Details for: SECTM1

Gene ID: 6398

Symbol: SECTM1

Ensembl ID: ENSG00000141574

Description: secreted and transmembrane 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.7751
    Cell Significance Index: -8.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.4919
    Cell Significance Index: -8.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 16.4371
    Cell Significance Index: -8.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9346
    Cell Significance Index: -8.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.1618
    Cell Significance Index: -8.4700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9728
    Cell Significance Index: 31.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5619
    Cell Significance Index: 297.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0254
    Cell Significance Index: 18.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7039
    Cell Significance Index: 13.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5260
    Cell Significance Index: 474.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5129
    Cell Significance Index: 50.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5117
    Cell Significance Index: 30.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5024
    Cell Significance Index: 10.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4786
    Cell Significance Index: 52.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4581
    Cell Significance Index: 6.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4021
    Cell Significance Index: 65.4000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.3240
    Cell Significance Index: 2.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3171
    Cell Significance Index: 21.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2495
    Cell Significance Index: 29.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2452
    Cell Significance Index: 27.9900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2163
    Cell Significance Index: 1.4100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1788
    Cell Significance Index: 1.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1488
    Cell Significance Index: 2.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1487
    Cell Significance Index: 6.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1482
    Cell Significance Index: 7.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0978
    Cell Significance Index: 4.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0950
    Cell Significance Index: 4.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0909
    Cell Significance Index: 2.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0722
    Cell Significance Index: 0.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0685
    Cell Significance Index: 8.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0414
    Cell Significance Index: 8.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0320
    Cell Significance Index: 14.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0227
    Cell Significance Index: 12.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0178
    Cell Significance Index: 2.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0176
    Cell Significance Index: 2.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0119
    Cell Significance Index: 0.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0094
    Cell Significance Index: 0.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0060
    Cell Significance Index: 1.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0052
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0022
    Cell Significance Index: -1.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0036
    Cell Significance Index: -0.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0086
    Cell Significance Index: -1.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0096
    Cell Significance Index: -1.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0097
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0173
    Cell Significance Index: -6.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0180
    Cell Significance Index: -0.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0186
    Cell Significance Index: -8.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0272
    Cell Significance Index: -7.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0294
    Cell Significance Index: -3.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0357
    Cell Significance Index: -7.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0452
    Cell Significance Index: -0.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0532
    Cell Significance Index: -7.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0537
    Cell Significance Index: -6.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0613
    Cell Significance Index: -0.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0666
    Cell Significance Index: -4.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0829
    Cell Significance Index: -8.6300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0932
    Cell Significance Index: -0.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1011
    Cell Significance Index: -8.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1013
    Cell Significance Index: -2.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1037
    Cell Significance Index: -2.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1041
    Cell Significance Index: -6.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1095
    Cell Significance Index: -2.9300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1112
    Cell Significance Index: -0.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1126
    Cell Significance Index: -8.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1197
    Cell Significance Index: -7.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1209
    Cell Significance Index: -3.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1324
    Cell Significance Index: -8.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1337
    Cell Significance Index: -8.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1516
    Cell Significance Index: -3.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1573
    Cell Significance Index: -6.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1598
    Cell Significance Index: -9.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1603
    Cell Significance Index: -9.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1714
    Cell Significance Index: -5.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1823
    Cell Significance Index: -9.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1869
    Cell Significance Index: -5.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1990
    Cell Significance Index: -5.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2002
    Cell Significance Index: -5.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2045
    Cell Significance Index: -3.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2068
    Cell Significance Index: -5.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2076
    Cell Significance Index: -7.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2148
    Cell Significance Index: -9.5000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2245
    Cell Significance Index: -3.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2312
    Cell Significance Index: -4.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2337
    Cell Significance Index: -8.1200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2409
    Cell Significance Index: -2.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2427
    Cell Significance Index: -7.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2431
    Cell Significance Index: -8.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2449
    Cell Significance Index: -7.8000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2497
    Cell Significance Index: -2.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2522
    Cell Significance Index: -9.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2669
    Cell Significance Index: -5.2100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2739
    Cell Significance Index: -3.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SECTM1 is a secreted and transmembrane protein, characterized by its unique structure, which enables it to interact with both the extracellular environment and the cell membrane. The protein exhibits a combination of hydrophobic and hydrophilic domains, allowing it to traverse cell membranes and engage in signaling events. SECTM1 is also highly conserved across species, suggesting its essential role in fundamental biological processes. **Pathways and Functions:** SECTM1 is involved in multiple signaling pathways, including: 1. **Cytokine activity:** SECTM1 modulates the production of cytokines, which are essential for the regulation of immune responses. 2. **Extracellular exosome:** SECTM1 is secreted into the extracellular environment, where it can interact with other cells and influence cellular behavior. 3. **Golgi apparatus:** SECTM1 is also involved in the regulation of protein processing and trafficking within the Golgi apparatus. 4. **Immune response:** SECTM1 plays a critical role in the regulation of immune responses, including the activation of immune cells and the modulation of inflammatory responses. 5. **Membrane:** SECTM1 interacts with the cell membrane, influencing cell signaling and adhesion events. SECTM1 functions as a modulator of immune responses, influencing the behavior of various immune cells, including monocytes and macrophages. It also regulates the development and differentiation of neurons, particularly in the cerebral cortex. **Clinical Significance:** SECTM1 has been implicated in various diseases, including: 1. **Autoimmune disorders:** SECTM1 has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, where its dysregulation can contribute to immune dysregulation. 2. **Neurological disorders:** SECTM1 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, where its dysregulation can contribute to neuronal dysfunction. 3. **Cancer:** SECTM1 has been identified as a potential oncogene, with its overexpression associated with cancer progression and metastasis. In conclusion, SECTM1 is a complex transmembrane protein that plays a critical role in immune response, cellular differentiation, and development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying SECTM1 function and its role in human disease.

Genular Protein ID: 4243587082

Symbol: SCTM1_HUMAN

Name: Secreted and transmembrane protein 1

UniProtKB Accession Codes:

Q8WVN6 B2R7H0 O00466

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9480746

Title: Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms.

PubMed ID: 9480746

DOI: 10.1006/geno.1997.5151

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10652336

Title: Identification of CD7 as a cognate of the human K12 (SECTM1) protein.

PubMed ID: 10652336

DOI: 10.1074/jbc.275.5.3431

PubMed ID: 15742156

Title: Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.

PubMed ID: 15742156

DOI: 10.1007/s10875-005-0356-5

Sequence Information:

  • Length: 248
  • Mass: 27039
  • Checksum: 21E3066B67920487
  • Sequence:
    • MQTCPLAFPG HVSQALGTLL FLAASLSAQN EGWDSPICTE GVVSVSWGEN TVMSCNISNA 
FSHVNIKLRA HGQESAIFNE VAPGYFSRDG WQLQVQGGVA QLVIKGARDS HAGLYMWHLV 
GHQRNNRQVT LEVSGAEPQS APDTGFWPVP AVVTAVFILL VALVMFAWYR CRCSQQRREK 
KFFLLEPQMK VAALRAGAQQ GLSRASAELW TPDSEPTPRP LALVFKPSPL GALELLSPQP 
LFPYAADP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.