Details for: TPM2
Gene ID: 7169
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TPM2
Ensembl ID: ENSG00000198467
Description: tropomyosin 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 41.86rCSI 59.74%PRS 88.22
-
CSI 40.78rCSI 56.48%PRS 84.43
-
CSI 40.36rCSI 32.79%PRS 87.23
-
CSI 39.37rCSI 41.08%PRS 86.8
-
CSI 36.89rCSI 75.75%PRS 92.16
-
CSI 31.74rCSI 80.3%PRS 90.89
-
CSI 31.51rCSI 40.11%PRS 91.83
-
CSI 30.85rCSI 21.54%PRS 91.16
-
CSI 30.8rCSI 73.44%PRS 82.71
-
CSI 26.89rCSI 47.42%PRS 91
-
CSI 23.58rCSI 28.3%PRS 86.62
-
CSI 21.58rCSI 20.78%PRS 86.82
-
CSI 21.07rCSI 39.83%PRS 94
-
CSI 20.51rCSI 66.54%PRS 85.85
-
CSI 18.29rCSI 50.27%PRS 91.66
-
CSI 18.11rCSI 28.89%PRS 80.13
-
CSI 17.97rCSI 16.73%PRS 88.94
-
CSI 17.52rCSI 13.85%PRS 79.64
-
CSI 17.44rCSI 50.5%PRS 87.01
-
CSI 16.92rCSI 13.11%PRS 90.9
-
CSI 16.88rCSI 35.03%PRS 85.71
-
CSI 15.82rCSI 16.03%PRS 94.44
-
CSI 15.25rCSI 40.25%PRS 92.27
-
CSI 14.95rCSI 58.43%PRS 81.64
-
CSI 13.63rCSI 18.94%PRS 86.34
-
CSI 12.08rCSI 34.33%PRS 83.86
-
CSI 12.08rCSI 30.67%PRS 82.34
-
CSI 11.92rCSI 33.55%PRS 83.55
-
CSI 11.76rCSI 10.62%PRS 86.68
-
CSI 11.43rCSI 11.02%PRS 83.18
-
CSI 11.3rCSI 12.38%PRS 89.36
-
CSI 11.01rCSI 17.83%PRS 82.35
-
CSI 11.01rCSI 9.49%PRS 87.47
-
CSI 10.85rCSI 15.64%PRS 91.45
-
CSI 10.83rCSI 13.35%PRS 88.17
-
CSI 10.75rCSI 13.03%PRS 68.43
-
CSI 10.69rCSI 11.07%PRS 90
-
CSI 10.58rCSI 12.26%PRS 83.91
-
CSI 10.47rCSI 14.27%PRS 57.22
-
CSI 9.84rCSI 13.39%PRS 93.1
-
CSI 9.7rCSI 33.24%PRS 91.73
-
CSI 9.65rCSI 7.99%PRS 89.88
-
CSI 9.65rCSI 11.14%PRS 80.65
-
CSI 9.42rCSI 8.27%PRS 91.62
-
CSI 9.37rCSI 24.94%PRS 64.46
-
CSI 9.34rCSI 54.33%PRS 89.84
-
CSI 8.83rCSI 37.13%PRS 90.46
-
CSI 8.74rCSI 12.6%PRS 90.99
-
CSI 8.73rCSI 25.77%PRS 86.89
-
CSI 8.66rCSI 19.73%PRS 80.95
-
CSI 8.08rCSI 17.78%PRS 90.5
-
CSI 7.89rCSI 10.79%PRS 91.16
-
CSI 7.72rCSI 10.52%PRS 81.15
-
CSI 7.66rCSI 18.28%PRS 90.38
-
CSI 7.6rCSI 9.75%PRS 89.82
-
CSI 7.54rCSI 6.96%PRS 88.97
-
CSI 6.93rCSI 18.51%PRS 81.53
-
CSI 6.84rCSI 6.82%PRS 82.16
-
CSI 6.76rCSI 10.76%PRS 82.51
-
CSI 6.74rCSI 10.65%PRS 88.75
-
CSI 6.72rCSI 21.64%PRS 84.56
-
CSI 6.64rCSI 26.79%PRS 88.33
-
CSI 6.53rCSI 20.96%PRS 88.07
-
CSI 6.42rCSI 8.24%PRS 78.94
-
CSI 6.42rCSI 18.76%PRS 94.25
-
CSI 6.4rCSI 23.96%PRS 82.37
-
CSI 6.39rCSI 28.41%PRS 88.59
-
CSI 6.27rCSI 7.25%PRS 81.75
-
CSI 6.11rCSI 49.73%PRS 83.92
-
CSI 6.1rCSI 8.16%PRS 96.83
-
CSI 6.1rCSI 15.86%PRS 91.82
-
CSI 5.68rCSI 16.35%PRS 79.4
-
CSI 5.63rCSI 10.04%PRS 92.59
-
CSI 5.53rCSI 21.04%PRS 80.65
-
CSI 5.42rCSI 11.19%PRS 82.84
-
CSI 5.26rCSI 25.19%PRS 83.89
-
CSI 5.18rCSI 6.93%PRS 85.37
-
CSI 4.97rCSI 7.03%PRS 84.54
-
CSI 4.94rCSI 8.1%PRS 79.76
-
CSI 4.87rCSI 13.43%PRS 84.48
-
CSI 4.67rCSI 5.42%PRS 89.12
-
CSI 4.62rCSI 4.1%PRS 85.34
-
CSI 4.55rCSI 6.52%PRS 79.34
-
CSI 4.45rCSI 2.95%PRS 89.78
-
CSI 4.19rCSI 18.18%PRS 90.28
-
CSI 4.18rCSI 7.24%PRS 81.58
-
CSI 4.12rCSI 11.92%PRS 91.55
-
CSI 3.92rCSI 58.89%PRS 92.82
-
CSI 3.78rCSI 8.47%PRS 73.97
-
CSI 3.74rCSI 5.72%PRS 90.26
-
CSI 3.65rCSI 4.18%PRS 93.44
-
CSI 3.45rCSI 5.51%PRS 90.83
-
CSI 3.44rCSI 56.45%PRS 89.79
-
CSI 3.24rCSI 43.18%PRS 82.66
-
CSI 3.24rCSI 6.4%PRS 92
-
CSI 3.23rCSI 18.01%PRS 89.06
-
CSI 3.12rCSI 10.16%PRS 85.04
-
CSI 3.09rCSI 5.48%PRS 58.3
-
CSI 3.08rCSI 31.86%PRS 81.85
-
CSI 3.06rCSI 33.24%PRS 89.97
-
CSI 0.4rCSI 4.6%PRS 91.8%
-
CSI 0.6rCSI 4.4%PRS 91.7%
-
CSI 0.6rCSI 15.8%PRS 94.9%
-
CSI 0.8rCSI 11.0%PRS 89.3%
-
CSI 0.8rCSI 3.4%PRS 91.3%
-
CSI 0.8rCSI 13.4%PRS 93.0%
-
CSI 0.9rCSI 8.8%PRS 93.2%
-
CSI 1.0rCSI 4.1%PRS 92.0%
-
CSI 1.1rCSI 7.8%PRS 93.0%
-
CSI 1.1rCSI 32.2%PRS 93.7%
-
CSI 1.3rCSI 7.8%PRS 81.0%
-
CSI 1.4rCSI 5.3%PRS 96.9%
-
CSI 1.4rCSI 3.4%PRS 89.3%
-
CSI 1.5rCSI 8.7%PRS 84.6%
-
CSI 1.6rCSI 30.8%PRS 92.9%
-
CSI 1.6rCSI 17.9%PRS 90.5%
-
CSI 1.7rCSI 2.1%PRS 93.6%
-
CSI 1.7rCSI 6.9%PRS 93.4%
-
CSI 1.8rCSI 46.7%PRS 91.9%
-
CSI 1.8rCSI 12.7%PRS 89.7%
-
CSI 1.9rCSI 2.7%PRS 91.6%
-
CSI 1.9rCSI 8.6%PRS 94.0%
-
CSI 1.9rCSI 9.7%PRS 94.1%
-
CSI 1.9rCSI 3.0%PRS 92.8%
-
CSI 2.0rCSI 4.2%PRS 90.8%
-
CSI 2.1rCSI 5.5%PRS 90.2%
-
CSI 2.1rCSI 3.4%PRS 57.4%
-
CSI 2.5rCSI 7.2%PRS 89.8%
-
CSI 2.6rCSI 14.7%PRS 88.1%
-
CSI 2.8rCSI 2.2%PRS 89.6%
-
CSI 2.8rCSI 3.5%PRS 86.3%
-
CSI 3.1rCSI 10.7%PRS 92.6%
-
CSI 3.1rCSI 33.2%PRS 90.0%
-
CSI 3.1rCSI 31.9%PRS 81.9%
-
CSI 3.1rCSI 5.5%PRS 58.3%
-
CSI 3.1rCSI 10.2%PRS 85.0%
-
CSI 3.2rCSI 18.0%PRS 89.1%
-
CSI 3.2rCSI 6.4%PRS 92.0%
-
CSI 3.2rCSI 43.2%PRS 82.7%
-
CSI 3.4rCSI 56.5%PRS 89.8%
-
CSI 3.5rCSI 5.5%PRS 90.8%
-
CSI 3.7rCSI 4.2%PRS 93.4%
-
CSI 3.7rCSI 5.7%PRS 90.3%
-
CSI 3.8rCSI 8.5%PRS 74.0%
-
CSI 3.9rCSI 58.9%PRS 92.8%
-
CSI 4.1rCSI 11.9%PRS 91.6%
-
CSI 4.2rCSI 7.2%PRS 81.6%
-
CSI 4.2rCSI 18.2%PRS 90.3%
-
CSI 4.5rCSI 3.0%PRS 89.8%
-
CSI 4.6rCSI 6.5%PRS 79.3%
-
CSI 4.6rCSI 4.1%PRS 85.3%
-
CSI 4.7rCSI 5.4%PRS 89.1%
-
CSI 4.9rCSI 13.4%PRS 84.5%
-
CSI 4.9rCSI 8.1%PRS 79.8%
-
CSI 5.0rCSI 7.0%PRS 84.5%
-
CSI 5.2rCSI 6.9%PRS 85.4%
-
CSI 5.3rCSI 25.2%PRS 83.9%
-
CSI 5.4rCSI 11.2%PRS 82.8%
-
CSI 5.5rCSI 21.0%PRS 80.7%
-
CSI 5.6rCSI 10.0%PRS 92.6%
-
CSI 5.7rCSI 16.4%PRS 79.4%
-
CSI 6.1rCSI 15.9%PRS 91.8%
-
CSI 6.1rCSI 8.2%PRS 96.8%
-
CSI 6.1rCSI 49.7%PRS 83.9%
-
CSI 6.3rCSI 7.3%PRS 81.8%
-
CSI 6.4rCSI 28.4%PRS 88.6%
-
CSI 6.4rCSI 24.0%PRS 82.4%
-
CSI 6.4rCSI 18.8%PRS 94.3%
-
CSI 6.4rCSI 8.2%PRS 78.9%
-
CSI 6.5rCSI 21.0%PRS 88.1%
-
CSI 6.6rCSI 26.8%PRS 88.3%
-
CSI 6.7rCSI 21.6%PRS 84.6%
-
CSI 6.7rCSI 10.7%PRS 88.8%
-
CSI 6.8rCSI 10.8%PRS 82.5%
-
CSI 6.8rCSI 6.8%PRS 82.2%
-
CSI 6.9rCSI 18.5%PRS 81.5%
-
CSI 7.5rCSI 7.0%PRS 89.0%
-
CSI 7.6rCSI 9.8%PRS 89.8%
-
CSI 7.7rCSI 18.3%PRS 90.4%
-
CSI 7.7rCSI 10.5%PRS 81.2%
-
CSI 7.9rCSI 10.8%PRS 91.2%
-
CSI 8.1rCSI 17.8%PRS 90.5%
-
CSI 8.7rCSI 19.7%PRS 81.0%
-
CSI 8.7rCSI 25.8%PRS 86.9%
-
CSI 8.7rCSI 12.6%PRS 91.0%
-
CSI 8.8rCSI 37.1%PRS 90.5%
-
CSI 9.3rCSI 54.3%PRS 89.8%
-
CSI 9.4rCSI 24.9%PRS 64.5%
-
CSI 9.4rCSI 8.3%PRS 91.6%
-
CSI 9.7rCSI 11.1%PRS 80.7%
-
CSI 9.7rCSI 8.0%PRS 89.9%
-
CSI 9.7rCSI 33.2%PRS 91.7%
-
CSI 9.8rCSI 13.4%PRS 93.1%
-
CSI 10.5rCSI 14.3%PRS 57.2%
-
CSI 10.6rCSI 12.3%PRS 83.9%
-
CSI 10.7rCSI 11.1%PRS 90.0%
-
CSI 10.8rCSI 13.0%PRS 68.4%
-
CSI 10.8rCSI 13.4%PRS 88.2%
-
CSI 10.9rCSI 15.6%PRS 91.5%
-
CSI 11.0rCSI 9.5%PRS 87.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3449325580
Symbol: TPM2_HUMAN
Name: Tropomyosin beta chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3865200
Title: A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism.
PubMed ID: 3865200
PubMed ID: 3368322
Title: Complete nucleotide sequence of the adult skeletal isoform of human skeletal muscle beta-tropomyosin.
PubMed ID: 3368322
PubMed ID: 2059197
Title: A cDNA encoding a muscle-type tropomyosin cloned from a human epithelial cell line: identity with human fibroblast tropomyosin TM1.
PubMed ID: 2059197
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2303454
Title: A nonmuscle tropomyosin is encoded by the smooth/skeletal beta-tropomyosin gene and its RNA is transcribed from an internal promoter.
PubMed ID: 2303454
PubMed ID: 11840567
Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.
PubMed ID: 11840567
DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 11738357
Title: Mutations in the beta-tropomyosin (TPM2) gene -- a rare cause of nemaline myopathy.
PubMed ID: 11738357
PubMed ID: 12592607
Title: Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes.
PubMed ID: 12592607
DOI: 10.1086/368294
PubMed ID: 17846275
Title: Congenital myopathy with nemaline rods and cap structures caused by a mutation in the beta-tropomyosin gene (TPM2).
PubMed ID: 17846275
PubMed ID: 17339586
Title: Distal arthrogryposis and muscle weakness associated with a beta-tropomyosin mutation.
PubMed ID: 17339586
PubMed ID: 17434307
Title: Cap disease caused by heterozygous deletion of the beta-tropomyosin gene TPM2.
PubMed ID: 17434307
PubMed ID: 19047562
Title: New morphologic and genetic findings in cap disease associated with beta-tropomyosin (TPM2) mutations.
PubMed ID: 19047562
PubMed ID: 19345583
Title: Cap disease due to mutation of the beta-tropomyosin gene (TPM2).
PubMed ID: 19345583
PubMed ID: 23678273
Title: First Korean family with a mutation in TPM2 associated with Sheldon-Hall syndrome.
PubMed ID: 23678273
PubMed ID: 24692096
Title: Mutation update and genotype-phenotype correlations of novel and previously described mutations in TPM2 and TPM3 causing congenital myopathies.
PubMed ID: 24692096
DOI: 10.1002/humu.22554
PubMed ID: 30285720
Title: Novel mutations in TPM2 and PIEZO2 are responsible for distal arthrogryposis (DA) 2B and mild DA in two Chinese families.
PubMed ID: 30285720
Sequence Information:
- Length: 284
- Mass: 32851
- Checksum: 18E330568E14E0BE
- Sequence:
MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESKC GDLEEELKIV TNNLKSLEAQ ADKYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE KTIDDLEDEV YAQKMKYKAI SEELDNALND ITSL
Genular Protein ID: 6141089
Symbol: A7XZE4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 284
- Mass: 33026
- Checksum: C1D4A215BBA197C1
- Sequence:
MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESRA RQLEEELRTM DQALKSLMAS EEEYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE KTIDDLEDEV YAQKMKYKAI SEELDNALND ITSL
Genular Protein ID: 3517933103
Symbol: Q5TCU3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 284
- Mass: 32815
- Checksum: 817AF2EB91639EB5
- Sequence:
MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESKC GDLEEELKIV TNNLKSLEAQ ADKYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE KTIDDLEETL ASAKEENVEI HQTLDQTLLE LNNL
Genular Protein ID: 476369656
Symbol: V9HW25_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 284
- Mass: 32990
- Checksum: 584D60A8A4D6E9CA
- Sequence:
MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESRA RQLEEELRTM DQALKSLMAS EEEYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE KTIDDLEETL ASAKEENVEI HQTLDQTLLE LNNL