Details for: HLA F

Gene ID: 3134

Symbol: HLA F

Ensembl ID: ENSG00000204642

Description: major histocompatibility complex, class I, F

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.6
    Marker Score: 2542.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.59
    Marker Score: 3047.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.38
    Marker Score: 10652
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.29
    Marker Score: 9230
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.01
    Marker Score: 7659.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.91
    Marker Score: 2446
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.88
    Marker Score: 4164
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.72
    Marker Score: 1173
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.66
    Marker Score: 7765
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.57
    Marker Score: 135750
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.55
    Marker Score: 1550
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.48
    Marker Score: 138504
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.44
    Marker Score: 803
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.39
    Marker Score: 2355.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.33
    Marker Score: 9972
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.31
    Marker Score: 6375
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.3
    Marker Score: 1385
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.28
    Marker Score: 2132
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.27
    Marker Score: 2198.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.27
    Marker Score: 1307
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.26
    Marker Score: 800
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.25
    Marker Score: 26203
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.23
    Marker Score: 690
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.16
    Marker Score: 1862
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.14
    Marker Score: 1067
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.1
    Marker Score: 4097
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.09
    Marker Score: 728.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.08
    Marker Score: 5070
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.07
    Marker Score: 1334
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.07
    Marker Score: 3041
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.05
    Marker Score: 3515
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2
    Marker Score: 1334
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.96
    Marker Score: 1539.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.96
    Marker Score: 1744
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.96
    Marker Score: 637
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.95
    Marker Score: 2104
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.91
    Marker Score: 7927.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.88
    Marker Score: 1420
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.87
    Marker Score: 1638
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.83
    Marker Score: 1719
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.82
    Marker Score: 1322
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.81
    Marker Score: 3238.5
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.8
    Marker Score: 456
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.77
    Marker Score: 11348
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.76
    Marker Score: 8449
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.72
    Marker Score: 886
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.68
    Marker Score: 382
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.67
    Marker Score: 1366.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.62
    Marker Score: 2498.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.61
    Marker Score: 990
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.59
    Marker Score: 744
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.58
    Marker Score: 2185
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.57
    Marker Score: 1152
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.57
    Marker Score: 1403
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.56
    Marker Score: 413
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.55
    Marker Score: 303
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.51
    Marker Score: 1102
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.51
    Marker Score: 1252
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.51
    Marker Score: 520
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.5
    Marker Score: 38467
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.49
    Marker Score: 1077
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.49
    Marker Score: 1656
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.49
    Marker Score: 871
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.48
    Marker Score: 867
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.45
    Marker Score: 439
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.44
    Marker Score: 10746
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.44
    Marker Score: 3468
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.43
    Marker Score: 1584
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.42
    Marker Score: 792.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.4
    Marker Score: 1751.5
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.4
    Marker Score: 862
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.39
    Marker Score: 596
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.38
    Marker Score: 1219
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.38
    Marker Score: 915
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.37
    Marker Score: 2730
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.31
    Marker Score: 1427
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.3
    Marker Score: 489
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.29
    Marker Score: 309
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.28
    Marker Score: 297
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.27
    Marker Score: 495
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.27
    Marker Score: 529
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.26
    Marker Score: 717
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.25
    Marker Score: 282.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.23
    Marker Score: 1252
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.23
    Marker Score: 748
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.22
    Marker Score: 359
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.22
    Marker Score: 304
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.21
    Marker Score: 290
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.21
    Marker Score: 1987
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.2
    Marker Score: 15964.5
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.2
    Marker Score: 2702
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.19
    Marker Score: 254
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.19
    Marker Score: 2485
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.18
    Marker Score: 812
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.17
    Marker Score: 258
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.17
    Marker Score: 299
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.17
    Marker Score: 644
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.16
    Marker Score: 2030.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.16
    Marker Score: 1113

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Other Information

**Key characteristics:** * The HLA F gene is located on chromosome 6p21.1. * It is a highly polymorphic gene, with over 20 different alleles encoding different versions of the protein. * The F gene is expressed in many different cell types, including APCs, dendritic cells, macrophages, and B cells. * The F gene is also expressed in some tissues outside the immune system, such as in the heart, liver, and brain. **Pathways and functions:** * The HLA F gene is involved in the adaptive immune response. * It is expressed on the surface of APCs, where it is presented with antigens derived from pathogens. * When an APC presents an antigen bound to an HLA F molecule, the T cell becomes activated and proliferates. * The F gene is also involved in the regulation of the immune response. * It is expressed in cells that are in contact with the immune system, such as macrophages and dendritic cells. * This expression helps to ensure that the immune system is only activated by antigens that are bound to MHC molecules. **Clinical significance:** * Mutations in the HLA F gene can lead to the formation of abnormal MHC molecules that are not able to bind to antigens. * These abnormal molecules can prevent the activation of T cells and can lead to autoimmune diseases. * The HLA F gene is also a target for immunotherapy, as it can be used to develop vaccines to activate T cells against pathogens. **Additional information:** * The HLA F gene is a key component of the immune system. * It is involved in the recognition of a wide range of pathogens. * Mutations in the HLA F gene can have a significant impact on the development of autoimmune diseases.

Genular Protein ID: 2465642269

Symbol: HLAF_HUMAN

Name: HLA class I histocompatibility antigen, alpha chain F

UniProtKB Accession Codes:

P30511 Q5JQI8 Q5JQJ1 Q5SPT5 Q860R0 Q8MGQ1 Q8WLP5 Q95HC0 Q9TP68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 48 EPD 1 Ensembl 9 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1688605

Title: Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element.

PubMed ID: 1688605

DOI: 10.1084/jem.171.1.1

PubMed ID: 1707659

Title: The human class I MHC gene HLA-F is expressed in lymphocytes.

PubMed ID: 1707659

DOI: 10.1093/intimm/2.6.531

PubMed ID: 10727083

Title: A 356-Kb sequence of the subtelomeric part of the MHC class I region.

PubMed ID: 10727083

DOI: 10.3109/10425179909033955

PubMed ID: 14705989

Title: Identification of a novel HLA-F allele - HLA-F*010102.

PubMed ID: 14705989

DOI: 10.1111/j.1399-0039.2004.00145.x

PubMed ID: 16570139

Title: HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes.

PubMed ID: 16570139

DOI: 10.1007/s00251-005-0076-z

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11169396

Title: Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.

PubMed ID: 11169396

DOI: 10.1002/1521-4141(200012)30:12<3552::aid-immu3552>3.0.co;2-l

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 16709803

Title: Selective export of HLA-F by its cytoplasmic tail.

PubMed ID: 16709803

DOI: 10.4049/jimmunol.176.11.6464

PubMed ID: 20865824

Title: HLA-F is a surface marker on activated lymphocytes.

PubMed ID: 20865824

DOI: 10.1002/eji.201040348

PubMed ID: 20483783

Title: HLA-F complex without peptide binds to MHC class I protein in the open conformer form.

PubMed ID: 20483783

DOI: 10.4049/jimmunol.1000078

PubMed ID: 23851683

Title: HLA-F and MHC-I open conformers cooperate in a MHC-I antigen cross-presentation pathway.

PubMed ID: 23851683

DOI: 10.4049/jimmunol.1300080

PubMed ID: 24018270

Title: HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.

PubMed ID: 24018270

DOI: 10.4049/jimmunol.1300081

PubMed ID: 27455421

Title: Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.

PubMed ID: 27455421

DOI: 10.1038/ni.3513

PubMed ID: 26928464

Title: Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.

PubMed ID: 26928464

DOI: 10.1038/nm.4052

PubMed ID: 28185362

Title: Definitive class I human leukocyte antigen expression in gestational placentation: HLA-F, HLA-E, HLA-C, and HLA-G in extravillous trophoblast invasion on placentation, pregnancy, and parturition.

PubMed ID: 28185362

DOI: 10.1111/aji.12643

PubMed ID: 28636952

Title: Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.

PubMed ID: 28636952

DOI: 10.1016/j.immuni.2017.06.002

Sequence Information:

  • Length: 346
  • Mass: 39062
  • Checksum: D4782968A67E9B7D
  • Sequence:
    • MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD 
AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN 
GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY 
LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR 
DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PPGEEQRYTC HVQHEGLPQP LILRWEQSPQ 
PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV

Genular Protein ID: 1043050740

Symbol: Q5JZ48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5JZ48

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 1 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 9 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 PhylomeDB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Sequence Information:

  • Length: 442
  • Mass: 50438
  • Checksum: 66109DEBE5EF2D57
  • Sequence:
    • MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD 
AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN 
GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY 
LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR 
DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PPGEEQRYTC HVQHEGLPQP LILRWEQSPQ 
PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAAYSVV SGNLMITWWS 
SLFLLGVLFQ GYLGCLRSHS VLGRRKVGDM WILFFLWLWT SFNTAFLALQ SLRFGFGFRR 
GRSFLLRSWH HLMKRVQIKI FD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.