Details for: HLA F
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 205.2779
Cell Significance Index: -31.9300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 115.1223
Cell Significance Index: -29.2000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 77.0337
Cell Significance Index: -39.6300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 74.8534
Cell Significance Index: -35.3400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 52.7106
Cell Significance Index: -35.3700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 25.8079
Cell Significance Index: -31.8200 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 15.4841
Cell Significance Index: 41.4800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.9078
Cell Significance Index: -27.3600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.1626
Cell Significance Index: -32.2100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.0417
Cell Significance Index: -17.6000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.8667
Cell Significance Index: -18.4000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.9783
Cell Significance Index: 73.5300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.8265
Cell Significance Index: 32.1100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.0253
Cell Significance Index: 59.4800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.9776
Cell Significance Index: 17.2800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.9042
Cell Significance Index: 58.3400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8414
Cell Significance Index: 91.5200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6936
Cell Significance Index: 306.6600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6345
Cell Significance Index: 572.9000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4988
Cell Significance Index: 49.3400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4756
Cell Significance Index: 22.3600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4614
Cell Significance Index: 54.4200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3652
Cell Significance Index: 9.7700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3525
Cell Significance Index: 67.0800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2506
Cell Significance Index: 32.1300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2191
Cell Significance Index: 11.3800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2097
Cell Significance Index: 25.7800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2084
Cell Significance Index: 5.2100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1742
Cell Significance Index: 23.9200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1694
Cell Significance Index: 3.6700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1410
Cell Significance Index: 9.9700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1158
Cell Significance Index: 20.8800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1021
Cell Significance Index: 5.1600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0885
Cell Significance Index: 3.1100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0738
Cell Significance Index: 46.0800 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.0724
Cell Significance Index: 0.5200 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0608
Cell Significance Index: 7.8500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0447
Cell Significance Index: 16.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0091
Cell Significance Index: 17.1300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0078
Cell Significance Index: 12.0000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0004
Cell Significance Index: -0.7600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0023
Cell Significance Index: -0.2300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0080
Cell Significance Index: -0.9200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0173
Cell Significance Index: -13.1300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0231
Cell Significance Index: -31.4600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0234
Cell Significance Index: -4.7000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0265
Cell Significance Index: -19.6500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0295
Cell Significance Index: -16.6400 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0349
Cell Significance Index: -19.0700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0367
Cell Significance Index: -23.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0419
Cell Significance Index: -1.9000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0476
Cell Significance Index: -34.9100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0500
Cell Significance Index: -5.7100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0517
Cell Significance Index: -8.8300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0609
Cell Significance Index: -27.6300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0999
Cell Significance Index: -21.0500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1000
Cell Significance Index: -14.5400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1038
Cell Significance Index: -20.6000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1214
Cell Significance Index: -34.9400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1806
Cell Significance Index: -21.0500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2075
Cell Significance Index: -4.4200 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2280
Cell Significance Index: -3.9300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2297
Cell Significance Index: -6.4200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2318
Cell Significance Index: -17.7900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2620
Cell Significance Index: -19.5300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2963
Cell Significance Index: -9.4900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3005
Cell Significance Index: -31.2900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3061
Cell Significance Index: -12.5400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3384
Cell Significance Index: -14.9700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3551
Cell Significance Index: -10.1800 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.3558
Cell Significance Index: -1.9400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3700
Cell Significance Index: -17.2500 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.3740
Cell Significance Index: -3.7500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3989
Cell Significance Index: -15.1100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4213
Cell Significance Index: -22.1200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4504
Cell Significance Index: -6.4800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4793
Cell Significance Index: -37.9600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5105
Cell Significance Index: -7.6500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5178
Cell Significance Index: -31.7500 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.5303
Cell Significance Index: -3.2900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5626
Cell Significance Index: -19.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6104
Cell Significance Index: -34.2500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.6150
Cell Significance Index: -16.7400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6225
Cell Significance Index: -20.3800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6472
Cell Significance Index: -40.7900 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.6536
Cell Significance Index: -5.4900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.6888
Cell Significance Index: -35.8800 - Cell Name: peg cell (CL4033014)
Fold Change: -0.6990
Cell Significance Index: -16.1500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7300
Cell Significance Index: -9.9600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.7414
Cell Significance Index: -32.2400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.7439
Cell Significance Index: -11.5100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.7955
Cell Significance Index: -22.9200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.8179
Cell Significance Index: -17.6700 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.8306
Cell Significance Index: -5.4200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8311
Cell Significance Index: -26.4700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8453
Cell Significance Index: -31.0300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8666
Cell Significance Index: -22.1400 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.9126
Cell Significance Index: -18.5700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.9582
Cell Significance Index: -25.2000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.0060
Cell Significance Index: -25.8600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2465642269
Symbol: HLAF_HUMAN
Name: HLA class I histocompatibility antigen, alpha chain F
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1688605
Title: Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element.
PubMed ID: 1688605
DOI: 10.1084/jem.171.1.1
PubMed ID: 1707659
Title: The human class I MHC gene HLA-F is expressed in lymphocytes.
PubMed ID: 1707659
PubMed ID: 10727083
Title: A 356-Kb sequence of the subtelomeric part of the MHC class I region.
PubMed ID: 10727083
PubMed ID: 14705989
Title: Identification of a novel HLA-F allele - HLA-F*010102.
PubMed ID: 14705989
PubMed ID: 16570139
Title: HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes.
PubMed ID: 16570139
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11169396
Title: Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.
PubMed ID: 11169396
DOI: 10.1002/1521-4141(200012)30:12<3552::aid-immu3552>3.0.co;2-l
PubMed ID: 10605026
Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.
PubMed ID: 10605026
PubMed ID: 16709803
Title: Selective export of HLA-F by its cytoplasmic tail.
PubMed ID: 16709803
PubMed ID: 20865824
Title: HLA-F is a surface marker on activated lymphocytes.
PubMed ID: 20865824
PubMed ID: 20483783
Title: HLA-F complex without peptide binds to MHC class I protein in the open conformer form.
PubMed ID: 20483783
PubMed ID: 23851683
Title: HLA-F and MHC-I open conformers cooperate in a MHC-I antigen cross-presentation pathway.
PubMed ID: 23851683
PubMed ID: 24018270
Title: HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.
PubMed ID: 24018270
PubMed ID: 27455421
Title: Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.
PubMed ID: 27455421
DOI: 10.1038/ni.3513
PubMed ID: 26928464
Title: Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.
PubMed ID: 26928464
DOI: 10.1038/nm.4052
PubMed ID: 28185362
Title: Definitive class I human leukocyte antigen expression in gestational placentation: HLA-F, HLA-E, HLA-C, and HLA-G in extravillous trophoblast invasion on placentation, pregnancy, and parturition.
PubMed ID: 28185362
DOI: 10.1111/aji.12643
PubMed ID: 28636952
Title: Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.
PubMed ID: 28636952
Sequence Information:
- Length: 346
- Mass: 39062
- Checksum: D4782968A67E9B7D
- Sequence:
MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PPGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV
Genular Protein ID: 1043050740
Symbol: Q5JZ48_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 442
- Mass: 50438
- Checksum: 66109DEBE5EF2D57
- Sequence:
MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PPGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAAYSVV SGNLMITWWS SLFLLGVLFQ GYLGCLRSHS VLGRRKVGDM WILFFLWLWT SFNTAFLALQ SLRFGFGFRR GRSFLLRSWH HLMKRVQIKI FD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.