ZEB2 | ENSG00000169554 | NCBI 9839

Details for: ZEB2

Gene ID: 9839

Symbol: ZEB2

Ensembl ID: ENSG00000169554

Description: zinc finger E-box binding homeobox 2

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Developmental biology
(R-HSA-1266738)
Formation of the anterior neural plate
(R-HSA-9823739)
Formation of the posterior neural plate
(R-HSA-9832991)
Gastrulation
(R-HSA-9758941)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 gene transcription
(R-HSA-9762293)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Anatomical structure development
(GO:0048856)
Astrocyte activation
(GO:0048143)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Developmental pigmentation
(GO:0048066)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Endothelial cell migration
(GO:0043542)
Endothelial cell proliferation
(GO:0001935)
Fibroblast activation
(GO:0072537)
Melanocyte migration
(GO:0097324)
Metal ion binding
(GO:0046872)
Myofibroblast differentiation
(GO:0036446)
Negative regulation of fibroblast migration
(GO:0010764)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatase regulator activity
(GO:0019208)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of melanin biosynthetic process
(GO:0048023)
Positive regulation of melanocyte differentiation
(GO:0045636)
Positive regulation of myofibroblast contraction
(GO:1904330)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Protein binding
(GO:0005515)
Pyroptosis
(GO:0070269)
Regulation of blood-brain barrier permeability
(GO:1905603)
Regulation of melanosome organization
(GO:1903056)
Regulation of myofibroblast cell apoptotic process
(GO:1904520)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to oxygen-glucose deprivation
(GO:0090649)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Stress fiber assembly
(GO:0043149)

Other Information

Proteins

Zinc finger E-box-binding homeobox 2

Genular Protein ID: 4111154467

Symbol: ZEB2_HUMAN

Name: Zinc finger E-box-binding homeobox 2

UniProtKB Accession Codes:

O60315 A0JP09 B7Z2P2 F5H814 Q9UED1

Database IDs:

Citations:

PubMed ID: 11448942

Title: Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease.

PubMed ID: 11448942

DOI: 10.1093/hmg/10.14.1503

PubMed ID: 11279515

Title: Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease.

PubMed ID: 11279515

DOI: 10.1038/86860

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9853615

Title: Selection system for genes encoding nuclear-targeted proteins.

PubMed ID: 9853615

DOI: 10.1038/4315

PubMed ID: 16061479

Title: Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.

PubMed ID: 16061479

DOI: 10.1074/jbc.m504477200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 12451214

Title: Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B.

PubMed ID: 12451214

DOI: 10.1212/01.wnl.0000034842.78350.4e

PubMed ID: 15384097

Title: Ocular coloboma and high myopia with Hirschsprung disease associated with a novel ZFHX1B missense mutation and trisomy 21.

PubMed ID: 15384097

DOI: 10.1002/ajmg.a.30312

PubMed ID: 16688751

Title: A missense mutation in the ZFHX1B gene associated with an atypical Mowat-Wilson syndrome phenotype.

PubMed ID: 16688751

DOI: 10.1002/ajmg.a.31267

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 20516212

Title: Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221.

PubMed ID: 20516212

DOI: 10.1128/mcb.01237-09

Sequence Information:

Length: 1214
Mass: 136447
Checksum: B578FD91339C3FDD
Sequence:

MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDTGSETDE EDKLHIAEDD GIANPLDQET 
SPASVPNHES SPHVSQALLP REEEEDEIRE GGVEHPWHNN EILQASVDGP EEMKEDYDTM 
GPEATIQTAI NNGTVKNANC TSDFEEYFAK RKLEERDGHA VSIEEYLQRS DTAIIYPEAP 
EELSRLGTPE ANGQEENDLP PGTPDAFAQL LTCPYCDRGY KRLTSLKEHI KYRHEKNEEN 
FSCPLCSYTF AYRTQLERHM VTHKPGTDQH QMLTQGAGNR KFKCTECGKA FKYKHHLKEH 
LRIHSGEKPY ECPNCKKRFS HSGSYSSHIS SKKCIGLISV NGRMRNNIKT GSSPNSVSSS 
PTNSAITQLR NKLENGKPLS MSEQTGLLKI KTEPLDFNDY KVLMATHGFS GTSPFMNGGL 
GATSPLGVHP SAQSPMQHLG VGMEAPLLGF PTMNSNLSEV QKVLQIVDNT VSRQKMDCKA 
EEISKLKGYH MKDPCSQPEE QGVTSPNIPP VGLPVVSHNG ATKSIIDYTL EKVNEAKACL 
QSLTTDSRRQ ISNIKKEKLR TLIDLVTDDK MIENHNISTP FSCQFCKESF PGPIPLHQHE 
RYLCKMNEEI KAVLQPHENI VPNKAGVFVD NKALLLSSVL SEKGMTSPIN PYKDHMSVLK 
AYYAMNMEPN SDELLKISIA VGLPQEFVKE WFEQRKVYQY SNSRSPSLER SSKPLAPNSN 
PPTKDSLLPR SPVKPMDSIT SPSIAELHNS VTNCDPPLRL TKPSHFTNIK PVEKLDHSRS 
NTPSPLNLSS TSSKNSHSSS YTPNSFSSEE LQAEPLDLSL PKQMKEPKSI IATKNKTKAS 
SISLDHNSVS SSSENSDEPL NLTFIKKEFS NSNNLDNKST NPVFSMNPFS AKPLYTALPP 
QSAFPPATFM PPVQTSIPGL RPYPGLDQMS FLPHMAYTYP TGAATFADMQ QRRKYQRKQG 
FQGELLDGAQ DYMSGLDDMT DSDSCLSRKK IKKTESGMYA CDLCDKTFQK SSSLLRHKYE 
HTGKRPHQCQ ICKKAFKHKH HLIEHSRLHS GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY 
CKREAEEREA AEREAREKGH LEPTELLMNR AYLQSITPQG YSDSEERESM PRDGESEKEH 
EKEGEDGYGK LGRQDGDEEF EEEEEESENK SMDTDPETIR DEEETGDHSM DDSSEDGKME 
TKSDHEEDNM EDGM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ZEB2

Associated with

Other Information

Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease. PubMed ID: 11448942

Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease. PubMed ID: 11279515

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9628581

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Selection system for genes encoding nuclear-targeted proteins. PubMed ID: 9853615

Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. PubMed ID: 16061479

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B. PubMed ID: 12451214

Ocular coloboma and high myopia with Hirschsprung disease associated with a novel ZFHX1B missense mutation and trisomy 21. PubMed ID: 15384097

A missense mutation in the ZFHX1B gene associated with an atypical Mowat-Wilson syndrome phenotype. PubMed ID: 16688751

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. PubMed ID: 20516212