Details for: RAP1B

Gene ID: 5908

Symbol: RAP1B

Ensembl ID: ENSG00000127314

Description: RAP1B, member of RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 539.0715
    Cell Significance Index: -83.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 285.9132
    Cell Significance Index: -72.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 205.6333
    Cell Significance Index: -83.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 200.2869
    Cell Significance Index: -94.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 181.0705
    Cell Significance Index: -93.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 141.0833
    Cell Significance Index: -94.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 89.0711
    Cell Significance Index: -85.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 71.9288
    Cell Significance Index: -88.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.9723
    Cell Significance Index: -90.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.7597
    Cell Significance Index: -60.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.8501
    Cell Significance Index: -64.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.1226
    Cell Significance Index: -44.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.8975
    Cell Significance Index: 104.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.7044
    Cell Significance Index: 318.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.5397
    Cell Significance Index: 132.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.5030
    Cell Significance Index: 71.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.4358
    Cell Significance Index: 45.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.2692
    Cell Significance Index: 66.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1371
    Cell Significance Index: 262.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9176
    Cell Significance Index: 345.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8595
    Cell Significance Index: 369.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.7641
    Cell Significance Index: 34.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7457
    Cell Significance Index: 82.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6855
    Cell Significance Index: 108.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3761
    Cell Significance Index: 188.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3496
    Cell Significance Index: 270.7200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2946
    Cell Significance Index: 18.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2293
    Cell Significance Index: 63.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0319
    Cell Significance Index: 133.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0095
    Cell Significance Index: 17.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9934
    Cell Significance Index: 542.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9801
    Cell Significance Index: 9.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9695
    Cell Significance Index: 24.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9164
    Cell Significance Index: 68.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7594
    Cell Significance Index: 20.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7302
    Cell Significance Index: 322.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6663
    Cell Significance Index: 37.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6161
    Cell Significance Index: 47.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5847
    Cell Significance Index: 16.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5811
    Cell Significance Index: 208.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5162
    Cell Significance Index: 66.1800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.4883
    Cell Significance Index: 2.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4401
    Cell Significance Index: 43.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3439
    Cell Significance Index: 7.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3153
    Cell Significance Index: 218.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3122
    Cell Significance Index: 141.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2564
    Cell Significance Index: 231.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2418
    Cell Significance Index: 455.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2188
    Cell Significance Index: 138.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1292
    Cell Significance Index: 24.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1110
    Cell Significance Index: 170.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1085
    Cell Significance Index: 18.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0868
    Cell Significance Index: 160.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0576
    Cell Significance Index: 4.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0122
    Cell Significance Index: 16.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0018
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0215
    Cell Significance Index: -15.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0274
    Cell Significance Index: -17.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0375
    Cell Significance Index: -0.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0768
    Cell Significance Index: -56.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0934
    Cell Significance Index: -70.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1201
    Cell Significance Index: -12.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1211
    Cell Significance Index: -68.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2161
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2223
    Cell Significance Index: -46.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2514
    Cell Significance Index: -15.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2546
    Cell Significance Index: -73.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2686
    Cell Significance Index: -39.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3028
    Cell Significance Index: -34.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3060
    Cell Significance Index: -13.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3498
    Cell Significance Index: -16.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4431
    Cell Significance Index: -51.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4640
    Cell Significance Index: -53.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4880
    Cell Significance Index: -24.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5041
    Cell Significance Index: -17.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5538
    Cell Significance Index: -57.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7211
    Cell Significance Index: -48.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7388
    Cell Significance Index: -10.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7534
    Cell Significance Index: -19.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7914
    Cell Significance Index: -49.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8205
    Cell Significance Index: -21.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9136
    Cell Significance Index: -40.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9316
    Cell Significance Index: -24.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0011
    Cell Significance Index: -79.2900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0791
    Cell Significance Index: -23.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0838
    Cell Significance Index: -37.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0843
    Cell Significance Index: -41.0600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.1522
    Cell Significance Index: -8.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.2200
    Cell Significance Index: -13.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.2264
    Cell Significance Index: -28.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.3799
    Cell Significance Index: -23.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.4551
    Cell Significance Index: -30.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.5283
    Cell Significance Index: -26.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5310
    Cell Significance Index: -93.8700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.5592
    Cell Significance Index: -22.3900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.5789
    Cell Significance Index: -7.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5977
    Cell Significance Index: -23.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.6673
    Cell Significance Index: -87.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.7085
    Cell Significance Index: -54.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.9674
    Cell Significance Index: -50.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAP1B is characterized by its small size (approximately 180 amino acids) and its ability to bind and hydrolyze GTP. It belongs to the RAS superfamily, which includes RAS, RHO, and RAFT proteins. RAP1B is a monomeric GTPase, meaning it exists as a single molecule, and it is activated by guanine nucleotide exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs). RAP1B is also known to interact with various proteins, including Grb2, SOS, and P130cas, which are involved in signaling pathways that regulate cell growth, survival, and migration. **Pathways and Functions** RAP1B is involved in numerous signaling pathways, including: 1. **Adaptive Immune System**: RAP1B regulates T cell activation, proliferation, and differentiation, particularly in gamma-delta T cells and alpha-beta T cells. 2. **Cell-Cell Junctions**: RAP1B is involved in the establishment of cell-cell junctions, which are essential for tissue structure and function. 3. **Cytoskeleton Remodeling**: RAP1B regulates the cytoskeleton, influencing cell migration, adhesion, and shape changes. 4. **Signaling by Receptor Tyrosine Kinases**: RAP1B interacts with receptor tyrosine kinases, such as MET, to regulate signaling cascades involved in cell growth, survival, and migration. 5. **GTPase Activity**: RAP1B's GTPase activity regulates the hydrolysis of GTP, which in turn influences downstream signaling pathways. **Clinical Significance** Dysregulation of RAP1B has been implicated in various diseases, including: 1. **Cancer**: RAP1B overexpression has been observed in several types of cancer, including prostate, breast, and colon cancer. 2. **Immune-Related Disorders**: RAP1B dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders**: RAP1B has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Diseases**: RAP1B dysregulation has been linked to cardiovascular diseases, including atherosclerosis and cardiac arrhythmias. In summary, RAP1B is a critical regulator of various cellular processes, including cell proliferation, differentiation, migration, and survival. Its dysregulation has been implicated in several diseases, highlighting the importance of RAP1B in maintaining normal cellular function and preventing disease.

Genular Protein ID: 370911712

Symbol: RAP1B_HUMAN

Name: Ras-related protein Rap-1b

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3137530

Title: Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B).

PubMed ID: 3137530

DOI: 10.1093/nar/16.15.7719

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3141412

Title: Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.

PubMed ID: 3141412

DOI: 10.1016/s0021-9258(18)37454-4

PubMed ID: 1696481

Title: Rap1-B is phosphorylated by protein kinase A in intact human platelets.

PubMed ID: 1696481

DOI: 10.1016/0006-291x(90)92182-y

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 2123345

Title: Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.

PubMed ID: 2123345

DOI: 10.1073/pnas.87.22.8960

PubMed ID: 8463283

Title: Mutational analysis of the cAMP-dependent protein kinase-mediated phosphorylation site of Rap1b.

PubMed ID: 8463283

DOI: 10.1016/s0021-9258(18)53207-5

PubMed ID: 17509819

Title: Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.

PubMed ID: 17509819

DOI: 10.1016/j.ygeno.2007.03.013

PubMed ID: 20332120

Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

PubMed ID: 20332120

DOI: 10.1242/jcs.059329

PubMed ID: 21840392

Title: Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.

PubMed ID: 21840392

DOI: 10.1016/j.cellsig.2011.07.022

PubMed ID: 24415755

Title: The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.

PubMed ID: 24415755

DOI: 10.1074/jbc.m113.527192

PubMed ID: 18309292

Title: The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.

PubMed ID: 18309292

DOI: 10.1038/emboj.2008.30

PubMed ID: 18660803

Title: Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B.

PubMed ID: 18660803

DOI: 10.1038/nature07187

PubMed ID: 22577140

Title: Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).

PubMed ID: 22577140

DOI: 10.1074/jbc.m112.361295

PubMed ID: 32627184

Title: De novo missense variants in the RAP1B gene identified in two patients with syndromic thrombocytopenia.

PubMed ID: 32627184

DOI: 10.1111/cge.13807

PubMed ID: 35451551

Title: Third reported patient with RAP1B-related syndromic thrombocytopenia and novel clinical findings.

PubMed ID: 35451551

DOI: 10.1002/ajmg.a.62760

PubMed ID: 37850357

Title: Adding to the evidence of gene-disease association of RAP1B and syndromic thrombocytopenia.

PubMed ID: 37850357

DOI: 10.1111/cge.14438

Sequence Information:

  • Length: 184
  • Mass: 20825
  • Checksum: CE976895E5965224
  • Sequence:
  • MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG 
    TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL 
    EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS 
    CQLL

Genular Protein ID: 3945187946

Symbol: B7ZAY2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 142
  • Mass: 15989
  • Checksum: ECF8A6F1F34A5525
  • Sequence:
  • MREYKLVVLG SGGVGKSALE QFTAMRDLYM KNGQGFALVY SITAQSTFND LQDLREQILR 
    VKDTADVPMI LVGNKCDLED ERVVGKEQGQ NLARQWNNCA FLESSAKSKI NVNEIFYDLV 
    RQINRKTPVP GKARKKSSCQ LL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.