Details for: IRF1

Gene ID: 3659

Symbol: IRF1

Ensembl ID: ENSG00000125347

Description: interferon regulatory factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.32
    Marker Score: 3270
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1
    Marker Score: 105549
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.03
    Marker Score: 8502
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.94
    Marker Score: 2477
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.88
    Marker Score: 8414
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.88
    Marker Score: 3970
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.86
    Marker Score: 7914
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.77
    Marker Score: 155132
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.77
    Marker Score: 3078
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.74
    Marker Score: 31908
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.74
    Marker Score: 8655
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.65
    Marker Score: 2262
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.63
    Marker Score: 26048
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.58
    Marker Score: 1113
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.56
    Marker Score: 4192
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.46
    Marker Score: 3563
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.46
    Marker Score: 5149
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.45
    Marker Score: 1475
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.42
    Marker Score: 798
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.4
    Marker Score: 24335
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.34
    Marker Score: 5753
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.34
    Marker Score: 3952.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.33
    Marker Score: 3435
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.31
    Marker Score: 122058
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.31
    Marker Score: 1890
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.28
    Marker Score: 5791
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.27
    Marker Score: 2125
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.25
    Marker Score: 966
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.22
    Marker Score: 1610
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.2
    Marker Score: 2125
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.19
    Marker Score: 5352
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.19
    Marker Score: 9409
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.19
    Marker Score: 680
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.19
    Marker Score: 8106
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.19
    Marker Score: 1123
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.19
    Marker Score: 1919
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.15
    Marker Score: 761
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.14
    Marker Score: 2311
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.11
    Marker Score: 2553
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.1
    Marker Score: 2115
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.09
    Marker Score: 1639
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.09
    Marker Score: 3731
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.08
    Marker Score: 1770
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.07
    Marker Score: 1336
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.04
    Marker Score: 1731
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.04
    Marker Score: 1813
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.04
    Marker Score: 4071
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.01
    Marker Score: 1526
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2
    Marker Score: 7723
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2
    Marker Score: 1721
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.99
    Marker Score: 1453
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.99
    Marker Score: 1357
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.99
    Marker Score: 1455
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.98
    Marker Score: 502
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.96
    Marker Score: 1747
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.95
    Marker Score: 7977
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.95
    Marker Score: 1277
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.94
    Marker Score: 3789
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.9
    Marker Score: 4317
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.89
    Marker Score: 944
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.87
    Marker Score: 1277
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.87
    Marker Score: 1149
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.85
    Marker Score: 1064
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.84
    Marker Score: 20679
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.81
    Marker Score: 2347
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.81
    Marker Score: 11562
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.81
    Marker Score: 1699
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8
    Marker Score: 2651
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.78
    Marker Score: 1179
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.77
    Marker Score: 1341
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.77
    Marker Score: 1703.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.75
    Marker Score: 1268
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.74
    Marker Score: 2034
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.72
    Marker Score: 3380
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.72
    Marker Score: 628
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.72
    Marker Score: 649
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.71
    Marker Score: 1534
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7
    Marker Score: 14936
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.7
    Marker Score: 995
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.69
    Marker Score: 709
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.69
    Marker Score: 1218
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.68
    Marker Score: 770
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.68
    Marker Score: 1825
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.67
    Marker Score: 2914
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.67
    Marker Score: 542
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.67
    Marker Score: 1120
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.66
    Marker Score: 975
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.65
    Marker Score: 10553
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.65
    Marker Score: 358
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.64
    Marker Score: 707
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.64
    Marker Score: 391
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.63
    Marker Score: 678
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.62
    Marker Score: 817
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.61
    Marker Score: 1107
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.61
    Marker Score: 1612
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.6
    Marker Score: 7867
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.59
    Marker Score: 876
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.58
    Marker Score: 390
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.58
    Marker Score: 552
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.58
    Marker Score: 1126

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Other Information

**Key characteristics:** * IRF1 is a protein of the interferon regulatory factor family, which are a group of proteins that regulate the immune response. * It is a transcription factor that can bind to DNA and regulate the expression of genes involved in immune cell development and function. * IRF1 is expressed in a variety of cell types, including macrophages, dendritic cells, and lymphocytes. * It is important for the development and maintenance of immune tolerance, as it helps to prevent the activation of autoreactive T cells. **Pathways and functions:** * IRF1 is involved in the regulation of the immune response through various pathways, including the cytokine signaling pathway, the DNA-binding transcription activator (DNA-BA) pathway, and the RNA polymerase II pathway. * In the cytokine signaling pathway, IRF1 is a key regulator of the production of type I interferons, which are cytokines that help to control inflammation and infection. * In the DNA-binding transcription activator (DNA-BA) pathway, IRF1 is a key regulator of the expression of genes involved in inflammation and cell death. * In the RNA polymerase II pathway, IRF1 is a key regulator of the expression of genes involved in the production of type I interferons. **Clinical significance:** IRF1 is a potential therapeutic target for a variety of diseases, including cancer, autoimmune disorders, and viral infections. By blocking IRF1 signaling, it has been shown to be effective in promoting tumor regression and improving disease outcomes. **Additional information:** * IRF1 is a highly conserved protein, with a similar sequence in humans, mice, and rats. * It is a member of the interferon regulatory factor family, which is a large family of proteins that are involved in regulating the immune response. * IRF1 is a key player in maintaining immune homeostasis and preventing excessive inflammation. * It is a potential therapeutic target for a variety of diseases, including cancer, autoimmune disorders, and viral infections.

Genular Protein ID: 3919857725

Symbol: IRF1_HUMAN

Name: Interferon regulatory factor 1

UniProtKB Accession Codes:

P10914 Q96GG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2726461

Title: Sequence of a cDNA coding for human IRF-1.

PubMed ID: 2726461

DOI: 10.1093/nar/17.8.3292

PubMed ID: 3409321

Title: Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements.

PubMed ID: 3409321

DOI: 10.1016/s0092-8674(88)91307-4

PubMed ID: 1382447

Title: Human interferon regulatory factor 1: intron-exon organization.

PubMed ID: 1382447

DOI: 10.1089/dna.1992.11.605

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8438156

Title: Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia.

PubMed ID: 8438156

DOI: 10.1126/science.8438156

PubMed ID: 10094406

Title: A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity.

PubMed ID: 10094406

DOI: 10.1023/a:1006850009017

PubMed ID: 11244049

Title: IRF family of transcription factors as regulators of host defense.

PubMed ID: 11244049

DOI: 10.1146/annurev.immunol.19.1.623

PubMed ID: 11846971

Title: Activities of IRF-1.

PubMed ID: 11846971

DOI: 10.1089/107999002753452610

PubMed ID: 11846974

Title: IRF-1 as a negative regulator of cell proliferation.

PubMed ID: 11846974

DOI: 10.1089/107999002753452647

PubMed ID: 15226432

Title: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.

PubMed ID: 15226432

DOI: 10.1128/mcb.24.14.6298-6310.2004

PubMed ID: 15509808

Title: Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.

PubMed ID: 15509808

DOI: 10.1128/mcb.24.22.10083-10098.2004

PubMed ID: 16932750

Title: IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.

PubMed ID: 16932750

DOI: 10.1038/nri1900

PubMed ID: 17516545

Title: Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression.

PubMed ID: 17516545

DOI: 10.1002/jcp.21128

PubMed ID: 18084608

Title: RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II.

PubMed ID: 18084608

DOI: 10.1593/neo.07640

PubMed ID: 17942705

Title: Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis.

PubMed ID: 17942705

DOI: 10.1073/pnas.0609852104

PubMed ID: 18497060

Title: IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis.

PubMed ID: 18497060

DOI: 10.1007/978-0-387-69080-3_35

PubMed ID: 18641303

Title: IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression.

PubMed ID: 18641303

DOI: 10.4049/jimmunol.181.3.1673

PubMed ID: 19404407

Title: Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages.

PubMed ID: 19404407

DOI: 10.1371/journal.pone.0005397

PubMed ID: 20049431

Title: Regulation of immunity and oncogenesis by the IRF transcription factor family.

PubMed ID: 20049431

DOI: 10.1007/s00262-009-0804-6

PubMed ID: 19851330

Title: IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells.

PubMed ID: 19851330

DOI: 10.1038/cdd.2009.156

PubMed ID: 21389130

Title: Human papillomavirus type 16 E5 protein induces expression of beta interferon through interferon regulatory factor 1 in human keratinocytes.

PubMed ID: 21389130

DOI: 10.1128/jvi.02114-10

PubMed ID: 22200613

Title: Interferon regulatory factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.

PubMed ID: 22200613

DOI: 10.1016/j.canlet.2011.12.027

PubMed ID: 22367195

Title: Interferon regulatory factor 1 transactivates the expression of human DNA polymerase eta in response to the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine.

PubMed ID: 22367195

DOI: 10.1074/jbc.m111.313429

PubMed ID: 32385160

Title: ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer.

PubMed ID: 32385160

DOI: 10.1073/pnas.1921484117

PubMed ID: 9679752

Title: Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer.

PubMed ID: 9679752

DOI: 10.1002/(sici)1097-0215(19980812)77:4<522::aid-ijc8>3.0.co;2-w

PubMed ID: 10395927

Title: Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding.

PubMed ID: 10395927

DOI: 10.1016/s0167-4781(99)00078-0

Sequence Information:

  • Length: 325
  • Mass: 36502
  • Checksum: 2E06245A212D1541
  • Sequence:
    • MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI 
HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPPLTKNQR 
KERKSKSSRD AKSKAKRKSC GDSSPDTFSD GLSSSTLPDD HSSYTVPGYM QDLEVEQALT 
PALSPCAVSS TLPDWHIPVE VVPDSTSDLY NFQVSPMPST SEATTDEDEE GKLPEDIMKL 
LEQSEWQPTN VDGKGYLLNE PGVQPTSVYG DFSCKEEPEI DSPGGDIGLS LQRVFTDLKN 
MDATWLDSLL TPVRLPSIQA IPCAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.