Details for: RAP1B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 539.0715
Cell Significance Index: -83.8500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 285.9132
Cell Significance Index: -72.5200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 205.6333
Cell Significance Index: -83.5400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 200.2869
Cell Significance Index: -94.5600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 181.0705
Cell Significance Index: -93.1400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 141.0833
Cell Significance Index: -94.6700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 89.0711
Cell Significance Index: -85.0400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 71.9288
Cell Significance Index: -88.6900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 22.9723
Cell Significance Index: -90.6500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.7597
Cell Significance Index: -60.9700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 20.8501
Cell Significance Index: -64.0400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.1226
Cell Significance Index: -44.0400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.8975
Cell Significance Index: 104.0700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.7044
Cell Significance Index: 318.9300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.5397
Cell Significance Index: 132.2900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.5030
Cell Significance Index: 71.7500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.4358
Cell Significance Index: 45.0200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.2692
Cell Significance Index: 66.6400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.1371
Cell Significance Index: 262.7800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.9176
Cell Significance Index: 345.6900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8595
Cell Significance Index: 369.0200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.7641
Cell Significance Index: 34.4300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.7457
Cell Significance Index: 82.0500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6855
Cell Significance Index: 108.7400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3761
Cell Significance Index: 188.9800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3496
Cell Significance Index: 270.7200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.2946
Cell Significance Index: 18.6200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.2293
Cell Significance Index: 63.8600 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.0319
Cell Significance Index: 133.3200 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.0095
Cell Significance Index: 17.8400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9934
Cell Significance Index: 542.5100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.9801
Cell Significance Index: 9.0300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.9695
Cell Significance Index: 24.9200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.9164
Cell Significance Index: 68.3000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.7594
Cell Significance Index: 20.6700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7302
Cell Significance Index: 322.8200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6663
Cell Significance Index: 37.3900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6161
Cell Significance Index: 47.2800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5847
Cell Significance Index: 16.8500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5811
Cell Significance Index: 208.4200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.5162
Cell Significance Index: 66.1800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.4883
Cell Significance Index: 2.9500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4401
Cell Significance Index: 43.5400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3439
Cell Significance Index: 7.4500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3153
Cell Significance Index: 218.0400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3122
Cell Significance Index: 141.6800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2564
Cell Significance Index: 231.5000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2418
Cell Significance Index: 455.2000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2188
Cell Significance Index: 138.9300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1292
Cell Significance Index: 24.6000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1110
Cell Significance Index: 170.9200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1085
Cell Significance Index: 18.5200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0868
Cell Significance Index: 160.0900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0576
Cell Significance Index: 4.0800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0122
Cell Significance Index: 16.5700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0018
Cell Significance Index: 0.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0215
Cell Significance Index: -15.9500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0274
Cell Significance Index: -17.1300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0375
Cell Significance Index: -0.7800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0768
Cell Significance Index: -56.3000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0934
Cell Significance Index: -70.7000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1201
Cell Significance Index: -12.2700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1211
Cell Significance Index: -68.3200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2161
Cell Significance Index: -6.0400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2223
Cell Significance Index: -46.8200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2514
Cell Significance Index: -15.4500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2546
Cell Significance Index: -73.2700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2686
Cell Significance Index: -39.0500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3028
Cell Significance Index: -34.5700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3060
Cell Significance Index: -13.8700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3498
Cell Significance Index: -16.3100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4431
Cell Significance Index: -51.6400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4640
Cell Significance Index: -53.1600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4880
Cell Significance Index: -24.6600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.5041
Cell Significance Index: -17.7200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5538
Cell Significance Index: -57.6600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7211
Cell Significance Index: -48.4900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7388
Cell Significance Index: -10.0800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.7534
Cell Significance Index: -19.8100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7914
Cell Significance Index: -49.8800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8205
Cell Significance Index: -21.9900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9136
Cell Significance Index: -40.4100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.9316
Cell Significance Index: -24.9200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0011
Cell Significance Index: -79.2900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.0791
Cell Significance Index: -23.0700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.0838
Cell Significance Index: -37.6600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.0843
Cell Significance Index: -41.0600 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -1.1522
Cell Significance Index: -8.2800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.2200
Cell Significance Index: -13.8600 - Cell Name: peg cell (CL4033014)
Fold Change: -1.2264
Cell Significance Index: -28.3400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.3799
Cell Significance Index: -23.2500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.4551
Cell Significance Index: -30.9900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.5283
Cell Significance Index: -26.1900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.5310
Cell Significance Index: -93.8700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -1.5592
Cell Significance Index: -22.3900 - Cell Name: perivascular cell (CL4033054)
Fold Change: -1.5789
Cell Significance Index: -7.2900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.5977
Cell Significance Index: -23.9400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.6673
Cell Significance Index: -87.5400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.7085
Cell Significance Index: -54.7200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.9674
Cell Significance Index: -50.2600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 370911712
Symbol: RAP1B_HUMAN
Name: Ras-related protein Rap-1b
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3137530
Title: Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B).
PubMed ID: 3137530
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3141412
Title: Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.
PubMed ID: 3141412
PubMed ID: 1696481
Title: Rap1-B is phosphorylated by protein kinase A in intact human platelets.
PubMed ID: 1696481
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 2123345
Title: Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.
PubMed ID: 2123345
PubMed ID: 8463283
Title: Mutational analysis of the cAMP-dependent protein kinase-mediated phosphorylation site of Rap1b.
PubMed ID: 8463283
PubMed ID: 17509819
Title: Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.
PubMed ID: 17509819
PubMed ID: 20332120
Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.
PubMed ID: 20332120
DOI: 10.1242/jcs.059329
PubMed ID: 21840392
Title: Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.
PubMed ID: 21840392
PubMed ID: 24415755
Title: The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.
PubMed ID: 24415755
PubMed ID: 18309292
Title: The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.
PubMed ID: 18309292
PubMed ID: 18660803
Title: Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B.
PubMed ID: 18660803
DOI: 10.1038/nature07187
PubMed ID: 22577140
Title: Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).
PubMed ID: 22577140
PubMed ID: 32627184
Title: De novo missense variants in the RAP1B gene identified in two patients with syndromic thrombocytopenia.
PubMed ID: 32627184
DOI: 10.1111/cge.13807
PubMed ID: 35451551
Title: Third reported patient with RAP1B-related syndromic thrombocytopenia and novel clinical findings.
PubMed ID: 35451551
DOI: 10.1002/ajmg.a.62760
PubMed ID: 37850357
Title: Adding to the evidence of gene-disease association of RAP1B and syndromic thrombocytopenia.
PubMed ID: 37850357
DOI: 10.1111/cge.14438
Sequence Information:
- Length: 184
- Mass: 20825
- Checksum: CE976895E5965224
- Sequence:
MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS CQLL
Genular Protein ID: 3945187946
Symbol: B7ZAY2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 142
- Mass: 15989
- Checksum: ECF8A6F1F34A5525
- Sequence:
MREYKLVVLG SGGVGKSALE QFTAMRDLYM KNGQGFALVY SITAQSTFND LQDLREQILR VKDTADVPMI LVGNKCDLED ERVVGKEQGQ NLARQWNNCA FLESSAKSKI NVNEIFYDLV RQINRKTPVP GKARKKSSCQ LL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.