Details for: HIC1

Gene ID: 3090

Symbol: HIC1

Ensembl ID: ENSG00000177374

Description: HIC ZBTB transcriptional repressor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.96
    Marker Score: 7256
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.83
    Marker Score: 2209
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1150
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169517
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.38
    Marker Score: 15525
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.25
    Marker Score: 8114
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.22
    Marker Score: 1355
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.2
    Marker Score: 417
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.16
    Marker Score: 15356
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.12
    Marker Score: 271
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.1
    Marker Score: 1036
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.01
    Marker Score: 8891
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.97
    Marker Score: 4198
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.93
    Marker Score: 1072
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5288
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.9
    Marker Score: 767
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.86
    Marker Score: 1331
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.86
    Marker Score: 356
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.85
    Marker Score: 1737
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.85
    Marker Score: 195
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13203
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.83
    Marker Score: 5009
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.8
    Marker Score: 249
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.79
    Marker Score: 2070
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1244
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.74
    Marker Score: 915
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.73
    Marker Score: 1055
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.73
    Marker Score: 171
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.73
    Marker Score: 416
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 540
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.7
    Marker Score: 443
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7
    Marker Score: 23657
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 328
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 409
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.65
    Marker Score: 160
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2683
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.61
    Marker Score: 594
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.59
    Marker Score: 815
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.58
    Marker Score: 241
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.57
    Marker Score: 604
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.56
    Marker Score: 316
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.56
    Marker Score: 651
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.51
    Marker Score: 160
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.49
    Marker Score: 441
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.48
    Marker Score: 282
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.47
    Marker Score: 1195
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.45
    Marker Score: 862
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.44
    Marker Score: 232
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.44
    Marker Score: 528
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.43
    Marker Score: 816
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.42
    Marker Score: 841
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.42
    Marker Score: 262
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.42
    Marker Score: 685.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.41
    Marker Score: 318
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.41
    Marker Score: 181
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.4
    Marker Score: 357
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.38
    Marker Score: 276
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.38
    Marker Score: 173
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.38
    Marker Score: 637
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.37
    Marker Score: 391
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.37
    Marker Score: 394
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.36
    Marker Score: 81
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 114.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.36
    Marker Score: 196
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.36
    Marker Score: 340
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.35
    Marker Score: 78
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.34
    Marker Score: 196
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.33
    Marker Score: 432
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.33
    Marker Score: 74
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 86
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.32
    Marker Score: 163
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 188
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.29
    Marker Score: 294
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.29
    Marker Score: 754
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.29
    Marker Score: 72
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.29
    Marker Score: 72
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.29
    Marker Score: 194
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.29
    Marker Score: 673
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.28
    Marker Score: 199
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.28
    Marker Score: 487
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.27
    Marker Score: 646
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.27
    Marker Score: 82
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.27
    Marker Score: 125

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Other Information

**Key characteristics:** * HIC1 is a protein of the immunoglobulin superfamily. * It is highly expressed in cells of the immune system, particularly in epithelial cells. * It is a transcriptional repressor, meaning that it blocks the binding of RNA polymerase II to DNA and inhibits transcription. * It is a key regulator of the immune response, as it can suppress the expression of genes that are involved in immune cell development and function. **Pathways and functions:** * HIC1 binds to DNA sequences known as DBE and blocks the binding of RNA polymerase II to those sites. * This prevents the initiation of transcription and can lead to the inhibition of gene expression. * HIC1 is involved in the regulation of a variety of immune responses, including inflammation, immune cell development, and tumor growth. * It is also involved in the regulation of cell cycle progression, apoptosis, and metabolism. **Clinical significance:** * Mutations in HIC1 have been linked to a number of human cancers. * Overexpression of HIC1 is associated with the development of cancer in several tumor types. * Inhibition of HIC1 can lead to the activation of transcription factors that are involved in the proliferation and survival of cancer cells. * Therefore, HIC1 is a promising target for the treatment of cancer.

Genular Protein ID: 1975442005

Symbol: HIC1_HUMAN

Name: Hypermethylated in cancer 1 protein

UniProtKB Accession Codes:

Q14526 D3DTI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7585125

Title: p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.

PubMed ID: 7585125

DOI: 10.1038/nm0695-570

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 10611298

Title: Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B.

PubMed ID: 10611298

DOI: 10.1073/pnas.96.26.14831

PubMed ID: 11554746

Title: Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1.

PubMed ID: 11554746

DOI: 10.1006/bbrc.2001.5624

PubMed ID: 12052894

Title: The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif.

PubMed ID: 12052894

DOI: 10.1128/mcb.22.13.4890-4901.2002

PubMed ID: 15231840

Title: The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.

PubMed ID: 15231840

DOI: 10.1074/jbc.m401610200

PubMed ID: 16269335

Title: Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.

PubMed ID: 16269335

DOI: 10.1016/j.cell.2005.08.011

PubMed ID: 16690027

Title: Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta.

PubMed ID: 16690027

DOI: 10.1016/j.bbrc.2006.04.052

PubMed ID: 16724116

Title: HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.

PubMed ID: 16724116

DOI: 10.1038/sj.emboj.7601147

PubMed ID: 16762039

Title: A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP.

PubMed ID: 16762039

DOI: 10.1111/j.1742-4658.2006.05301.x

PubMed ID: 17283066

Title: An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity.

PubMed ID: 17283066

DOI: 10.1128/mcb.01098-06

PubMed ID: 17213307

Title: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex.

PubMed ID: 17213307

DOI: 10.1073/pnas.0610590104

PubMed ID: 25646486

Title:

PubMed ID: 25646486

DOI: 10.1073/pnas.1501052112

PubMed ID: 18347096

Title: Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.

PubMed ID: 18347096

DOI: 10.1101/gad.1640908

PubMed ID: 19486893

Title: HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A.

PubMed ID: 19486893

DOI: 10.1016/j.bbrc.2009.05.115

PubMed ID: 19525223

Title: Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).

PubMed ID: 19525223

DOI: 10.1074/jbc.m109.022350

PubMed ID: 20547755

Title: Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.

PubMed ID: 20547755

DOI: 10.1128/mcb.00582-09

PubMed ID: 20154726

Title: A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.

PubMed ID: 20154726

DOI: 10.1038/onc.2010.12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 733
  • Mass: 76508
  • Checksum: 6DDD0F49C4E490D3
  • Sequence:
    • MTFPEADILL KSGECAGQTM LDTMEAPGHS RQLLLQLNNQ RTKGFLCDVI IVVQNALFRA 
HKNVLAASSA YLKSLVVHDN LLNLDHDMVS PAVFRLVLDF IYTGRLADGA EAAAAAAVAP 
GAEPSLGAVL AAASYLQIPD LVALCKKRLK RHGKYCHLRG GGGGGGGYAP YGRPGRGLRA 
ATPVIQACYP SPVGPPPPPA AEPPSGPEAA VNTHCAELYA SGPGPAAALC ASERRCSPLC 
GLDLSKKSPP GSAAPERPLA ERELPPRPDS PPSAGPAAYK EPPLALPSLP PLPFQKLEEA 
APPSDPFRGG SGSPGPEPPG RPDGPSLLYR WMKHEPGLGS YGDELGRERG SPSERCEERG 
GDAAVSPGGP PLGLAPPPRY PGSLDGPGAG GDGDDYKSSS EETGSSEDPS PPGGHLEGYP 
CPHLAYGEPE SFGDNLYVCI PCGKGFPSSE QLNAHVEAHV EEEEALYGRA EAAEVAAGAA 
GLGPPFGGGG DKVAGAPGGL GELLRPYRCA SCDKSYKDPA TLRQHEKTHW LTRPYPCTIC 
GKKFTQRGTM TRHMRSHLGL KPFACDACGM RFTRQYRLTE HMRIHSGEKP YECQVCGGKF 
AQQRNLISHM KMHAVGGAAG AAGALAGLGG LPGVPGPDGK GKLDFPEGVF AVARLTAEQL 
SLKQQDKAAA AELLAQTTHF LHDPKVALES LYPLAKFTAE LGLSPDKAAE VLSQGAHLAA 
GPDGRTIDRF SPT

Genular Protein ID: 3532470486

Symbol: A0PJI1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0PJI1

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 141
  • Mass: 15222
  • Checksum: 1B780DC577812D29
  • Sequence:
    • RGEDGPAGQT DRGPGGRRAA QPRPPWIRRQ PGPGLSTCPP GECAGQTMLD TMEAPGHSRQ 
LLLQLNNQRT KGFLCDVIIV VQNALFRAHK NVLAASSAYL KSLVVHDNLL NLDHDMVSPA 
VFRLVLDFIY TGRLADGAEA A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.