Details for: DNASE1L3

Gene ID: 1776

Symbol: DNASE1L3

Ensembl ID: ENSG00000163687

Description: deoxyribonuclease 1L3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 3
    Marker Score: 3218
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.23
    Marker Score: 518
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.22
    Marker Score: 1858
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.07
    Marker Score: 2246
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.72
    Marker Score: 2120
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.56
    Marker Score: 341
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.49
    Marker Score: 361
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.45
    Marker Score: 1745.5
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.4
    Marker Score: 384
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.96
    Marker Score: 255
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5218
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.91
    Marker Score: 285
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13974
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1779
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.86
    Marker Score: 1496
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.81
    Marker Score: 816
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.79
    Marker Score: 1134
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.74
    Marker Score: 502
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.72
    Marker Score: 153
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.71
    Marker Score: 1812
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.7
    Marker Score: 1021
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.69
    Marker Score: 167
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.66
    Marker Score: 173
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.64
    Marker Score: 443
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.64
    Marker Score: 5482
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.62
    Marker Score: 625
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.6
    Marker Score: 1624.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.58
    Marker Score: 4510
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.56
    Marker Score: 135
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.56
    Marker Score: 561
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.49
    Marker Score: 177
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.49
    Marker Score: 1146
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.45
    Marker Score: 762
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.43
    Marker Score: 736
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 382
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.42
    Marker Score: 225
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.41
    Marker Score: 178
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.41
    Marker Score: 112
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.4
    Marker Score: 125
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.4
    Marker Score: 227
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.4
    Marker Score: 353
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.38
    Marker Score: 325
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.37
    Marker Score: 119
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 220
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.36
    Marker Score: 596
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.35
    Marker Score: 90
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 218
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.33
    Marker Score: 207
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.31
    Marker Score: 72
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.31
    Marker Score: 109
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.31
    Marker Score: 71
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.31
    Marker Score: 610
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3
    Marker Score: 1212
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.29
    Marker Score: 87
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.29
    Marker Score: 199
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.29
    Marker Score: 358
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.29
    Marker Score: 179
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 134
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.28
    Marker Score: 296
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.26
    Marker Score: 60
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.25
    Marker Score: 225
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 109
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.24
    Marker Score: 243
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.24
    Marker Score: 264
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.24
    Marker Score: 265
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.23
    Marker Score: 217
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.23
    Marker Score: 111
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 128
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.22
    Marker Score: 234
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.22
    Marker Score: 143
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.21
    Marker Score: 556
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.21
    Marker Score: 81
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 123
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.2
    Marker Score: 127
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2
    Marker Score: 106
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.2
    Marker Score: 320
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.2
    Marker Score: 148
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.18
    Marker Score: 265
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.18
    Marker Score: 69
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.18
    Marker Score: 103
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.18
    Marker Score: 107

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Other Information

**Key characteristics:** - It is a protein of the DNASE1 family of DNA glycosylases. - It is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is found in the endoplasmic reticulum and the nucleus. **Pathways and functions:** - It is involved in the apoptotic pathway of DNA fragmentation. - It is a key regulator of the inflammatory response. - It is also involved in cell development and survival. **Clinical significance:** - Mutations in DNASE1L3 have been linked to a number of human diseases, including liver cancer, kidney cancer, and inflammatory bowel disease. - DNASE1L3 inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional notes:** - It is a highly conserved protein, with a similar protein found in other mammals. - It is a relatively new protein, with the gene first identified in humans in 2004.

Genular Protein ID: 147515919

Symbol: DNSL3_HUMAN

Name: Deoxyribonuclease gamma

UniProtKB Accession Codes:

Q13609 B2R8B1 B7Z707 O75803

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9205125

Title: Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I.

PubMed ID: 9205125

DOI: 10.1006/geno.1997.4748

PubMed ID: 9070308

Title: Cloning and characterization of a novel human DNase.

PubMed ID: 9070308

DOI: 10.1006/bbrc.1996.5923

PubMed ID: 9714828

Title: Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages.

PubMed ID: 9714828

DOI: 10.1016/s0378-1119(98)00281-9

PubMed ID: 14646506

Title: cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein.

PubMed ID: 14646506

DOI: 10.1023/a:1009692807692

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10807908

Title: A role of the Ca2+/Mg2+-dependent endonuclease in apoptosis and its inhibition by poly(ADP-ribose) polymerase.

PubMed ID: 10807908

DOI: 10.1074/jbc.m001087200

PubMed ID: 11141064

Title: Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis.

PubMed ID: 11141064

DOI: 10.1021/bi001041a

PubMed ID: 22019780

Title: Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus.

PubMed ID: 22019780

DOI: 10.1038/ng.975

PubMed ID: 23229555

Title: Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis.

PubMed ID: 23229555

DOI: 10.1074/jbc.m112.423061

PubMed ID: 24312463

Title: DNase gamma is the effector endonuclease for internucleosomal DNA fragmentation in necrosis.

PubMed ID: 24312463

DOI: 10.1371/journal.pone.0080223

PubMed ID: 27293190

Title: Digestion of chromatin in apoptotic cell microparticles prevents autoimmunity.

PubMed ID: 27293190

DOI: 10.1016/j.cell.2016.05.034

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 19559017

Title: Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme.

PubMed ID: 19559017

DOI: 10.1016/j.cca.2009.06.022

PubMed ID: 21692081

Title: Global genetic analysis of all single nucleotide polymorphisms in exons of the human deoxyribonuclease I-like 3 gene and their effect on its catalytic activity.

PubMed ID: 21692081

DOI: 10.1002/elps.201100064

Sequence Information:

  • Length: 305
  • Mass: 35504
  • Checksum: BAB9F1A0341E6048
  • Sequence:
    • MSRELAPLLL LLLSIHSALA MRICSFNVRS FGESKQEDKN AMDVIVKVIK RCDIILVMEI 
KDSNNRICPI LMEKLNRNSR RGITYNYVIS SRLGRNTYKE QYAFLYKEKL VSVKRSYHYH 
DYQDGDADVF SREPFVVWFQ SPHTAVKDFV IIPLHTTPET SVKEIDELVE VYTDVKHRWK 
AENFIFMGDF NAGCSYVPKK AWKNIRLRTD PRFVWLIGDQ EDTTVKKSTN CAYDRIVLRG 
QEIVSSVVPK SNSVFDFQKA YKLTEEEALD VSDHFPVEFK LQSSRAFTNS KKSVTLRKKT 
KSKRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.