Details for: SSR2

Gene ID: 6746

Symbol: SSR2

Ensembl ID: ENSG00000163479

Description: signal sequence receptor subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 549.6794
    Cell Significance Index: -85.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 248.6365
    Cell Significance Index: -63.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 239.4843
    Cell Significance Index: -98.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 224.0699
    Cell Significance Index: -91.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 201.8331
    Cell Significance Index: -95.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 193.2598
    Cell Significance Index: -99.4100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 142.5586
    Cell Significance Index: -95.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 97.3142
    Cell Significance Index: -92.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 74.2525
    Cell Significance Index: -91.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.2521
    Cell Significance Index: -95.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.3096
    Cell Significance Index: -62.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4174
    Cell Significance Index: -43.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 6.8074
    Cell Significance Index: 87.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.7028
    Cell Significance Index: 140.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.9075
    Cell Significance Index: 673.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.7060
    Cell Significance Index: 138.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.5098
    Cell Significance Index: 210.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.1651
    Cell Significance Index: 45.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.1232
    Cell Significance Index: 108.4200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.1118
    Cell Significance Index: 32.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.0487
    Cell Significance Index: 140.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.8611
    Cell Significance Index: 181.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.3035
    Cell Significance Index: 246.2100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.2306
    Cell Significance Index: 18.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1991
    Cell Significance Index: 91.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.1620
    Cell Significance Index: 408.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.0527
    Cell Significance Index: 1667.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.4877
    Cell Significance Index: 318.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3637
    Cell Significance Index: 290.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3348
    Cell Significance Index: 150.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.2318
    Cell Significance Index: 157.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1661
    Cell Significance Index: 390.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1546
    Cell Significance Index: 129.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.0552
    Cell Significance Index: 350.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0358
    Cell Significance Index: 201.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0115
    Cell Significance Index: 889.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6774
    Cell Significance Index: 197.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5197
    Cell Significance Index: 79.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4524
    Cell Significance Index: 16.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0505
    Cell Significance Index: 24.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0287
    Cell Significance Index: 204.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9763
    Cell Significance Index: 26.0700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.9290
    Cell Significance Index: 17.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8838
    Cell Significance Index: 45.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6280
    Cell Significance Index: 17.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5684
    Cell Significance Index: 10.0500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5054
    Cell Significance Index: 3.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4906
    Cell Significance Index: 371.3800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4899
    Cell Significance Index: 3.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4154
    Cell Significance Index: 3.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3777
    Cell Significance Index: 17.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2696
    Cell Significance Index: 18.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2687
    Cell Significance Index: 51.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1650
    Cell Significance Index: 149.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1494
    Cell Significance Index: 2.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1452
    Cell Significance Index: 29.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0987
    Cell Significance Index: 16.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0592
    Cell Significance Index: 1.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0302
    Cell Significance Index: 22.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0283
    Cell Significance Index: 1.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0047
    Cell Significance Index: -2.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0123
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0272
    Cell Significance Index: -20.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0279
    Cell Significance Index: -19.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0368
    Cell Significance Index: -69.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0522
    Cell Significance Index: -18.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0576
    Cell Significance Index: -106.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0706
    Cell Significance Index: -108.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0809
    Cell Significance Index: -109.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1189
    Cell Significance Index: -67.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1336
    Cell Significance Index: -84.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1733
    Cell Significance Index: -36.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1992
    Cell Significance Index: -90.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2046
    Cell Significance Index: -23.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2928
    Cell Significance Index: -7.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2953
    Cell Significance Index: -84.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3216
    Cell Significance Index: -10.3000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3459
    Cell Significance Index: -2.1400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3476
    Cell Significance Index: -2.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3675
    Cell Significance Index: -10.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4131
    Cell Significance Index: -23.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5044
    Cell Significance Index: -57.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5226
    Cell Significance Index: -32.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5572
    Cell Significance Index: -64.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6137
    Cell Significance Index: -89.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8220
    Cell Significance Index: -22.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8841
    Cell Significance Index: -55.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9171
    Cell Significance Index: -95.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9735
    Cell Significance Index: -21.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0145
    Cell Significance Index: -80.3500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0268
    Cell Significance Index: -17.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1537
    Cell Significance Index: -88.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2733
    Cell Significance Index: -85.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3473
    Cell Significance Index: -82.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3948
    Cell Significance Index: -37.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5638
    Cell Significance Index: -39.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.5746
    Cell Significance Index: -16.3000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.6648
    Cell Significance Index: -34.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8147
    Cell Significance Index: -53.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9142
    Cell Significance Index: -84.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SSR2 is a highly expressed gene in various cell types, including mesodermal cells, mature T cells, and fibroblasts in the mammary gland. Its expression is also significant in immune cells such as gamma-delta T cells, alpha-beta T cells, and natural killer (NK) cells. SSR2 is a component of the SSR complex, which is responsible for binding to specific signal sequences on proteins and facilitating their translocation to the endoplasmic reticulum (ER) membrane. This process is crucial for the proper folding and maturation of proteins, which is essential for their subsequent function. **Pathways and Functions:** SSR2 is involved in several key pathways, including: 1. **Cotranslational protein targeting to membrane:** SSR2 plays a critical role in the targeting of proteins to the ER membrane, a process that is essential for their maturation and function. 2. **Endoplasmic reticulum (ER) and ER membrane:** SSR2 is involved in the proper functioning of the ER and its associated membranes, which are critical for protein folding, lipid synthesis, and calcium storage. 3. **Metabolism of proteins:** SSR2 is involved in the regulation of protein metabolism, including protein synthesis, degradation, and quality control. 4. **Protein binding:** SSR2 interacts with other proteins to facilitate the targeting of proteins to the ER membrane and to regulate protein function. **Clinical Significance:** Dysregulation of SSR2 has been implicated in various immune-related diseases, including: 1. **Autoimmune diseases:** Alterations in SSR2 expression and function have been linked to autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** SSR2 has been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma. 3. **Immune deficiencies:** SSR2 mutations have been associated with impaired immune function and increased susceptibility to infections. In conclusion, SSR2 is a critical gene that plays a central role in the development and function of immune cells. Its dysregulation has been implicated in various immune-related diseases, highlighting the importance of further research into the mechanisms of SSR2 function and its role in human health and disease.

Genular Protein ID: 1293434496

Symbol: SSRB_HUMAN

Name: Translocon-associated protein subunit beta

UniProtKB Accession Codes:

P43308 B2R9K9 D3DVA7 Q53HI0 Q5VY95 Q5VY96 Q6IB31 Q9BWE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8286409

Title: Cloning and sequence analysis of the beta subunit of the human translocon-associated protein.

PubMed ID: 8286409

PubMed ID: 7789174

Title: Isolation and mapping of the human beta-signal sequence receptor gene (SSR2).

PubMed ID: 7789174

DOI: 10.1159/000134036

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18724357

Title: STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.

PubMed ID: 18724357

DOI: 10.1038/nature07317

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 183
  • Mass: 20135
  • Checksum: 575715449B8586D8
  • Sequence:
    • MRLLSFVVLA LFAVTQAEEG ARLLASKSLL NRYAVEGRDL TLQYNIYNVG SSAALDVELS 
DDSFPPEDFG IVSGMLNVKW DRIAPASNVS HTVVLRPLKA GYFNFTSATI TYLAQEDGPV 
VIGSTSAPGQ GGILAQREFD RRFSPHFLDW AAFGVMTLPS IGIPLLLWYS SKRKYDTPKT 
KKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.