Details for: HLA F

Gene ID: 3134

Symbol: HLA F

Ensembl ID: ENSG00000204642

Description: major histocompatibility complex, class I, F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 205.2779
    Cell Significance Index: -31.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.1223
    Cell Significance Index: -29.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.0337
    Cell Significance Index: -39.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.8534
    Cell Significance Index: -35.3400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 52.7106
    Cell Significance Index: -35.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.8079
    Cell Significance Index: -31.8200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 15.4841
    Cell Significance Index: 41.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9078
    Cell Significance Index: -27.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1626
    Cell Significance Index: -32.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0417
    Cell Significance Index: -17.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8667
    Cell Significance Index: -18.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.9783
    Cell Significance Index: 73.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.8265
    Cell Significance Index: 32.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0253
    Cell Significance Index: 59.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9776
    Cell Significance Index: 17.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9042
    Cell Significance Index: 58.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8414
    Cell Significance Index: 91.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6936
    Cell Significance Index: 306.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6345
    Cell Significance Index: 572.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4988
    Cell Significance Index: 49.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4756
    Cell Significance Index: 22.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4614
    Cell Significance Index: 54.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3652
    Cell Significance Index: 9.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3525
    Cell Significance Index: 67.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2506
    Cell Significance Index: 32.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2191
    Cell Significance Index: 11.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2097
    Cell Significance Index: 25.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2084
    Cell Significance Index: 5.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1742
    Cell Significance Index: 23.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1694
    Cell Significance Index: 3.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1410
    Cell Significance Index: 9.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1158
    Cell Significance Index: 20.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1021
    Cell Significance Index: 5.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0885
    Cell Significance Index: 3.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0738
    Cell Significance Index: 46.0800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0724
    Cell Significance Index: 0.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0608
    Cell Significance Index: 7.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0447
    Cell Significance Index: 16.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0091
    Cell Significance Index: 17.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0078
    Cell Significance Index: 12.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0023
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0080
    Cell Significance Index: -0.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0173
    Cell Significance Index: -13.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0231
    Cell Significance Index: -31.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0234
    Cell Significance Index: -4.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0265
    Cell Significance Index: -19.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0295
    Cell Significance Index: -16.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0349
    Cell Significance Index: -19.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0367
    Cell Significance Index: -23.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0419
    Cell Significance Index: -1.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0476
    Cell Significance Index: -34.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0500
    Cell Significance Index: -5.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0517
    Cell Significance Index: -8.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0609
    Cell Significance Index: -27.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0999
    Cell Significance Index: -21.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1000
    Cell Significance Index: -14.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1038
    Cell Significance Index: -20.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1214
    Cell Significance Index: -34.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1806
    Cell Significance Index: -21.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2075
    Cell Significance Index: -4.4200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2280
    Cell Significance Index: -3.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2297
    Cell Significance Index: -6.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2318
    Cell Significance Index: -17.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2620
    Cell Significance Index: -19.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2963
    Cell Significance Index: -9.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3005
    Cell Significance Index: -31.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3061
    Cell Significance Index: -12.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3384
    Cell Significance Index: -14.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3551
    Cell Significance Index: -10.1800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3558
    Cell Significance Index: -1.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3700
    Cell Significance Index: -17.2500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3740
    Cell Significance Index: -3.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3989
    Cell Significance Index: -15.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4213
    Cell Significance Index: -22.1200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4504
    Cell Significance Index: -6.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4793
    Cell Significance Index: -37.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5105
    Cell Significance Index: -7.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5178
    Cell Significance Index: -31.7500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.5303
    Cell Significance Index: -3.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5626
    Cell Significance Index: -19.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6104
    Cell Significance Index: -34.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6150
    Cell Significance Index: -16.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6225
    Cell Significance Index: -20.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6472
    Cell Significance Index: -40.7900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6536
    Cell Significance Index: -5.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6888
    Cell Significance Index: -35.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6990
    Cell Significance Index: -16.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7300
    Cell Significance Index: -9.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7414
    Cell Significance Index: -32.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7439
    Cell Significance Index: -11.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7955
    Cell Significance Index: -22.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8179
    Cell Significance Index: -17.6700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.8306
    Cell Significance Index: -5.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8311
    Cell Significance Index: -26.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8453
    Cell Significance Index: -31.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8666
    Cell Significance Index: -22.1400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9126
    Cell Significance Index: -18.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9582
    Cell Significance Index: -25.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0060
    Cell Significance Index: -25.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HLA F is a non-polymorphic gene, meaning that it does not exhibit significant variations among individuals. However, it is highly conserved across species, suggesting its critical role in the adaptive immune system. The HLA F gene is part of the HLA class I complex, which is composed of two subunits: alpha and beta. The alpha subunit, encoded by the HLA F gene, is responsible for presenting peptides to T-cells. The beta subunit, encoded by the HLA A, B, and C genes, interacts with the alpha subunit to form the HLA class I complex. **Pathways and Functions** The HLA F gene is involved in several pathways, including: 1. **Antigen Presentation**: HLA F is responsible for presenting endogenously synthesized peptides to T-cells, which is a critical step in the adaptive immune response. 2. **Adaptive Immune System**: HLA F plays a key role in the adaptive immune response by presenting antigens to T-cells, which then activate immune cells to respond to the infection. 3. **Antigen Processing and Presentation**: HLA F is involved in the processing and presentation of exogenous peptides via the HLA class I pathway. 4. **Interferon Signaling**: HLA F is involved in the regulation of interferon signaling, which is essential for the immune response against viral infections. **Clinical Significance** The HLA F gene has significant clinical implications, particularly in the context of viral infections and cancer. Variations in the HLA F gene have been associated with susceptibility to certain diseases, such as HIV-1 and hepatitis B. Additionally, HLA F plays a crucial role in the immune response against tumor cells, and its expression is often downregulated in cancer cells. In the context of SARS-CoV-2 infection, HLA F has been shown to modulate innate and adaptive immune responses, which is essential for controlling the infection. Understanding the mechanisms of HLA F in the context of SARS-CoV-2 infection can provide valuable insights into the development of novel therapeutic strategies. In conclusion, the HLA F gene plays a critical role in the adaptive immune system, and its dysregulation can have significant clinical implications. Further research is needed to fully understand the mechanisms of HLA F and its role in different diseases.

Genular Protein ID: 2465642269

Symbol: HLAF_HUMAN

Name: HLA class I histocompatibility antigen, alpha chain F

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1688605

Title: Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element.

PubMed ID: 1688605

DOI: 10.1084/jem.171.1.1

PubMed ID: 1707659

Title: The human class I MHC gene HLA-F is expressed in lymphocytes.

PubMed ID: 1707659

DOI: 10.1093/intimm/2.6.531

PubMed ID: 10727083

Title: A 356-Kb sequence of the subtelomeric part of the MHC class I region.

PubMed ID: 10727083

DOI: 10.3109/10425179909033955

PubMed ID: 14705989

Title: Identification of a novel HLA-F allele - HLA-F*010102.

PubMed ID: 14705989

DOI: 10.1111/j.1399-0039.2004.00145.x

PubMed ID: 16570139

Title: HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes.

PubMed ID: 16570139

DOI: 10.1007/s00251-005-0076-z

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11169396

Title: Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.

PubMed ID: 11169396

DOI: 10.1002/1521-4141(200012)30:12<3552::aid-immu3552>3.0.co;2-l

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 16709803

Title: Selective export of HLA-F by its cytoplasmic tail.

PubMed ID: 16709803

DOI: 10.4049/jimmunol.176.11.6464

PubMed ID: 20865824

Title: HLA-F is a surface marker on activated lymphocytes.

PubMed ID: 20865824

DOI: 10.1002/eji.201040348

PubMed ID: 20483783

Title: HLA-F complex without peptide binds to MHC class I protein in the open conformer form.

PubMed ID: 20483783

DOI: 10.4049/jimmunol.1000078

PubMed ID: 23851683

Title: HLA-F and MHC-I open conformers cooperate in a MHC-I antigen cross-presentation pathway.

PubMed ID: 23851683

DOI: 10.4049/jimmunol.1300080

PubMed ID: 24018270

Title: HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.

PubMed ID: 24018270

DOI: 10.4049/jimmunol.1300081

PubMed ID: 27455421

Title: Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.

PubMed ID: 27455421

DOI: 10.1038/ni.3513

PubMed ID: 26928464

Title: Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.

PubMed ID: 26928464

DOI: 10.1038/nm.4052

PubMed ID: 28185362

Title: Definitive class I human leukocyte antigen expression in gestational placentation: HLA-F, HLA-E, HLA-C, and HLA-G in extravillous trophoblast invasion on placentation, pregnancy, and parturition.

PubMed ID: 28185362

DOI: 10.1111/aji.12643

PubMed ID: 28636952

Title: Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.

PubMed ID: 28636952

DOI: 10.1016/j.immuni.2017.06.002

Sequence Information:

  • Length: 346
  • Mass: 39062
  • Checksum: D4782968A67E9B7D
  • Sequence:
  • MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD 
    AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN 
    GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY 
    LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR 
    DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PPGEEQRYTC HVQHEGLPQP LILRWEQSPQ 
    PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV

Genular Protein ID: 1043050740

Symbol: Q5JZ48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 442
  • Mass: 50438
  • Checksum: 66109DEBE5EF2D57
  • Sequence:
  • MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD 
    AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN 
    GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY 
    LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR 
    DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PPGEEQRYTC HVQHEGLPQP LILRWEQSPQ 
    PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAAYSVV SGNLMITWWS 
    SLFLLGVLFQ GYLGCLRSHS VLGRRKVGDM WILFFLWLWT SFNTAFLALQ SLRFGFGFRR 
    GRSFLLRSWH HLMKRVQIKI FD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.