Details for: NME2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 290.9122
Cell Significance Index: -45.2500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 176.1134
Cell Significance Index: -44.6700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 124.8945
Cell Significance Index: -51.4500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 100.3139
Cell Significance Index: -51.6000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 98.0889
Cell Significance Index: -46.3100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 37.1060
Cell Significance Index: -45.7500 - Cell Name: colon endothelial cell (CL1001572)
Fold Change: 36.3854
Cell Significance Index: 27.7700 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 27.4328
Cell Significance Index: 235.7300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.7053
Cell Significance Index: -47.4300 - Cell Name: peg cell (CL4033014)
Fold Change: 15.5023
Cell Significance Index: 358.1600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.6167
Cell Significance Index: -45.8400 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 11.2992
Cell Significance Index: 81.1500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 10.4791
Cell Significance Index: 300.3900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 8.8226
Cell Significance Index: 259.1100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 7.8385
Cell Significance Index: 100.3900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 7.6194
Cell Significance Index: 70.1700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 7.1071
Cell Significance Index: 80.7400 - Cell Name: perivascular cell (CL4033054)
Fold Change: 5.9278
Cell Significance Index: 27.3700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 5.2006
Cell Significance Index: 639.4700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.1835
Cell Significance Index: 934.4300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 5.0842
Cell Significance Index: 93.9700 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 3.6876
Cell Significance Index: 17.9400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.9977
Cell Significance Index: 353.5200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.4055
Cell Significance Index: 60.1300 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 2.1521
Cell Significance Index: 21.7100 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.0922
Cell Significance Index: 268.2100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.0271
Cell Significance Index: 220.4900 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.8581
Cell Significance Index: 5.3300 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.7283
Cell Significance Index: 26.7400 - Cell Name: germ cell (CL0000586)
Fold Change: 1.3257
Cell Significance Index: 10.0100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.0119
Cell Significance Index: 29.1600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.9988
Cell Significance Index: 69.0700 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.8940
Cell Significance Index: 4.4600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7515
Cell Significance Index: 19.7600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6767
Cell Significance Index: 66.9500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6690
Cell Significance Index: 108.8100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6158
Cell Significance Index: 37.8500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5487
Cell Significance Index: 110.0700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3527
Cell Significance Index: 48.4400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3400
Cell Significance Index: 307.0100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1680
Cell Significance Index: 60.2700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1506
Cell Significance Index: 82.2200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1442
Cell Significance Index: 6.7800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1440
Cell Significance Index: 3.1200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1357
Cell Significance Index: 0.8200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0803
Cell Significance Index: 35.4900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0427
Cell Significance Index: 1.5000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0386
Cell Significance Index: 7.3500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0107
Cell Significance Index: -0.2900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0244
Cell Significance Index: -45.8500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0260
Cell Significance Index: -48.0200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0296
Cell Significance Index: -22.4400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0313
Cell Significance Index: -5.3500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0313
Cell Significance Index: -48.1700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0523
Cell Significance Index: -38.7100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0537
Cell Significance Index: -5.4900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0609
Cell Significance Index: -38.0400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0651
Cell Significance Index: -47.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0657
Cell Significance Index: -37.0300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0786
Cell Significance Index: -49.9500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0960
Cell Significance Index: -12.4000 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.0960
Cell Significance Index: -0.8300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1030
Cell Significance Index: -46.7700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1146
Cell Significance Index: -5.7900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1260
Cell Significance Index: -36.2700 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.1479
Cell Significance Index: -0.9100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1554
Cell Significance Index: -11.9300 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.1835
Cell Significance Index: -1.1400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2126
Cell Significance Index: -8.7100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2249
Cell Significance Index: -44.6300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2290
Cell Significance Index: -48.2400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2559
Cell Significance Index: -14.3600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2564
Cell Significance Index: -29.8900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3066
Cell Significance Index: -6.3600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3189
Cell Significance Index: -10.2200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3296
Cell Significance Index: -7.0200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3398
Cell Significance Index: -49.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3491
Cell Significance Index: -40.0000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3688
Cell Significance Index: -27.4900 - Cell Name: glioblast (CL0000030)
Fold Change: -0.3695
Cell Significance Index: -2.3200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4108
Cell Significance Index: -29.0500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4131
Cell Significance Index: -11.2500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4199
Cell Significance Index: -8.7900 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.4248
Cell Significance Index: -6.8200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4271
Cell Significance Index: -19.9200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.4331
Cell Significance Index: -19.6300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5484
Cell Significance Index: -28.4900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5617
Cell Significance Index: -34.4400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5853
Cell Significance Index: -36.8900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6253
Cell Significance Index: -49.5200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.6467
Cell Significance Index: -41.7300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6963
Cell Significance Index: -46.8200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.7560
Cell Significance Index: -18.1300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7734
Cell Significance Index: -34.2100 - Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
Fold Change: -0.8057
Cell Significance Index: -5.3800 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.8208
Cell Significance Index: -5.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8630
Cell Significance Index: -45.3100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9758
Cell Significance Index: -36.9500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0840
Cell Significance Index: -35.4900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.0951
Cell Significance Index: -40.2000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2286737950
Symbol: NDKB_HUMAN
Name: Nucleoside diphosphate kinase B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1988104
Title: Identification of a second human nm23 gene, nm23-H2.
PubMed ID: 1988104
PubMed ID: 1851158
Title: Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.
PubMed ID: 1851158
PubMed ID: 8392752
Title: Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis.
PubMed ID: 8392752
PubMed ID: 16442775
Title: Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.
PubMed ID: 16442775
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7488060
Title: Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396.
PubMed ID: 7488060
PubMed ID: 11919189
Title: Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement.
PubMed ID: 11919189
PubMed ID: 15249197
Title: Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2.
PubMed ID: 15249197
PubMed ID: 17532299
Title: NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling.
PubMed ID: 17532299
PubMed ID: 20946858
Title: Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1.
PubMed ID: 20946858
PubMed ID: 25679041
Title: The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA.
PubMed ID: 25679041
DOI: 10.1021/bi501284g
PubMed ID: 7658474
Title: The crystal structure of a human nucleoside diphosphate kinase, NM23-H2.
PubMed ID: 7658474
PubMed ID: 8747457
Title: X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2-A resolution.
PubMed ID: 8747457
PubMed ID: 19435876
Title: NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).
PubMed ID: 19435876
Sequence Information:
- Length: 152
- Mass: 17298
- Checksum: 1A5C3F84D7AD272C
- Sequence:
MANLERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ HYIDLKDRPF FPGLVKYMNS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVKSAEKEI SLWFKPEELV DYKSCAHDWV YE
Genular Protein ID: 2497541259
Symbol: F6XY72_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
Sequence Information:
- Length: 82
- Mass: 9583
- Checksum: 9227057EC5B12B55
- Sequence:
MANLERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ HYIDLKDRPF FPGLVKYMNS GPVVAMEHHS WQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.