Details for: NKG7

Gene ID: 4818

Symbol: NKG7

Ensembl ID: ENSG00000105374

Description: natural killer cell granule protein 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.5203
    Cell Significance Index: -14.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.5495
    Cell Significance Index: -29.8800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 66.2366
    Cell Significance Index: 177.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.8729
    Cell Significance Index: -15.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.4387
    Cell Significance Index: -30.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.6706
    Cell Significance Index: -21.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 12.1934
    Cell Significance Index: 252.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 11.2588
    Cell Significance Index: 395.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9412
    Cell Significance Index: -13.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8734
    Cell Significance Index: -18.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9847
    Cell Significance Index: -19.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.8155
    Cell Significance Index: 138.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.8127
    Cell Significance Index: 120.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.4704
    Cell Significance Index: 119.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.0700
    Cell Significance Index: 62.9700
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 3.3123
    Cell Significance Index: 8.4800
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.7642
    Cell Significance Index: 23.5600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.3149
    Cell Significance Index: 24.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1513
    Cell Significance Index: 138.7900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.1465
    Cell Significance Index: 14.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0930
    Cell Significance Index: 61.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0697
    Cell Significance Index: 44.8400
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.9761
    Cell Significance Index: 11.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2320
    Cell Significance Index: 234.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0412
    Cell Significance Index: 103.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8149
    Cell Significance Index: 735.7500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.6549
    Cell Significance Index: 5.1000
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.5459
    Cell Significance Index: 1.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4905
    Cell Significance Index: 79.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3057
    Cell Significance Index: 33.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2548
    Cell Significance Index: 3.8400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.2515
    Cell Significance Index: 1.8100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.2327
    Cell Significance Index: 1.8600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0495
    Cell Significance Index: 0.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0425
    Cell Significance Index: 2.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0346
    Cell Significance Index: 26.2000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0303
    Cell Significance Index: 0.2800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0123
    Cell Significance Index: 0.1200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.0083
    Cell Significance Index: 0.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0066
    Cell Significance Index: -0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0100
    Cell Significance Index: -18.8900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0158
    Cell Significance Index: -0.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0163
    Cell Significance Index: -22.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0165
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0178
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0279
    Cell Significance Index: -20.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0371
    Cell Significance Index: -20.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0408
    Cell Significance Index: -1.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0411
    Cell Significance Index: -1.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0453
    Cell Significance Index: -0.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0457
    Cell Significance Index: -29.0000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0534
    Cell Significance Index: -0.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0589
    Cell Significance Index: -26.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0604
    Cell Significance Index: -21.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0682
    Cell Significance Index: -14.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0830
    Cell Significance Index: -3.6100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0855
    Cell Significance Index: -1.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0867
    Cell Significance Index: -1.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0887
    Cell Significance Index: -25.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0961
    Cell Significance Index: -19.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0985
    Cell Significance Index: -6.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1013
    Cell Significance Index: -20.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1094
    Cell Significance Index: -15.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1203
    Cell Significance Index: -20.5500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1383
    Cell Significance Index: -1.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1400
    Cell Significance Index: -25.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1441
    Cell Significance Index: -14.7200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1454
    Cell Significance Index: -1.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1559
    Cell Significance Index: -19.9900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1631
    Cell Significance Index: -2.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1779
    Cell Significance Index: -10.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1838
    Cell Significance Index: -21.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1902
    Cell Significance Index: -8.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1904
    Cell Significance Index: -23.4100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1911
    Cell Significance Index: -2.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1911
    Cell Significance Index: -24.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1989
    Cell Significance Index: -28.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2056
    Cell Significance Index: -23.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2884
    Cell Significance Index: -22.1400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3057
    Cell Significance Index: -3.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3184
    Cell Significance Index: -5.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3300
    Cell Significance Index: -24.6000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.3316
    Cell Significance Index: -1.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3328
    Cell Significance Index: -22.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3525
    Cell Significance Index: -9.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3715
    Cell Significance Index: -29.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3791
    Cell Significance Index: -23.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3931
    Cell Significance Index: -10.1100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.3947
    Cell Significance Index: -4.0900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3953
    Cell Significance Index: -4.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4291
    Cell Significance Index: -22.2900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4421
    Cell Significance Index: -5.2200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.4749
    Cell Significance Index: -4.7400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4774
    Cell Significance Index: -8.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5066
    Cell Significance Index: -23.6200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.5347
    Cell Significance Index: -5.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5354
    Cell Significance Index: -23.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5633
    Cell Significance Index: -29.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5861
    Cell Significance Index: -19.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NKG7 is a type II transmembrane protein, characterized by its ability to bind to specific ligands, such as MICA and MICB, on the surface of target cells. This binding event triggers a signaling cascade that ultimately leads to the activation of NK cells and the induction of cytotoxicity. NKG7 is also involved in the regulation of inflammatory responses, acting as a positive regulator of the inflammatory response. Furthermore, NKG7 has been shown to interact with other immune molecules, such as CD4 and CD8, to modulate T cell activation and function. **Pathways and Functions:** The NKG7 protein is involved in several key immune pathways, including: 1. **Granzyme-mediated programmed cell death signaling pathway**: NKG7 facilitates the release of granzymes, which are cytotoxic granules that induce apoptosis in target cells. 2. **Cytolytic granule membrane**: NKG7 is a component of the cytolytic granule membrane, which is essential for the release of cytotoxic molecules, such as granzymes and perforin. 3. **Killing of cells of another organism**: NKG7 is involved in the recognition and killing of tumor cells and other aberrant cells. 4. **Natural killer cell degranulation**: NKG7 plays a crucial role in the degranulation of NK cells, which is essential for the release of cytotoxic molecules. **Clinical Significance:** Dysregulation of NKG7 has been implicated in various diseases, including: 1. **Cancer**: NKG7 has been shown to be overexpressed in various types of cancer, including melanoma, lung cancer, and leukemia. This overexpression can contribute to the development of cancer by promoting tumor cell survival and immune evasion. 2. **Autoimmune disorders**: NKG7 has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. Dysregulation of NKG7 can contribute to the development of autoimmunity by promoting the activation of autoreactive T cells. 3. **Infectious diseases**: NKG7 has been shown to play a role in the regulation of immune responses to infectious diseases, such as tuberculosis and HIV. In conclusion, NKG7 is a complex protein that plays a critical role in the regulation of immune responses, particularly in the context of tumor immunity and inflammation. Further research is needed to fully understand the mechanisms by which NKG7 regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1701892643

Symbol: NKG7_HUMAN

Name: Protein NKG7

UniProtKB Accession Codes:

Q16617

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8458737

Title: Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells.

PubMed ID: 8458737

DOI: 10.1016/0198-8859(93)90006-m

PubMed ID: 7510105

Title: Molecular cloning and characterization of G-CSF induced gene cDNA.

PubMed ID: 7510105

DOI: 10.1006/bbrc.1994.1187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8570616

Title: Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition.

PubMed ID: 8570616

DOI: 10.1073/pnas.93.2.685

PubMed ID: 32839608

Title: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.

PubMed ID: 32839608

DOI: 10.1038/s41590-020-0758-6

Sequence Information:

  • Length: 165
  • Mass: 17665
  • Checksum: CEE2901B6DC42A8C
  • Sequence:
    • MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI ISGYIHVTQT 
FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA AAISMVVAMA VYTSERWDQP 
PHPQIQTFFS WSFYLGWVSA ILLLCTGALS LGAHCGGPRP GYETL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.