Details for: ZEB2
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 87.79rCSI 67.64%PRS 83.76
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CSI 73.87rCSI 88.24%PRS 63.48
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CSI 70.56rCSI 87.78%PRS 61.26
-
CSI 66.31rCSI 85.49%PRS 64.54
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CSI 59.5rCSI 90.7%PRS 77.86
-
CSI 55.05rCSI 92.4%PRS 63.28
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CSI 53.33rCSI 85.77%PRS 64.88
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CSI 50.21rCSI 75.75%PRS 85.91
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CSI 49.18rCSI 42.18%PRS 86.75
-
CSI 46.85rCSI 31.22%PRS 91.73
-
CSI 41.25rCSI 32.6%PRS 70.19
-
CSI 39.37rCSI 69.53%PRS 62.75
-
CSI 37.78rCSI 51.69%PRS 72.53
-
CSI 35.16rCSI 26.36%PRS 95.15
-
CSI 35.11rCSI 45.08%PRS 71.26
-
CSI 33.55rCSI 49.73%PRS 92.43
-
CSI 33.15rCSI 96.07%PRS 70.75
-
CSI 32.53rCSI 96.12%PRS 72.46
-
CSI 32.4rCSI 73.94%PRS 72.72
-
CSI 31.74rCSI 26.71%PRS 92.44
-
CSI 31.01rCSI 23.58%PRS 92.44
-
CSI 30.8rCSI 58.14%PRS 88.3
-
CSI 30.66rCSI 79.91%PRS 82.06
-
CSI 30.18rCSI 27.25%PRS 79.13
-
CSI 29.68rCSI 72.14%PRS 61.36
-
CSI 29.28rCSI 59.41%PRS 59.85
-
CSI 28.73rCSI 41.63%PRS 92.34
-
CSI 28.24rCSI 93.61%PRS 85.3
-
CSI 28.22rCSI 88.26%PRS 67.38
-
CSI 27.57rCSI 50.1%PRS 72.69
-
CSI 27.34rCSI 57.84%PRS 90.97
-
CSI 27.1rCSI 43.44%PRS 90.75
-
CSI 26.61rCSI 34.87%PRS 90.72
-
CSI 26.6rCSI 55.19%PRS 77.8
-
CSI 26.25rCSI 50.06%PRS 89.99
-
CSI 25.89rCSI 23.78%PRS 88.12
-
CSI 24.78rCSI 20.04%PRS 83.06
-
CSI 23.77rCSI 17.75%PRS 91.87
-
CSI 23.5rCSI 29.5%PRS 88.84
-
CSI 23.4rCSI 60.96%PRS 75.7
-
CSI 23.19rCSI 17.35%PRS 92.36
-
CSI 22.44rCSI 49.39%PRS 63.41
-
CSI 22.29rCSI 48.36%PRS 68.82
-
CSI 21.89rCSI 86.7%PRS 76.22
-
CSI 21.19rCSI 26.39%PRS 89.28
-
CSI 20.82rCSI 18.02%PRS 84.75
-
CSI 20.45rCSI 63.9%PRS 65.03
-
CSI 20.22rCSI 14.97%PRS 74.82
-
CSI 20.21rCSI 17.42%PRS 81.87
-
CSI 20.14rCSI 18.59%PRS 82.5
-
CSI 19.52rCSI 33.76%PRS 72.85
-
CSI 19.37rCSI 22.75%PRS 92.92
-
CSI 19.32rCSI 55.92%PRS 80.4
-
CSI 18.94rCSI 34.45%PRS 87.34
-
CSI 18.74rCSI 49.92%PRS 68.65
-
CSI 18.7rCSI 16.38%PRS 87.84
-
CSI 18.65rCSI 16.99%PRS 91.56
-
CSI 18.24rCSI 24.94%PRS 85.37
-
CSI 18.23rCSI 32.95%PRS 85.69
-
CSI 18.18rCSI 62.27%PRS 67.29
-
CSI 17.72rCSI 13.31%PRS 86.38
-
CSI 17.66rCSI 12.33%PRS 84.36
-
CSI 17.44rCSI 18.22%PRS 92.56
-
CSI 17.03rCSI 14.8%PRS 89.52
-
CSI 16.93rCSI 21.65%PRS 89.81
-
CSI 16.9rCSI 14.1%PRS 80.6
-
CSI 16.78rCSI 24.2%PRS 86.16
-
CSI 16.53rCSI 14.52%PRS 85.69
-
CSI 16.2rCSI 80.52%PRS 75.82
-
CSI 15.89rCSI 84.46%PRS 71.07
-
CSI 15.82rCSI 12.31%PRS 93.08
-
CSI 15.6rCSI 64.73%PRS 78.27
-
CSI 15.39rCSI 12.51%PRS 80.37
-
CSI 15.33rCSI 50.39%PRS 67.06
-
CSI 15.04rCSI 20.83%PRS 78.22
-
CSI 14.97rCSI 34.55%PRS 69.18
-
CSI 14.84rCSI 33.67%PRS 81.31
-
CSI 14.7rCSI 47.82%PRS 78.75
-
CSI 14.67rCSI 30.12%PRS 89.48
-
CSI 14.47rCSI 13.47%PRS 81.87
-
CSI 14.47rCSI 15.85%PRS 82.89
-
CSI 14.46rCSI 9.61%PRS 83.55
-
CSI 14.22rCSI 24.93%PRS 75.3
-
CSI 14.2rCSI 57.85%PRS 73.17
-
CSI 14.19rCSI 18.21%PRS 77.07
-
CSI 14.09rCSI 28.29%PRS 71.52
-
CSI 13.92rCSI 13.68%PRS 92.8
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CSI 13.78rCSI 39.63%PRS 75.75
-
CSI 13.67rCSI 63.16%PRS 91.82
-
CSI 13.65rCSI 63.9%PRS 91.14
-
CSI 13.63rCSI 24.03%PRS 85.98
-
CSI 13.44rCSI 48.37%PRS 61.32
-
CSI 13.42rCSI 16.03%PRS 94.14
-
CSI 13.28rCSI 36.6%PRS 76.29
-
CSI 13.27rCSI 78.15%PRS 64.04
-
CSI 13.21rCSI 13.38%PRS 92.67
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CSI 13.03rCSI 10.79%PRS 83.26
-
CSI 12.69rCSI 14.87%PRS 92.96
-
CSI 12.35rCSI 8.32%PRS 92.44
-
CSI 12.2rCSI 49.09%PRS 82.48
-
CSI 0.3rCSI 3.4%PRS 94.8%
-
CSI 0.5rCSI 4.7%PRS 77.2%
-
CSI 0.6rCSI 0.9%PRS 80.0%
-
CSI 0.7rCSI 5.5%PRS 71.3%
-
CSI 0.9rCSI 4.6%PRS 88.1%
-
CSI 1.0rCSI 12.5%PRS 81.8%
-
CSI 1.1rCSI 12.2%PRS 90.5%
-
CSI 1.1rCSI 6.7%PRS 86.8%
-
CSI 1.2rCSI 18.9%PRS 90.6%
-
CSI 1.2rCSI 3.1%PRS 77.6%
-
CSI 1.2rCSI 9.6%PRS 85.9%
-
CSI 1.2rCSI 7.9%PRS 77.0%
-
CSI 1.2rCSI 8.8%PRS 74.1%
-
CSI 1.3rCSI 6.7%PRS 95.3%
-
CSI 1.3rCSI 8.5%PRS 93.3%
-
CSI 1.3rCSI 2.5%PRS 96.8%
-
CSI 1.4rCSI 20.0%PRS 87.0%
-
CSI 1.4rCSI 8.5%PRS 72.9%
-
CSI 1.5rCSI 8.5%PRS 84.6%
-
CSI 1.5rCSI 10.7%PRS 88.8%
-
CSI 1.5rCSI 16.1%PRS 86.2%
-
CSI 1.7rCSI 35.4%PRS 72.1%
-
CSI 1.8rCSI 11.1%PRS 85.9%
-
CSI 1.9rCSI 10.7%PRS 85.7%
-
CSI 2.0rCSI 11.2%PRS 83.9%
-
CSI 2.0rCSI 2.4%PRS 90.1%
-
CSI 2.0rCSI 18.7%PRS 81.9%
-
CSI 2.0rCSI 9.5%PRS 72.3%
-
CSI 2.1rCSI 3.7%PRS 94.4%
-
CSI 2.1rCSI 4.3%PRS 77.8%
-
CSI 2.2rCSI 5.9%PRS 86.1%
-
CSI 2.2rCSI 58.7%PRS 89.1%
-
CSI 2.3rCSI 17.9%PRS 82.8%
-
CSI 2.4rCSI 9.9%PRS 86.0%
-
CSI 2.4rCSI 7.5%PRS 82.7%
-
CSI 2.4rCSI 3.7%PRS 74.3%
-
CSI 2.4rCSI 17.4%PRS 68.7%
-
CSI 2.4rCSI 12.8%PRS 86.5%
-
CSI 2.4rCSI 7.0%PRS 92.2%
-
CSI 2.5rCSI 50.6%PRS 70.9%
-
CSI 2.7rCSI 12.0%PRS 81.7%
-
CSI 2.8rCSI 31.5%PRS 69.3%
-
CSI 2.8rCSI 50.6%PRS 95.1%
-
CSI 2.8rCSI 2.2%PRS 95.6%
-
CSI 2.8rCSI 69.4%PRS 76.5%
-
CSI 2.9rCSI 16.8%PRS 84.0%
-
CSI 3.0rCSI 13.0%PRS 85.8%
-
CSI 3.1rCSI 12.5%PRS 89.2%
-
CSI 3.2rCSI 2.9%PRS 93.7%
-
CSI 3.2rCSI 4.3%PRS 94.0%
-
CSI 3.2rCSI 7.2%PRS 91.9%
-
CSI 3.4rCSI 10.4%PRS 85.1%
-
CSI 3.5rCSI 6.9%PRS 76.7%
-
CSI 3.7rCSI 4.6%PRS 85.9%
-
CSI 3.7rCSI 16.1%PRS 69.5%
-
CSI 3.7rCSI 16.3%PRS 90.1%
-
CSI 3.8rCSI 59.7%PRS 82.2%
-
CSI 3.8rCSI 13.9%PRS 93.7%
-
CSI 3.9rCSI 9.8%PRS 74.5%
-
CSI 3.9rCSI 9.4%PRS 92.5%
-
CSI 4.0rCSI 15.6%PRS 94.1%
-
CSI 4.0rCSI 67.7%PRS 89.9%
-
CSI 4.0rCSI 6.5%PRS 84.6%
-
CSI 4.1rCSI 20.4%PRS 91.6%
-
CSI 4.1rCSI 33.3%PRS 75.6%
-
CSI 4.2rCSI 19.9%PRS 77.4%
-
CSI 4.3rCSI 5.2%PRS 62.0%
-
CSI 4.6rCSI 6.5%PRS 71.0%
-
CSI 4.7rCSI 13.4%PRS 95.3%
-
CSI 4.7rCSI 9.0%PRS 95.6%
-
CSI 4.8rCSI 8.3%PRS 92.3%
-
CSI 4.9rCSI 15.9%PRS 77.8%
-
CSI 5.2rCSI 14.5%PRS 76.2%
-
CSI 5.2rCSI 6.0%PRS 90.6%
-
CSI 5.3rCSI 10.5%PRS 91.5%
-
CSI 5.3rCSI 22.4%PRS 73.4%
-
CSI 5.6rCSI 8.6%PRS 81.1%
-
CSI 5.7rCSI 8.3%PRS 74.1%
-
CSI 5.7rCSI 4.0%PRS 91.5%
-
CSI 5.8rCSI 7.9%PRS 94.5%
-
CSI 5.8rCSI 19.8%PRS 91.5%
-
CSI 5.8rCSI 14.9%PRS 94.8%
-
CSI 5.9rCSI 16.1%PRS 87.4%
-
CSI 5.9rCSI 12.6%PRS 75.2%
-
CSI 5.9rCSI 21.5%PRS 94.5%
-
CSI 6.1rCSI 29.3%PRS 81.0%
-
CSI 6.1rCSI 24.8%PRS 80.9%
-
CSI 6.2rCSI 34.8%PRS 67.3%
-
CSI 6.3rCSI 23.6%PRS 73.8%
-
CSI 6.3rCSI 8.6%PRS 89.0%
-
CSI 6.3rCSI 65.4%PRS 74.6%
-
CSI 6.5rCSI 9.9%PRS 88.9%
-
CSI 6.6rCSI 9.0%PRS 82.7%
-
CSI 6.6rCSI 12.4%PRS 69.6%
-
CSI 6.7rCSI 27.9%PRS 81.3%
-
CSI 6.7rCSI 37.6%PRS 82.1%
-
CSI 6.9rCSI 45.0%PRS 94.8%
-
CSI 6.9rCSI 15.1%PRS 84.5%
-
CSI 6.9rCSI 26.0%PRS 63.9%
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CSI 7.0rCSI 9.9%PRS 77.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4111154467
Symbol: ZEB2_HUMAN
Name: Zinc finger E-box-binding homeobox 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11448942
Title: Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease.
PubMed ID: 11448942
PubMed ID: 11279515
Title: Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease.
PubMed ID: 11279515
DOI: 10.1038/86860
PubMed ID: 9628581
Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9628581
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9853615
Title: Selection system for genes encoding nuclear-targeted proteins.
PubMed ID: 9853615
DOI: 10.1038/4315
PubMed ID: 16061479
Title: Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.
PubMed ID: 16061479
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 12451214
Title: Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B.
PubMed ID: 12451214
PubMed ID: 15384097
Title: Ocular coloboma and high myopia with Hirschsprung disease associated with a novel ZFHX1B missense mutation and trisomy 21.
PubMed ID: 15384097
DOI: 10.1002/ajmg.a.30312
PubMed ID: 16688751
Title: A missense mutation in the ZFHX1B gene associated with an atypical Mowat-Wilson syndrome phenotype.
PubMed ID: 16688751
DOI: 10.1002/ajmg.a.31267
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 20516212
Title: Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221.
PubMed ID: 20516212
DOI: 10.1128/mcb.01237-09
Sequence Information:
- Length: 1214
- Mass: 136447
- Checksum: B578FD91339C3FDD
- Sequence:
MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDTGSETDE EDKLHIAEDD GIANPLDQET SPASVPNHES SPHVSQALLP REEEEDEIRE GGVEHPWHNN EILQASVDGP EEMKEDYDTM GPEATIQTAI NNGTVKNANC TSDFEEYFAK RKLEERDGHA VSIEEYLQRS DTAIIYPEAP EELSRLGTPE ANGQEENDLP PGTPDAFAQL LTCPYCDRGY KRLTSLKEHI KYRHEKNEEN FSCPLCSYTF AYRTQLERHM VTHKPGTDQH QMLTQGAGNR KFKCTECGKA FKYKHHLKEH LRIHSGEKPY ECPNCKKRFS HSGSYSSHIS SKKCIGLISV NGRMRNNIKT GSSPNSVSSS PTNSAITQLR NKLENGKPLS MSEQTGLLKI KTEPLDFNDY KVLMATHGFS GTSPFMNGGL GATSPLGVHP SAQSPMQHLG VGMEAPLLGF PTMNSNLSEV QKVLQIVDNT VSRQKMDCKA EEISKLKGYH MKDPCSQPEE QGVTSPNIPP VGLPVVSHNG ATKSIIDYTL EKVNEAKACL QSLTTDSRRQ ISNIKKEKLR TLIDLVTDDK MIENHNISTP FSCQFCKESF PGPIPLHQHE RYLCKMNEEI KAVLQPHENI VPNKAGVFVD NKALLLSSVL SEKGMTSPIN PYKDHMSVLK AYYAMNMEPN SDELLKISIA VGLPQEFVKE WFEQRKVYQY SNSRSPSLER SSKPLAPNSN PPTKDSLLPR SPVKPMDSIT SPSIAELHNS VTNCDPPLRL TKPSHFTNIK PVEKLDHSRS NTPSPLNLSS TSSKNSHSSS YTPNSFSSEE LQAEPLDLSL PKQMKEPKSI IATKNKTKAS SISLDHNSVS SSSENSDEPL NLTFIKKEFS NSNNLDNKST NPVFSMNPFS AKPLYTALPP QSAFPPATFM PPVQTSIPGL RPYPGLDQMS FLPHMAYTYP TGAATFADMQ QRRKYQRKQG FQGELLDGAQ DYMSGLDDMT DSDSCLSRKK IKKTESGMYA CDLCDKTFQK SSSLLRHKYE HTGKRPHQCQ ICKKAFKHKH HLIEHSRLHS GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY CKREAEEREA AEREAREKGH LEPTELLMNR AYLQSITPQG YSDSEERESM PRDGESEKEH EKEGEDGYGK LGRQDGDEEF EEEEEESENK SMDTDPETIR DEEETGDHSM DDSSEDGKME TKSDHEEDNM EDGM