Details for: RAC2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 136.2948
Cell Significance Index: -21.2000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 77.3156
Cell Significance Index: -39.7700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 61.2129
Cell Significance Index: -28.9000 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 29.1689
Cell Significance Index: 78.1400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.2002
Cell Significance Index: -22.4400 - Cell Name: centroblast (CL0009112)
Fold Change: 17.7492
Cell Significance Index: 41.4100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 10.2100
Cell Significance Index: 299.8600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.9692
Cell Significance Index: -30.6200 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 7.0351
Cell Significance Index: 44.9100 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 6.9429
Cell Significance Index: 46.0600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.1885
Cell Significance Index: -24.4200 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 5.8765
Cell Significance Index: 17.9100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 4.9247
Cell Significance Index: 580.7700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.1049
Cell Significance Index: 75.8700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.0546
Cell Significance Index: 261.5900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.8523
Cell Significance Index: 282.1600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.5371
Cell Significance Index: 295.6700 - Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 1.3007
Cell Significance Index: 9.3500 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.0801
Cell Significance Index: 10.8300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.9670
Cell Significance Index: 20.6000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9591
Cell Significance Index: 156.0000 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.8914
Cell Significance Index: 3.7100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.5447
Cell Significance Index: 14.5700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4504
Cell Significance Index: 31.1500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3404
Cell Significance Index: 20.4400 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.3316
Cell Significance Index: 2.9000 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.2531
Cell Significance Index: 1.3800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1791
Cell Significance Index: 97.7900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0712
Cell Significance Index: 13.5500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0686
Cell Significance Index: 42.8400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0305
Cell Significance Index: 1.0700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0093
Cell Significance Index: -1.8400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0124
Cell Significance Index: -23.3000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0134
Cell Significance Index: -5.9200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0139
Cell Significance Index: -25.6600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0141
Cell Significance Index: -10.4100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0166
Cell Significance Index: -25.5900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0180
Cell Significance Index: -0.4500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0184
Cell Significance Index: -13.9200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0188
Cell Significance Index: -25.5200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0260
Cell Significance Index: -1.3100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0282
Cell Significance Index: -15.8900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0286
Cell Significance Index: -0.7300 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0287
Cell Significance Index: -0.4200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0288
Cell Significance Index: -10.3500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0306
Cell Significance Index: -5.5200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0421
Cell Significance Index: -1.7300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0430
Cell Significance Index: -2.0200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0564
Cell Significance Index: -41.3800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0609
Cell Significance Index: -2.7600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0611
Cell Significance Index: -12.8700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0614
Cell Significance Index: -1.3300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0643
Cell Significance Index: -40.8600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0696
Cell Significance Index: -11.8900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0810
Cell Significance Index: -36.7500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0831
Cell Significance Index: -23.9100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0911
Cell Significance Index: -1.5700 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.0971
Cell Significance Index: -1.2300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0990
Cell Significance Index: -19.8600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1019
Cell Significance Index: -12.5300 - Cell Name: activated type II NK T cell (CL0000931)
Fold Change: -0.1172
Cell Significance Index: -0.3000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1199
Cell Significance Index: -12.2500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1386
Cell Significance Index: -17.9100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1390
Cell Significance Index: -19.0900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1561
Cell Significance Index: -8.1100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1881
Cell Significance Index: -5.4200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2016
Cell Significance Index: -23.0100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2019
Cell Significance Index: -23.1400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2273
Cell Significance Index: -23.6700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2595
Cell Significance Index: -33.2700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2799
Cell Significance Index: -40.6900 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.2820
Cell Significance Index: -4.7900 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.2879
Cell Significance Index: -2.2400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3012
Cell Significance Index: -22.4500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3340
Cell Significance Index: -25.6300 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.3535
Cell Significance Index: -2.6300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3978
Cell Significance Index: -10.4600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3992
Cell Significance Index: -26.8400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4281
Cell Significance Index: -30.2800 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.4529
Cell Significance Index: -5.8000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4721
Cell Significance Index: -26.4900 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.4892
Cell Significance Index: -4.8400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4904
Cell Significance Index: -25.7500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4977
Cell Significance Index: -21.6400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5226
Cell Significance Index: -32.1200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5232
Cell Significance Index: -41.4400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5283
Cell Significance Index: -32.3900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5366
Cell Significance Index: -25.0200 - Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.5398
Cell Significance Index: -5.0500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5957
Cell Significance Index: -26.3500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6200
Cell Significance Index: -20.3000 - Cell Name: lymphocyte (CL0000542)
Fold Change: -0.6248
Cell Significance Index: -8.5000 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.6278
Cell Significance Index: -5.3000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6628
Cell Significance Index: -23.2200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6664
Cell Significance Index: -21.2300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.6716
Cell Significance Index: -18.7700 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.6919
Cell Significance Index: -6.5600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6959
Cell Significance Index: -22.2900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6977
Cell Significance Index: -26.4200 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.7150
Cell Significance Index: -13.9800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3527844392
Symbol: RAC2_HUMAN
Name: Ras-related C3 botulinum toxin substrate 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2674130
Title: Rac, a novel ras-related family of proteins that are botulinum toxin substrates.
PubMed ID: 2674130
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1316893
Title: Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins.
PubMed ID: 1316893
PubMed ID: 1660188
Title: Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2.
PubMed ID: 1660188
PubMed ID: 1902092
Title: A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation.
PubMed ID: 1902092
PubMed ID: 8504089
Title: Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.
PubMed ID: 8504089
DOI: 10.1021/bi00072a029
PubMed ID: 1903399
Title: Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA.
PubMed ID: 1903399
PubMed ID: 10559471
Title: Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins.
PubMed ID: 10559471
PubMed ID: 15642721
Title: The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.
PubMed ID: 15642721
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24141704
Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
PubMed ID: 24141704
DOI: 10.1038/nsmb.2688
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 10655614
Title: The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.
PubMed ID: 10655614
DOI: 10.1038/72392
PubMed ID: 10758162
Title: Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation.
PubMed ID: 10758162
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 25512081
Title: RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency.
PubMed ID: 25512081
PubMed ID: 30723080
Title: Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects.
PubMed ID: 30723080
PubMed ID: 31071452
Title: Heterozygous activating mutation in RAC2 causes infantile-onset combined immunodeficiency with susceptibility to viral infections.
PubMed ID: 31071452
PubMed ID: 30654050
Title: A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency.
PubMed ID: 30654050
PubMed ID: 31382036
Title: A dominant activating RAC2 variant associated with immunodeficiency and pulmonary disease.
PubMed ID: 31382036
Sequence Information:
- Length: 192
- Mass: 21429
- Checksum: 2A1F1266B07C3210
- Sequence:
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE VRHHCPSTPI ILVGTKLDLR DDKDTIEKLK EKKLAPITYP QGLALAKEID SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ PTRQQKRACS LL
Genular Protein ID: 223410304
Symbol: V9H0H7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
Sequence Information:
- Length: 201
- Mass: 22269
- Checksum: D91C32E83A22C51A
- Sequence:
MDPGWPCCPL PVAFLSRWLQ SFVDGLFCTG GLLRQRTCKF AGAASQAPHA PAFLRARGEP QDPLSHPRVP AVSANCRMWK HLPVHSSPTP RLTPLWKLQA RWLLPQLVYL QGWGSYSLLR PAALISMVLL AREFLYPAKM SVSEVCSSGL SSPLLEQHKT NLIFYASGDI CSANGKSGFN QPLPFLKTFC STHRILSCTY L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.