Details for: GZMH

Gene ID: 2999

Symbol: GZMH

Ensembl ID: ENSG00000100450

Description: granzyme H

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.98
    Marker Score: 162052
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.05
    Marker Score: 5967
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.84
    Marker Score: 3375
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.49
    Marker Score: 11005
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.32
    Marker Score: 9702
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.25
    Marker Score: 1791
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.82
    Marker Score: 27937
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.03
    Marker Score: 5604
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.02
    Marker Score: 5658
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1982
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.93
    Marker Score: 2670
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.93
    Marker Score: 1863
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.87
    Marker Score: 424
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.76
    Marker Score: 758
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1160
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.53
    Marker Score: 1291
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.49
    Marker Score: 1081
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.38
    Marker Score: 3377
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.35
    Marker Score: 584
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.29
    Marker Score: 649
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 847
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.24
    Marker Score: 712
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 480
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4798
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.11
    Marker Score: 806
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.09
    Marker Score: 360
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.06
    Marker Score: 1731.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.05
    Marker Score: 645
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.03
    Marker Score: 2015
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.97
    Marker Score: 570
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.96
    Marker Score: 1250
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.94
    Marker Score: 10877
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5334
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 420.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.84
    Marker Score: 212
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.83
    Marker Score: 645
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.82
    Marker Score: 692
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.81
    Marker Score: 545
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.77
    Marker Score: 677
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.75
    Marker Score: 615
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.65
    Marker Score: 332
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.63
    Marker Score: 194
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.55
    Marker Score: 284
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.55
    Marker Score: 253
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.52
    Marker Score: 169
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 303
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.5
    Marker Score: 378
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.49
    Marker Score: 158
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.49
    Marker Score: 275.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.45
    Marker Score: 401
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.4
    Marker Score: 139
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.4
    Marker Score: 233
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.36
    Marker Score: 690
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.36
    Marker Score: 279
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.33
    Marker Score: 17444
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 323
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.31
    Marker Score: 317
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.3
    Marker Score: 208
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.29
    Marker Score: 384
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.29
    Marker Score: 647
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.28
    Marker Score: 162
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.28
    Marker Score: 560
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.27
    Marker Score: 683
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.27
    Marker Score: 347
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 160
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.23
    Marker Score: 215
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.23
    Marker Score: 247
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.23
    Marker Score: 122
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.22
    Marker Score: 59
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.21
    Marker Score: 46
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 233
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.2
    Marker Score: 93
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2
    Marker Score: 193
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.2
    Marker Score: 47
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.2
    Marker Score: 222
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 191

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Other Information

**Key characteristics:** * GZMH is a serine protease that is expressed in high levels in immune cells. * It is a key effector of the innate immune response. * It is involved in the regulation of inflammation, cell death, and cancer. **Pathways and functions:** * GZMH is a key effector of the innate immune response. It is expressed in high levels in immune cells, including macrophages, dendritic cells, and neutrophils. * It is involved in the regulation of inflammation by promoting the maturation and activation of dendritic cells. * It is also involved in the regulation of cell death by promoting apoptosis in tumor cells. * GZMH is also involved in the metabolism of angiotensinogen to angiotensins. * It is involved in the metabolism of proteins by cleaving them into smaller peptides. **Clinical significance:** GZMH is a potential therapeutic target for a variety of diseases, including cancer, autoimmune diseases, and infectious diseases. By blocking GZMH, it is possible to inhibit the inflammatory and tumorigenic effects of this protein. **Additional notes:** * GZMH is a highly conserved protein. It is found in humans, mice, and rats. * It is a member of the granzyme family of serine proteases. * It is a highly potent cytokine that can kill target cells with high precision.

Genular Protein ID: 965541921

Symbol: GRAH_HUMAN

Name: Granzyme H

UniProtKB Accession Codes:

P20718 G3V2C5 Q6XGZ0 Q6XGZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2193684

Title: Cloning of a gene that encodes a new member of the human cytotoxic cell protease family.

PubMed ID: 2193684

DOI: 10.1021/bi00469a003

PubMed ID: 2049336

Title: Structure and evolutionary origin of the human granzyme H gene.

PubMed ID: 2049336

DOI: 10.1093/intimm/3.1.57

PubMed ID: 2402757

Title: Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C).

PubMed ID: 2402757

DOI: 10.1111/j.1399-0039.1990.tb01787.x

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22156497

Title: Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif.

PubMed ID: 22156497

DOI: 10.4049/jimmunol.1101381

PubMed ID: 23269243

Title: Identification of SERPINB1 as a physiological inhibitor of human granzyme H.

PubMed ID: 23269243

DOI: 10.4049/jimmunol.1202542

Sequence Information:

  • Length: 246
  • Mass: 27315
  • Checksum: CA6A87F3DA5F1E71
  • Sequence:
    • MQPFLLLLAF LLTPGAGTEE IIGGHEAKPH SRPYMAFVQF LQEKSRKRCG GILVRKDFVL 
TAAHCQGSSI NVTLGAHNIK EQERTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKW 
TTAVRPLRLP SSKAQVKPGQ LCSVAGWGYV SMSTLATTLQ EVLLTVQKDC QCERLFHGNY 
SRATEICVGD PKKTQTGFKG DSGGPLVCKD VAQGILSYGN KKGTPPGVYI KVSHFLPWIK 
RTMKRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.