Details for: HPGDS

Gene ID: 27306

Symbol: HPGDS

Ensembl ID: ENSG00000163106

Description: hematopoietic prostaglandin D synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 45.0030
    Cell Significance Index: -7.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 20.1425
    Cell Significance Index: 164.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.7536
    Cell Significance Index: -6.4000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 5.9675
    Cell Significance Index: 60.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.7017
    Cell Significance Index: -7.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.5335
    Cell Significance Index: 672.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.1074
    Cell Significance Index: 99.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4414
    Cell Significance Index: 241.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 2.4050
    Cell Significance Index: -0.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1213
    Cell Significance Index: 32.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4987
    Cell Significance Index: -3.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2878
    Cell Significance Index: 209.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2092
    Cell Significance Index: 131.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8954
    Cell Significance Index: 19.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7086
    Cell Significance Index: 49.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6373
    Cell Significance Index: 38.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2239
    Cell Significance Index: 5.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.1782
    Cell Significance Index: 37.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0839
    Cell Significance Index: 16.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0612
    Cell Significance Index: 38.2300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0346
    Cell Significance Index: 0.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0338
    Cell Significance Index: 0.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0248
    Cell Significance Index: 0.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0168
    Cell Significance Index: 0.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0113
    Cell Significance Index: 2.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0057
    Cell Significance Index: 10.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0010
    Cell Significance Index: 1.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0006
    Cell Significance Index: 0.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0022
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0026
    Cell Significance Index: -1.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0069
    Cell Significance Index: -5.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0072
    Cell Significance Index: -4.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0075
    Cell Significance Index: -4.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0121
    Cell Significance Index: -4.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0177
    Cell Significance Index: -3.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0206
    Cell Significance Index: -5.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0218
    Cell Significance Index: -3.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0245
    Cell Significance Index: -3.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0270
    Cell Significance Index: -4.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0321
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0362
    Cell Significance Index: -4.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0375
    Cell Significance Index: -1.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0444
    Cell Significance Index: -4.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0499
    Cell Significance Index: -6.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0537
    Cell Significance Index: -6.6000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0554
    Cell Significance Index: -0.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0556
    Cell Significance Index: -5.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0642
    Cell Significance Index: -8.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0728
    Cell Significance Index: -8.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0755
    Cell Significance Index: -5.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0780
    Cell Significance Index: -5.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0826
    Cell Significance Index: -5.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0839
    Cell Significance Index: -9.6100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0966
    Cell Significance Index: -1.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0979
    Cell Significance Index: -4.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1052
    Cell Significance Index: -6.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1090
    Cell Significance Index: -2.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1095
    Cell Significance Index: -8.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1139
    Cell Significance Index: -5.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1196
    Cell Significance Index: -4.5300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1234
    Cell Significance Index: -1.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1273
    Cell Significance Index: -8.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1353
    Cell Significance Index: -7.0500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1358
    Cell Significance Index: -1.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1383
    Cell Significance Index: -7.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1405
    Cell Significance Index: -2.9200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.1490
    Cell Significance Index: -0.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1502
    Cell Significance Index: -7.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1506
    Cell Significance Index: -2.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1557
    Cell Significance Index: -4.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1634
    Cell Significance Index: -4.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1724
    Cell Significance Index: -6.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1765
    Cell Significance Index: -5.7800
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.1808
    Cell Significance Index: -1.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1906
    Cell Significance Index: -6.0700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1967
    Cell Significance Index: -6.2200
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.2074
    Cell Significance Index: -1.7500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2120
    Cell Significance Index: -3.6000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2130
    Cell Significance Index: -1.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2170
    Cell Significance Index: -7.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2200
    Cell Significance Index: -6.4600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2228
    Cell Significance Index: -2.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2236
    Cell Significance Index: -7.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2351
    Cell Significance Index: -3.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2390
    Cell Significance Index: -6.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2451
    Cell Significance Index: -11.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2466
    Cell Significance Index: -1.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2548
    Cell Significance Index: -7.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2598
    Cell Significance Index: -3.8400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2656
    Cell Significance Index: -2.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2658
    Cell Significance Index: -6.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2670
    Cell Significance Index: -7.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2731
    Cell Significance Index: -6.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HPGDS is a member of the glutathione S-transferase (GST) family of enzymes, which are involved in the conjugation of glutathione to electrophilic compounds, including prostaglandins. HPGDS is a sigma-class GST enzyme that exhibits high specificity for the conjugation of PGE2 to glutathione, resulting in the formation of PGD2. The enzyme is characterized by its high affinity for PGE2 and its ability to catalyze the conjugation reaction in a highly efficient manner. **Pathways and Functions:** HPGDS is involved in several key pathways, including: 1. **Arachidonic acid metabolism:** HPGDS is a critical enzyme in the biosynthesis of PGD2, which is a metabolite of arachidonic acid. 2. **Prostaglandin biosynthesis:** HPGDS is involved in the conversion of PGE2 to PGD2, which plays a significant role in various physiological and pathological processes. 3. **Glutathione conjugation:** HPGDS is a GST enzyme that catalyzes the conjugation of glutathione to electrophilic compounds, including prostaglandins. 4. **Signal transduction:** PGD2, produced by HPGDS, acts as a signaling molecule that regulates various cellular processes, including immune response and inflammation. **Clinical Significance:** Dysregulation of HPGDS has been implicated in various diseases, including: 1. **Autoimmune disorders:** HPGDS has been shown to play a role in the development of autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Allergic reactions:** HPGDS has been implicated in the pathogenesis of allergic reactions, including asthma and atopic dermatitis. 3. **Cancer:** PGD2, produced by HPGDS, has been shown to have anti-tumor effects, and its dysregulation has been implicated in various types of cancer. 4. **Inflammatory diseases:** HPGDS has been shown to play a role in the regulation of inflammation, and its dysregulation has been implicated in various inflammatory diseases, including atherosclerosis and inflammatory bowel disease. In conclusion, HPGDS is a critical enzyme involved in the regulation of prostaglandin biosynthesis and its implications in immune response and disease. Further research is necessary to fully understand the role of HPGDS in human health and disease.

Genular Protein ID: 2332894383

Symbol: HPGDS_HUMAN

Name: GST class-sigma

UniProtKB Accession Codes:

O60760 Q6FHT9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 14 DrugCentral 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 30 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 5 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10824118

Title: Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase.

PubMed ID: 10824118

DOI: 10.1046/j.1432-1327.2000.01362.x

PubMed ID: 11672424

Title: Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases.

PubMed ID: 11672424

DOI: 10.1042/0264-6021:3590507

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9425264

Title: Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester.

PubMed ID: 9425264

DOI: 10.1006/bbrc.1997.7803

PubMed ID: 9353279

Title: Prostaglandin D synthase in human megakaryoblastic cells.

PubMed ID: 9353279

DOI: 10.1074/jbc.272.45.28263

PubMed ID: 12244105

Title: Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.

PubMed ID: 12244105

DOI: 10.1074/jbc.m206788200

PubMed ID: 12627223

Title: Mechanism of metal activation of human hematopoietic prostaglandin D synthase.

PubMed ID: 12627223

DOI: 10.1038/nsb907

PubMed ID: 15113825

Title: First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase.

PubMed ID: 15113825

DOI: 10.1093/jb/mvh033

PubMed ID: 16547010

Title: Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase.

PubMed ID: 16547010

DOI: 10.1074/jbc.m506431200

PubMed ID: 18341273

Title: Novel prostaglandin D synthase inhibitors generated by fragment-based drug design.

PubMed ID: 18341273

DOI: 10.1021/jm701509k

PubMed ID: 19939518

Title: Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.

PubMed ID: 19939518

DOI: 10.1016/j.ejmech.2009.10.025

Sequence Information:

  • Length: 199
  • Mass: 23344
  • Checksum: A4ED2476B16CC5C3
  • Sequence:
    • MPNYKLTYFN MRGRAEIIRY IFAYLDIQYE DHRIEQADWP EIKSTLPFGK IPILEVDGLT 
LHQSLAIARY LTKNTDLAGN TEMEQCHVDA IVDTLDDFMS CFPWAEKKQD VKEQMFNELL 
TYNAPHLMQD LDTYLGGREW LIGNSVTWAD FYWEICSTTL LVFKPDLLDN HPRLVTLRKK 
VQAIPAVANW IKRRPQTKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.