Details for: PLAAT4

Gene ID: 5920

Symbol: PLAAT4

Ensembl ID: ENSG00000133321

Description: phospholipase A and acyltransferase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 219.7432
    Cell Significance Index: -34.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 105.4139
    Cell Significance Index: -43.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.1552
    Cell Significance Index: -39.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.8723
    Cell Significance Index: -21.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.7979
    Cell Significance Index: -42.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.3401
    Cell Significance Index: -38.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 57.8520
    Cell Significance Index: -38.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.4303
    Cell Significance Index: -40.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.8599
    Cell Significance Index: -34.3500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 16.2978
    Cell Significance Index: 43.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.5939
    Cell Significance Index: -35.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.0242
    Cell Significance Index: -35.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.4795
    Cell Significance Index: 94.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2982
    Cell Significance Index: 171.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5152
    Cell Significance Index: 44.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4841
    Cell Significance Index: 190.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0427
    Cell Significance Index: 134.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8713
    Cell Significance Index: 119.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6320
    Cell Significance Index: 16.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6155
    Cell Significance Index: 75.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5918
    Cell Significance Index: 323.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5777
    Cell Significance Index: 27.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5078
    Cell Significance Index: 9.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3932
    Cell Significance Index: 70.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3697
    Cell Significance Index: 40.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3643
    Cell Significance Index: 16.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2513
    Cell Significance Index: 13.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2284
    Cell Significance Index: 172.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2105
    Cell Significance Index: 14.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1862
    Cell Significance Index: 35.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1426
    Cell Significance Index: 4.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1333
    Cell Significance Index: 120.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1325
    Cell Significance Index: 58.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1287
    Cell Significance Index: 8.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0988
    Cell Significance Index: 2.4700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0767
    Cell Significance Index: 0.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0381
    Cell Significance Index: 1.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0298
    Cell Significance Index: 1.5100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0110
    Cell Significance Index: 0.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0126
    Cell Significance Index: -23.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0152
    Cell Significance Index: -1.5100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0174
    Cell Significance Index: -0.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0187
    Cell Significance Index: -0.9700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0189
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0212
    Cell Significance Index: -39.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0262
    Cell Significance Index: -40.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0302
    Cell Significance Index: -41.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0407
    Cell Significance Index: -6.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0428
    Cell Significance Index: -31.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0475
    Cell Significance Index: -35.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0537
    Cell Significance Index: -34.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0543
    Cell Significance Index: -2.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0655
    Cell Significance Index: -36.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0838
    Cell Significance Index: -38.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1030
    Cell Significance Index: -20.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1033
    Cell Significance Index: -37.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1045
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1091
    Cell Significance Index: -12.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1213
    Cell Significance Index: -34.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1305
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1352
    Cell Significance Index: -23.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1476
    Cell Significance Index: -10.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1665
    Cell Significance Index: -19.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1814
    Cell Significance Index: -36.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1818
    Cell Significance Index: -8.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1899
    Cell Significance Index: -39.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2064
    Cell Significance Index: -30.0000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2501
    Cell Significance Index: -1.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2676
    Cell Significance Index: -31.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2984
    Cell Significance Index: -3.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3079
    Cell Significance Index: -6.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3155
    Cell Significance Index: -9.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3453
    Cell Significance Index: -35.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3616
    Cell Significance Index: -7.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3757
    Cell Significance Index: -10.5000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4030
    Cell Significance Index: -2.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4476
    Cell Significance Index: -27.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4610
    Cell Significance Index: -35.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4932
    Cell Significance Index: -39.0600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.5138
    Cell Significance Index: -3.1800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.5328
    Cell Significance Index: -2.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5707
    Cell Significance Index: -35.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5895
    Cell Significance Index: -18.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6251
    Cell Significance Index: -32.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6290
    Cell Significance Index: -38.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6447
    Cell Significance Index: -9.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6546
    Cell Significance Index: -17.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7022
    Cell Significance Index: -39.4100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7420
    Cell Significance Index: -12.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7584
    Cell Significance Index: -6.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7633
    Cell Significance Index: -20.0700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8355
    Cell Significance Index: -12.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8551
    Cell Significance Index: -25.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8578
    Cell Significance Index: -31.4900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.8588
    Cell Significance Index: -11.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8903
    Cell Significance Index: -39.3800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.8951
    Cell Significance Index: -9.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9060
    Cell Significance Index: -16.0100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9323
    Cell Significance Index: -11.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PLAAT4 exhibits several distinct characteristics that set it apart from other phospholipase A enzymes: 1. **Dual enzymatic activity**: PLAAT4 possesses both phospholipase A and acyltransferase activities, allowing it to modify phospholipid acyl chains and participate in various cellular processes. 2. **High expression in immune cells**: PLAAT4 is significantly expressed in effector memory CD4-positive T cells, alpha-beta T cells, and other immune cells, indicating its potential involvement in immune regulation. 3. **Regulation of cell proliferation and differentiation**: PLAAT4 has been shown to negatively regulate cell population proliferation and positively regulate keratinocyte differentiation, suggesting its role in controlling cellular growth and development. 4. **Association with lipid metabolism**: PLAAT4 is involved in the regulation of phospholipid metabolic processes, including glycerophospholipid biosynthesis and phospholipid catabolism. **Pathways and Functions** PLAAT4 is involved in several cellular pathways, including: 1. **Acyl chain remodeling of phosphatidylethanolamine**: PLAAT4 participates in the acylation of phosphatidylethanolamine, a process that is essential for the regulation of cellular signaling and membrane dynamics. 2. **Glycerophospholipid biosynthesis**: PLAAT4 is involved in the synthesis of glycerophospholipids, which are essential components of cellular membranes. 3. **Phospholipid catabolism**: PLAAT4 participates in the degradation of phospholipids, which is necessary for the regulation of cellular lipid metabolism. 4. **Regulation of protein-glutamine gamma-glutamyltransferase activity**: PLAAT4 positively regulates the activity of this enzyme, which is involved in the synthesis of glutathione and the maintenance of cellular redox balance. **Clinical Significance** The clinical significance of PLAAT4 is still being explored, but its involvement in immune regulation and lipid metabolism suggests potential implications for various diseases, including: 1. **Immunological disorders**: Alterations in PLAAT4 expression or function may contribute to the development of immunological disorders, such as autoimmune diseases or cancer. 2. **Metabolic disorders**: Dysregulation of PLAAT4 may contribute to metabolic disorders, such as dyslipidemia or obesity. 3. **Neurological disorders**: PLAAT4's involvement in lipid metabolism and cellular signaling suggests potential implications for neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, PLAAT4 is a complex gene that plays a crucial role in regulating cellular processes, including lipid metabolism, cell proliferation, and differentiation. Further research is needed to fully understand the clinical significance of PLAAT4 and its potential implications for human disease.

Genular Protein ID: 3229939613

Symbol: PLAT4_HUMAN

Name: HRAS-like suppressor 4

UniProtKB Accession Codes:

Q9UL19 B2R599 B4DDW2 E7ENZ7 O95200

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 65 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 Rhea 26 SASBDB 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9843971

Title: Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene.

PubMed ID: 9843971

DOI: 10.1073/pnas.95.25.14811

PubMed ID: 10687848

Title: Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells.

PubMed ID: 10687848

DOI: 10.1016/s0303-7207(99)00207-5

PubMed ID: 19615464

Title: Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes.

PubMed ID: 19615464

DOI: 10.1016/j.bbalip.2009.07.001

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17762858

Title: Localization of the TIG3 transglutaminase interaction domain and demonstration that the amino-terminal region is required for TIG3 function as a keratinocyte differentiation regulator.

PubMed ID: 17762858

DOI: 10.1038/sj.jid.5701035

PubMed ID: 22605381

Title: Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.

PubMed ID: 22605381

DOI: 10.1074/jbc.m112.361550

PubMed ID: 22825852

Title: Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family.

PubMed ID: 22825852

DOI: 10.1074/jbc.m112.368712

PubMed ID: 26503625

Title: The HRASLS (PLA/AT) subfamily of enzymes.

PubMed ID: 26503625

DOI: 10.1186/s12929-015-0210-7

Sequence Information:

  • Length: 164
  • Mass: 18179
  • Checksum: 95625B8FD375FD38
  • Sequence:
    • MASPHQEPKP GDLIEIFRLG YEHWALYIGD GYVIHLAPPS EYPGAGSSSV FSVLSNSAEV 
KRERLEDVVG GCCYRVNNSL DHEYQPRPVE VIISSAKEMV GQKMKYSIVS RNCEHFVTQL 
RYGKSRCKQV EKAKVEVGVA TALGILVVAG CSFAIRRYQK KATA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.