Details for: TINAG

Gene ID: 27283

Symbol: TINAG

Ensembl ID: ENSG00000137251

Description: tubulointerstitial nephritis antigen

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 3.5461
    Cell Significance Index: 30.1400
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.5519
    Cell Significance Index: 24.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.5509
    Cell Significance Index: 16.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3129
    Cell Significance Index: 78.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2361
    Cell Significance Index: 201.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2330
    Cell Significance Index: 121.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1157
    Cell Significance Index: 50.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0813
    Cell Significance Index: 31.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0193
    Cell Significance Index: 920.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9977
    Cell Significance Index: 108.5200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.8389
    Cell Significance Index: 14.3400
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.7952
    Cell Significance Index: 6.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7836
    Cell Significance Index: 18.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5161
    Cell Significance Index: 35.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4090
    Cell Significance Index: 8.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3099
    Cell Significance Index: 4.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2585
    Cell Significance Index: 8.2800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2104
    Cell Significance Index: 1.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1887
    Cell Significance Index: 35.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1329
    Cell Significance Index: 15.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1320
    Cell Significance Index: 3.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1269
    Cell Significance Index: 2.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1039
    Cell Significance Index: 7.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0791
    Cell Significance Index: 15.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0354
    Cell Significance Index: 1.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0129
    Cell Significance Index: 8.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0053
    Cell Significance Index: 1.9000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0039
    Cell Significance Index: 0.0300
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0009
    Cell Significance Index: -0.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -3.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0061
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0066
    Cell Significance Index: -3.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0070
    Cell Significance Index: -1.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0074
    Cell Significance Index: -4.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0110
    Cell Significance Index: -6.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0112
    Cell Significance Index: -1.1400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0113
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0113
    Cell Significance Index: -5.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0138
    Cell Significance Index: -0.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0148
    Cell Significance Index: -0.9100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0176
    Cell Significance Index: -0.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0195
    Cell Significance Index: -5.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0203
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0223
    Cell Significance Index: -4.7100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0280
    Cell Significance Index: -0.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0286
    Cell Significance Index: -3.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0312
    Cell Significance Index: -1.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0347
    Cell Significance Index: -0.7200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0372
    Cell Significance Index: -0.5100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0372
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0377
    Cell Significance Index: -4.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0392
    Cell Significance Index: -7.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0408
    Cell Significance Index: -4.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0427
    Cell Significance Index: -2.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0446
    Cell Significance Index: -6.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0467
    Cell Significance Index: -1.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0496
    Cell Significance Index: -0.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0506
    Cell Significance Index: -1.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0511
    Cell Significance Index: -1.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0577
    Cell Significance Index: -4.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0592
    Cell Significance Index: -7.2800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0615
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0641
    Cell Significance Index: -4.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0644
    Cell Significance Index: -2.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0662
    Cell Significance Index: -1.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0692
    Cell Significance Index: -1.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0715
    Cell Significance Index: -4.0100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0756
    Cell Significance Index: -1.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0841
    Cell Significance Index: -3.7200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0844
    Cell Significance Index: -2.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0850
    Cell Significance Index: -3.2200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0878
    Cell Significance Index: -1.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0886
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0965
    Cell Significance Index: -0.8700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0973
    Cell Significance Index: -1.4800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0974
    Cell Significance Index: -3.0800
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.1039
    Cell Significance Index: -0.6100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1042
    Cell Significance Index: -2.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1044
    Cell Significance Index: -6.4200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1092
    Cell Significance Index: -1.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1101
    Cell Significance Index: -2.7500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1219
    Cell Significance Index: -1.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1278
    Cell Significance Index: -2.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1288
    Cell Significance Index: -3.4500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1320
    Cell Significance Index: -1.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1358
    Cell Significance Index: -2.0400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1380
    Cell Significance Index: -1.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1466
    Cell Significance Index: -6.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1467
    Cell Significance Index: -4.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1565
    Cell Significance Index: -4.1800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1591
    Cell Significance Index: -2.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1637
    Cell Significance Index: -2.0300
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: -0.1661
    Cell Significance Index: -1.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1686
    Cell Significance Index: -2.7300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1693
    Cell Significance Index: -2.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TINAG is a gene that codes for a protein, TINAG_HUMAN, which is involved in maintaining tissue homeostasis. The protein is expressed in a wide range of cell types, including endothelial cells, epithelial cells, and interneurons. TINAG is also involved in regulating cell adhesion, proteolysis, and signaling pathways, which are critical for maintaining tissue integrity and function. **Pathways and Functions** TINAG is involved in several cellular pathways, including: 1. **Basement membrane formation**: TINAG helps to regulate the formation and maintenance of the basement membrane, a critical structure that separates epithelial and endothelial cells from the underlying connective tissue. 2. **Cell adhesion**: TINAG is involved in regulating cell adhesion molecules, which are essential for maintaining tissue structure and function. 3. **Proteolysis**: TINAG regulates the activity of proteases, which are enzymes that break down proteins. Dysregulation of proteolysis can lead to tissue damage and disease. 4. **Signaling pathways**: TINAG is involved in regulating signaling pathways that are critical for maintaining tissue homeostasis, including the PI3K/AKT and MAPK/ERK pathways. **Clinical Significance** Dysregulation of TINAG has been implicated in various diseases, including: 1. **Kidney diseases**: TINAG has been implicated in the pathogenesis of kidney diseases, including tubulointerstitial nephritis, a condition characterized by inflammation and scarring of the kidney tissue. 2. **Cardiovascular disorders**: TINAG has been implicated in the pathogenesis of cardiovascular disorders, including atherosclerosis and myocardial infarction. 3. **Neurological conditions**: TINAG has been implicated in the pathogenesis of neurological conditions, including Alzheimer's disease and Parkinson's disease. In conclusion, TINAG is a critical gene that plays a key role in maintaining tissue homeostasis and function. Its dysregulation has been implicated in various diseases, including kidney diseases, cardiovascular disorders, and neurological conditions. Further research is needed to fully understand the mechanisms by which TINAG regulates tissue homeostasis and to develop effective therapeutic strategies for diseases associated with TINAG dysfunction.

Genular Protein ID: 3310963742

Symbol: TINAG_HUMAN

Name: Tubulointerstitial nephritis antigen

UniProtKB Accession Codes:

Q9UJW2 Q5T467 Q9UJW1 Q9ULZ4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10652240

Title: Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen.

PubMed ID: 10652240

DOI: 10.1006/bbrc.2000.2103

PubMed ID: 10752525

Title: Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag).

PubMed ID: 10752525

DOI: 10.1681/asn.v114658

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 3553704

Title: Identification of a target antigen in human anti-tubular basement membrane nephritis.

PubMed ID: 3553704

DOI: 10.1038/ki.1987.69

PubMed ID: 1762287

Title: Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms.

PubMed ID: 1762287

DOI: 10.1038/ki.1991.283

PubMed ID: 1466368

Title: Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy.

PubMed ID: 1466368

DOI: 10.1016/0002-9343(92)90205-p

PubMed ID: 8770961

Title: Receptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen.

PubMed ID: 8770961

DOI: 10.1038/ki.1996.20

PubMed ID: 9643646

Title: Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron.

PubMed ID: 9643646

DOI: 10.3109/03008209809028899

Sequence Information:

  • Length: 476
  • Mass: 54605
  • Checksum: 6D90C734DAC3A5AE
  • Sequence:
    • MWTGYKILIF SYLTTEIWME KQYLSQREVD LEAYFTRNHT VLQGTRFKRA IFQGQYCRNF 
GCCEDRDDGC VTEFYAANAL CYCDKFCDRE NSDCCPDYKS FCREEKEWPP HTQPWYPEGC 
FKDGQHYEEG SVIKENCNSC TCSGQQWKCS QHVCLVRSEL IEQVNKGDYG WTAQNYSQFW 
GMTLEDGFKF RLGTLPPSPM LLSMNEMTAS LPATTDLPEF FVASYKWPGW THGPLDQKNC 
AASWAFSTAS VAADRIAIQS KGRYTANLSP QNLISCCAKN RHGCNSGSID RAWWYLRKRG 
LVSHACYPLF KDQNATNNGC AMASRSDGRG KRHATKPCPN NVEKSNRIYQ CSPPYRVSSN 
ETEIMKEIMQ NGPVQAIMQV REDFFHYKTG IYRHVTSTNK ESEKYRKLQT HAVKLTGWGT 
LRGAQGQKEK FWIAANSWGK SWGENGYFRI LRGVNESDIE KLIIAAWGQL TSSDEP

Genular Protein ID: 2535752037

Symbol: Q6NSC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NSC1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 476
  • Mass: 54630
  • Checksum: 2B96BDEA5CE090CD
  • Sequence:
    • MWTGYKILIF SYLTTEIWME KRYLSQREVD LEAYFTRNHT VLQGTRFKRA IFQGQYCRNF 
GCCEDRDDGC VTEFYAANAL CYCDKFCDRE NSDCCPDYKS FCREEKEWPP HTQPWYPEGC 
FKDGQHYEEG SVIKENCNSC TCSGQQWKCS QHVCLVRSEL IEQVNKGDYG WTAQNYSQFW 
GMTLEDGFKF RLGTLPPSLM LLSMNEMTAS LPATTDLPEF FVASYKWPGW THGPLDQKNC 
AASWAFSTAS VAADRIAIQS KGRYTANLSP QNLISCCAKN RHGCNSGSID RAWWYLRKRG 
LVSHACYPLF KDQNATNNGC AMASRSDGRG KRHATKPCPN NVEKSNRIYQ CSPPYRVSSN 
ETEIMKEIMQ NGPVQAIMQV HEDFFHYKTG IYRHVTSTNK ESEKYRKLQT HAVKLTGWGT 
LRGAQGQKEK FWIAANSWGK SWGENGYFRI LRGVNESDIE KLIIAAWGQL TSSDEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.