Details for: PLEK

Gene ID: 5341

Symbol: PLEK

Ensembl ID: ENSG00000115956

Description: pleckstrin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 117.9721
    Cell Significance Index: -18.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.5251
    Cell Significance Index: -23.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 50.5404
    Cell Significance Index: -20.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.3672
    Cell Significance Index: -24.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.3075
    Cell Significance Index: -7.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.8549
    Cell Significance Index: -23.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.9397
    Cell Significance Index: -18.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8130
    Cell Significance Index: -20.9300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 7.6720
    Cell Significance Index: 20.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.2599
    Cell Significance Index: 115.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.2338
    Cell Significance Index: 80.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8048
    Cell Significance Index: -18.9600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.5303
    Cell Significance Index: 28.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.1393
    Cell Significance Index: 103.4700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.9711
    Cell Significance Index: 26.3500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 3.2692
    Cell Significance Index: 23.5000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.1672
    Cell Significance Index: 9.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8835
    Cell Significance Index: 40.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3569
    Cell Significance Index: 160.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3560
    Cell Significance Index: 61.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0390
    Cell Significance Index: 197.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8503
    Cell Significance Index: 22.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7346
    Cell Significance Index: 11.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7148
    Cell Significance Index: 70.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6038
    Cell Significance Index: 545.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3617
    Cell Significance Index: 58.8300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.3457
    Cell Significance Index: 2.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3122
    Cell Significance Index: 20.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2301
    Cell Significance Index: 25.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1928
    Cell Significance Index: 133.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1698
    Cell Significance Index: 6.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1063
    Cell Significance Index: 4.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0096
    Cell Significance Index: -18.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0132
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0144
    Cell Significance Index: -26.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0168
    Cell Significance Index: -25.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0198
    Cell Significance Index: -26.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0206
    Cell Significance Index: -15.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0318
    Cell Significance Index: -23.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0327
    Cell Significance Index: -24.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0341
    Cell Significance Index: -21.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0341
    Cell Significance Index: -18.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0427
    Cell Significance Index: -24.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0437
    Cell Significance Index: -27.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0524
    Cell Significance Index: -23.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0525
    Cell Significance Index: -5.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0555
    Cell Significance Index: -3.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0569
    Cell Significance Index: -20.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0615
    Cell Significance Index: -3.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0638
    Cell Significance Index: -12.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0681
    Cell Significance Index: -19.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0713
    Cell Significance Index: -14.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0774
    Cell Significance Index: -5.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0805
    Cell Significance Index: -1.7200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1029
    Cell Significance Index: -1.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1072
    Cell Significance Index: -5.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1081
    Cell Significance Index: -6.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1094
    Cell Significance Index: -23.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1103
    Cell Significance Index: -19.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1143
    Cell Significance Index: -2.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1305
    Cell Significance Index: -17.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1467
    Cell Significance Index: -25.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1524
    Cell Significance Index: -22.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1701
    Cell Significance Index: -20.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1740
    Cell Significance Index: -22.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1741
    Cell Significance Index: -22.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1885
    Cell Significance Index: -3.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2155
    Cell Significance Index: -9.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2162
    Cell Significance Index: -10.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2180
    Cell Significance Index: -24.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2430
    Cell Significance Index: -18.6500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2476
    Cell Significance Index: -3.2900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2820
    Cell Significance Index: -4.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2979
    Cell Significance Index: -9.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3036
    Cell Significance Index: -22.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3113
    Cell Significance Index: -20.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3287
    Cell Significance Index: -2.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3365
    Cell Significance Index: -13.7900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3420
    Cell Significance Index: -4.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3449
    Cell Significance Index: -17.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3574
    Cell Significance Index: -21.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3585
    Cell Significance Index: -7.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3903
    Cell Significance Index: -21.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4008
    Cell Significance Index: -11.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4029
    Cell Significance Index: -9.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4124
    Cell Significance Index: -21.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4558
    Cell Significance Index: -21.2500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.4650
    Cell Significance Index: -4.1400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4653
    Cell Significance Index: -4.7500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4699
    Cell Significance Index: -5.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4700
    Cell Significance Index: -29.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5295
    Cell Significance Index: -13.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5369
    Cell Significance Index: -18.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5771
    Cell Significance Index: -18.3800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.5928
    Cell Significance Index: -5.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5930
    Cell Significance Index: -21.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5971
    Cell Significance Index: -19.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6131
    Cell Significance Index: -16.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6846
    Cell Significance Index: -23.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Pleckstrin is a 58-kDa protein that belongs to the pleckstrin homology (PH) domain-containing family. It is characterized by its ability to bind to phosphatidylinositol-3,4-bisphosphate (PIP2) and phospholipase C (PLC) through its PH domain. This binding property allows pleckstrin to regulate PLC activity and modulate intracellular signaling pathways. Additionally, pleckstrin exhibits homodimerization activity and interacts with various proteins, including protein kinase C (PKC), integrins, and actin-binding proteins. **Pathways and Functions** Pleckstrin is involved in several signaling pathways, including: 1. **Actin cytoskeleton organization**: Pleckstrin modulates the assembly and disassembly of actin filaments, influencing cell shape, motility, and signaling. 2. **Integrin-mediated signaling pathway**: Pleckstrin interacts with integrins to regulate cell adhesion, migration, and signaling. 3. **Platelet activation and aggregation**: Pleckstrin is essential for the regulation of platelet activation, aggregation, and secretion. 4. **Negative regulation of calcium-mediated signaling**: Pleckstrin inhibits calcium-dependent signaling pathways, which are involved in platelet activation and aggregation. Pleckstrin's functions include: 1. **Protein binding**: Pleckstrin interacts with various proteins, including PKC, integrins, and actin-binding proteins. 2. **Protein homodimerization activity**: Pleckstrin forms homodimers, which may regulate its activity and interactions. 3. **Regulation of cell diameter**: Pleckstrin modulates cell shape and size by regulating the assembly and disassembly of actin filaments. 4. **Response to elevated platelet cytosolic Ca2+**: Pleckstrin is activated by increased intracellular calcium concentrations, which is a key event in platelet activation. **Clinical Significance** Pleckstrin's dysregulation is implicated in various hematological disorders, including: 1. **Thrombocytopenia**: Pleckstrin deficiency or dysfunction is associated with platelet dysfunction and thrombocytopenia. 2. **Leukemia**: Pleckstrin alterations are observed in certain types of leukemia, including acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). 3. **Immune disorders**: Pleckstrin's role in immune cell signaling and regulation may contribute to the development of autoimmune disorders, such as rheumatoid arthritis and lupus. In conclusion, pleckstrin is a multifunctional protein that plays a crucial role in various cellular processes, including cell signaling, cytoskeleton organization, and membrane dynamics. Its dysregulation is implicated in various hematological disorders, highlighting the importance of pleckstrin in maintaining normal hematopoiesis and immune function.

Genular Protein ID: 2469487947

Symbol: PLEK_HUMAN

Name: Pleckstrin

UniProtKB Accession Codes:

P08567 B2R9E8 Q53SU8 Q6FGM8 Q6FGQ1 Q8WV81

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2897630

Title: Molecular cloning and expression of the major protein kinase C substrate of platelets.

PubMed ID: 2897630

DOI: 10.1038/333470a0

PubMed ID: 2768345

Title: Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets.

PubMed ID: 2768345

DOI: 10.1002/jcb.240400202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8615792

Title: Phosphorylation of human pleckstrin on Ser-113 and Ser-117 by protein kinase C.

PubMed ID: 8615792

DOI: 10.1042/bj3140937

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8208296

Title: Solution structure of a pleckstrin-homology domain.

PubMed ID: 8208296

DOI: 10.1038/369672a0

PubMed ID: 15573383

Title: Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily.

PubMed ID: 15573383

DOI: 10.1002/prot.20320

Sequence Information:

  • Length: 350
  • Mass: 40125
  • Checksum: 2E292CB18B533261
  • Sequence:
    • MEPKRIREGY LVKKGSVFNT WKPMWVVLLE DGIEFYKKKS DNSPKGMIPL KGSTLTSPCQ 
DFGKRMFVFK ITTTKQQDHF FQAAFLEERD AWVRDIKKAI KCIEGGQKFA RKSTRRSIRL 
PETIDLGALY LSMKDTEKGI KELNLEKDKK IFNHCFTGNC VIDWLVSNQS VRNRQEGLMI 
ASSLLNEGYL QPAGDMSKSA VDGTAENPFL DNPDAFYYFP DSGFFCEENS SDDDVILKEE 
FRGVIIKQGC LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AGAEDPLGAI HLRGCVVTSV 
ESNSNGRKSE EENLFEIITA DEVHYFLQAA TPKERTEWIR AIQMASRTGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.