Details for: GZMB

Gene ID: 3002

Symbol: GZMB

Ensembl ID: ENSG00000100453

Description: granzyme B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.44
    Marker Score: 15880
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.38
    Marker Score: 12094
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.67
    Marker Score: 5407
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.2
    Marker Score: 1766
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.19
    Marker Score: 10065
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.77
    Marker Score: 1196
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.48
    Marker Score: 1066
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.38
    Marker Score: 2645
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.38
    Marker Score: 783
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.16
    Marker Score: 2978
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.12
    Marker Score: 1865
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.98
    Marker Score: 1434
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.82
    Marker Score: 461
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.7
    Marker Score: 386
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.69
    Marker Score: 1306
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.67
    Marker Score: 1617
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1152
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.48
    Marker Score: 455
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.47
    Marker Score: 848
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.4
    Marker Score: 13899
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.2
    Marker Score: 807
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.19
    Marker Score: 313
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.11
    Marker Score: 1440
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.09
    Marker Score: 2068
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.05
    Marker Score: 628
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.03
    Marker Score: 11961
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 784
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.02
    Marker Score: 2487
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.01
    Marker Score: 521
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71785
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48010
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.99
    Marker Score: 837
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 663.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 406
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.97
    Marker Score: 1586
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.93
    Marker Score: 763
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5265
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.88
    Marker Score: 455.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.88
    Marker Score: 640
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.8
    Marker Score: 707
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.79
    Marker Score: 5080
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.78
    Marker Score: 394
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.78
    Marker Score: 659
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1568
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.74
    Marker Score: 435
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3101
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.7
    Marker Score: 1969
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.66
    Marker Score: 408
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.62
    Marker Score: 285
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 391
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9365
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.58
    Marker Score: 190
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.58
    Marker Score: 314
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.58
    Marker Score: 455
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.54
    Marker Score: 718
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.52
    Marker Score: 237
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.51
    Marker Score: 372
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.51
    Marker Score: 185
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.47
    Marker Score: 272.5
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.46
    Marker Score: 301
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 272
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.46
    Marker Score: 345
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.45
    Marker Score: 399
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.45
    Marker Score: 1006
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.44
    Marker Score: 152
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.42
    Marker Score: 609
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 196
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.41
    Marker Score: 441.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.4
    Marker Score: 644
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 220
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.37
    Marker Score: 912
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.34
    Marker Score: 350
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.34
    Marker Score: 323
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.34
    Marker Score: 878
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.33
    Marker Score: 64
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.31
    Marker Score: 179
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.31
    Marker Score: 402
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.3
    Marker Score: 76
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.3
    Marker Score: 297
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.29
    Marker Score: 69
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.29
    Marker Score: 566
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.29
    Marker Score: 62.5
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.28
    Marker Score: 62

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GZMB is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in immune cells, including natural killer (NK) cells, activated CD8+ T cells, and macrophages. * GZMB is a key regulator of apoptosis in immune cells. * It is involved in the regulation of inflammation and cancer development. **Pathways and functions:** * GZMB is involved in the activation of the intrinsic pathway for apoptosis. * It is also involved in the regulation of the Notch2 intracellular domain, which is a key regulator of apoptosis. * GZMB is a key regulator of cancer growth and metastasis. * It is involved in the regulation of inflammation and autoimmune diseases. **Clinical significance:** * Mutations in the GZMB gene have been linked to the development of several human cancers, including lung cancer, colorectal cancer, and melanoma. * Targeting GZMB has been shown to be a promising strategy for the treatment of cancer. **Conclusion:** GZMB is an important protein that is involved in the regulation of apoptosis, immune responses, and cancer development. Mutations in the GZMB gene have been linked to the development of several human cancers, and targeting GZMB has been shown to be a promising strategy for the treatment of cancer.

Genular Protein ID: 2848280664

Symbol: GRAB_HUMAN

Name: C11

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2953813

Title: Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.

PubMed ID: 2953813

PubMed ID: 3258865

Title: Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.

PubMed ID: 3258865

DOI: 10.1016/s0021-9258(18)68794-0

PubMed ID: 3261871

Title: Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.

PubMed ID: 3261871

DOI: 10.1073/pnas.85.18.6924

PubMed ID: 2788607

Title: Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes.

PubMed ID: 2788607

DOI: 10.1016/0888-7543(89)90093-1

PubMed ID: 2365998

Title: Nucleotide sequence and genomic organization of a human T lymphocyte serine protease gene.

PubMed ID: 2365998

PubMed ID: 2332171

Title: Structural organization of the hCTLA-1 gene encoding human granzyme B.

PubMed ID: 2332171

DOI: 10.1016/0378-1119(90)90311-e

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2323780

Title: Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14.

PubMed ID: 2323780

DOI: 10.1007/bf00195821

PubMed ID: 3262682

Title: Characterization of three serine esterases isolated from human IL-2 activated killer cells.

PubMed ID: 3262682

PubMed ID: 3263427

Title: Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes.

PubMed ID: 3263427

PubMed ID: 8258716

Title: Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.

PubMed ID: 8258716

PubMed ID: 1985927

Title: Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

PubMed ID: 1985927

DOI: 10.1016/s0021-9258(18)52407-8

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9852092

Title: Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

PubMed ID: 9852092

DOI: 10.1074/jbc.273.51.34278

PubMed ID: 20038786

Title: Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.

PubMed ID: 20038786

DOI: 10.1182/blood-2009-10-246116

PubMed ID: 24088571

Title: Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

PubMed ID: 24088571

DOI: 10.1091/mbc.e13-05-0259

PubMed ID: 32188940

Title: Gasdermin E suppresses tumour growth by activating anti-tumour immunity.

PubMed ID: 32188940

DOI: 10.1038/s41586-020-2071-9

PubMed ID: 31953257

Title: Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome.

PubMed ID: 31953257

DOI: 10.1126/sciimmunol.aax7969

PubMed ID: 11209755

Title: Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue.

PubMed ID: 11209755

DOI: 10.1515/bc.2000.148

PubMed ID: 11325591

Title: The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.

PubMed ID: 11325591

DOI: 10.1016/s1074-5521(01)00018-7

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 247
  • Mass: 27716
  • Checksum: C652271918EF24F9
  • Sequence:
  • MQPILLLLAF LLLPRADAGE IIGGHEAKPH SRPYMAYLMI WDQKSLKRCG GFLIRDDFVL 
    TAAHCWGSSI NVTLGAHNIK EQEPTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKR 
    TRAVQPLRLP SNKAQVKPGQ TCSVAGWGQT APLGKHSHTL QEVKMTVQED RKCESDLRHY 
    YDSTIELCVG DPEIKKTSFK GDSGGPLVCN KVAQGIVSYG RNNGMPPRAC TKVSSFVHWI 
    KKTMKRY

Genular Protein ID: 644944040

Symbol: Q67BC3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 281
  • Mass: 31392
  • Checksum: 6CAD21A1A7E9DA44
  • Sequence:
  • MKSLSLLHLF PLPRAKREQG GNNSSSNQGS LPEKMQPILL LLAFLLLPRA DAGEIIGGHE 
    AKPHSRPYMA YLMIWDQKSL KRCGGFLIQD DFVLTAAHCW GSSINVTLGA HNIKEQEPTQ 
    QFIPVKRPIP HPAYNPKNFS NDIMLLQLER KAKRTRAVQP LRLPSNKAQV KPGQTCSVAG 
    WGQTAPLGKH SHTLQEVKMT VQEDRKCESD LRHYYDSTIE LCVGDPEIKK TSFKGDSGGP 
    LVCNKVAQGI VSYGRNNGMP PRACTKVSSF VHWIKKTMKR Y

Genular Protein ID: 2503191846

Symbol: Q6XGZ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 235
  • Mass: 26389
  • Checksum: E80E1075882803F8
  • Sequence:
  • MQTFPSGEII GGHEAKPHSR PYMAYLMIWD QKSLKRCGGF LIQDDFVLTA AHCWGSSINV 
    TLGAHNIKEQ EPTQQFIPVK RPIPHPAYNP KNFSNDIMLL QLERKAKRTR AVQPLRLPSN 
    KAQVKPGQTC SVAGWGQTAP LGKHSHTLQE VKMTVQEDRK CESDLRHYYD STIELCVGDP 
    EIKKTSFKGD SGGPLVCNKV AQGIVSYGRN NGMPPRACTK VSSFVHWIKK TMKRY

Genular Protein ID: 3781808694

Symbol: J3KQ52_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 235
  • Mass: 26417
  • Checksum: 4613C1694635D3FA
  • Sequence:
  • MQTFPSGEII GGHEAKPHSR PYMAYLMIWD QKSLKRCGGF LIRDDFVLTA AHCWGSSINV 
    TLGAHNIKEQ EPTQQFIPVK RPIPHPAYNP KNFSNDIMLL QLERKAKRTR AVQPLRLPSN 
    KAQVKPGQTC SVAGWGQTAP LGKHSHTLQE VKMTVQEDRK CESDLRHYYD STIELCVGDP 
    EIKKTSFKGD SGGPLVCNKV AQGIVSYGRN NGMPPRACTK VSSFVHWIKK TMKRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.