sequence:
MSEQSICQAR ASVMVYDDTS KKWVPIKPGQ QGFSRINIYH NTASNTFRVV GVKLQDQQVV INYSIVKGLK YNQATPTFHQ WRDARQVYGL NFASKEEATT FSNAMLFALN IMNSQEGGPS SQRQVQNGPS PDEMDIQRRQ VMEQHQQQRQ ESLERRTSAT GPILPPGHPS SAASAPVSCS GPPPPPPPPV PPPPTGATPP PPPPLPAGGA QGSSHDESSM SGLAAAIAGA KLRRVQRPED ASGGSSPSGT SKSDANRASS GGGGGGLMEE MNKLLAKRRK AASQSDKPAE KKEDESQMED PSTSPSPGTR AASQPPNSSE AGRKPWERSN SVEKPVSSIL SRTPSVAKSP EAKSPLQSQP HSRMKPAGSV NDMALDAFDL DRMKQEILEE VVRELHKVKE EIIDAIRQEL SGISTT