Details for: DNASE1L3

Gene ID: 1776

Symbol: DNASE1L3

Ensembl ID: ENSG00000163687

Description: deoxyribonuclease 1L3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 33.4951
    Cell Significance Index: -5.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.7378
    Cell Significance Index: -5.2600
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 6.1268
    Cell Significance Index: 21.3200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 5.9616
    Cell Significance Index: 47.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.2094
    Cell Significance Index: -5.1900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 3.2884
    Cell Significance Index: 31.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.2270
    Cell Significance Index: 25.3000
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.9106
    Cell Significance Index: 5.0400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 1.3684
    Cell Significance Index: 5.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.3330
    Cell Significance Index: -5.2600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.2436
    Cell Significance Index: 12.8800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.1711
    Cell Significance Index: 20.1200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.9649
    Cell Significance Index: 8.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8254
    Cell Significance Index: 13.1000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6557
    Cell Significance Index: 10.1500
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.6036
    Cell Significance Index: 4.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5653
    Cell Significance Index: 9.9900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.5373
    Cell Significance Index: 7.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3973
    Cell Significance Index: 10.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3276
    Cell Significance Index: 4.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1286
    Cell Significance Index: 3.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1136
    Cell Significance Index: 1.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1123
    Cell Significance Index: 2.4000
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.0997
    Cell Significance Index: 0.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0844
    Cell Significance Index: 16.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0518
    Cell Significance Index: 6.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0082
    Cell Significance Index: 3.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0047
    Cell Significance Index: -0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0051
    Cell Significance Index: -6.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0052
    Cell Significance Index: -3.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0067
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0088
    Cell Significance Index: -5.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0096
    Cell Significance Index: -5.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0097
    Cell Significance Index: -1.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0105
    Cell Significance Index: -5.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0108
    Cell Significance Index: -3.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0122
    Cell Significance Index: -5.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0189
    Cell Significance Index: -5.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0189
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0256
    Cell Significance Index: -4.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0260
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0260
    Cell Significance Index: -5.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0281
    Cell Significance Index: -1.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0292
    Cell Significance Index: -4.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0341
    Cell Significance Index: -4.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0376
    Cell Significance Index: -3.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0384
    Cell Significance Index: -1.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0386
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0402
    Cell Significance Index: -4.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0403
    Cell Significance Index: -5.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0410
    Cell Significance Index: -5.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0451
    Cell Significance Index: -1.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0487
    Cell Significance Index: -0.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0521
    Cell Significance Index: -5.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0562
    Cell Significance Index: -4.4500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0678
    Cell Significance Index: -0.4500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0698
    Cell Significance Index: -0.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0712
    Cell Significance Index: -1.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0717
    Cell Significance Index: -3.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0739
    Cell Significance Index: -3.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0741
    Cell Significance Index: -5.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0797
    Cell Significance Index: -6.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0801
    Cell Significance Index: -5.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0837
    Cell Significance Index: -2.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0920
    Cell Significance Index: -5.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0992
    Cell Significance Index: -6.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1001
    Cell Significance Index: -6.1400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1058
    Cell Significance Index: -0.7600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1147
    Cell Significance Index: -2.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1152
    Cell Significance Index: -5.2200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1157
    Cell Significance Index: -2.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1166
    Cell Significance Index: -4.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1182
    Cell Significance Index: -6.6300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1201
    Cell Significance Index: -1.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1209
    Cell Significance Index: -1.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1224
    Cell Significance Index: -6.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1268
    Cell Significance Index: -5.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1273
    Cell Significance Index: -5.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1274
    Cell Significance Index: -2.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1298
    Cell Significance Index: -6.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1300
    Cell Significance Index: -2.1900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1309
    Cell Significance Index: -1.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1356
    Cell Significance Index: -4.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1357
    Cell Significance Index: -3.8900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1427
    Cell Significance Index: -1.5500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1473
    Cell Significance Index: -0.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1479
    Cell Significance Index: -5.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1500
    Cell Significance Index: -4.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1564
    Cell Significance Index: -4.9800
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.1713
    Cell Significance Index: -1.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1736
    Cell Significance Index: -2.9100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1749
    Cell Significance Index: -2.5400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1774
    Cell Significance Index: -2.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Deoxyribonuclease activity**: The protein encoded by DNASE1L3 exhibits deoxyribonuclease activity, which is essential for the degradation of DNA. 2. **Apoptotic DNA fragmentation**: DNASE1L3 is involved in the regulation of apoptotic DNA fragmentation, a process crucial for programmed cell death. 3. **Neutrophil activation**: DNASE1L3 is expressed in neutrophils, a type of immune cell, suggesting its role in regulating neutrophil-mediated cytotoxicity. 4. **Regulation of acute inflammatory response**: DNASE1L3 is involved in the regulation of acute inflammatory responses, which are critical for the resolution of inflammation. **Pathways and Functions:** 1. **Apoptotic DNA fragmentation**: DNASE1L3 is involved in the regulation of apoptotic DNA fragmentation, a process that involves the degradation of DNA into smaller fragments. 2. **Calcium ion binding**: The protein encoded by DNASE1L3 binds to calcium ions, which are essential for various cellular processes, including signaling and DNA metabolism. 3. **Deoxyribonuclease i activity**: DNASE1L3 exhibits deoxyribonuclease i activity, which is involved in the degradation of DNA. 4. **DNA metabolic process**: DNASE1L3 is involved in the regulation of DNA metabolic processes, including DNA replication and repair. **Clinical Significance:** Dysregulation of DNASE1L3 has been implicated in various diseases, including: 1. **Autoimmune disorders**: DNASE1L3 has been shown to regulate the immune response and prevent autoimmune disorders, such as rheumatoid arthritis. 2. **Cancer**: DNASE1L3 has been implicated in the regulation of programmed cell death and may play a role in cancer development and progression. 3. **Neurological disorders**: DNASE1L3 has been shown to be involved in the regulation of programmed cell death in the brain and may play a role in neurological disorders, such as Alzheimer's disease. In conclusion, DNASE1L3 is a gene that plays a crucial role in regulating various cellular processes, including immune response, programmed cell death, and DNA metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the function of this gene in health and disease.

Genular Protein ID: 147515919

Symbol: DNSL3_HUMAN

Name: Deoxyribonuclease gamma

UniProtKB Accession Codes:

Q13609 B2R8B1 B7Z707 O75803

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9205125

Title: Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I.

PubMed ID: 9205125

DOI: 10.1006/geno.1997.4748

PubMed ID: 9070308

Title: Cloning and characterization of a novel human DNase.

PubMed ID: 9070308

DOI: 10.1006/bbrc.1996.5923

PubMed ID: 9714828

Title: Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages.

PubMed ID: 9714828

DOI: 10.1016/s0378-1119(98)00281-9

PubMed ID: 14646506

Title: cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein.

PubMed ID: 14646506

DOI: 10.1023/a:1009692807692

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10807908

Title: A role of the Ca2+/Mg2+-dependent endonuclease in apoptosis and its inhibition by poly(ADP-ribose) polymerase.

PubMed ID: 10807908

DOI: 10.1074/jbc.m001087200

PubMed ID: 11141064

Title: Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis.

PubMed ID: 11141064

DOI: 10.1021/bi001041a

PubMed ID: 22019780

Title: Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus.

PubMed ID: 22019780

DOI: 10.1038/ng.975

PubMed ID: 23229555

Title: Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis.

PubMed ID: 23229555

DOI: 10.1074/jbc.m112.423061

PubMed ID: 24312463

Title: DNase gamma is the effector endonuclease for internucleosomal DNA fragmentation in necrosis.

PubMed ID: 24312463

DOI: 10.1371/journal.pone.0080223

PubMed ID: 27293190

Title: Digestion of chromatin in apoptotic cell microparticles prevents autoimmunity.

PubMed ID: 27293190

DOI: 10.1016/j.cell.2016.05.034

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 19559017

Title: Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme.

PubMed ID: 19559017

DOI: 10.1016/j.cca.2009.06.022

PubMed ID: 21692081

Title: Global genetic analysis of all single nucleotide polymorphisms in exons of the human deoxyribonuclease I-like 3 gene and their effect on its catalytic activity.

PubMed ID: 21692081

DOI: 10.1002/elps.201100064

Sequence Information:

  • Length: 305
  • Mass: 35504
  • Checksum: BAB9F1A0341E6048
  • Sequence:
    • MSRELAPLLL LLLSIHSALA MRICSFNVRS FGESKQEDKN AMDVIVKVIK RCDIILVMEI 
KDSNNRICPI LMEKLNRNSR RGITYNYVIS SRLGRNTYKE QYAFLYKEKL VSVKRSYHYH 
DYQDGDADVF SREPFVVWFQ SPHTAVKDFV IIPLHTTPET SVKEIDELVE VYTDVKHRWK 
AENFIFMGDF NAGCSYVPKK AWKNIRLRTD PRFVWLIGDQ EDTTVKKSTN CAYDRIVLRG 
QEIVSSVVPK SNSVFDFQKA YKLTEEEALD VSDHFPVEFK LQSSRAFTNS KKSVTLRKKT 
KSKRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.