Details for: FCER1A

Gene ID: 2205

Symbol: FCER1A

Ensembl ID: ENSG00000179639

Description: Fc epsilon receptor Ia

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophil (CL0000767)
    Fold Change: 2.85
    Marker Score: 1355
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.81
    Marker Score: 1841
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.73
    Marker Score: 554
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.56
    Marker Score: 4033
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251808
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2437
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5327
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.93
    Marker Score: 1756
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 641
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 794
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.78
    Marker Score: 235
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1369
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 458
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.55
    Marker Score: 318
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.53
    Marker Score: 535
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.5
    Marker Score: 176
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.5
    Marker Score: 361
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.5
    Marker Score: 798
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.48
    Marker Score: 248.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.47
    Marker Score: 354
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.45
    Marker Score: 274
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 433
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.43
    Marker Score: 121
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.41
    Marker Score: 237
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.41
    Marker Score: 281
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.38
    Marker Score: 463
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.37
    Marker Score: 196
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.37
    Marker Score: 5718
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.35
    Marker Score: 118
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.34
    Marker Score: 85
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.32
    Marker Score: 172
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.29
    Marker Score: 1932
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.28
    Marker Score: 214
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.28
    Marker Score: 77
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.28
    Marker Score: 189
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.27
    Marker Score: 132
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.26
    Marker Score: 86
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 107
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.26
    Marker Score: 340
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.25
    Marker Score: 91
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.25
    Marker Score: 281
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.24
    Marker Score: 271
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.24
    Marker Score: 192
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 111
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.22
    Marker Score: 233
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.22
    Marker Score: 67
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.19
    Marker Score: 81
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.18
    Marker Score: 117
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.18
    Marker Score: 120
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.17
    Marker Score: 127.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.17
    Marker Score: 144
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.17
    Marker Score: 527
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.17
    Marker Score: 82
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 94
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.16
    Marker Score: 47
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.15
    Marker Score: 211
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.14
    Marker Score: 50
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.14
    Marker Score: 85
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.13
    Marker Score: 57
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.13
    Marker Score: 1502
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.12
    Marker Score: 60
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.12
    Marker Score: 153
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.12
    Marker Score: 744
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.11
    Marker Score: 88
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 120
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 96
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.1
    Marker Score: 89
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.1
    Marker Score: 243
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.09
    Marker Score: 54
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.09
    Marker Score: 62

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Other Information

**Key characteristics:** * It is a single-exon gene with a single protein product. * It is a member of the immunoglobulin superfamily, which are cell surface receptors that recognize glycoproteins. * It is expressed on the surface of immune cells and non-immune cells. * It is a high-affinity receptor, with a high affinity for its ligand, IgE. * It is involved in the regulation of type 2 immune responses, where it plays a critical role in the recruitment of immune cells to allergic inflammation sites. **Pathways and functions:** * **Cell surface receptor signaling pathway:** FcER1A is a cell surface receptor that binds to IgE. Upon binding to IgE, it undergoes a conformational change that activates its intracellular signaling pathways. * **Fc-epsilon receptor signaling pathway:** FcER1A is also a member of the Fc-epsilon receptor signaling pathway, which is involved in the regulation of inflammation and immune responses. * **Fc epsilon receptor (fceri) signaling:** FcER1A is a key component of the Fc epsilon receptor (fceri) signaling pathway, which is involved in the regulation of allergic inflammation. * **Fceri mediated ca+2 mobilization:** FcER1A is a key regulator of calcium signaling, and its activation by IgE leads to the mobilization of calcium ions, which is essential for the activation of downstream signaling pathways. * **Fceri mediated mapk activation:** Activation of FcER1A by IgE leads to the activation of the mitogen-activated protein kinase (MAPK) pathway, which is a major signaling pathway involved in inflammation and immune responses. **Clinical significance:** * Mutations in FCER1A have been linked to the development of inflammatory diseases, including asthma, allergies, and autoimmune disorders. * Targeting FcER1A signaling has emerged as a promising therapeutic strategy for these diseases. * In preclinical studies, inhibition of FcER1A signaling has been shown to be effective in reducing inflammation and airway hyperresponsiveness.

Genular Protein ID: 1707605779

Symbol: FCERA_HUMAN

Name: High affinity immunoglobulin epsilon receptor subunit alpha

UniProtKB Accession Codes:

P12319

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 3 EMDB 3 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 11 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2967464

Title: Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor.

PubMed ID: 2967464

DOI: 10.1093/nar/16.8.3584

PubMed ID: 2964640

Title: Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.

PubMed ID: 2964640

DOI: 10.1073/pnas.85.6.1907

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8125119

Title: High-level expression of the truncated alpha chain of human high-affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product.

PubMed ID: 8125119

DOI: 10.1111/j.1432-1033.1994.tb18660.x

PubMed ID: 8114916

Title: High-affinity IgE receptor on eosinophils is involved in defence against parasites.

PubMed ID: 8114916

DOI: 10.1038/367183a0

PubMed ID: 8551243

Title: Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.

PubMed ID: 8551243

DOI: 10.1084/jem.183.1.49

PubMed ID: 1472946

Title: A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E.

PubMed ID: 1472946

PubMed ID: 9875849

Title: Crystal structure of the human high-affinity IgE receptor.

PubMed ID: 9875849

DOI: 10.1016/s0092-8674(00)81719-5

PubMed ID: 10917520

Title: Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.

PubMed ID: 10917520

DOI: 10.1038/35018500

PubMed ID: 11531339

Title: The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms.

PubMed ID: 11531339

DOI: 10.1006/jmbi.2001.4929

Sequence Information:

  • Length: 257
  • Mass: 29596
  • Checksum: F183BB2357DDAD58
  • Sequence:
    • MAPAMESPTL LCVALLFFAP DGVLAVPQKP KVSLNPPWNR IFKGENVTLT CNGNNFFEVS 
STKWFHNGSL SEETNSSLNI VNAKFEDSGE YKCQHQQVNE SEPVYLEVFS DWLLLQASAE 
VVMEGQPLFL RCHGWRNWDV YKVIYYKDGE ALKYWYENHN ISITNATVED SGTYYCTGKV 
WQLDYESEPL NITVIKAPRE KYWLQFFIPL LVVILFAVDT GLFISTQQQV TFLLKIKRTR 
KGFRLLNPHP KPNPKNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.