Details for: SLC13A1

Gene ID: 6561

Symbol: SLC13A1

Ensembl ID: ENSG00000081800

Description: solute carrier family 13 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 4.9297
    Cell Significance Index: 41.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5556
    Cell Significance Index: 12.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8928
    Cell Significance Index: 169.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7658
    Cell Significance Index: 18.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5220
    Cell Significance Index: 31.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4732
    Cell Significance Index: 13.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4287
    Cell Significance Index: 42.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3789
    Cell Significance Index: 342.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3660
    Cell Significance Index: 39.8200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3408
    Cell Significance Index: 3.5300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.2832
    Cell Significance Index: 2.1700
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2633
    Cell Significance Index: 2.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2316
    Cell Significance Index: 37.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2058
    Cell Significance Index: 14.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1742
    Cell Significance Index: 3.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1188
    Cell Significance Index: 1.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0840
    Cell Significance Index: 2.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0541
    Cell Significance Index: 2.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0385
    Cell Significance Index: 3.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0282
    Cell Significance Index: 19.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0125
    Cell Significance Index: 0.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0063
    Cell Significance Index: 0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0060
    Cell Significance Index: 1.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0041
    Cell Significance Index: 0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0005
    Cell Significance Index: -0.7300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0014
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0036
    Cell Significance Index: -2.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0040
    Cell Significance Index: -1.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -2.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0056
    Cell Significance Index: -1.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0056
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0069
    Cell Significance Index: -1.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0074
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0111
    Cell Significance Index: -2.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0113
    Cell Significance Index: -0.1900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0134
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0142
    Cell Significance Index: -1.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0161
    Cell Significance Index: -0.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0170
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0173
    Cell Significance Index: -1.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0182
    Cell Significance Index: -1.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0188
    Cell Significance Index: -0.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0204
    Cell Significance Index: -2.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0219
    Cell Significance Index: -0.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0229
    Cell Significance Index: -1.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0233
    Cell Significance Index: -2.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0273
    Cell Significance Index: -1.2800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0274
    Cell Significance Index: -0.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0294
    Cell Significance Index: -0.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0319
    Cell Significance Index: -1.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0344
    Cell Significance Index: -2.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0345
    Cell Significance Index: -1.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0356
    Cell Significance Index: -2.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0357
    Cell Significance Index: -0.6200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0373
    Cell Significance Index: -0.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0385
    Cell Significance Index: -0.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0385
    Cell Significance Index: -1.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0390
    Cell Significance Index: -2.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0428
    Cell Significance Index: -1.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0429
    Cell Significance Index: -1.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0436
    Cell Significance Index: -1.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0465
    Cell Significance Index: -1.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0470
    Cell Significance Index: -1.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0475
    Cell Significance Index: -1.1600
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0485
    Cell Significance Index: -0.3000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0495
    Cell Significance Index: -0.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0510
    Cell Significance Index: -1.9300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0510
    Cell Significance Index: -1.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0532
    Cell Significance Index: -2.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0535
    Cell Significance Index: -2.5200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0544
    Cell Significance Index: -0.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0575
    Cell Significance Index: -1.5400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0591
    Cell Significance Index: -1.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0600
    Cell Significance Index: -0.8100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0614
    Cell Significance Index: -0.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0619
    Cell Significance Index: -1.5900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0661
    Cell Significance Index: -0.4100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0706
    Cell Significance Index: -0.8200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0711
    Cell Significance Index: -0.7400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0714
    Cell Significance Index: -1.7800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0720
    Cell Significance Index: -0.9600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0725
    Cell Significance Index: -1.1700
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0756
    Cell Significance Index: -0.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0760
    Cell Significance Index: -2.6400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0777
    Cell Significance Index: -1.5300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0789
    Cell Significance Index: -1.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0799
    Cell Significance Index: -2.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0815
    Cell Significance Index: -1.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0820
    Cell Significance Index: -2.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0865
    Cell Significance Index: -0.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0888
    Cell Significance Index: -1.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0905
    Cell Significance Index: -1.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ion Transport:** SLC13A1 is a sodium-coupled symporter, which means it uses the energy from sodium ions to transport sulfate, di- and tri-carboxylates, and other molecules across the plasma membrane. 2. **Widespread Expression:** SLC13A1 is expressed in various cell types, including blood vessel endothelial cells, epithelial cells of the proximal tubule, cardiac endothelial cells, and immature innate lymphoid cells. 3. **Cellular Localization:** SLC13A1 is primarily localized to the apical plasma membrane, where it plays a crucial role in maintaining the ion balance across the epithelial cell layer. 4. **Tissue-Specific Function:** The gene's expression and function vary across different tissues, suggesting tissue-specific roles for SLC13A1. **Pathways and Functions:** 1. **Sodium-Sulfate Symporter Activity:** SLC13A1 is involved in the transport of sulfate ions across the plasma membrane, using the energy from sodium ions. 2. **Monoatomic Anion Transmembrane Transport:** The gene is also involved in the transport of other monoatomic anions, such as chloride and bicarbonate. 3. **Transmembrane Transport of Small Molecules:** SLC13A1 plays a role in the transport of small molecules, including bile salts, organic acids, metal ions, and amine compounds. 4. **SLC-Mediated Transmembrane Transport:** The gene is part of the solute carrier family, which is involved in the transport of various ions and molecules across cell membranes. **Clinical Significance:** 1. **Sulfate Metabolism:** Abnormalities in SLC13A1 expression and function have been implicated in various metabolic disorders, including sulfate metabolism disorders. 2. **Ion Homeostasis:** Dysregulation of SLC13A1 can lead to disturbances in ion homeostasis, which can contribute to various diseases, including hypertension and cardiovascular disease. 3. **Developmental Disorders:** The gene's expression and function during development are crucial for proper cellular differentiation and tissue morphogenesis. 4. **Cancer and Inflammation:** SLC13A1 has been implicated in the transport of molecules involved in cancer progression and inflammation, suggesting potential roles in cancer and inflammatory diseases. In conclusion, SLC13A1 is a critical gene involved in maintaining the delicate balance of various ions and molecules across cell membranes. Its widespread expression and tissue-specific function suggest that it plays a vital role in various physiological processes, including ion homeostasis, metabolism, and development. Further research is needed to fully elucidate the functions and clinical significance of SLC13A1.

Genular Protein ID: 2510921571

Symbol: S13A1_HUMAN

Name: Solute carrier family 13 member 1

UniProtKB Accession Codes:

Q9BZW2 Q9H5Z0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 2 EMDB 4 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 3 SMR 1 STRING 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11161786

Title: The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization.

PubMed ID: 11161786

DOI: 10.1006/geno.2000.6404

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 595
  • Mass: 66134
  • Checksum: A4C48EC180F6DA14
  • Sequence:
    • MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT EALPLSVTAL 
LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL KMVMMVGVNP 
AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI AEAVVQQIIN AEAEVEATQM TYFNGSTNHG 
LEIDESVNGH EINERKEKTK PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT 
CLCIAYSSTI GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW 
IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT LVLFIIMALL 
WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP AKTLTKTTPT GEIVAFDYSP 
LITWKEFQSF MPWDIAILVG GGFALADGCE ESGLSKWIGN KLSPLGSLPA WLIILISSLM 
VTSLTEVASN PATITLFLPI LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF 
SYGHLKVIDM VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP

Genular Protein ID: 3912788770

Symbol: Q2NKK0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2NKK0

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 161
  • Mass: 17929
  • Checksum: 76D6E6D0B1058B1F
  • Sequence:
    • MLPMFGIMPS KKVASAYFKD FHLLLIGVIC LATSIEKWNL HKRIALKMVM MVGVNPAWLT 
LGFMSSTAFL SMWLSNTSTA AMVMPIAEAV VQQIINAEAE VEATQMTYFS GSTNHGLEID 
ESVNGHEINE RKEKTKPVPG YNNDTGKISS KVELEKYLQV R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.