Gene INHBA - ENSG00000122641 | NCBI Gene ID: 3624

Details for: INHBA

Gene ID: 3624

Symbol: INHBA

Ensembl ID: ENSG00000122641

Description: inhibin subunit beta A

Associated with

Antagonism of activin by follistatin
(R-HSA-2473224)
Glycoprotein hormones
(R-HSA-209822)
Metabolism of proteins
(R-HSA-392499)
Peptide hormone biosynthesis
(R-HSA-209952)
Peptide hormone metabolism
(R-HSA-2980736)
Signaling by activin
(R-HSA-1502540)
Signaling by bmp
(R-HSA-201451)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Activin a complex
(GO:0043509)
Activin receptor signaling pathway
(GO:0032924)
Autophagy
(GO:0006914)
Cardiac fibroblast cell development
(GO:0060936)
Cell-cell signaling
(GO:0007267)
Cell differentiation
(GO:0030154)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to angiotensin
(GO:1904385)
Cellular response to cholesterol
(GO:0071397)
Cellular response to follicle-stimulating hormone stimulus
(GO:0071372)
Cellular response to hypoxia
(GO:0071456)
Cellular response to oxygen-glucose deprivation
(GO:0090650)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Defense response
(GO:0006952)
Endodermal cell differentiation
(GO:0035987)
Erythrocyte differentiation
(GO:0030218)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Eyelid development in camera-type eye
(GO:0061029)
Gabaergic neuron differentiation
(GO:0097154)
Growth factor activity
(GO:0008083)
Hair follicle development
(GO:0001942)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Hemoglobin biosynthetic process
(GO:0042541)
Hormone activity
(GO:0005179)
Identical protein binding
(GO:0042802)
Inhibin a complex
(GO:0043512)
Male gonad development
(GO:0008584)
Mesodermal cell differentiation
(GO:0048333)
Negative regulation of b cell differentiation
(GO:0045578)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of follicle-stimulating hormone secretion
(GO:0046882)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of macrophage differentiation
(GO:0045650)
Negative regulation of phosphorylation
(GO:0042326)
Negative regulation of type ii interferon production
(GO:0032689)
Nervous system development
(GO:0007399)
Odontogenesis
(GO:0042476)
Ovarian follicle development
(GO:0001541)
Peptide hormone binding
(GO:0017046)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001241)
Positive regulation of follicle-stimulating hormone secretion
(GO:0046881)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of ovulation
(GO:0060279)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription by rna polymerase iii
(GO:0045945)
Progesterone secretion
(GO:0042701)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of follicle-stimulating hormone secretion
(GO:0046880)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to aldosterone
(GO:1904044)
Response to wounding
(GO:0009611)
Roof of mouth development
(GO:0060021)
Smad protein signal transduction
(GO:0060395)
Striatal medium spiny neuron differentiation
(GO:0021773)
Transcription by rna polymerase ii
(GO:0006366)
Type ii activin receptor binding
(GO:0070699)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: endocardial cell (CL0002350)
Fold Change: 3.79
Marker Score: 2140
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.76
Marker Score: 3801
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.34
Marker Score: 3145
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.21
Marker Score: 56589
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.06
Marker Score: 2497
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1158
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169024
Cell Name: trophoblast giant cell (CL0002488)
Fold Change: 1.42
Marker Score: 461
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 846
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.24
Marker Score: 279
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.21
Marker Score: 502
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 479
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4798
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.12
Marker Score: 457
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.08
Marker Score: 495
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.01
Marker Score: 1087
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71809
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48034.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.94
Marker Score: 1779
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5345
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 368
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.92
Marker Score: 228
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.91
Marker Score: 228
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9
Marker Score: 14130
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.89
Marker Score: 2028.5
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.88
Marker Score: 5372
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5281
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.85
Marker Score: 28865
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.82
Marker Score: 516.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.82
Marker Score: 799
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.81
Marker Score: 1919
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.77
Marker Score: 1575
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 589
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.74
Marker Score: 1419
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.72
Marker Score: 4312
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 455
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.65
Marker Score: 166
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.65
Marker Score: 341
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.64
Marker Score: 2477
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.64
Marker Score: 2742
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.61
Marker Score: 247
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.61
Marker Score: 1569
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.58
Marker Score: 332
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.55
Marker Score: 1578
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.55
Marker Score: 229
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.54
Marker Score: 249
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 171
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.53
Marker Score: 2871
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.53
Marker Score: 169
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.52
Marker Score: 3357
Cell Name: muscle cell (CL0000187)
Fold Change: 0.52
Marker Score: 147
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.52
Marker Score: 167
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.52
Marker Score: 341
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.51
Marker Score: 438
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.5
Marker Score: 132
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.5
Marker Score: 232
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.48
Marker Score: 737
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.48
Marker Score: 1253
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.47
Marker Score: 314
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.45
Marker Score: 273
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.45
Marker Score: 216
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.45
Marker Score: 444
Cell Name: supporting cell (CL0000630)
Fold Change: 0.44
Marker Score: 833
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.43
Marker Score: 520.5
Cell Name: fibroblast (CL0000057)
Fold Change: 0.43
Marker Score: 414
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.43
Marker Score: 179
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.41
Marker Score: 295
Cell Name: PP cell (CL0000696)
Fold Change: 0.41
Marker Score: 92
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.4
Marker Score: 386
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.39
Marker Score: 479
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.38
Marker Score: 167
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.38
Marker Score: 1887
Cell Name: osteoblast (CL0000062)
Fold Change: 0.38
Marker Score: 203
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.38
Marker Score: 248
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.38
Marker Score: 142
Cell Name: myometrial cell (CL0002366)
Fold Change: 0.36
Marker Score: 104
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.36
Marker Score: 880
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.35
Marker Score: 223
Cell Name: pericyte (CL0000669)
Fold Change: 0.35
Marker Score: 205
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.33
Marker Score: 86
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.33
Marker Score: 453
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.3
Marker Score: 137
Cell Name: monocyte (CL0000576)
Fold Change: 0.3
Marker Score: 394
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.3
Marker Score: 301
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.3
Marker Score: 478
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.3
Marker Score: 77
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.3
Marker Score: 202
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.29
Marker Score: 646
Cell Name: myelocyte (CL0002193)
Fold Change: 0.29
Marker Score: 127

Hover over a box to see details here...

**Key characteristics:** * Inhibin is a glycoprotein with a molecular weight of approximately 130 kDa. * It is expressed in a variety of cell types, including endocardial cells, bronchus fibroblasts of the lung, anterior lens cells, alveolar macrophages, lens epithelial cells, colon goblet cells, mural cells, trophoblast giant cells, and intestinal crypt stem cells. * Inhibin binds to the activin receptor and inhibits its activity by blocking the binding of the receptor to its ligand, activin. * Activin is a protein that is involved in the regulation of female reproductive function. * Inhibin is a key negative regulator of the female reproductive system, and its expression is often associated with fertility. **Pathways and functions:** * Inhibin works by binding to the activin receptor and inhibiting its activity. This prevents the activation of the receptor's downstream signaling pathways, which can lead to the inhibition of female reproductive functions. * Inhibin also inhibits the activity of other signaling pathways, including those involving BMP, TGF-beta, and estrogen receptors. * As a result of its inhibitory effects, inhibin helps to control the development and maintenance of female reproductive structures, such as the uterus, fallopian tubes, and ovaries. **Clinical significance:** * Mutations in the INHBA gene have been linked to infertility in humans. * Inhibin is a potential therapeutic target for infertility, as it can be used to treat conditions such as polycystic ovary syndrome (PCOS). * Inhibin is currently being investigated as a potential treatment for endometriosis, a condition characterized by pain and infertility.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Inhibin beta A chain

Genular Protein ID: 1440607932

Symbol: INHBA_HUMAN

Name: Inhibin beta A chain

UniProtKB Accession Codes:

P08476 Q14599

Database IDs:

Citations:

PubMed ID: 3754442

Title: Structure of two human ovarian inhibins.

PubMed ID: 3754442

DOI: 10.1016/0006-291x(86)91021-1

PubMed ID: 3267209

Title: Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.

PubMed ID: 3267209

DOI: 10.1073/pnas.85.8.2434

PubMed ID: 1777673

Title: Structure and sequence analysis of the human activin beta A subunit gene.

PubMed ID: 1777673

DOI: 10.3109/10425179109039678

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3758355

Title: Human inhibin genes. Genomic characterisation and sequencing.

PubMed ID: 3758355

DOI: 10.1016/0014-5793(86)81006-7

PubMed ID: 12697670

Title: Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG).

PubMed ID: 12697670

DOI: 10.1210/en.2002-0203

PubMed ID: 12660162

Title: Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.

PubMed ID: 12660162

DOI: 10.1093/emboj/cdg156

PubMed ID: 18768470

Title: The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity.

PubMed ID: 18768470

DOI: 10.1074/jbc.m801266200

PubMed ID: 24302632

Title: Germline mutations of inhibins in early-onset ovarian epithelial tumors.

PubMed ID: 24302632

DOI: 10.1002/humu.22489

Sequence Information:

Length: 426
Mass: 47442
Checksum: 201CDEDF99CB6919
Sequence:

MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS QPEMVEAVKK 
HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT 
SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRTK VTIRLFQQQK 
HPQGSLDTGE EAEEVGLKGE RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV 
RIACEQCQES GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS 
EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG 
TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV 
EECGCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: INHBA

Associated with

Cells (max top 100)

Other Information

Structure of two human ovarian inhibins. PubMed ID: 3754442

Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. PubMed ID: 3267209

Structure and sequence analysis of the human activin beta A subunit gene. PubMed ID: 1777673

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human inhibin genes. Genomic characterisation and sequencing. PubMed ID: 3758355

Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). PubMed ID: 12697670

Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions. PubMed ID: 12660162

The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. PubMed ID: 18768470

Germline mutations of inhibins in early-onset ovarian epithelial tumors. PubMed ID: 24302632