Details for: TSPAN13

Gene ID: 27075

Symbol: TSPAN13

Ensembl ID: ENSG00000106537

Description: tetraspanin 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 187.7910
    Cell Significance Index: -29.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 145.8741
    Cell Significance Index: -37.0000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.3283
    Cell Significance Index: -41.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.6377
    Cell Significance Index: -42.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.0447
    Cell Significance Index: -34.5500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 62.6954
    Cell Significance Index: -42.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.3868
    Cell Significance Index: -34.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.9493
    Cell Significance Index: -40.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.5850
    Cell Significance Index: -41.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7703
    Cell Significance Index: -42.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1520
    Cell Significance Index: -28.1100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.7725
    Cell Significance Index: 35.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9941
    Cell Significance Index: -10.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.2666
    Cell Significance Index: 198.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7754
    Cell Significance Index: 206.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0506
    Cell Significance Index: 202.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8127
    Cell Significance Index: 94.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8070
    Cell Significance Index: 16.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7923
    Cell Significance Index: 359.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.5945
    Cell Significance Index: 12.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3904
    Cell Significance Index: 73.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2748
    Cell Significance Index: 34.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2374
    Cell Significance Index: 675.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1877
    Cell Significance Index: 193.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1481
    Cell Significance Index: 59.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0637
    Cell Significance Index: 191.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0475
    Cell Significance Index: 113.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0424
    Cell Significance Index: 72.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8836
    Cell Significance Index: 57.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8254
    Cell Significance Index: 101.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7699
    Cell Significance Index: 13.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6603
    Cell Significance Index: 236.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6555
    Cell Significance Index: 77.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6549
    Cell Significance Index: 7.4400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6014
    Cell Significance Index: 6.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5608
    Cell Significance Index: 25.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5579
    Cell Significance Index: 5.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5492
    Cell Significance Index: 93.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4902
    Cell Significance Index: 13.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3857
    Cell Significance Index: 49.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3559
    Cell Significance Index: 10.2600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.3520
    Cell Significance Index: 2.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3285
    Cell Significance Index: 62.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2442
    Cell Significance Index: 6.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1820
    Cell Significance Index: 5.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1439
    Cell Significance Index: 28.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1397
    Cell Significance Index: 105.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1278
    Cell Significance Index: 6.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1249
    Cell Significance Index: 55.2300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1238
    Cell Significance Index: 1.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1160
    Cell Significance Index: 7.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0649
    Cell Significance Index: 2.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0319
    Cell Significance Index: 3.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0230
    Cell Significance Index: 0.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0015
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0216
    Cell Significance Index: -40.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0223
    Cell Significance Index: -0.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0348
    Cell Significance Index: -64.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0417
    Cell Significance Index: -64.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0437
    Cell Significance Index: -24.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0484
    Cell Significance Index: -35.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0488
    Cell Significance Index: -66.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0581
    Cell Significance Index: -36.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0667
    Cell Significance Index: -14.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0851
    Cell Significance Index: -9.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0861
    Cell Significance Index: -9.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0932
    Cell Significance Index: -42.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1043
    Cell Significance Index: -30.0000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1367
    Cell Significance Index: -2.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1560
    Cell Significance Index: -10.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1562
    Cell Significance Index: -20.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2045
    Cell Significance Index: -2.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2088
    Cell Significance Index: -21.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2312
    Cell Significance Index: -31.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2438
    Cell Significance Index: -35.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2445
    Cell Significance Index: -6.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2599
    Cell Significance Index: -5.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2629
    Cell Significance Index: -18.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3006
    Cell Significance Index: -8.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3289
    Cell Significance Index: -9.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3619
    Cell Significance Index: -8.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4064
    Cell Significance Index: -42.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4145
    Cell Significance Index: -23.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4578
    Cell Significance Index: -11.7000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4791
    Cell Significance Index: -6.1700
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.4839
    Cell Significance Index: -2.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4937
    Cell Significance Index: -39.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5263
    Cell Significance Index: -9.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5264
    Cell Significance Index: -40.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5432
    Cell Significance Index: -11.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5652
    Cell Significance Index: -34.6500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5764
    Cell Significance Index: -3.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5928
    Cell Significance Index: -20.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6181
    Cell Significance Index: -15.4500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6469
    Cell Significance Index: -5.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6526
    Cell Significance Index: -20.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6628
    Cell Significance Index: -41.7800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.6825
    Cell Significance Index: -7.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6898
    Cell Significance Index: -22.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSPAN13 is a type I transmembrane protein consisting of four tandem copies of a hydrophobic motif, which inserts into the plasma membrane. This unique structure allows for interactions with other proteins and lipids, regulating various cellular processes. TSPAN13 is characterized by its ability to modulate calcium ion transport across cellular membranes, influencing cellular homeostasis and signaling pathways. **Pathways and Functions:** TSPAN13 is involved in regulating calcium ion transmembrane transport through its interactions with calcium channels and pumps. This process is crucial for maintaining cellular calcium homeostasis, which is essential for various cellular functions, including muscle contraction, neurotransmission, and cell signaling. Additionally, TSPAN13 has been implicated in the regulation of membrane fluidity and cell-cell adhesion, influencing the integrity of epithelial tissues. **Clinical Significance:** Dysregulation of TSPAN13 has been linked to various diseases, including respiratory and gastrointestinal disorders. Mutations in the TSPAN13 gene have been associated with congenital diaphragmatic hernia, a condition characterized by a hole in the diaphragm, leading to respiratory distress. Furthermore, TSPAN13 has been implicated in the pathogenesis of asthma, a chronic inflammatory disease of the airways. In the intestine, dysregulation of TSPAN13 has been linked to inflammatory bowel disease, highlighting the protein's role in maintaining epithelial barrier function. In conclusion, TSPAN13 is a multifaceted protein that plays a critical role in regulating calcium ion transport and cellular homeostasis. Its dysregulation has been implicated in various diseases, emphasizing the need for further research into the mechanisms underlying TSPAN13's functions and the development of therapeutic strategies to target this protein. As an expert in immunology, it is essential to continue investigating the complex roles of TSPAN13 in maintaining human health and disease.

Genular Protein ID: 677182455

Symbol: TSN13_HUMAN

Name: Tetraspanin-13

UniProtKB Accession Codes:

O95857

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 204
  • Mass: 22147
  • Checksum: 5928646BCD83C0D6
  • Sequence:
    • MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI AVGIFLFLIA 
LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN QEQQGQLLEV GWNNTASARN 
DIQRNLNCCG FRSVNPNDTC LASCVKSDHS CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE 
ILGVWLTYRY RNQKDPRANP SAFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.