Details for: GZMB

Gene ID: 3002

Symbol: GZMB

Ensembl ID: ENSG00000100453

Description: granzyme B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.9359
    Cell Significance Index: -17.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.2919
    Cell Significance Index: -18.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.4114
    Cell Significance Index: -20.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.5654
    Cell Significance Index: -21.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.5925
    Cell Significance Index: -18.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9016
    Cell Significance Index: -17.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7313
    Cell Significance Index: -18.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.6131
    Cell Significance Index: 115.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8609
    Cell Significance Index: 40.3200
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 1.6757
    Cell Significance Index: 4.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6470
    Cell Significance Index: 48.3700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.6091
    Cell Significance Index: 17.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5803
    Cell Significance Index: 24.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1826
    Cell Significance Index: 225.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0544
    Cell Significance Index: 104.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8037
    Cell Significance Index: 725.7100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.5296
    Cell Significance Index: 6.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4679
    Cell Significance Index: 76.1100
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.3461
    Cell Significance Index: 2.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1778
    Cell Significance Index: 2.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0763
    Cell Significance Index: 5.2800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0709
    Cell Significance Index: 0.1900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0028
    Cell Significance Index: 0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0013
    Cell Significance Index: 0.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0010
    Cell Significance Index: -0.0300
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.0078
    Cell Significance Index: -0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0100
    Cell Significance Index: -0.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0100
    Cell Significance Index: -6.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0100
    Cell Significance Index: -18.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0129
    Cell Significance Index: -0.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0221
    Cell Significance Index: -1.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0223
    Cell Significance Index: -9.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0267
    Cell Significance Index: -19.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0355
    Cell Significance Index: -20.0200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0443
    Cell Significance Index: -0.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0448
    Cell Significance Index: -20.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0546
    Cell Significance Index: -3.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0614
    Cell Significance Index: -17.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0752
    Cell Significance Index: -3.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0765
    Cell Significance Index: -9.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0884
    Cell Significance Index: -2.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0925
    Cell Significance Index: -1.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0942
    Cell Significance Index: -18.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0954
    Cell Significance Index: -18.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1023
    Cell Significance Index: -18.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1174
    Cell Significance Index: -20.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1290
    Cell Significance Index: -17.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1403
    Cell Significance Index: -8.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1420
    Cell Significance Index: -17.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1533
    Cell Significance Index: -19.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1571
    Cell Significance Index: -16.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1632
    Cell Significance Index: -19.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1733
    Cell Significance Index: -19.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1784
    Cell Significance Index: -3.7000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2224
    Cell Significance Index: -1.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2373
    Cell Significance Index: -12.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2501
    Cell Significance Index: -11.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2554
    Cell Significance Index: -19.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2671
    Cell Significance Index: -19.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3029
    Cell Significance Index: -19.5400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3407
    Cell Significance Index: -3.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.3428
    Cell Significance Index: -2.7400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3433
    Cell Significance Index: -5.8300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3548
    Cell Significance Index: -3.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3746
    Cell Significance Index: -19.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3828
    Cell Significance Index: -20.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3904
    Cell Significance Index: -10.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3976
    Cell Significance Index: -10.6400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3999
    Cell Significance Index: -5.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4277
    Cell Significance Index: -18.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4324
    Cell Significance Index: -20.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4381
    Cell Significance Index: -11.2600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.4519
    Cell Significance Index: -6.6100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4764
    Cell Significance Index: -4.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5010
    Cell Significance Index: -18.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5388
    Cell Significance Index: -19.7800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.5437
    Cell Significance Index: -5.3000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5812
    Cell Significance Index: -10.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5966
    Cell Significance Index: -20.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6342
    Cell Significance Index: -18.6800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.6415
    Cell Significance Index: -11.0200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.6418
    Cell Significance Index: -5.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6887
    Cell Significance Index: -18.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6942
    Cell Significance Index: -19.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7094
    Cell Significance Index: -19.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7097
    Cell Significance Index: -18.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7097
    Cell Significance Index: -18.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7106
    Cell Significance Index: -20.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7150
    Cell Significance Index: -10.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7248
    Cell Significance Index: -19.4200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.7310
    Cell Significance Index: -8.6300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7315
    Cell Significance Index: -18.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7567
    Cell Significance Index: -19.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7567
    Cell Significance Index: -18.8800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.7587
    Cell Significance Index: -11.3500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.7986
    Cell Significance Index: -9.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8066
    Cell Significance Index: -19.6800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.8143
    Cell Significance Index: -4.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8207
    Cell Significance Index: -20.4700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.8336
    Cell Significance Index: -6.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Granzyme B is a serine protease with a molecular weight of approximately 17 kDa. It is a member of the granzyme family, which also includes granzyme A, granzyme K, and granzyme F. GZMB is characterized by its ability to induce apoptosis in target cells, primarily through the activation of caspase-8 and caspase-3. It is also known to be involved in the regulation of cell death pathways, including pyroptosis and regulated necrosis. GZMB is highly specific to target cells and is not toxic to healthy cells. **Pathways and Functions** The granzyme B-mediated pathway involves the activation of various signaling molecules, including Bid and Bax, which ultimately lead to the release of cytochrome c from the mitochondria, triggering the apoptotic cascade. GZMB also interacts with other proteins, such as GRAB (Granzyme B-Associated Protein), which regulates its activity and localization. The GZMB-mediated pathway is involved in various physiological and pathological processes, including: * Immune surveillance and elimination of infected cells and tumor cells * Regulation of apoptosis and cell death pathways * Modulation of the immune response, including the activation of cytotoxic T cells and NK cells * Inflammation and tissue damage, particularly in autoimmune diseases and cancer **Clinical Significance** Granzyme B has significant implications in various diseases, including: * Cancer: Elevated levels of GZMB have been observed in various types of cancer, including breast, lung, and colon cancer. GZMB is involved in the regulation of tumor cell apoptosis and the immune response against cancer. * Autoimmune diseases: GZMB has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it contributes to tissue damage and inflammation. * Infectious diseases: GZMB plays a crucial role in the immune response against viral infections, such as HIV and herpes simplex virus. * Transplantation: Elevated levels of GZMB have been observed in patients with acute rejection, suggesting its potential role as a biomarker for immune-mediated rejection. In conclusion, granzyme B is a critical component of the immune system, involved in the regulation of apoptosis and cytotoxicity mediated by NK cells and cytotoxic T cells. Its dysregulation has significant implications in various diseases, including cancer, autoimmune diseases, and infectious diseases. Further research is needed to fully understand the role of GZMB in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 2848280664

Symbol: GRAB_HUMAN

Name: C11

UniProtKB Accession Codes:

P10144 Q8N1D2 Q9UCC1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2953813

Title: Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.

PubMed ID: 2953813

PubMed ID: 3258865

Title: Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.

PubMed ID: 3258865

DOI: 10.1016/s0021-9258(18)68794-0

PubMed ID: 3261871

Title: Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.

PubMed ID: 3261871

DOI: 10.1073/pnas.85.18.6924

PubMed ID: 2788607

Title: Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes.

PubMed ID: 2788607

DOI: 10.1016/0888-7543(89)90093-1

PubMed ID: 2365998

Title: Nucleotide sequence and genomic organization of a human T lymphocyte serine protease gene.

PubMed ID: 2365998

PubMed ID: 2332171

Title: Structural organization of the hCTLA-1 gene encoding human granzyme B.

PubMed ID: 2332171

DOI: 10.1016/0378-1119(90)90311-e

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2323780

Title: Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14.

PubMed ID: 2323780

DOI: 10.1007/bf00195821

PubMed ID: 3262682

Title: Characterization of three serine esterases isolated from human IL-2 activated killer cells.

PubMed ID: 3262682

PubMed ID: 3263427

Title: Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes.

PubMed ID: 3263427

PubMed ID: 8258716

Title: Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.

PubMed ID: 8258716

PubMed ID: 1985927

Title: Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

PubMed ID: 1985927

DOI: 10.1016/s0021-9258(18)52407-8

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9852092

Title: Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

PubMed ID: 9852092

DOI: 10.1074/jbc.273.51.34278

PubMed ID: 20038786

Title: Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.

PubMed ID: 20038786

DOI: 10.1182/blood-2009-10-246116

PubMed ID: 24088571

Title: Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

PubMed ID: 24088571

DOI: 10.1091/mbc.e13-05-0259

PubMed ID: 32188940

Title: Gasdermin E suppresses tumour growth by activating anti-tumour immunity.

PubMed ID: 32188940

DOI: 10.1038/s41586-020-2071-9

PubMed ID: 31953257

Title: Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome.

PubMed ID: 31953257

DOI: 10.1126/sciimmunol.aax7969

PubMed ID: 11209755

Title: Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue.

PubMed ID: 11209755

DOI: 10.1515/bc.2000.148

PubMed ID: 11325591

Title: The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.

PubMed ID: 11325591

DOI: 10.1016/s1074-5521(01)00018-7

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 247
  • Mass: 27716
  • Checksum: C652271918EF24F9
  • Sequence:
    • MQPILLLLAF LLLPRADAGE IIGGHEAKPH SRPYMAYLMI WDQKSLKRCG GFLIRDDFVL 
TAAHCWGSSI NVTLGAHNIK EQEPTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKR 
TRAVQPLRLP SNKAQVKPGQ TCSVAGWGQT APLGKHSHTL QEVKMTVQED RKCESDLRHY 
YDSTIELCVG DPEIKKTSFK GDSGGPLVCN KVAQGIVSYG RNNGMPPRAC TKVSSFVHWI 
KKTMKRY

Genular Protein ID: 644944040

Symbol: Q67BC3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q67BC3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 6 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 281
  • Mass: 31392
  • Checksum: 6CAD21A1A7E9DA44
  • Sequence:
    • MKSLSLLHLF PLPRAKREQG GNNSSSNQGS LPEKMQPILL LLAFLLLPRA DAGEIIGGHE 
AKPHSRPYMA YLMIWDQKSL KRCGGFLIQD DFVLTAAHCW GSSINVTLGA HNIKEQEPTQ 
QFIPVKRPIP HPAYNPKNFS NDIMLLQLER KAKRTRAVQP LRLPSNKAQV KPGQTCSVAG 
WGQTAPLGKH SHTLQEVKMT VQEDRKCESD LRHYYDSTIE LCVGDPEIKK TSFKGDSGGP 
LVCNKVAQGI VSYGRNNGMP PRACTKVSSF VHWIKKTMKR Y

Genular Protein ID: 3781808694

Symbol: J3KQ52_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KQ52

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 235
  • Mass: 26417
  • Checksum: 4613C1694635D3FA
  • Sequence:
    • MQTFPSGEII GGHEAKPHSR PYMAYLMIWD QKSLKRCGGF LIRDDFVLTA AHCWGSSINV 
TLGAHNIKEQ EPTQQFIPVK RPIPHPAYNP KNFSNDIMLL QLERKAKRTR AVQPLRLPSN 
KAQVKPGQTC SVAGWGQTAP LGKHSHTLQE VKMTVQEDRK CESDLRHYYD STIELCVGDP 
EIKKTSFKGD SGGPLVCNKV AQGIVSYGRN NGMPPRACTK VSSFVHWIKK TMKRY

Genular Protein ID: 2503191846

Symbol: Q6XGZ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6XGZ4

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 6 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 235
  • Mass: 26389
  • Checksum: E80E1075882803F8
  • Sequence:
    • MQTFPSGEII GGHEAKPHSR PYMAYLMIWD QKSLKRCGGF LIQDDFVLTA AHCWGSSINV 
TLGAHNIKEQ EPTQQFIPVK RPIPHPAYNP KNFSNDIMLL QLERKAKRTR AVQPLRLPSN 
KAQVKPGQTC SVAGWGQTAP LGKHSHTLQE VKMTVQEDRK CESDLRHYYD STIELCVGDP 
EIKKTSFKGD SGGPLVCNKV AQGIVSYGRN NGMPPRACTK VSSFVHWIKK TMKRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.