Details for: KLRF1

Gene ID: 51348

Symbol: KLRF1

Ensembl ID: ENSG00000150045

Description: killer cell lectin like receptor F1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.5518
    Cell Significance Index: -4.1300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 19.4652
    Cell Significance Index: 52.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.5193
    Cell Significance Index: -4.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 10.0398
    Cell Significance Index: -4.7400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 4.7727
    Cell Significance Index: 50.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 4.2721
    Cell Significance Index: 136.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.4227
    Cell Significance Index: -4.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.1246
    Cell Significance Index: 130.2600
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 1.1367
    Cell Significance Index: 2.9100
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.0134
    Cell Significance Index: 7.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8367
    Cell Significance Index: 17.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6700
    Cell Significance Index: 30.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6580
    Cell Significance Index: 125.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6488
    Cell Significance Index: -1.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4188
    Cell Significance Index: 41.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3214
    Cell Significance Index: 290.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2915
    Cell Significance Index: 31.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2717
    Cell Significance Index: 16.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2452
    Cell Significance Index: 39.8900
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.1613
    Cell Significance Index: 1.3800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: 0.1531
    Cell Significance Index: 1.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1338
    Cell Significance Index: 9.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0885
    Cell Significance Index: 1.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0092
    Cell Significance Index: 0.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0092
    Cell Significance Index: 4.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0023
    Cell Significance Index: 1.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0014
    Cell Significance Index: -1.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0033
    Cell Significance Index: -4.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0037
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0057
    Cell Significance Index: -0.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0059
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0080
    Cell Significance Index: -0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0090
    Cell Significance Index: -0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0090
    Cell Significance Index: -1.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0102
    Cell Significance Index: -3.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0107
    Cell Significance Index: -4.8600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0108
    Cell Significance Index: -0.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0134
    Cell Significance Index: -0.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0163
    Cell Significance Index: -1.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0166
    Cell Significance Index: -4.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0169
    Cell Significance Index: -3.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0174
    Cell Significance Index: -3.4900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0199
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0213
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0223
    Cell Significance Index: -4.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0244
    Cell Significance Index: -3.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0246
    Cell Significance Index: -1.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0275
    Cell Significance Index: -2.8100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0303
    Cell Significance Index: -0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0322
    Cell Significance Index: -4.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0336
    Cell Significance Index: -3.8500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0376
    Cell Significance Index: -0.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0388
    Cell Significance Index: -5.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0395
    Cell Significance Index: -1.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0411
    Cell Significance Index: -1.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0416
    Cell Significance Index: -4.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0420
    Cell Significance Index: -4.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0462
    Cell Significance Index: -0.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0489
    Cell Significance Index: -3.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0516
    Cell Significance Index: -3.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0559
    Cell Significance Index: -2.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0575
    Cell Significance Index: -1.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0605
    Cell Significance Index: -4.7900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0610
    Cell Significance Index: -0.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0625
    Cell Significance Index: -2.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0633
    Cell Significance Index: -4.7200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0653
    Cell Significance Index: -0.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0662
    Cell Significance Index: -3.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0681
    Cell Significance Index: -4.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0692
    Cell Significance Index: -1.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0696
    Cell Significance Index: -1.7900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0749
    Cell Significance Index: -0.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0760
    Cell Significance Index: -2.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0779
    Cell Significance Index: -1.8000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0787
    Cell Significance Index: -3.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0792
    Cell Significance Index: -4.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0793
    Cell Significance Index: -1.6600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0859
    Cell Significance Index: -1.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0863
    Cell Significance Index: -4.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0974
    Cell Significance Index: -3.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0980
    Cell Significance Index: -5.1100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1012
    Cell Significance Index: -1.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1022
    Cell Significance Index: -4.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1053
    Cell Significance Index: -1.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1100
    Cell Significance Index: -1.2500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1166
    Cell Significance Index: -1.9800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1176
    Cell Significance Index: -1.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1190
    Cell Significance Index: -4.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1236
    Cell Significance Index: -4.3300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1265
    Cell Significance Index: -1.8000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1281
    Cell Significance Index: -1.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1281
    Cell Significance Index: -2.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KLRF1 is a transmembrane receptor that belongs to the killer cell lectin-like receptor subfamily F. It is characterized by its ability to bind to specific carbohydrate ligands, which triggers signaling pathways involved in immune responses. KLRF1 is expressed in various cell types, including polychromatophilic erythroblasts, hepatic pit cells, and hematopoietic oligopotent progenitor cells. Its expression in smooth muscle fibers and epithelial cells suggests a broader role in tissue homeostasis. **Pathways and Functions** KLRF1 is involved in multiple immune-related pathways, including: 1. **Adaptive Immune System**: KLRF1 plays a role in the activation of cytotoxic T cells, particularly alpha-beta T cells, and natural killer T (NKT) cells. This activation is crucial for the elimination of infected cells and tumor cells. 2. **Innate Immune Response**: KLRF1 is involved in the recognition of carbohydrate ligands on the surface of pathogens, triggering an innate immune response. 3. **Carbohydrate Binding**: KLRF1 binds to specific carbohydrate ligands, which activates signaling pathways involved in immune responses. 4. **Cell Surface Receptor Signaling Pathway**: KLRF1 transduces signals through its associated adapter proteins, influencing downstream signaling pathways involved in immune responses. 5. **Immunoregulatory Interactions**: KLRF1 interacts with non-lymphoid cells, such as smooth muscle fibers and epithelial cells, to regulate immune responses and maintain immune homeostasis. **Clinical Significance** KLRF1 has been implicated in various diseases, including: 1. **Autoimmune Disorders**: KLRF1 has been associated with autoimmune disorders, such as multiple sclerosis and type 1 diabetes, where its dysregulation leads to immune system dysfunction. 2. **Cancer**: KLRF1 has been shown to inhibit tumor cell growth and invasion in certain types of cancer, such as melanoma and lung cancer. 3. **Infectious Diseases**: KLRF1 has been implicated in the recognition of pathogens, such as bacteria and viruses, and the activation of immune responses to eliminate these pathogens. In conclusion, KLRF1 is a multifunctional receptor that plays a critical role in the immune system. Its involvement in adaptive and innate immune responses, carbohydrate binding, and cell surface receptor signaling pathways highlights its potential as a therapeutic target for various diseases. Further research is needed to fully elucidate the functions of KLRF1 and its role in human disease.

Genular Protein ID: 2157753890

Symbol: KLRF1_HUMAN

Name: Killer cell lectin-like receptor subfamily F member 1

UniProtKB Accession Codes:

Q9NZS2 A0A0C4DGY9 Q4KMT5 Q96PR2 Q96PR3 Q9NZS1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10671213

Title: Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis.

PubMed ID: 10671213

DOI: 10.1002/1521-4141(200002)30:2<568::aid-immu568>3.0.co;2-y

PubMed ID: 11513955

Title: Molecular characterization of two novel alternative spliced variants of the KLRF1 gene and subcellular distribution of KLRF1 isoforms.

PubMed ID: 11513955

DOI: 10.1016/s0167-4781(01)00261-5

PubMed ID: 11265639

Title: Identification of NKp80, a novel triggering molecule expressed by human natural killer cells.

PubMed ID: 11265639

DOI: 10.1002/1521-4141(200101)31:1<233::aid-immu233>3.0.co;2-4

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17057721

Title: Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction.

PubMed ID: 17057721

DOI: 10.1038/ni1402

PubMed ID: 21149606

Title: Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity.

PubMed ID: 21149606

DOI: 10.4049/jimmunol.0904117

Sequence Information:

  • Length: 231
  • Mass: 26563
  • Checksum: A2F7BE6D4341AFDE
  • Sequence:
    • MQDEERYMTL NVQSKKRSSA QTSQLTFKDY SVTLHWYKIL LGISGTVNGI LTLTLISLIL 
LVSQGVLLKC QKGSCSNATQ YEDTGDLKVN NGTRRNISNK DLCASRSADQ TVLCQSEWLK 
YQGKCYWFSN EMKSWSDSYV YCLERKSHLL IIHDQLEMAF IQKNLRQLNY VWIGLNFTSL 
KMTWTWVDGS PIDSKIFFIK GPAKENSCAA IKESKIFSET CSSVFKWICQ Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.