Details for: CXCL10

Gene ID: 3627

Symbol: CXCL10

Ensembl ID: ENSG00000169245

Description: C-X-C motif chemokine ligand 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.25
    Marker Score: 5258
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1991
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.54
    Marker Score: 1207.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.09
    Marker Score: 1787
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5324
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.93
    Marker Score: 2612
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 391.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.66
    Marker Score: 275
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.54
    Marker Score: 1399
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.44
    Marker Score: 631
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.44
    Marker Score: 700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.4
    Marker Score: 185
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.4
    Marker Score: 89
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.35
    Marker Score: 374
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.32
    Marker Score: 184
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.29
    Marker Score: 98
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.26
    Marker Score: 321
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.26
    Marker Score: 659
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.26
    Marker Score: 163
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.25
    Marker Score: 172
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.25
    Marker Score: 116
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.24
    Marker Score: 13456
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.24
    Marker Score: 593
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.23
    Marker Score: 112
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.23
    Marker Score: 82
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.22
    Marker Score: 224
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 140
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2
    Marker Score: 402
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.19
    Marker Score: 466
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.19
    Marker Score: 365
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.18
    Marker Score: 250
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.18
    Marker Score: 93
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.18
    Marker Score: 233
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 159
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.17
    Marker Score: 126
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 187
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.17
    Marker Score: 244
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.17
    Marker Score: 289
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.17
    Marker Score: 87
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.16
    Marker Score: 610.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.16
    Marker Score: 274
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.16
    Marker Score: 114
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 170
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.15
    Marker Score: 53
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.14
    Marker Score: 275
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.14
    Marker Score: 68
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.14
    Marker Score: 27
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.14
    Marker Score: 170
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.14
    Marker Score: 138
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 131
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.13
    Marker Score: 4495
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 404
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.13
    Marker Score: 111
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.13
    Marker Score: 79
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.13
    Marker Score: 526
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.12
    Marker Score: 349
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.12
    Marker Score: 158
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.12
    Marker Score: 594
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.12
    Marker Score: 1600
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.12
    Marker Score: 78
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.12
    Marker Score: 214

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Other Information

**Key characteristics:** - CXCL10 is a chemokine that is expressed in the central nervous system (CNS) and in immune cells. - It is a chemoattractant for neutrophils, macrophages, and dendritic cells. - It is a potent activator of the Camp-dependent protein kinase (CDPK) signaling pathway. - It also has chemoattractant and activating properties for immune cells. **Pathways and functions:** - CXCL10 binds to chemokine receptors on immune cells, such as CXCR2 (G alpha (i) signaling events and Gpcr downstream signaling). - This binding triggers the activation of the CDPK signaling pathway, leading to the phosphorylation of downstream targets and the subsequent modulation of immune cell function. - CXCL10 also plays a role in the regulation of inflammation and tissue repair. **Clinical significance:** - Dysregulation of CXCL10 has been implicated in various diseases, including multiple sclerosis, inflammatory bowel disease, and cancer. - CXCL10 inhibitors are being investigated as potential therapeutics for these diseases. **Conclusion:** CXCL10 is a critical chemokine that plays a significant role in immune regulation by promoting the migration and activation of immune cells. Its dysregulation has been linked to various diseases, highlighting its potential clinical significance.

Genular Protein ID: 3028561569

Symbol: CXL10_HUMAN

Name: C-X-C motif chemokine 10

UniProtKB Accession Codes:

P02778 Q96QJ5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 2 Ensembl 1 EvolutionaryTrace 1 GO 44 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3925348

Title: Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins.

PubMed ID: 3925348

DOI: 10.1038/315672a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8423327

Title: Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8.

PubMed ID: 8423327

PubMed ID: 7540647

Title: Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

PubMed ID: 7540647

DOI: 10.1084/jem.182.1.155

PubMed ID: 9064356

Title: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.

PubMed ID: 9064356

DOI: 10.1084/jem.184.3.963

PubMed ID: 10233762

Title: Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).

PubMed ID: 10233762

DOI: 10.1046/j.1523-1747.1999.00581.x

PubMed ID: 11559369

Title: Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity.

PubMed ID: 11559369

DOI: 10.1046/j.0014-2956.2001.02433.x

PubMed ID: 11157474

Title: Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus.

PubMed ID: 11157474

DOI: 10.1182/blood.v97.3.601

PubMed ID: 12750173

Title: CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.

PubMed ID: 12750173

DOI: 10.1182/blood-2002-12-3945

PubMed ID: 12663757

Title: CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10.

PubMed ID: 12663757

DOI: 10.1128/jvi.77.8.4502-4515.2003

PubMed ID: 18645041

Title: Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation.

PubMed ID: 18645041

DOI: 10.1182/blood-2008-04-149039

PubMed ID: 19151743

Title: Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10.

PubMed ID: 19151743

DOI: 10.1038/aps.2008.24

PubMed ID: 21183794

Title: Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV.

PubMed ID: 21183794

DOI: 10.1172/jci40594

PubMed ID: 22652417

Title: CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro.

PubMed ID: 22652417

DOI: 10.1016/j.cyto.2012.05.002

PubMed ID: 12173928

Title: The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.

PubMed ID: 12173928

DOI: 10.1021/bi026020q

PubMed ID: 12737818

Title: Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.

PubMed ID: 12737818

DOI: 10.1016/s0969-2126(03)00070-4

Sequence Information:

  • Length: 98
  • Mass: 10881
  • Checksum: 44AE51967C58DDFF
  • Sequence:
    • MNQTAILICC LIFLTLSGIQ GVPLSRTVRC TCISISNQPV NPRSLEKLEI IPASQFCPRV 
EIIATMKKKG EKRCLNPESK AIKNLLKAVS KERSKRSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.