IGLV1 40 | ENSG00000211653 | NCBI 28825

Details for: IGLV1 40

Gene ID: 28825

Symbol: IGLV1 40

Ensembl ID: ENSG00000211653

Description: immunoglobulin lambda variable 1-40

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin production
(GO:0002377)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 3.05
Marker Score: 2,363
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.56
Marker Score: 3,877
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 865
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.33
Marker Score: 1,116
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7,688
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.08
Marker Score: 1,170
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,796
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 791
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,426
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,306
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,738
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,293
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.79
Marker Score: 1,277
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703
Cell Name: blood cell (CL0000081)
Fold Change: 0.75
Marker Score: 8,695
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.63
Marker Score: 762
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.63
Marker Score: 612
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.58
Marker Score: 520
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 459
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 145
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.5
Marker Score: 427
Cell Name: plasmablast (CL0000980)
Fold Change: 0.5
Marker Score: 662
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.5
Marker Score: 207
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.49
Marker Score: 257
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.47
Marker Score: 913
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.45
Marker Score: 279
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.43
Marker Score: 246
Cell Name: immature B cell (CL0000816)
Fold Change: 0.42
Marker Score: 281
Cell Name: glial cell (CL0000125)
Fold Change: 0.4
Marker Score: 436
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.34
Marker Score: 95
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.32
Marker Score: 84
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.31
Marker Score: 141
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.31
Marker Score: 180
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.3
Marker Score: 76
Cell Name: B cell (CL0000236)
Fold Change: 0.29
Marker Score: 279
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.29
Marker Score: 262
Cell Name: plasma cell (CL0000786)
Fold Change: 0.29
Marker Score: 319
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.28
Marker Score: 591
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.26
Marker Score: 92
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.26
Marker Score: 219
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.22
Marker Score: 96
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.21
Marker Score: 74
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.21
Marker Score: 140
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.2
Marker Score: 190
Cell Name: platelet (CL0000233)
Fold Change: 0.19
Marker Score: 88
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.19
Marker Score: 306
Cell Name: memory B cell (CL0000787)
Fold Change: 0.18
Marker Score: 134
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.17
Marker Score: 376
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.17
Marker Score: 450
Cell Name: keratocyte (CL0002363)
Fold Change: 0.16
Marker Score: 37
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.16
Marker Score: 36
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.16
Marker Score: 158
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.14
Marker Score: 38
Cell Name: mast cell (CL0000097)
Fold Change: 0.14
Marker Score: 81
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.14
Marker Score: 228
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.14
Marker Score: 97
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.14
Marker Score: 36
Cell Name: naive B cell (CL0000788)
Fold Change: 0.14
Marker Score: 122
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.13
Marker Score: 32
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.13
Marker Score: 163
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.13
Marker Score: 30
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.13
Marker Score: 168
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.13
Marker Score: 37
Cell Name: enucleated reticulocyte (CL0002422)
Fold Change: 0.12
Marker Score: 46
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.12
Marker Score: 65
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.12
Marker Score: 54
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.12
Marker Score: 187
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.12
Marker Score: 36
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.12
Marker Score: 95
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.11
Marker Score: 58
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.11
Marker Score: 88
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.11
Marker Score: 120
Cell Name: ionocyte (CL0005006)
Fold Change: 0.11
Marker Score: 33
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.11
Marker Score: 35
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.11
Marker Score: 74
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.11
Marker Score: 73
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.1
Marker Score: 89
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.1
Marker Score: 43
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.1
Marker Score: 69
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.1
Marker Score: 36
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.1
Marker Score: 61
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.1
Marker Score: 58
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.1
Marker Score: 216
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.09
Marker Score: 32
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.09
Marker Score: 5,158
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.09
Marker Score: 32
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.09
Marker Score: 49
Cell Name: fibroblast (CL0000057)
Fold Change: 0.09
Marker Score: 88
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.09
Marker Score: 47
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.09
Marker Score: 29
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.09
Marker Score: 66
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.09
Marker Score: 54
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.09
Marker Score: 211
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.09
Marker Score: 26
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.09
Marker Score: 63
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.09
Marker Score: 22
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.09
Marker Score: 87
Cell Name: T cell (CL0000084)
Fold Change: 0.09
Marker Score: 147

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics** IGLV1-40 shares several key characteristics with other immunoglobulin genes, including: 1. **Variable region**: IGLV1-40 encodes the variable region of the lambda light chain, which is responsible for antigen recognition and binding. 2. **Immunoglobulin structure**: The lambda light chain is a crucial component of the immunoglobulin molecule, which consists of two heavy chains and two light chains. 3. **Significant expression**: IGLV1-40 is expressed in various immune cells, including natural killer cells, monocytes, and T cells, indicating its importance in immune function. 4. **Multiple pathways**: IGLV1-40 is involved in multiple pathways, including antigen binding, complement activation, and phagocytosis, highlighting its multifaceted role in the immune system. **Pathways and Functions** IGLV1-40 is involved in several key pathways, including: 1. **Antigen binding**: IGLV1-40 recognizes and binds to specific antigens, triggering an immune response. 2. **Complement activation**: IGLV1-40 is involved in the classical pathway of complement activation, which leads to the formation of the membrane attack complex and the opsonization of pathogens. 3. **Phagocytosis**: IGLV1-40 is involved in the phagocytic process, where immune cells recognize and engulf pathogens. 4. **Regulation of immune responses**: IGLV1-40 is involved in the regulation of immune responses, including the activation of natural killer cells and the modulation of T cell responses. **Clinical Significance** IGLV1-40 has significant clinical implications, particularly in the context of: 1. **Leishmania infections**: IGLV1-40 is involved in the regulation of immune responses to Leishmania parasites, highlighting its potential as a target for therapeutic interventions. 2. **Infectious diseases**: IGLV1-40 is involved in the regulation of immune responses to various infectious diseases, including viral and bacterial infections. 3. **Autoimmune diseases**: IGLV1-40 may play a role in the regulation of immune responses in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cancer immunotherapy**: IGLV1-40 may be involved in the regulation of immune responses to cancer cells, highlighting its potential as a target for cancer immunotherapy. In conclusion, IGLV1-40 is a gene that plays a crucial role in the regulation of immune responses, particularly in the context of antigen binding, complement activation, and phagocytosis. Its significant expression in various immune cells and its involvement in multiple pathways highlight its importance in the immune system. The gene's clinical significance is particularly evident in the context of Leishmania infections, infectious diseases, autoimmune diseases, and cancer immunotherapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.