Details for: IRF1

Gene ID: 3659

Symbol: IRF1

Ensembl ID: ENSG00000125347

Description: interferon regulatory factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 320.9999
    Cell Significance Index: -49.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.4542
    Cell Significance Index: -42.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 129.6654
    Cell Significance Index: -52.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 112.2894
    Cell Significance Index: -57.7600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 81.6068
    Cell Significance Index: -54.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.8635
    Cell Significance Index: -54.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.8425
    Cell Significance Index: -51.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.1594
    Cell Significance Index: -43.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.1372
    Cell Significance Index: -51.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7177
    Cell Significance Index: -31.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.9904
    Cell Significance Index: 141.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.5701
    Cell Significance Index: 159.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.0426
    Cell Significance Index: 93.2000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.9056
    Cell Significance Index: 30.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.2484
    Cell Significance Index: 209.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0295
    Cell Significance Index: 82.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.3946
    Cell Significance Index: 124.7300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 2.2845
    Cell Significance Index: 6.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2005
    Cell Significance Index: 164.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1944
    Cell Significance Index: 103.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1070
    Cell Significance Index: 61.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6850
    Cell Significance Index: 35.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5919
    Cell Significance Index: 205.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3401
    Cell Significance Index: 145.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2444
    Cell Significance Index: 153.0100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.1326
    Cell Significance Index: 5.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1291
    Cell Significance Index: 67.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1041
    Cell Significance Index: 51.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0494
    Cell Significance Index: 134.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9367
    Cell Significance Index: 511.5500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.9149
    Cell Significance Index: 5.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8890
    Cell Significance Index: 19.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8383
    Cell Significance Index: 370.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8377
    Cell Significance Index: 43.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7629
    Cell Significance Index: 34.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7023
    Cell Significance Index: 126.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6901
    Cell Significance Index: 7.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5876
    Cell Significance Index: 13.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5340
    Cell Significance Index: 73.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5137
    Cell Significance Index: 17.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4621
    Cell Significance Index: 12.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4352
    Cell Significance Index: 30.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4325
    Cell Significance Index: 51.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4208
    Cell Significance Index: 10.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3177
    Cell Significance Index: 31.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2204
    Cell Significance Index: 41.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0918
    Cell Significance Index: 4.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0079
    Cell Significance Index: 1.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0163
    Cell Significance Index: -30.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0171
    Cell Significance Index: -12.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0194
    Cell Significance Index: -12.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0290
    Cell Significance Index: -53.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0305
    Cell Significance Index: -46.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0358
    Cell Significance Index: -20.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0365
    Cell Significance Index: -27.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0407
    Cell Significance Index: -55.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0439
    Cell Significance Index: -30.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0575
    Cell Significance Index: -9.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0586
    Cell Significance Index: -5.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0661
    Cell Significance Index: -48.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0712
    Cell Significance Index: -1.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0773
    Cell Significance Index: -49.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0834
    Cell Significance Index: -9.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1116
    Cell Significance Index: -40.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1173
    Cell Significance Index: -53.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1416
    Cell Significance Index: -29.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1555
    Cell Significance Index: -44.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1607
    Cell Significance Index: -32.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1849
    Cell Significance Index: -3.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1895
    Cell Significance Index: -5.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2050
    Cell Significance Index: -23.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2063
    Cell Significance Index: -5.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2229
    Cell Significance Index: -25.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2536
    Cell Significance Index: -3.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2783
    Cell Significance Index: -40.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2959
    Cell Significance Index: -12.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4384
    Cell Significance Index: -14.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4971
    Cell Significance Index: -8.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5021
    Cell Significance Index: -52.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5028
    Cell Significance Index: -38.5900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.5042
    Cell Significance Index: -4.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5189
    Cell Significance Index: -13.6500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.5282
    Cell Significance Index: -2.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6411
    Cell Significance Index: -33.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7182
    Cell Significance Index: -56.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7888
    Cell Significance Index: -53.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7946
    Cell Significance Index: -50.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8826
    Cell Significance Index: -54.2500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.8946
    Cell Significance Index: -6.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8982
    Cell Significance Index: -55.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9680
    Cell Significance Index: -54.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9995
    Cell Significance Index: -35.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9997
    Cell Significance Index: -13.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0247
    Cell Significance Index: -20.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1593
    Cell Significance Index: -51.2800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.2011
    Cell Significance Index: -25.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2345
    Cell Significance Index: -12.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2411
    Cell Significance Index: -45.5600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -1.2608
    Cell Significance Index: -21.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3088
    Cell Significance Index: -45.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IRF1 is a transcription factor that belongs to the interferon regulatory factor family. It is a DNA-binding protein that regulates the expression of interferon-stimulated genes (ISGs) and other immune-related genes. IRF1 has a high degree of sequence similarity to IRF2, but its expression is primarily restricted to cells of the innate immune system. IRF1 is characterized by its ability to bind to specific DNA sequences, known as interferon-stimulated response elements (ISREs), and to regulate the expression of ISGs. **Pathways and Functions:** IRF1 is involved in several key pathways and functions, including: 1. **Interferon Signaling:** IRF1 is a key regulator of interferon signaling, and its expression is induced by interferons. IRF1 regulates the expression of ISGs, which are critical for the induction of a antiviral state in cells. 2. **Apoptosis:** IRF1 has been shown to regulate apoptosis in various cell types, including T cells and B cells. 3. **Cell Proliferation and Differentiation:** IRF1 regulates the expression of genes involved in cell proliferation and differentiation, including those involved in the development of immune cells. 4. **Immune Response:** IRF1 is involved in the regulation of immune responses, including the activation of natural killer cells and the regulation of T cell responses. 5. **Chromatin Modification:** IRF1 has been shown to regulate chromatin modification, which is critical for the regulation of gene expression. **Clinical Significance:** IRF1 has been implicated in various diseases, including: 1. **Viral Infections:** IRF1 has been shown to play a critical role in the regulation of interferon signaling and the induction of an antiviral state in cells. 2. **Autoimmune Diseases:** IRF1 has been implicated in the regulation of immune responses and the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** IRF1 has been shown to regulate the expression of genes involved in cell proliferation and differentiation, and has been implicated in the development of cancer. 4. **Immunodeficiency Diseases:** IRF1 has been implicated in the regulation of immune responses and the development of immunodeficiency diseases, such as severe combined immunodeficiency (SCID). In conclusion, IRF1 is a critical regulator of interferon signaling and immune response, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of IRF1 in the regulation of immune responses and its implications for human health.

Genular Protein ID: 3919857725

Symbol: IRF1_HUMAN

Name: Interferon regulatory factor 1

UniProtKB Accession Codes:

P10914 Q96GG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2726461

Title: Sequence of a cDNA coding for human IRF-1.

PubMed ID: 2726461

DOI: 10.1093/nar/17.8.3292

PubMed ID: 3409321

Title: Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements.

PubMed ID: 3409321

DOI: 10.1016/s0092-8674(88)91307-4

PubMed ID: 1382447

Title: Human interferon regulatory factor 1: intron-exon organization.

PubMed ID: 1382447

DOI: 10.1089/dna.1992.11.605

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8438156

Title: Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia.

PubMed ID: 8438156

DOI: 10.1126/science.8438156

PubMed ID: 10094406

Title: A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity.

PubMed ID: 10094406

DOI: 10.1023/a:1006850009017

PubMed ID: 11244049

Title: IRF family of transcription factors as regulators of host defense.

PubMed ID: 11244049

DOI: 10.1146/annurev.immunol.19.1.623

PubMed ID: 11846971

Title: Activities of IRF-1.

PubMed ID: 11846971

DOI: 10.1089/107999002753452610

PubMed ID: 11846974

Title: IRF-1 as a negative regulator of cell proliferation.

PubMed ID: 11846974

DOI: 10.1089/107999002753452647

PubMed ID: 15226432

Title: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.

PubMed ID: 15226432

DOI: 10.1128/mcb.24.14.6298-6310.2004

PubMed ID: 15509808

Title: Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.

PubMed ID: 15509808

DOI: 10.1128/mcb.24.22.10083-10098.2004

PubMed ID: 16932750

Title: IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.

PubMed ID: 16932750

DOI: 10.1038/nri1900

PubMed ID: 17516545

Title: Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression.

PubMed ID: 17516545

DOI: 10.1002/jcp.21128

PubMed ID: 18084608

Title: RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II.

PubMed ID: 18084608

DOI: 10.1593/neo.07640

PubMed ID: 17942705

Title: Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis.

PubMed ID: 17942705

DOI: 10.1073/pnas.0609852104

PubMed ID: 18497060

Title: IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis.

PubMed ID: 18497060

DOI: 10.1007/978-0-387-69080-3_35

PubMed ID: 18641303

Title: IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression.

PubMed ID: 18641303

DOI: 10.4049/jimmunol.181.3.1673

PubMed ID: 19404407

Title: Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages.

PubMed ID: 19404407

DOI: 10.1371/journal.pone.0005397

PubMed ID: 20049431

Title: Regulation of immunity and oncogenesis by the IRF transcription factor family.

PubMed ID: 20049431

DOI: 10.1007/s00262-009-0804-6

PubMed ID: 19851330

Title: IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells.

PubMed ID: 19851330

DOI: 10.1038/cdd.2009.156

PubMed ID: 21389130

Title: Human papillomavirus type 16 E5 protein induces expression of beta interferon through interferon regulatory factor 1 in human keratinocytes.

PubMed ID: 21389130

DOI: 10.1128/jvi.02114-10

PubMed ID: 22200613

Title: Interferon regulatory factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.

PubMed ID: 22200613

DOI: 10.1016/j.canlet.2011.12.027

PubMed ID: 22367195

Title: Interferon regulatory factor 1 transactivates the expression of human DNA polymerase eta in response to the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine.

PubMed ID: 22367195

DOI: 10.1074/jbc.m111.313429

PubMed ID: 32385160

Title: ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer.

PubMed ID: 32385160

DOI: 10.1073/pnas.1921484117

PubMed ID: 37622993

Title: SPOP targets the immune transcription factor IRF1 for proteasomal degradation.

PubMed ID: 37622993

DOI: 10.7554/elife.89951

PubMed ID: 9679752

Title: Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer.

PubMed ID: 9679752

DOI: 10.1002/(sici)1097-0215(19980812)77:4<522::aid-ijc8>3.0.co;2-w

PubMed ID: 10395927

Title: Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding.

PubMed ID: 10395927

DOI: 10.1016/s0167-4781(99)00078-0

PubMed ID: 36736301

Title: Human IRF1 governs macrophagic IFN-gamma immunity to mycobacteria.

PubMed ID: 36736301

DOI: 10.1016/j.cell.2022.12.038

Sequence Information:

  • Length: 325
  • Mass: 36502
  • Checksum: 2E06245A212D1541
  • Sequence:
    • MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI 
HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPPLTKNQR 
KERKSKSSRD AKSKAKRKSC GDSSPDTFSD GLSSSTLPDD HSSYTVPGYM QDLEVEQALT 
PALSPCAVSS TLPDWHIPVE VVPDSTSDLY NFQVSPMPST SEATTDEDEE GKLPEDIMKL 
LEQSEWQPTN VDGKGYLLNE PGVQPTSVYG DFSCKEEPEI DSPGGDIGLS LQRVFTDLKN 
MDATWLDSLL TPVRLPSIQA IPCAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.