Details for: PPP1CA

Gene ID: 5499

Symbol: PPP1CA

Ensembl ID: ENSG00000172531

Description: protein phosphatase 1 catalytic subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 237.4229
    Cell Significance Index: -36.9300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 152.4830
    Cell Significance Index: -62.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.5694
    Cell Significance Index: -37.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 143.3329
    Cell Significance Index: -58.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 123.5696
    Cell Significance Index: -58.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 121.3099
    Cell Significance Index: -62.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 87.5679
    Cell Significance Index: -58.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.1055
    Cell Significance Index: -58.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.0348
    Cell Significance Index: -53.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.3575
    Cell Significance Index: -47.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.5209
    Cell Significance Index: -57.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6631
    Cell Significance Index: -18.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.5814
    Cell Significance Index: 163.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.6720
    Cell Significance Index: 433.0400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.5645
    Cell Significance Index: 28.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.4512
    Cell Significance Index: 222.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.4311
    Cell Significance Index: 264.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3777
    Cell Significance Index: 110.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3661
    Cell Significance Index: 82.2200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.1669
    Cell Significance Index: 18.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0560
    Cell Significance Index: 334.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0531
    Cell Significance Index: 1121.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.0024
    Cell Significance Index: 27.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9743
    Cell Significance Index: 36.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7497
    Cell Significance Index: 315.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7141
    Cell Significance Index: 15.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5795
    Cell Significance Index: 1426.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5662
    Cell Significance Index: 192.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4710
    Cell Significance Index: 38.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3730
    Cell Significance Index: 135.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2548
    Cell Significance Index: 10.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0045
    Cell Significance Index: 444.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9664
    Cell Significance Index: 50.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9533
    Cell Significance Index: 71.0500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.9130
    Cell Significance Index: 2.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8269
    Cell Significance Index: 58.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8113
    Cell Significance Index: 104.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7979
    Cell Significance Index: 109.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7730
    Cell Significance Index: 21.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7082
    Cell Significance Index: 18.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7034
    Cell Significance Index: 15.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6034
    Cell Significance Index: 12.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5836
    Cell Significance Index: 6.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5756
    Cell Significance Index: 8.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4877
    Cell Significance Index: 22.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4366
    Cell Significance Index: 10.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4150
    Cell Significance Index: 53.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4009
    Cell Significance Index: 79.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3404
    Cell Significance Index: 9.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3175
    Cell Significance Index: 60.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2279
    Cell Significance Index: 7.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2128
    Cell Significance Index: 42.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1893
    Cell Significance Index: 5.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1886
    Cell Significance Index: 2.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1753
    Cell Significance Index: 5.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1189
    Cell Significance Index: 90.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0464
    Cell Significance Index: 16.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0332
    Cell Significance Index: 0.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0178
    Cell Significance Index: 0.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0026
    Cell Significance Index: 1.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0020
    Cell Significance Index: -0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0073
    Cell Significance Index: -0.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0302
    Cell Significance Index: -55.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0367
    Cell Significance Index: -56.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0392
    Cell Significance Index: -53.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0678
    Cell Significance Index: -50.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0782
    Cell Significance Index: -49.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0960
    Cell Significance Index: -54.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1026
    Cell Significance Index: -64.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1289
    Cell Significance Index: -58.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1571
    Cell Significance Index: -45.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1887
    Cell Significance Index: -4.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2142
    Cell Significance Index: -7.5300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2269
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2382
    Cell Significance Index: -27.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2696
    Cell Significance Index: -31.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3178
    Cell Significance Index: -66.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3254
    Cell Significance Index: -6.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3667
    Cell Significance Index: -53.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3724
    Cell Significance Index: -2.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4373
    Cell Significance Index: -22.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4458
    Cell Significance Index: -28.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5089
    Cell Significance Index: -23.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5386
    Cell Significance Index: -56.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5803
    Cell Significance Index: -45.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6479
    Cell Significance Index: -49.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6616
    Cell Significance Index: -44.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7029
    Cell Significance Index: -17.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7177
    Cell Significance Index: -21.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7255
    Cell Significance Index: -40.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7571
    Cell Significance Index: -46.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7695
    Cell Significance Index: -47.3000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7764
    Cell Significance Index: -10.8900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7834
    Cell Significance Index: -8.1100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8400
    Cell Significance Index: -14.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9063
    Cell Significance Index: -47.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9065
    Cell Significance Index: -40.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0682
    Cell Significance Index: -40.4500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.1244
    Cell Significance Index: -19.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Catalytic subunit of PP1**: PPP1CA is the catalytic subunit of PP1, which is responsible for dephosphorylating and regulating the activity of numerous substrates. 2. **Serine/threonine phosphatase activity**: PP1 has a wide range of substrates, including proteins, lipids, and other phospholipids, and plays a crucial role in regulating their activity and localization. 3. **Cellular localization**: PP1 is found in various cellular compartments, including the cytosol, nucleus, and endoplasmic reticulum. 4. **Expression in immune cells**: PPP1CA is highly expressed in immune cells, including monocytes, T cells, and dendritic cells, where it plays a role in regulating immune responses and cell signaling. 5. **Regulation of glycogen metabolism**: PP1 is involved in regulating glycogen biosynthesis and catabolism, and its activity is essential for maintaining glycogen homeostasis in cells. **Pathways and Functions** 1. **Cell cycle regulation**: PP1 regulates the activity of cyclin-dependent kinases (CDKs) and other cell cycle regulators, ensuring proper cell cycle progression and preventing uncontrolled proliferation. 2. **Signal transduction**: PP1 modulates the activity of various signaling pathways, including the Wnt/β-catenin pathway, the TGF-β pathway, and the GPCR signaling pathway. 3. **Glycogen metabolism**: PP1 regulates glycogen biosynthesis and catabolism, ensuring proper glycogen homeostasis in cells. 4. **Immune responses**: PP1 plays a role in regulating immune responses, including the activation and differentiation of immune cells, and the regulation of cytokine production. 5. **Circadian rhythm regulation**: PP1 is involved in regulating the circadian rhythm, and its activity is essential for maintaining proper circadian clock function. **Clinical Significance** 1. **Cancer**: Alterations in PPP1CA expression have been associated with various types of cancer, including breast, colon, and lung cancer. 2. **Neurodegenerative diseases**: PP1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: Dysregulation of PP1 activity has been linked to immune disorders, including autoimmune diseases and immunodeficiency syndromes. 4. **Circadian rhythm disorders**: Alterations in PP1 activity have been associated with circadian rhythm disorders, including delayed sleep phase syndrome and non-24-hour sleep-wake disorder. 5. **Metabolic disorders**: PP1 is involved in regulating glycogen metabolism, and its activity is essential for maintaining proper glycogen homeostasis in cells, which is critical for maintaining energy balance and preventing metabolic disorders. In conclusion, the PPP1CA gene plays a crucial role in regulating various cellular processes, including signal transduction, cell cycle regulation, and glycogen metabolism. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, immune disorders, and metabolic disorders. Further research is needed to fully understand the mechanisms by which PPP1CA regulates cellular processes and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 2840058225

Symbol: PP1A_HUMAN

Name: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

UniProtKB Accession Codes:

P62136 A6NNR3 B2R908 P08129 P20653 P22802 Q07161

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 ELM 1 EMBL 10 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 6 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8392016

Title: Cloning and characterization of a human protein phosphatase 1-encoding cDNA.

PubMed ID: 8392016

DOI: 10.1016/0378-1119(93)90282-8

PubMed ID: 8384581

Title: The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

PubMed ID: 8384581

DOI: 10.1101/gad.7.4.555

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2161401

Title: Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13.

PubMed ID: 2161401

DOI: 10.1016/0888-7543(90)90536-4

PubMed ID: 9023344

Title: The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase.

PubMed ID: 9023344

DOI: 10.1073/pnas.94.3.843

PubMed ID: 11739654

Title: Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.

PubMed ID: 11739654

DOI: 10.1242/jcs.114.23.4219

PubMed ID: 11564868

Title: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

PubMed ID: 11564868

DOI: 10.1128/mcb.21.20.6841-6850.2001

PubMed ID: 12226088

Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

PubMed ID: 12226088

DOI: 10.1074/jbc.m206838200

PubMed ID: 11839776

Title: Protein phosphatase 1 -- targeted in many directions.

PubMed ID: 11839776

DOI: 10.1242/jcs.115.2.241

PubMed ID: 16263087

Title: The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation.

PubMed ID: 16263087

DOI: 10.1016/j.bbrc.2005.10.089

PubMed ID: 15705855

Title: A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

PubMed ID: 15705855

DOI: 10.1126/science.1101902

PubMed ID: 16732323

Title: Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells.

PubMed ID: 16732323

DOI: 10.1038/sj.onc.1209695

PubMed ID: 17890166

Title: The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G.

PubMed ID: 17890166

DOI: 10.1016/j.bbapap.2007.07.015

PubMed ID: 17283141

Title: Protein phosphatase-1alpha regulates centrosome splitting through Nek2.

PubMed ID: 17283141

DOI: 10.1158/0008-5472.can-06-3071

PubMed ID: 17626005

Title: Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase.

PubMed ID: 17626005

DOI: 10.1074/jbc.m704969200

PubMed ID: 17965019

Title: NOM1 targets protein phosphatase I to the nucleolus.

PubMed ID: 17965019

DOI: 10.1074/jbc.m706708200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19826001

Title: Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion.

PubMed ID: 19826001

DOI: 10.1074/jbc.m109.059592

PubMed ID: 19389623

Title: Docking motif-guided mapping of the interactome of protein phosphatase-1.

PubMed ID: 19389623

DOI: 10.1016/j.chembiol.2009.02.012

PubMed ID: 19377461

Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 19377461

DOI: 10.1038/nature07954

PubMed ID: 24336203

Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 24336203

DOI: 10.1038/nature12896

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 19581931

Title: Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.

PubMed ID: 19581931

DOI: 10.1038/onc.2009.157

PubMed ID: 20516061

Title: Identification and characterization of a novel human PP1 phosphatase complex.

PubMed ID: 20516061

DOI: 10.1074/jbc.m110.109801

PubMed ID: 20424263

Title: SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.

PubMed ID: 20424263

DOI: 10.1126/scisignal.2000781

PubMed ID: 21712997

Title: Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.

PubMed ID: 21712997

DOI: 10.1371/journal.pone.0021325

PubMed ID: 23213405

Title: Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1alpha) docking protein.

PubMed ID: 23213405

DOI: 10.1242/bio.2011049

PubMed ID: 23846654

Title: Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

PubMed ID: 23846654

DOI: 10.1038/nature12308

PubMed ID: 23396208

Title: Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis.

PubMed ID: 23396208

DOI: 10.1038/nm.3085

PubMed ID: 26083323

Title: ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.

PubMed ID: 26083323

DOI: 10.1080/15548627.2015.1060386

PubMed ID: 25556658

Title: Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.

PubMed ID: 25556658

DOI: 10.1016/j.devcel.2014.11.030

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26981768

Title: The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores.

PubMed ID: 26981768

DOI: 10.7554/elife.12902

PubMed ID: 28216226

Title: NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres.

PubMed ID: 28216226

DOI: 10.1016/j.molcel.2017.01.016

PubMed ID: 29769351

Title: Protein phosphatase 1alpha interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral replication through modulation of capsid phosphorylation.

PubMed ID: 29769351

DOI: 10.1128/jvi.02068-17

PubMed ID: 18992256

Title: Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors.

PubMed ID: 18992256

DOI: 10.1016/j.jmb.2008.10.053

PubMed ID: 20305656

Title: Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.

PubMed ID: 20305656

DOI: 10.1038/nsmb.1786

PubMed ID: 26095357

Title: Structural and Functional Analysis of the GADD34:PP1 eIF2alpha Phosphatase.

PubMed ID: 26095357

DOI: 10.1016/j.celrep.2015.05.043

Sequence Information:

  • Length: 330
  • Mass: 37512
  • Checksum: 60C37E1AD9831DAC
  • Sequence:
    • MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP ILLELEAPLK 
ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 
LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 
QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD 
LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD 
KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK

Genular Protein ID: 3634996073

Symbol: A0A140VJS9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJS9

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 DNASU 1 DisGeNET 1 EC 2 EMBL 2 ExpressionAtlas 1 GO 7 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 2 PhylomeDB 1 RefSeq 1 Rhea 6 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 341
  • Mass: 38631
  • Checksum: CE50F8B9DC84AB6F
  • Sequence:
    • MSDSEKLNLD SIIGRLLEGS RVLTPHCAPV QGSRPGKNVQ LTENEIRGLC LKSREIFLSQ 
PILLELEAPL KICGDIHGQY YDLLRLFEYG GFPPESNYLF LGDYVDRGKQ SLETICLLLA 
YKIKYPENFF LLRGNHECAS INRIYGFYDE CKRRYNIKLW KTFTDCFNCL PIAAIVDEKI 
FCCHGGLSPD LQSMEQIRRI MRPTDVPDQG LLCDLLWSDP DKDVQGWGEN DRGVSFTFGA 
EVVAKFLHKH DLDLICRAHQ VVEDGYEFFA KRQLVTLFSA PNYCGEFDNA GAMMSVDETL 
MCSFQILKPA DKNKGKYGQF SGLNPGGRPI TPPRNSAKAK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.