Details for: SSR2

Gene ID: 6746

Symbol: SSR2

Ensembl ID: ENSG00000163479

Description: signal sequence receptor subunit 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.97
    Marker Score: 52353
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.75
    Marker Score: 37113
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.61
    Marker Score: 11390
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.48
    Marker Score: 183903.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.41
    Marker Score: 115927.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.36
    Marker Score: 21860
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.32
    Marker Score: 2829
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.29
    Marker Score: 38187
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.26
    Marker Score: 13971
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.22
    Marker Score: 9406
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.2
    Marker Score: 2259
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.2
    Marker Score: 4930
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.2
    Marker Score: 8840
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.13
    Marker Score: 3021.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.12
    Marker Score: 5569
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.01
    Marker Score: 2533
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.93
    Marker Score: 1464
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.89
    Marker Score: 4966
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.88
    Marker Score: 1811
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.88
    Marker Score: 1689
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.85
    Marker Score: 98771
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.85
    Marker Score: 10990
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.84
    Marker Score: 6917
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.83
    Marker Score: 1129
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.83
    Marker Score: 1272
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.8
    Marker Score: 2616
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.79
    Marker Score: 6367
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.79
    Marker Score: 2491.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.79
    Marker Score: 2186
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.78
    Marker Score: 7801.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.77
    Marker Score: 2434
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.77
    Marker Score: 1021
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.76
    Marker Score: 1974.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.75
    Marker Score: 3326
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.75
    Marker Score: 4425
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.75
    Marker Score: 2448
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.75
    Marker Score: 17593
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.75
    Marker Score: 11849
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.73
    Marker Score: 4025
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.72
    Marker Score: 650.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7
    Marker Score: 30451.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.7
    Marker Score: 151154.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.7
    Marker Score: 4298
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.69
    Marker Score: 862
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.69
    Marker Score: 2032
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.68
    Marker Score: 2643
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.68
    Marker Score: 1937.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.67
    Marker Score: 3783
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.67
    Marker Score: 5228
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.67
    Marker Score: 35817
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.65
    Marker Score: 10856.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.63
    Marker Score: 1693
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.63
    Marker Score: 2345
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.62
    Marker Score: 6868
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.61
    Marker Score: 5456
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.6
    Marker Score: 16972
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.6
    Marker Score: 7075
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.59
    Marker Score: 1478
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.58
    Marker Score: 4498
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.57
    Marker Score: 2413
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.57
    Marker Score: 2414
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.57
    Marker Score: 1546
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.56
    Marker Score: 793
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.55
    Marker Score: 2088
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.54
    Marker Score: 25605.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.54
    Marker Score: 2718
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.53
    Marker Score: 5746
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.52
    Marker Score: 4598
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.5
    Marker Score: 3086
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.5
    Marker Score: 1679
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.49
    Marker Score: 2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.49
    Marker Score: 4228.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.48
    Marker Score: 879
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.48
    Marker Score: 1071
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.48
    Marker Score: 1278
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.48
    Marker Score: 4824
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.47
    Marker Score: 5815
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.47
    Marker Score: 1463.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.46
    Marker Score: 12922
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.46
    Marker Score: 3378
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.45
    Marker Score: 1788.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.44
    Marker Score: 5957
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.44
    Marker Score: 4579
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.44
    Marker Score: 1344
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.43
    Marker Score: 2639
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.42
    Marker Score: 4297
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.42
    Marker Score: 2009
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.42
    Marker Score: 636.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.42
    Marker Score: 837
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.42
    Marker Score: 1141
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.41
    Marker Score: 24405
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.41
    Marker Score: 637.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.41
    Marker Score: 1384
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 2.4
    Marker Score: 2119.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.4
    Marker Score: 3316
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.4
    Marker Score: 10006
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.39
    Marker Score: 2640
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.38
    Marker Score: 1084
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.38
    Marker Score: 1393
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.38
    Marker Score: 3898

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Other Information

**Key Characteristics:** SSR2 is a highly expressed gene in various cell types, including mesodermal cells, mature T cells, and fibroblasts in the mammary gland. Its expression is also significant in immune cells such as gamma-delta T cells, alpha-beta T cells, and natural killer (NK) cells. SSR2 is a component of the SSR complex, which is responsible for binding to specific signal sequences on proteins and facilitating their translocation to the endoplasmic reticulum (ER) membrane. This process is crucial for the proper folding and maturation of proteins, which is essential for their subsequent function. **Pathways and Functions:** SSR2 is involved in several key pathways, including: 1. **Cotranslational protein targeting to membrane:** SSR2 plays a critical role in the targeting of proteins to the ER membrane, a process that is essential for their maturation and function. 2. **Endoplasmic reticulum (ER) and ER membrane:** SSR2 is involved in the proper functioning of the ER and its associated membranes, which are critical for protein folding, lipid synthesis, and calcium storage. 3. **Metabolism of proteins:** SSR2 is involved in the regulation of protein metabolism, including protein synthesis, degradation, and quality control. 4. **Protein binding:** SSR2 interacts with other proteins to facilitate the targeting of proteins to the ER membrane and to regulate protein function. **Clinical Significance:** Dysregulation of SSR2 has been implicated in various immune-related diseases, including: 1. **Autoimmune diseases:** Alterations in SSR2 expression and function have been linked to autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** SSR2 has been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma. 3. **Immune deficiencies:** SSR2 mutations have been associated with impaired immune function and increased susceptibility to infections. In conclusion, SSR2 is a critical gene that plays a central role in the development and function of immune cells. Its dysregulation has been implicated in various immune-related diseases, highlighting the importance of further research into the mechanisms of SSR2 function and its role in human health and disease.

Genular Protein ID: 1293434496

Symbol: SSRB_HUMAN

Name: Translocon-associated protein subunit beta

UniProtKB Accession Codes:

P43308 B2R9K9 D3DVA7 Q53HI0 Q5VY95 Q5VY96 Q6IB31 Q9BWE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8286409

Title: Cloning and sequence analysis of the beta subunit of the human translocon-associated protein.

PubMed ID: 8286409

PubMed ID: 7789174

Title: Isolation and mapping of the human beta-signal sequence receptor gene (SSR2).

PubMed ID: 7789174

DOI: 10.1159/000134036

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18724357

Title: STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.

PubMed ID: 18724357

DOI: 10.1038/nature07317

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 183
  • Mass: 20135
  • Checksum: 575715449B8586D8
  • Sequence:
    • MRLLSFVVLA LFAVTQAEEG ARLLASKSLL NRYAVEGRDL TLQYNIYNVG SSAALDVELS 
DDSFPPEDFG IVSGMLNVKW DRIAPASNVS HTVVLRPLKA GYFNFTSATI TYLAQEDGPV 
VIGSTSAPGQ GGILAQREFD RRFSPHFLDW AAFGVMTLPS IGIPLLLWYS SKRKYDTPKT 
KKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.