Details for: FCER1A

Gene ID: 2205

Symbol: FCER1A

Ensembl ID: ENSG00000179639

Description: Fc epsilon receptor Ia

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.8522
    Cell Significance Index: -5.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.1357
    Cell Significance Index: -4.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.1352
    Cell Significance Index: -4.9300
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 4.3729
    Cell Significance Index: 18.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.1851
    Cell Significance Index: -5.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.4825
    Cell Significance Index: -5.8500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.3897
    Cell Significance Index: 9.9900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.2472
    Cell Significance Index: 3.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.1641
    Cell Significance Index: 18.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1194
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4951
    Cell Significance Index: 366.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4254
    Cell Significance Index: 11.3800
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.4041
    Cell Significance Index: 3.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3990
    Cell Significance Index: 84.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3617
    Cell Significance Index: 203.9700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.0734
    Cell Significance Index: 0.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0631
    Cell Significance Index: 39.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0025
    Cell Significance Index: 0.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0008
    Cell Significance Index: 0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0032
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0036
    Cell Significance Index: -0.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0049
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0051
    Cell Significance Index: -6.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0075
    Cell Significance Index: -5.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0094
    Cell Significance Index: -0.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0118
    Cell Significance Index: -1.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0159
    Cell Significance Index: -7.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0178
    Cell Significance Index: -6.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0251
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0252
    Cell Significance Index: -2.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0297
    Cell Significance Index: -5.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0329
    Cell Significance Index: -6.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0344
    Cell Significance Index: -4.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0367
    Cell Significance Index: -5.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0410
    Cell Significance Index: -5.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0508
    Cell Significance Index: -2.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0516
    Cell Significance Index: -6.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0552
    Cell Significance Index: -5.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0570
    Cell Significance Index: -2.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0669
    Cell Significance Index: -3.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0869
    Cell Significance Index: -6.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0886
    Cell Significance Index: -6.6000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0903
    Cell Significance Index: -1.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0999
    Cell Significance Index: -6.4500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: -0.1059
    Cell Significance Index: -0.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1078
    Cell Significance Index: -5.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1089
    Cell Significance Index: -5.6700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1107
    Cell Significance Index: -1.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1171
    Cell Significance Index: -6.5700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1302
    Cell Significance Index: -1.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1311
    Cell Significance Index: -3.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1438
    Cell Significance Index: -6.5200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1455
    Cell Significance Index: -1.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1463
    Cell Significance Index: -6.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1501
    Cell Significance Index: -2.1500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1528
    Cell Significance Index: -1.7300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1578
    Cell Significance Index: -1.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1612
    Cell Significance Index: -4.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1639
    Cell Significance Index: -3.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1658
    Cell Significance Index: -5.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1662
    Cell Significance Index: -6.1000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1688
    Cell Significance Index: -1.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1709
    Cell Significance Index: -6.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1800
    Cell Significance Index: -4.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1843
    Cell Significance Index: -6.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1862
    Cell Significance Index: -5.9300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1862
    Cell Significance Index: -2.3600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1869
    Cell Significance Index: -1.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1901
    Cell Significance Index: -5.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1967
    Cell Significance Index: -5.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1978
    Cell Significance Index: -5.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2000
    Cell Significance Index: -5.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2032
    Cell Significance Index: -2.7000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2064
    Cell Significance Index: -2.7900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2086
    Cell Significance Index: -5.3200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2119
    Cell Significance Index: -3.6400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2247
    Cell Significance Index: -3.6400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2256
    Cell Significance Index: -3.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2274
    Cell Significance Index: -5.6700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2280
    Cell Significance Index: -3.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2302
    Cell Significance Index: -6.2700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2320
    Cell Significance Index: -4.7200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2352
    Cell Significance Index: -3.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2353
    Cell Significance Index: -4.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2369
    Cell Significance Index: -6.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2393
    Cell Significance Index: -5.9700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2422
    Cell Significance Index: -4.8300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2458
    Cell Significance Index: -3.0400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2470
    Cell Significance Index: -5.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2516
    Cell Significance Index: -4.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2537
    Cell Significance Index: -6.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2551
    Cell Significance Index: -6.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2580
    Cell Significance Index: -3.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2639
    Cell Significance Index: -5.1500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2716
    Cell Significance Index: -3.2100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2786
    Cell Significance Index: -4.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FCER1A is a transmembrane receptor that belongs to the immunoglobulin superfamily. It is composed of two immunoglobulin-like domains and a cytoplasmic tail, which mediates signaling events upon binding to its ligand, IgE. The receptor is expressed on the surface of various immune cells, including basophils, dendritic cells, and mast cells, where it plays a crucial role in the regulation of immune responses. FCER1A is also known for its involvement in the regulation of calcium mobilization, which is essential for various cellular processes, including cell signaling and degranulation. **Pathways and Functions:** FCER1A is involved in several signaling pathways, including: 1. **Fc-epsilon receptor signaling pathway**: FCER1A mediates the signaling events triggered by IgE binding, leading to the activation of various downstream pathways, including the MAPK and NF-κB pathways. 2. **Eosinophil degranulation**: FCER1A is expressed on eosinophils, where it plays a crucial role in the regulation of eosinophil degranulation, a process essential for the elimination of parasites and the regulation of immune responses. 3. **Mast cell degranulation**: FCER1A is also expressed on mast cells, where it mediates the signaling events triggered by IgE binding, leading to the release of histamine and other mediators. 4. **Calcium mobilization**: FCER1A is involved in the regulation of calcium mobilization, which is essential for various cellular processes, including cell signaling and degranulation. **Clinical Significance:** The FCER1A gene has been implicated in several immune-related disorders, including: 1. **Atopic diseases**: FCER1A is involved in the regulation of allergic responses, and its dysregulation has been implicated in atopic diseases, such as asthma and allergic rhinitis. 2. **Autoimmune diseases**: FCER1A has been implicated in the regulation of immune responses, and its dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: FCER1A has been implicated in the regulation of immune responses, and its dysregulation has been linked to cancer, including breast cancer and lung cancer. In conclusion, FCER1A is a complex gene that plays a pivotal role in the regulation of the immune system. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into the mechanisms underlying FCER1A function and its potential as a therapeutic target.

Genular Protein ID: 1707605779

Symbol: FCERA_HUMAN

Name: High affinity immunoglobulin epsilon receptor subunit alpha

UniProtKB Accession Codes:

P12319

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 3 EMDB 5 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2967464

Title: Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor.

PubMed ID: 2967464

DOI: 10.1093/nar/16.8.3584

PubMed ID: 2964640

Title: Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.

PubMed ID: 2964640

DOI: 10.1073/pnas.85.6.1907

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8125119

Title: High-level expression of the truncated alpha chain of human high-affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product.

PubMed ID: 8125119

DOI: 10.1111/j.1432-1033.1994.tb18660.x

PubMed ID: 8114916

Title: High-affinity IgE receptor on eosinophils is involved in defence against parasites.

PubMed ID: 8114916

DOI: 10.1038/367183a0

PubMed ID: 8551243

Title: Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.

PubMed ID: 8551243

DOI: 10.1084/jem.183.1.49

PubMed ID: 1472946

Title: A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E.

PubMed ID: 1472946

PubMed ID: 9875849

Title: Crystal structure of the human high-affinity IgE receptor.

PubMed ID: 9875849

DOI: 10.1016/s0092-8674(00)81719-5

PubMed ID: 10917520

Title: Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.

PubMed ID: 10917520

DOI: 10.1038/35018500

PubMed ID: 11531339

Title: The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms.

PubMed ID: 11531339

DOI: 10.1006/jmbi.2001.4929

Sequence Information:

  • Length: 257
  • Mass: 29596
  • Checksum: F183BB2357DDAD58
  • Sequence:
    • MAPAMESPTL LCVALLFFAP DGVLAVPQKP KVSLNPPWNR IFKGENVTLT CNGNNFFEVS 
STKWFHNGSL SEETNSSLNI VNAKFEDSGE YKCQHQQVNE SEPVYLEVFS DWLLLQASAE 
VVMEGQPLFL RCHGWRNWDV YKVIYYKDGE ALKYWYENHN ISITNATVED SGTYYCTGKV 
WQLDYESEPL NITVIKAPRE KYWLQFFIPL LVVILFAVDT GLFISTQQQV TFLLKIKRTR 
KGFRLLNPHP KPNPKNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.