Details for: NME2

Gene ID: 4831

Symbol: NME2

Ensembl ID: ENSG00000243678

Description: NME/NM23 nucleoside diphosphate kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 290.9122
    Cell Significance Index: -45.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 176.1134
    Cell Significance Index: -44.6700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 124.8945
    Cell Significance Index: -51.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 100.3139
    Cell Significance Index: -51.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 98.0889
    Cell Significance Index: -46.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.1060
    Cell Significance Index: -45.7500
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 36.3854
    Cell Significance Index: 27.7700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 27.4328
    Cell Significance Index: 235.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.7053
    Cell Significance Index: -47.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 15.5023
    Cell Significance Index: 358.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6167
    Cell Significance Index: -45.8400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 11.2992
    Cell Significance Index: 81.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.4791
    Cell Significance Index: 300.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.8226
    Cell Significance Index: 259.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 7.8385
    Cell Significance Index: 100.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 7.6194
    Cell Significance Index: 70.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.1071
    Cell Significance Index: 80.7400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 5.9278
    Cell Significance Index: 27.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.2006
    Cell Significance Index: 639.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.1835
    Cell Significance Index: 934.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.0842
    Cell Significance Index: 93.9700
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 3.6876
    Cell Significance Index: 17.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.9977
    Cell Significance Index: 353.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.4055
    Cell Significance Index: 60.1300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.1521
    Cell Significance Index: 21.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.0922
    Cell Significance Index: 268.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0271
    Cell Significance Index: 220.4900
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.8581
    Cell Significance Index: 5.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.7283
    Cell Significance Index: 26.7400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.3257
    Cell Significance Index: 10.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0119
    Cell Significance Index: 29.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9988
    Cell Significance Index: 69.0700
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.8940
    Cell Significance Index: 4.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7515
    Cell Significance Index: 19.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6767
    Cell Significance Index: 66.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6690
    Cell Significance Index: 108.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6158
    Cell Significance Index: 37.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5487
    Cell Significance Index: 110.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3527
    Cell Significance Index: 48.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3400
    Cell Significance Index: 307.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1680
    Cell Significance Index: 60.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1506
    Cell Significance Index: 82.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1442
    Cell Significance Index: 6.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1440
    Cell Significance Index: 3.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1357
    Cell Significance Index: 0.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0803
    Cell Significance Index: 35.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0427
    Cell Significance Index: 1.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0386
    Cell Significance Index: 7.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0107
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0244
    Cell Significance Index: -45.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0260
    Cell Significance Index: -48.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0296
    Cell Significance Index: -22.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0313
    Cell Significance Index: -5.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0313
    Cell Significance Index: -48.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0523
    Cell Significance Index: -38.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0537
    Cell Significance Index: -5.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0609
    Cell Significance Index: -38.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0651
    Cell Significance Index: -47.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0657
    Cell Significance Index: -37.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0786
    Cell Significance Index: -49.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0960
    Cell Significance Index: -12.4000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0960
    Cell Significance Index: -0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1030
    Cell Significance Index: -46.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1146
    Cell Significance Index: -5.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1260
    Cell Significance Index: -36.2700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1479
    Cell Significance Index: -0.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1554
    Cell Significance Index: -11.9300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1835
    Cell Significance Index: -1.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2126
    Cell Significance Index: -8.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2249
    Cell Significance Index: -44.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2290
    Cell Significance Index: -48.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2559
    Cell Significance Index: -14.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2564
    Cell Significance Index: -29.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3066
    Cell Significance Index: -6.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3189
    Cell Significance Index: -10.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3296
    Cell Significance Index: -7.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3398
    Cell Significance Index: -49.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3491
    Cell Significance Index: -40.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3688
    Cell Significance Index: -27.4900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3695
    Cell Significance Index: -2.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4108
    Cell Significance Index: -29.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4131
    Cell Significance Index: -11.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4199
    Cell Significance Index: -8.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4248
    Cell Significance Index: -6.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4271
    Cell Significance Index: -19.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4331
    Cell Significance Index: -19.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5484
    Cell Significance Index: -28.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5617
    Cell Significance Index: -34.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5853
    Cell Significance Index: -36.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6253
    Cell Significance Index: -49.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6467
    Cell Significance Index: -41.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6963
    Cell Significance Index: -46.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7560
    Cell Significance Index: -18.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7734
    Cell Significance Index: -34.2100
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: -0.8057
    Cell Significance Index: -5.3800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.8208
    Cell Significance Index: -5.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8630
    Cell Significance Index: -45.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9758
    Cell Significance Index: -36.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0840
    Cell Significance Index: -35.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0951
    Cell Significance Index: -40.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Nucleoside Diphosphate Kinase Activity:** NME2 possesses nucleoside diphosphate kinase (NDK) activity, which is essential for the regulation of nucleotide metabolism. 2. **Cell Signaling:** NME2 is involved in various signaling pathways, including the adenylate cyclase-activating G protein-coupled receptor signaling pathway, integrin-mediated signaling pathway, and the regulation of apoptotic processes. 3. **Immune Response:** NME2 is significantly expressed in immune cells, including monocytes, dendritic cells, and B cells, and plays a role in the regulation of immune responses, including neutrophil degranulation and the response to oxidative stress. 4. **Cellular Localization:** NME2 is primarily localized to the cytosol and nucleus, where it regulates various cellular processes, including metabolism, differentiation, and apoptosis. **Pathways and Functions:** 1. **Nucleotide Metabolism:** NME2 regulates the metabolism of nucleotides, including the conversion of nucleoside triphosphates to nucleoside diphosphates. 2. **Cell Signaling:** NME2 is involved in various signaling pathways, including the regulation of cell proliferation, differentiation, and apoptosis. 3. **Immune Response:** NME2 plays a role in the regulation of immune responses, including neutrophil degranulation and the response to oxidative stress. 4. **Metabolism of Fatty Acids:** NME2 is involved in the regulation of fatty acid metabolism, including the conversion of fatty acids to fatty acid esters. **Clinical Significance:** 1. **Cancer:** NME2 has been implicated in the regulation of cancer cell proliferation, differentiation, and apoptosis. Its dysregulation has been observed in various types of cancer, including breast, prostate, and lung cancer. 2. **Cardiovascular Disease:** NME2 has been implicated in the regulation of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Neurodegenerative Disorders:** NME2 has been implicated in the regulation of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Infectious Diseases:** NME2 has been implicated in the regulation of immune responses to infectious diseases, including tuberculosis and HIV. In conclusion, NME2 is a multifaceted gene that plays a crucial role in various cellular processes, including metabolism, immune response, and cell signaling. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Further research is needed to fully understand the functions and clinical significance of NME2.

Genular Protein ID: 2286737950

Symbol: NDKB_HUMAN

Name: Nucleoside diphosphate kinase B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1988104

Title: Identification of a second human nm23 gene, nm23-H2.

PubMed ID: 1988104

PubMed ID: 1851158

Title: Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.

PubMed ID: 1851158

DOI: 10.1016/s0021-9258(18)31515-1

PubMed ID: 8392752

Title: Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis.

PubMed ID: 8392752

DOI: 10.1126/science.8392752

PubMed ID: 16442775

Title: Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.

PubMed ID: 16442775

DOI: 10.1016/j.ygeno.2005.11.004

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7488060

Title: Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396.

PubMed ID: 7488060

DOI: 10.1006/bbrc.1995.2550

PubMed ID: 11919189

Title: Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement.

PubMed ID: 11919189

DOI: 10.1074/jbc.m200200200

PubMed ID: 15249197

Title: Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2.

PubMed ID: 15249197

DOI: 10.1016/j.bbrc.2004.06.067

PubMed ID: 17532299

Title: NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling.

PubMed ID: 17532299

DOI: 10.1016/j.bbrc.2007.05.090

PubMed ID: 20946858

Title: Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1.

PubMed ID: 20946858

DOI: 10.1016/s0076-6879(10)71020-x

PubMed ID: 25679041

Title: The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA.

PubMed ID: 25679041

DOI: 10.1021/bi501284g

PubMed ID: 7658474

Title: The crystal structure of a human nucleoside diphosphate kinase, NM23-H2.

PubMed ID: 7658474

DOI: 10.1006/jmbi.1995.0457

PubMed ID: 8747457

Title: X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2-A resolution.

PubMed ID: 8747457

DOI: 10.1016/s0969-2126(01)00268-4

PubMed ID: 19435876

Title: NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).

PubMed ID: 19435876

DOI: 10.1158/1535-7163.mct-08-1093

Sequence Information:

  • Length: 152
  • Mass: 17298
  • Checksum: 1A5C3F84D7AD272C
  • Sequence:
  • MANLERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ HYIDLKDRPF 
    FPGLVKYMNS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS 
    DSVKSAEKEI SLWFKPEELV DYKSCAHDWV YE

Genular Protein ID: 2497541259

Symbol: F6XY72_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 82
  • Mass: 9583
  • Checksum: 9227057EC5B12B55
  • Sequence:
  • MANLERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ HYIDLKDRPF 
    FPGLVKYMNS GPVVAMEHHS WQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.