Details for: PTH2R

Gene ID: 5746

Symbol: PTH2R

Ensembl ID: ENSG00000144407

Description: parathyroid hormone 2 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.9708
    Cell Significance Index: -7.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.9383
    Cell Significance Index: -7.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.8351
    Cell Significance Index: -9.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9248
    Cell Significance Index: -7.3100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 3.8639
    Cell Significance Index: 40.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9122
    Cell Significance Index: -4.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7447
    Cell Significance Index: 117.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.7383
    Cell Significance Index: 109.5600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.1515
    Cell Significance Index: 14.5000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8555
    Cell Significance Index: 9.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7772
    Cell Significance Index: 9.2700
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.5726
    Cell Significance Index: 5.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5547
    Cell Significance Index: 15.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3478
    Cell Significance Index: 5.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3003
    Cell Significance Index: 14.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2967
    Cell Significance Index: 18.1900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2792
    Cell Significance Index: 3.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2332
    Cell Significance Index: 46.7800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2321
    Cell Significance Index: 3.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1899
    Cell Significance Index: 2.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1526
    Cell Significance Index: 6.7500
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1465
    Cell Significance Index: 1.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1084
    Cell Significance Index: 20.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0906
    Cell Significance Index: 1.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0850
    Cell Significance Index: 3.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0829
    Cell Significance Index: 16.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0614
    Cell Significance Index: 6.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0515
    Cell Significance Index: 0.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0411
    Cell Significance Index: 14.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0380
    Cell Significance Index: 2.1300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0368
    Cell Significance Index: 0.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0316
    Cell Significance Index: 21.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0161
    Cell Significance Index: 14.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0139
    Cell Significance Index: 25.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0121
    Cell Significance Index: 8.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0115
    Cell Significance Index: 15.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0114
    Cell Significance Index: 17.5600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0078
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0071
    Cell Significance Index: 13.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0052
    Cell Significance Index: 0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0047
    Cell Significance Index: 0.6800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0025
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0056
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0081
    Cell Significance Index: -5.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0110
    Cell Significance Index: -4.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0115
    Cell Significance Index: -0.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0141
    Cell Significance Index: -7.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0146
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0147
    Cell Significance Index: -9.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0166
    Cell Significance Index: -3.0000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0178
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0178
    Cell Significance Index: -3.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0187
    Cell Significance Index: -5.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0232
    Cell Significance Index: -2.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0237
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0283
    Cell Significance Index: -5.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0322
    Cell Significance Index: -1.1300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0347
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0384
    Cell Significance Index: -4.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0408
    Cell Significance Index: -6.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0422
    Cell Significance Index: -1.2200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0428
    Cell Significance Index: -0.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0452
    Cell Significance Index: -4.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0481
    Cell Significance Index: -6.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0501
    Cell Significance Index: -6.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0582
    Cell Significance Index: -4.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0601
    Cell Significance Index: -7.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0630
    Cell Significance Index: -0.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0640
    Cell Significance Index: -3.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0658
    Cell Significance Index: -6.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0679
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0680
    Cell Significance Index: -7.9300
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0704
    Cell Significance Index: -0.7500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0723
    Cell Significance Index: -0.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0724
    Cell Significance Index: -1.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0741
    Cell Significance Index: -5.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0826
    Cell Significance Index: -1.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0846
    Cell Significance Index: -9.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0953
    Cell Significance Index: -4.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1020
    Cell Significance Index: -8.0800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1075
    Cell Significance Index: -0.9800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1094
    Cell Significance Index: -1.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1142
    Cell Significance Index: -5.9300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1150
    Cell Significance Index: -1.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1173
    Cell Significance Index: -8.7400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1201
    Cell Significance Index: -1.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1202
    Cell Significance Index: -5.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1208
    Cell Significance Index: -1.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1280
    Cell Significance Index: -4.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1333
    Cell Significance Index: -4.6700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1340
    Cell Significance Index: -1.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1363
    Cell Significance Index: -7.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1503
    Cell Significance Index: -4.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1562
    Cell Significance Index: -4.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1589
    Cell Significance Index: -5.0600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1590
    Cell Significance Index: -3.8800
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1619
    Cell Significance Index: -1.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1662
    Cell Significance Index: -6.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PTH2R exhibits several distinct characteristics that enable it to regulate various cellular processes: 1. **G protein-coupled receptor structure**: PTH2R belongs to the class B/2 secretin receptor family, featuring a characteristic seven-transmembrane domain structure. 2. **Specific ligand binding**: PTH2R is specifically activated by PTH2, a peptide hormone that binds to the receptor's extracellular domain. 3. **Adenylate cyclase modulation**: Activation of PTH2R triggers the modulation of adenylate cyclase activity, leading to changes in intracellular cAMP levels. 4. **Wide tissue distribution**: PTH2R is expressed in various tissues, including the parathyroid glands, kidneys, lungs, and gastrointestinal tract. **Pathways and Functions** PTH2R's activation triggers a signaling cascade that involves the following pathways: 1. **G protein-coupled receptor signaling pathway**: PTH2R activation activates G proteins, which in turn modulate adenylate cyclase activity, influencing cAMP levels. 2. **Cell surface receptor signaling pathway**: PTH2R's activation triggers the activation of downstream signaling molecules, including kinases and transcription factors. 3. **Signaling by GPCRs**: PTH2R's activation is a classic example of G protein-coupled receptor signaling, where receptor activation triggers the modulation of adenylate cyclase activity. 4. **Signal transduction**: PTH2R's activation triggers a signaling cascade that modulates gene expression, cell proliferation, and differentiation. **Clinical Significance** PTH2R plays a crucial role in various physiological processes, including: 1. **Calcium homeostasis**: PTH2R's activation regulates calcium levels in the body by influencing parathyroid hormone secretion and renal calcium reabsorption. 2. **Thermogenesis**: PTH2R's activation stimulates cold-induced thermogenesis, a process that generates heat in response to cold exposure. 3. **Gastrointestinal function**: PTH2R's activation regulates gastrointestinal motility, secretion, and blood flow. 4. **Kidney function**: PTH2R's activation regulates renal function, including calcium reabsorption and blood pressure regulation. Dysregulation of PTH2R has been implicated in various diseases, including: 1. **Primary hyperparathyroidism**: Overexpression of PTH2R has been linked to primary hyperparathyroidism, a condition characterized by excessive parathyroid hormone secretion. 2. **Thyroid disorders**: PTH2R's activation has been implicated in thyroid disorders, including hyperthyroidism and hypothyroidism. 3. **Gastrointestinal disorders**: Dysregulation of PTH2R has been linked to gastrointestinal disorders, including irritable bowel syndrome and inflammatory bowel disease. In conclusion, PTH2R plays a crucial role in various physiological processes, including calcium homeostasis, thermogenesis, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding PTH2R's structure, function, and clinical significance.

Genular Protein ID: 582547757

Symbol: PTH2R_HUMAN

Name: Parathyroid hormone 2 receptor

UniProtKB Accession Codes:

P49190 Q8N429

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 5 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7797535

Title: Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.

PubMed ID: 7797535

DOI: 10.1074/jbc.270.26.15455

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8921382

Title: Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.

PubMed ID: 8921382

DOI: 10.1006/geno.1996.0532

PubMed ID: 11861531

Title: Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.

PubMed ID: 11861531

DOI: 10.1210/endo.143.3.8698

Sequence Information:

  • Length: 550
  • Mass: 62236
  • Checksum: 2ADD14DBA68A9BF8
  • Sequence:
    • MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL NITAQLQEGE 
GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF RHCNPNGTWD FMHSLNKTWA 
NYSDCLRFLQ PDISIGKQEF FERLYVMYTV GYSISFGSLA VAILIIGYFR RLHCTRNYIH 
MHLFVSFMLR ATSIFVKDRV VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV 
VMFIYFLATN YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT 
LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV GHDTRKQYRK 
LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF FNSFQGFFVS IIYCYCNGEV 
QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS VLTTVTHSTS SQSQVAASTR MVLISGKAAK 
IASRQPDSHI TLPGYVWSNS EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE 
GCQGETEDVL

Genular Protein ID: 2390462431

Symbol: B4DFN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DFN8

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OMA 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 439
  • Mass: 50021
  • Checksum: D83A15E331461576
  • Sequence:
    • MHSLNKTWAN YSDCLRFLQP DISIGKQEFF ERLYVMYTVG YSISFGSLAV AILIIGYFRR 
LHCTRNYIHM HLFVSFMLRA TSIFVKDRVV HAHIGVKELE SLIMQDDPQN SIEATSVDKS 
QYIGCKIAVV MFIYFLATNY YWILVEGLYL HNLIFVAFFS DTKYLWGFIL IGWGFPAAFV 
AAWAVARATL ADARCWELSA GDIKWIYQAP ILAAIGLNFI LFLNTVRVLA TKIWETNAVG 
HDTRKQYRKL AKSTLVLVLV FGVHYIVFVC LPHSFTGLGW EIRMHCELFF NSFQGFFVSI 
IYCYCNGEVQ AEVKKMWSRW NLSVDWKRTP PCGSRRCGSV LTTVTHSTSS QSQVAASTRM 
VLISGKAAKI ASRQPDSHIT LPGYVWSNSE QDCLPHSFHE ETKEDSGRQG DDILMEKPSR 
PMESNPDTEG CQGETEDVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.