Details for: PPP1R14B

Gene ID: 26472

Symbol: PPP1R14B

Ensembl ID: ENSG00000173457

Description: protein phosphatase 1 regulatory inhibitor subunit 14B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 288.9835
    Cell Significance Index: -44.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 169.5688
    Cell Significance Index: -43.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.6076
    Cell Significance Index: -36.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.5281
    Cell Significance Index: -43.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 69.1333
    Cell Significance Index: -46.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.6756
    Cell Significance Index: -37.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.1360
    Cell Significance Index: -47.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.7679
    Cell Significance Index: -42.2400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 15.4661
    Cell Significance Index: 132.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1185
    Cell Significance Index: -47.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.4874
    Cell Significance Index: -29.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 6.7368
    Cell Significance Index: 180.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.1331
    Cell Significance Index: 38.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.6761
    Cell Significance Index: 84.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.2233
    Cell Significance Index: 27.0800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.0483
    Cell Significance Index: 18.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.8092
    Cell Significance Index: 30.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8030
    Cell Significance Index: 145.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7138
    Cell Significance Index: 175.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6779
    Cell Significance Index: 125.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.6777
    Cell Significance Index: 30.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.5298
    Cell Significance Index: 178.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.5206
    Cell Significance Index: 454.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3540
    Cell Significance Index: 289.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3280
    Cell Significance Index: 1271.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.2475
    Cell Significance Index: 993.6600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.0407
    Cell Significance Index: 12.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9599
    Cell Significance Index: 91.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5254
    Cell Significance Index: 197.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4104
    Cell Significance Index: 63.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0443
    Cell Significance Index: 77.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9623
    Cell Significance Index: 50.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8971
    Cell Significance Index: 123.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8181
    Cell Significance Index: 23.4500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.7376
    Cell Significance Index: 7.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6711
    Cell Significance Index: 109.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6022
    Cell Significance Index: 16.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4989
    Cell Significance Index: 13.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4069
    Cell Significance Index: 77.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2983
    Cell Significance Index: 4.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2628
    Cell Significance Index: 16.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2386
    Cell Significance Index: 28.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2073
    Cell Significance Index: 41.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0977
    Cell Significance Index: 16.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0826
    Cell Significance Index: 1.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0709
    Cell Significance Index: 2.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0698
    Cell Significance Index: 62.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0688
    Cell Significance Index: 50.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0629
    Cell Significance Index: 0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0216
    Cell Significance Index: 16.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0041
    Cell Significance Index: 1.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0038
    Cell Significance Index: 0.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0119
    Cell Significance Index: -1.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0151
    Cell Significance Index: -1.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0190
    Cell Significance Index: -35.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0302
    Cell Significance Index: -55.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0356
    Cell Significance Index: -24.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0386
    Cell Significance Index: -59.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0457
    Cell Significance Index: -62.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0459
    Cell Significance Index: -13.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0560
    Cell Significance Index: -35.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0588
    Cell Significance Index: -43.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0638
    Cell Significance Index: -12.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0705
    Cell Significance Index: -7.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0806
    Cell Significance Index: -45.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0893
    Cell Significance Index: -55.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0979
    Cell Significance Index: -44.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1158
    Cell Significance Index: -6.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1763
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1959
    Cell Significance Index: -22.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2380
    Cell Significance Index: -6.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2403
    Cell Significance Index: -28.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2535
    Cell Significance Index: -20.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2589
    Cell Significance Index: -37.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2601
    Cell Significance Index: -54.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2705
    Cell Significance Index: -6.9100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.3029
    Cell Significance Index: -2.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3034
    Cell Significance Index: -4.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3294
    Cell Significance Index: -10.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3296
    Cell Significance Index: -11.4600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3446
    Cell Significance Index: -2.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3544
    Cell Significance Index: -9.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3596
    Cell Significance Index: -20.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3627
    Cell Significance Index: -6.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3639
    Cell Significance Index: -7.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3988
    Cell Significance Index: -9.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4550
    Cell Significance Index: -34.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4578
    Cell Significance Index: -47.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4633
    Cell Significance Index: -29.2000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.5371
    Cell Significance Index: -2.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6055
    Cell Significance Index: -37.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6981
    Cell Significance Index: -46.9400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7465
    Cell Significance Index: -30.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8489
    Cell Significance Index: -44.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8839
    Cell Significance Index: -44.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8882
    Cell Significance Index: -23.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9021
    Cell Significance Index: -26.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0139
    Cell Significance Index: -37.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0255
    Cell Significance Index: -26.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0608
    Cell Significance Index: -25.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPPP1R14B is a protein phosphatase 1 regulatory subunit, which implies its role in modulating the activity of protein phosphatase 1 (PP1), a crucial phosphatase involved in dephosphorylation and regulation of various cellular processes. The gene's subunit designation (14B) suggests its involvement in specific cellular processes, possibly related to the regulation of phosphorylation events. Notably, PPP1R14B has been identified in various cell types, including stem cells, epithelial cells, and muscle cells, highlighting its potential role in maintaining cellular homeostasis and differentiation. **Pathways and Functions:** PPPP1R14B's involvement in the regulation of phosphorylation events is likely to be mediated through its interaction with PP1. The gene's expression in various tissues suggests its involvement in distinct cellular processes, including: 1. **Innate Immune Response:** PPP1R14B's expression in immune cells, such as bladder urothelial cells, implies its potential role in modulating the innate immune response. 2. **Protein Serine/Threonine Phosphatase Inhibitor Activity:** As a regulatory subunit of PP1, PPP1R14B may inhibit the activity of PP1, thereby regulating the phosphorylation status of downstream targets. 3. **Regulation of Phosphorylation:** PPP1R14B's involvement in various cellular processes, including cell growth, differentiation, and apoptosis, suggests its role in regulating phosphorylation events. **Clinical Significance:** The clinical significance of PPP1R14B remains poorly understood, but its expression in various tissues and cell types suggests potential implications in human disease. For instance: 1. **Cancer:** Alterations in PPP1R14B expression have been observed in certain types of cancer, including breast cancer. Further investigation is needed to determine its role in tumorigenesis and cancer progression. 2. **Neurological Disorders:** PPP1R14B's involvement in neuronal function and signaling pathways suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Muscular Disorders:** PPP1R14B's expression in skeletal muscle satellite stem cells implies its potential role in muscular dystrophy and other muscle-related disorders. In conclusion, PPP1R14B is a multifaceted gene with a complex role in cellular regulation. Further investigation into its pathways, functions, and clinical significance is necessary to fully elucidate its importance in human health and disease. As an expert immunologist, I hope that this review has shed light on the enigmatic role of PPP1R14B and has sparked further research into its potential applications in human medicine.

Genular Protein ID: 1170428202

Symbol: PP14B_HUMAN

Name: Protein phosphatase 1 regulatory subunit 14B

UniProtKB Accession Codes:

Q96C90 Q504S7 Q7KZD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8838322

Title: Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13.

PubMed ID: 8838322

DOI: 10.1006/geno.1996.0063

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 147
  • Mass: 15911
  • Checksum: 2932A4EA9F312451
  • Sequence:
    • MADSGTAGGA ALAAPAPGPG SGGPGPRVYF QSPPGAAGEG PGGADDEGPV RRQGKVTVKY 
DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL LDMESDDARA ARVKELLVDC 
YKPTEAFISG LLDKIRGMQK LSTPQKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.