IRF7 | ENSG00000185507 | NCBI 3665

Details for: IRF7

Gene ID: 3665

Symbol: IRF7

Ensembl ID: ENSG00000185507

Description: interferon regulatory factor 7

Associated with

Activation of irf3, irf7 mediated by tbk1, ikkε (ikbke)
(R-HSA-936964)
Cytokine signaling in immune system
(R-HSA-1280215)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Dex/h-box helicases activate type i ifn and inflammatory cytokines production
(R-HSA-3134963)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Ticam1-dependent activation of irf3/irf7
(R-HSA-9013973)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Traf3-dependent irf activation pathway
(R-HSA-918233)
Traf6 mediated irf7 activation
(R-HSA-933541)
Traf6 mediated irf7 activation in tlr7/8 or 9 signaling
(R-HSA-975110)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Cytoplasmic pattern recognition receptor signaling pathway
(GO:0002753)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Endosome membrane
(GO:0010008)
Establishment of viral latency
(GO:0019043)
Immune system process
(GO:0002376)
Immunoglobulin mediated immune response
(GO:0016064)
Innate immune response
(GO:0045087)
Mda-5 signaling pathway
(GO:0039530)
Negative regulation of macrophage apoptotic process
(GO:2000110)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type i interferon-mediated signaling pathway
(GO:0060340)
Positive regulation of type i interferon production
(GO:0032481)
Protein binding
(GO:0005515)
Regulation of adaptive immune response
(GO:0002819)
Regulation of immune response
(GO:0050776)
Regulation of monocyte differentiation
(GO:0045655)
Regulation of myd88-dependent toll-like receptor signaling pathway
(GO:0034124)
Regulation of myd88-independent toll-like receptor signaling pathway
(GO:0034127)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of type i interferon production
(GO:0032479)
Response to virus
(GO:0009615)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Type i interferon-mediated signaling pathway
(GO:0060337)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 125.8476
Cell Significance Index: -19.5800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 70.0196
Cell Significance Index: -17.7600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 48.5530
Cell Significance Index: -19.7300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 43.1000
Cell Significance Index: -22.1700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 30.4163
Cell Significance Index: -20.4100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 20.7962
Cell Significance Index: -19.8600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.1441
Cell Significance Index: -19.9100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.2191
Cell Significance Index: -16.6600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.6325
Cell Significance Index: -17.3000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.0861
Cell Significance Index: -20.0700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.6867
Cell Significance Index: -5.8800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.2700
Cell Significance Index: 41.9600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.9685
Cell Significance Index: 229.4100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.9005
Cell Significance Index: 33.5900
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.6021
Cell Significance Index: 26.4000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.5120
Cell Significance Index: 97.5500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8954
Cell Significance Index: 145.6300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8524
Cell Significance Index: 24.5600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.8419
Cell Significance Index: 22.5200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8333
Cell Significance Index: 752.4500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8187
Cell Significance Index: 37.1100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.7058
Cell Significance Index: 19.2100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6068
Cell Significance Index: 31.6100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6063
Cell Significance Index: 59.9800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5101
Cell Significance Index: 26.5000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4316
Cell Significance Index: 50.9000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4008
Cell Significance Index: 29.8700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3609
Cell Significance Index: 16.9600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3466
Cell Significance Index: 12.1800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3437
Cell Significance Index: 23.7700
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.3370
Cell Significance Index: 2.4200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2676
Cell Significance Index: 34.3000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2239
Cell Significance Index: 10.4400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2157
Cell Significance Index: 117.7800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2016
Cell Significance Index: 5.9200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1688
Cell Significance Index: 4.8400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1580
Cell Significance Index: 30.0700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1396
Cell Significance Index: 3.6700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1344
Cell Significance Index: 16.5300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1328
Cell Significance Index: 3.7100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1322
Cell Significance Index: 58.4600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1032
Cell Significance Index: 18.6100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0878
Cell Significance Index: 12.0600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0763
Cell Significance Index: 1.1800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0667
Cell Significance Index: 8.6200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0634
Cell Significance Index: 0.7200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0216
Cell Significance Index: 2.4800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0164
Cell Significance Index: 0.8300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0158
Cell Significance Index: 1.8100
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0021
Cell Significance Index: 0.2100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0019
Cell Significance Index: -3.6400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0025
Cell Significance Index: -4.6900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0047
Cell Significance Index: -7.2800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0090
Cell Significance Index: -5.6100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0106
Cell Significance Index: -8.0400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0110
Cell Significance Index: -8.1400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0111
Cell Significance Index: -1.9000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0182
Cell Significance Index: -24.7000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0196
Cell Significance Index: -13.5600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0207
Cell Significance Index: -11.6500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0229
Cell Significance Index: -14.5400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0248
Cell Significance Index: -18.1800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0318
Cell Significance Index: -1.3100
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0360
Cell Significance Index: -0.2400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0429
Cell Significance Index: -19.4500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0436
Cell Significance Index: -9.1900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0459
Cell Significance Index: -9.1000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0487
Cell Significance Index: -1.0100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0525
Cell Significance Index: -3.7100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0545
Cell Significance Index: -19.5400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0563
Cell Significance Index: -16.1900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0570
Cell Significance Index: -8.2800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0902
Cell Significance Index: -1.9200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1023
Cell Significance Index: -6.4500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1026
Cell Significance Index: -20.5800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1099
Cell Significance Index: -2.3800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1180
Cell Significance Index: -2.9500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1213
Cell Significance Index: -3.1000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1238
Cell Significance Index: -3.3100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1939
Cell Significance Index: -20.1900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2292
Cell Significance Index: -7.3400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2371
Cell Significance Index: -18.2000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2612
Cell Significance Index: -20.6900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3137
Cell Significance Index: -4.2800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3160
Cell Significance Index: -10.9800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3293
Cell Significance Index: -20.1900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3412
Cell Significance Index: -5.7100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3507
Cell Significance Index: -7.3400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3630
Cell Significance Index: -20.3700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3746
Cell Significance Index: -19.6700
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.4167
Cell Significance Index: -5.8400
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.4438
Cell Significance Index: -2.4200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4596
Cell Significance Index: -20.3300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4767
Cell Significance Index: -2.8800
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.4768
Cell Significance Index: -8.2200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4786
Cell Significance Index: -17.5700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.4787
Cell Significance Index: -7.0600
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.4911
Cell Significance Index: -8.2600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5206
Cell Significance Index: -7.8000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.5305
Cell Significance Index: -13.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** IRF7 is a type II IFN-inducible transcription factor that belongs to the IRF family of proteins. It is a DNA-binding protein that regulates the expression of target genes involved in the IFN signaling pathway. IRF7 is activated by the phosphorylation of specific tyrosine residues, which is mediated by the kinase TBK1 (TANK-binding kinase 1). Once activated, IRF7 translocates to the nucleus, where it regulates the expression of IFN-stimulated genes (ISGs) that are essential for the antiviral response. IRF7 is highly expressed in cells of the innate immune system, including dendritic cells, macrophages, and natural killer cells. It is also expressed in certain populations of T cells, such as CD8+ T cells and alpha-beta T cells. IRF7 is significantly expressed in the context of viral infections, such as SARS-CoV-2, where it plays a crucial role in the regulation of the IFN response. **Pathways and Functions** IRF7 is involved in several signaling pathways that regulate the immune response, including: 1. **Interferon Signaling Pathway**: IRF7 regulates the expression of type I IFNs, which are essential for defending against viral infections. IRF7 also regulates the expression of ISGs that are involved in the antiviral response. 2. **Pattern Recognition Receptor Signaling Pathway**: IRF7 is activated by the phosphorylation of specific tyrosine residues, which is mediated by the kinase TBK1. This activation event triggers the translocation of IRF7 to the nucleus, where it regulates the expression of ISGs. 3. **Cytokine Signaling Pathway**: IRF7 regulates the production of cytokines, such as IFN-alpha and IFN-beta, which are essential for the regulation of the immune response. 4. **DNA Damage Response**: IRF7 is involved in the regulation of the DNA damage response, which is essential for the maintenance of genome stability. IRF7 plays a critical role in the regulation of immune cell differentiation, cytokine production, and the activation of PRRs. Its dysregulation has been implicated in various diseases, including viral infections, autoimmune disorders, and cancer. **Clinical Significance** IRF7 is a critical component of the innate immune response against viral infections. Its dysregulation has been implicated in various diseases, including: 1. **Viral Infections**: IRF7 plays a crucial role in the regulation of the IFN response against viral infections, such as SARS-CoV-2. 2. **Autoimmune Disorders**: IRF7 dysregulation has been implicated in autoimmune disorders, such as lupus and rheumatoid arthritis. 3. **Cancer**: IRF7 is involved in the regulation of immune cell differentiation and cytokine production, which is essential for the maintenance of immune homeostasis. Its dysregulation has been implicated in various cancers, including melanoma and lung cancer. In conclusion, IRF7 is a critical transcription factor that plays a pivotal role in the innate and adaptive immune responses against viral infections. Its dysregulation has been implicated in various diseases, including viral infections, autoimmune disorders, and cancer. Further research is needed to understand the mechanisms of IRF7 regulation and its clinical significance in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 3100312569

Symbol: IRF7_HUMAN

Name: Interferon regulatory factor 7

UniProtKB Accession Codes:

Q92985 B9EGL3 O00331 O00332 O00333 O75924 Q9UE79

Database IDs:

Citations:

PubMed ID: 9315633

Title: IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency.

PubMed ID: 9315633

DOI: 10.1128/mcb.17.10.5748

PubMed ID: 9786932

Title: Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes.

PubMed ID: 9786932

DOI: 10.1074/jbc.273.44.29210

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11073981

Title: Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain.

PubMed ID: 11073981

DOI: 10.1128/mcb.20.23.8803-8814.2000

PubMed ID: 11124948

Title: IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.

PubMed ID: 11124948

DOI: 10.1074/jbc.m008717200

PubMed ID: 11314014

Title: HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators.

PubMed ID: 11314014

DOI: 10.1038/sj.onc.1204163

PubMed ID: 12374802

Title: Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.

PubMed ID: 12374802

DOI: 10.1074/jbc.m207484200

PubMed ID: 11846980

Title: Structure and function of IRF-7.

PubMed ID: 11846980

DOI: 10.1089/107999002753452700

PubMed ID: 11943871

Title: A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation.

PubMed ID: 11943871

DOI: 10.1073/pnas.082420599

PubMed ID: 14517278

Title: LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

PubMed ID: 14517278

DOI: 10.1084/jem.20031023

PubMed ID: 14739303

Title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

PubMed ID: 14739303

DOI: 10.1074/jbc.m311629200

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15367631

Title: Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.

PubMed ID: 15367631

DOI: 10.1128/jvi.78.19.10636-10649.2004

PubMed ID: 15492225

Title: Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.

PubMed ID: 15492225

DOI: 10.1073/pnas.0406933101

PubMed ID: 15361868

Title: Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.

PubMed ID: 15361868

DOI: 10.1038/ni1118

PubMed ID: 15767370

Title: Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.

PubMed ID: 15767370

DOI: 10.1084/jem.20042372

PubMed ID: 16846591

Title: Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.

PubMed ID: 16846591

DOI: 10.1016/j.bcp.2006.06.002

PubMed ID: 16979567

Title: Type I interferon gene induction by the interferon regulatory factor family of transcription factors.

PubMed ID: 16979567

DOI: 10.1016/j.immuni.2006.08.009

PubMed ID: 17404045

Title: IRF-7: new role in the regulation of genes involved in adaptive immunity.

PubMed ID: 17404045

DOI: 10.1196/annals.1397.036

PubMed ID: 17301153

Title: Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7.

PubMed ID: 17301153

DOI: 10.1128/jvi.02498-06

PubMed ID: 19017798

Title: IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3.

PubMed ID: 19017798

DOI: 10.1073/pnas.0809933105

PubMed ID: 18987133

Title: Epstein-Barr virus LF2: an antagonist to type I interferon.

PubMed ID: 18987133

DOI: 10.1128/jvi.00602-08

PubMed ID: 19557165

Title: Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery.

PubMed ID: 19557165

DOI: 10.1371/journal.ppat.1000493

PubMed ID: 20049431

Title: Regulation of immunity and oncogenesis by the IRF transcription factor family.

PubMed ID: 20049431

DOI: 10.1007/s00262-009-0804-6

PubMed ID: 21167755

Title: The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.

PubMed ID: 21167755

DOI: 10.1016/j.immuni.2010.11.027

PubMed ID: 21490621

Title: IRF7: activation, regulation, modification and function.

PubMed ID: 21490621

DOI: 10.1038/gene.2011.21

PubMed ID: 21940674

Title: Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.

PubMed ID: 21940674

DOI: 10.4049/jimmunol.1101704

PubMed ID: 25907537

Title: TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7.

PubMed ID: 25907537

DOI: 10.1016/j.febslet.2015.04.019

PubMed ID: 26608321

Title: 3C Protease of Enterovirus D68 Inhibits Cellular Defense Mediated by Interferon Regulatory Factor 7.

PubMed ID: 26608321

DOI: 10.1128/jvi.02395-15

PubMed ID: 28768861

Title: Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ.

PubMed ID: 28768861

DOI: 10.1128/jvi.00853-17

PubMed ID: 28768858

Title: Human Metapneumovirus M2-2 Protein Acts as a Negative Regulator of Alpha Interferon Production by Plasmacytoid Dendritic Cells.

PubMed ID: 28768858

DOI: 10.1128/jvi.00579-17

PubMed ID: 23175366

Title: Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses.

PubMed ID: 23175366

DOI: 10.1128/jvi.01855-12

PubMed ID: 28342865

Title: KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production.

PubMed ID: 28342865

DOI: 10.1016/j.bbrc.2017.03.101

PubMed ID: 29427864

Title: Seneca Valley Virus 3Cpro abrogates the IRF3- and IRF7-mediated innate immune response by degrading IRF3 and IRF7.

PubMed ID: 29427864

DOI: 10.1016/j.virol.2018.01.028

PubMed ID: 30598516

Title: Suppression of the IFN-alpha and -beta Induction through Sequestering IRF7 into Viral Inclusion Bodies by Nonstructural Protein NSs in Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection.

PubMed ID: 30598516

DOI: 10.4049/jimmunol.1800576

PubMed ID: 35792897

Title: E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.

PubMed ID: 35792897

DOI: 10.1096/fj.202200316r

PubMed ID: 17574024

Title: An atomic model of the interferon-beta enhanceosome.

PubMed ID: 17574024

DOI: 10.1016/j.cell.2007.05.019

PubMed ID: 25814066

Title: Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.

PubMed ID: 25814066

DOI: 10.1126/science.aaa1578

PubMed ID: 32972995

Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

PubMed ID: 32972995

DOI: 10.1126/science.abd4570

Sequence Information:

Length: 503
Mass: 54278
Checksum: 9863C147514652DE
Sequence:

MALAPERAAP RVLFGEWLLG EISSGCYEGL QWLDEARTCF RVPWKHFARK DLSEADARIF 
KAWAVARGRW PPSSRGGGPP PEAETAERAG WKTNFRCALR STRRFVMLRD NSGDPADPHK 
VYALSRELCW REGPGTDQTE AEAPAAVPPP QGGPPGPFLA HTHAGLQAPG PLPAPAGDKG 
DLLLQAVQQS CLADHLLTAS WGADPVPTKA PGEGQEGLPL TGACAGGPGL PAGELYGWAV 
ETTPSPGPQP AALTTGEAAA PESPHQAEPY LSPSPSACTA VQEPSPGALD VTIMYKGRTV 
LQKVVGHPSC TFLYGPPDPA VRATDPQQVA FPSPAELPDQ KQLRYTEELL RHVAPGLHLE 
LRGPQLWARR MGKCKVYWEV GGPPGSASPS TPACLLPRNC DTPIFDFRVF FQELVEFRAR 
QRRGSPRYTI YLGFGQDLSA GRPKEKSLVL VKLEPWLCRV HLEGTQREGV SSLDSSSLSL 
CLSSANSLYD DIECFLMELE QPA

Genular Protein ID: 3890565348

Symbol: M9RSF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

M9RSF4

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

Length: 487
Mass: 52817
Checksum: 10E6D498EC01F43C
Sequence:

MPVPERPAAG PDSPRPGTRR AAPRVLFGEW LLGEISSGCY EGLQWLDEAR TCFRVPWKHF 
ARKDLSEADA RIFKAWAVAR GRWPPSSRGG GPPPEAETAE RAGWKTNFRC ALRSTRRFVM 
LRDNSGDPAD PHKVYALSRE LCWREGPGTD QTEAEAPAAV PPPQGGPPGP FLAHTHAGLQ 
APGPLPAPAG DKGDLLLQAV QQSCLADHLL TASWGADPVP TKAPGEGQEG LPLTGACAGG 
EAAAPESPHQ AEPYLSPSPS ACTAVQEPSP GALDVTIMYK GRTVLQKVVG HPSCTFLYGP 
PDPAVRATDP QQVAFPSPAE LPDQKQLRYT EELLRHVAPG LHLELRGPQL WARRMGKCKV 
YWEVGGPPGS ASPSTPACLL PRNCDTPIFD FRVFFQELVE FRARQRRGSP RYTIYLGFGQ 
DLSAGRPKEK SLVLVKLEPW LCRVHLEGTQ REGVSSLDSS SLSLCLSSAN SLYDDIECFL 
MELEQPA

Genular Protein ID: 1506306157

Symbol: B4E1B1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E1B1

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 210
Mass: 23592
Checksum: 45895671CEAA18F5
Sequence:

MYKGRTVLQK VVGHPSCTFL YGPPDPAVRA TDPQQVAFPS PAELPDQKQL RYTEELLRHV 
APGLHLELRG PQLWARRMGK CKVYWEVGGP PGSASPSTPA CLLPRNCDTP IFDFRVFFQE 
LVEFRARQRR GSPRYTIYLG FGQDLSAGRP KEKSLVLVKL EPWLCRVHLE GTQREGVSSL 
DSSSLSLCLS SANSLYDDIE CFLMELEQPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IRF7

Associated with

Cells (max top 100)

Other Information

IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency. PubMed ID: 9315633

Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. PubMed ID: 9786932

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. PubMed ID: 11073981

IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. PubMed ID: 11124948

HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. PubMed ID: 11314014

Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. PubMed ID: 12374802

Structure and function of IRF-7. PubMed ID: 11846980

A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. PubMed ID: 11943871

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. PubMed ID: 14517278

Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. PubMed ID: 14739303

An unappreciated role for RNA surveillance. PubMed ID: 14759258

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. PubMed ID: 15367631

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. PubMed ID: 15492225

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. PubMed ID: 15361868

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. PubMed ID: 15767370

Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages. PubMed ID: 16846591

Type I interferon gene induction by the interferon regulatory factor family of transcription factors. PubMed ID: 16979567

IRF-7: new role in the regulation of genes involved in adaptive immunity. PubMed ID: 17404045

Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7. PubMed ID: 17301153

IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3. PubMed ID: 19017798

Epstein-Barr virus LF2: an antagonist to type I interferon. PubMed ID: 18987133

Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PubMed ID: 19557165

Regulation of immunity and oncogenesis by the IRF transcription factor family. PubMed ID: 20049431

The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3. PubMed ID: 21167755

IRF7: activation, regulation, modification and function. PubMed ID: 21490621

Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7. PubMed ID: 21940674

TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7. PubMed ID: 25907537

3C Protease of Enterovirus D68 Inhibits Cellular Defense Mediated by Interferon Regulatory Factor 7. PubMed ID: 26608321

Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ. PubMed ID: 28768861

Human Metapneumovirus M2-2 Protein Acts as a Negative Regulator of Alpha Interferon Production by Plasmacytoid Dendritic Cells. PubMed ID: 28768858

Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses. PubMed ID: 23175366

KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production. PubMed ID: 28342865

Seneca Valley Virus 3Cpro abrogates the IRF3- and IRF7-mediated innate immune response by degrading IRF3 and IRF7. PubMed ID: 29427864

Suppression of the IFN-alpha and -beta Induction through Sequestering IRF7 into Viral Inclusion Bodies by Nonstructural Protein NSs in Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection. PubMed ID: 30598516

E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7. PubMed ID: 35792897

An atomic model of the interferon-beta enhanceosome. PubMed ID: 17574024

Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency. PubMed ID: 25814066

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. PubMed ID: 32972995

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The sequence of the human genome. PubMed ID: 11181995

Database document:

PubMed ID: 9315633

PubMed ID: 9786932

PubMed ID: 15489334

PubMed ID: 11073981

PubMed ID: 11124948

PubMed ID: 11314014

PubMed ID: 12374802

PubMed ID: 11846980

PubMed ID: 11943871

PubMed ID: 14517278

PubMed ID: 14739303

PubMed ID: 14759258

PubMed ID: 15367631

PubMed ID: 15492225

PubMed ID: 15361868

PubMed ID: 15767370

PubMed ID: 16846591

PubMed ID: 16979567

PubMed ID: 17404045

PubMed ID: 17301153

PubMed ID: 19017798

PubMed ID: 18987133

PubMed ID: 19557165

PubMed ID: 20049431

PubMed ID: 21167755

PubMed ID: 21490621

PubMed ID: 21940674

PubMed ID: 25907537

PubMed ID: 26608321

PubMed ID: 28768861

PubMed ID: 28768858

PubMed ID: 23175366

PubMed ID: 28342865

PubMed ID: 29427864

PubMed ID: 30598516

PubMed ID: 35792897

PubMed ID: 17574024

PubMed ID: 25814066

PubMed ID: 32972995

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16554811

PubMed ID: 11181995