Gene GZMM - ENSG00000197540 | NCBI Gene ID: 3004

Details for: GZMM

Gene ID: 3004

Symbol: GZMM

Ensembl ID: ENSG00000197540

Description: granzyme M

Associated with

Alternative complement activation
(R-HSA-173736)
Complement cascade
(R-HSA-166658)
Immune system
(R-HSA-168256)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Apoptotic process
(GO:0006915)
Extracellular region
(GO:0005576)
Innate immune response
(GO:0045087)
Killing of cells of another organism
(GO:0031640)
Membrane
(GO:0016020)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase activity
(GO:0008236)
T cell mediated cytotoxicity
(GO:0001913)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.17
Marker Score: 13158
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.62
Marker Score: 10557
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.4
Marker Score: 5011
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.35
Marker Score: 9401
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.13
Marker Score: 2752
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.06
Marker Score: 7465
Cell Name: mature T cell (CL0002419)
Fold Change: 2.93
Marker Score: 29000
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.84
Marker Score: 1225
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.71
Marker Score: 2284
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.52
Marker Score: 2438
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.42
Marker Score: 2153
Cell Name: ILC1, human (CL0001077)
Fold Change: 2.39
Marker Score: 607
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 2.38
Marker Score: 1314
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.22
Marker Score: 730
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.08
Marker Score: 1510
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.01
Marker Score: 5555
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.01
Marker Score: 3584
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.99
Marker Score: 1226
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.92
Marker Score: 596
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.9
Marker Score: 2619
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 1.87
Marker Score: 609
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.76
Marker Score: 400
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.76
Marker Score: 905.5
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.73
Marker Score: 91643
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.7
Marker Score: 995
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 1.64
Marker Score: 1820
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.63
Marker Score: 10423
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1161
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.59
Marker Score: 1484
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.51
Marker Score: 869
Cell Name: memory T cell (CL0000813)
Fold Change: 1.47
Marker Score: 630
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.46
Marker Score: 1456
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.39
Marker Score: 5954
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.39
Marker Score: 1496
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.37
Marker Score: 684
Cell Name: blood cell (CL0000081)
Fold Change: 1.35
Marker Score: 15692
Cell Name: naive T cell (CL0000898)
Fold Change: 1.33
Marker Score: 857
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.29
Marker Score: 2531
Cell Name: Unknown (CL0000548)
Fold Change: 1.24
Marker Score: 907
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 1.21
Marker Score: 2078
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.19
Marker Score: 1008
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.18
Marker Score: 926.5
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.16
Marker Score: 838
Cell Name: natural killer cell (CL0000623)
Fold Change: 1.15
Marker Score: 1489
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 1.14
Marker Score: 393
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.11
Marker Score: 813
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 1.07
Marker Score: 1739
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251783
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.02
Marker Score: 691
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1
Marker Score: 416
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71802
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48026
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.99
Marker Score: 770
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.98
Marker Score: 805
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.98
Marker Score: 740
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 503
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5278
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2734
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.91
Marker Score: 279
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.89
Marker Score: 736
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.87
Marker Score: 1657
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.86
Marker Score: 951.5
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.85
Marker Score: 751
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.84
Marker Score: 568
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.84
Marker Score: 643.5
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.83
Marker Score: 1871
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.78
Marker Score: 3263
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.78
Marker Score: 845
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1256
Cell Name: T follicular regulatory cell (CL0009113)
Fold Change: 0.77
Marker Score: 209.5
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 687
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.74
Marker Score: 1052
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.74
Marker Score: 344
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.71
Marker Score: 360
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.63
Marker Score: 168
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.63
Marker Score: 139
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.62
Marker Score: 394
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.61
Marker Score: 338
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.6
Marker Score: 209.5
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.57
Marker Score: 263.5
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.57
Marker Score: 221
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 450
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.55
Marker Score: 8560
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.54
Marker Score: 164
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.52
Marker Score: 137
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.51
Marker Score: 166
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.5
Marker Score: 314
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.44
Marker Score: 267
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.44
Marker Score: 139
Cell Name: T cell (CL0000084)
Fold Change: 0.44
Marker Score: 757
Cell Name: type II NK T cell (CL0000922)
Fold Change: 0.42
Marker Score: 130
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.41
Marker Score: 234

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**Key characteristics:** * GZMM is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a serine endopeptidase that is involved in the activation of the alternative complement pathway. * It is expressed in high levels in tissues that are exposed to pathogens, such as the gut and respiratory tract. **Pathways and functions:** * GZMM is a key regulator of the alternative complement pathway. * It is involved in the killing of infected cells and tumor cells. * It is also involved in the regulation of inflammation and immune responses. * It can be activated by various stimuli, including bacterial lipopolysaccharide, zymosin A, and zymosin B. **Clinical significance:** * Mutations in the GZMM gene have been linked to several human diseases, including systemic sclerosis, rheumatoid arthritis, and inflammatory bowel disease. * GZMM inhibitors are being investigated as potential treatments for these diseases. **Other important points:** * GZMM is a highly conserved protein that is found in mammals. * It is expressed in high levels in humans, particularly in tissues such as the gut, lungs, and skin. * GZMM is a potent activator of the alternative complement pathway.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Granzyme M

Genular Protein ID: 1504862673

Symbol: GRAM_HUMAN

Name: Granzyme M

UniProtKB Accession Codes:

P51124

Database IDs:

Citations:

PubMed ID: 8245461

Title: Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells.

PubMed ID: 8245461

PubMed ID: 7713495

Title: The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3.

PubMed ID: 7713495

DOI: 10.1006/geno.1994.1651

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18523284

Title: NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.

PubMed ID: 18523284

DOI: 10.4049/jimmunol.180.12.8184

PubMed ID: 20406824

Title: Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells.

PubMed ID: 20406824

DOI: 10.1074/jbc.m109.083170

PubMed ID: 19542453

Title: Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M.

PubMed ID: 19542453

DOI: 10.4049/jimmunol.0803088

Sequence Information:

Length: 257
Mass: 27545
Checksum: B4E815CE455F7371
Sequence:

MEACVSSLLV LALGALSVGS SFGTQIIGGR EVIPHSRPYM ASLQRNGSHL CGGVLVHPKW 
VLTAAHCLAQ RMAQLRLVLG LHTLDSPGLT FHIKAAIQHP RYKPVPALEN DLALLQLDGK 
VKPSRTIRPL ALPSKRQVVA AGTRCSMAGW GLTHQGGRLS RVLRELDLQV LDTRMCNNSR 
FWNGSLSPSM VCLAADSKDQ APCKGDSGGP LVCGKGRVLA RVLSFSSRVC TDIFKPPVAT 
AVAPYVSWIR KVTGRSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GZMM

Associated with

Cells (max top 100)

Other Information

Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. PubMed ID: 8245461

The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. PubMed ID: 7713495

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network. PubMed ID: 18523284

Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells. PubMed ID: 20406824

Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M. PubMed ID: 19542453