Details for: PYCARD

Gene ID: 29108

Symbol: PYCARD

Ensembl ID: ENSG00000103490

Description: PYD and CARD domain containing

Associated with

  • C-type lectin receptors (clrs)
    (R-HSA-5621481)
  • Cell recruitment (pro-inflammatory response)
    (R-HSA-9664424)
  • Clec7a (dectin-1) signaling
    (R-HSA-5607764)
  • Clec7a/inflammasome pathway
    (R-HSA-5660668)
  • Disease
    (R-HSA-1643685)
  • Immune system
    (R-HSA-168256)
  • Infectious disease
    (R-HSA-5663205)
  • Inflammasomes
    (R-HSA-622312)
  • Innate immune system
    (R-HSA-168249)
  • Leishmania infection
    (R-HSA-9658195)
  • Neutrophil degranulation
    (R-HSA-6798695)
  • Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
    (R-HSA-168643)
  • Parasitic infection pathways
    (R-HSA-9824443)
  • Purinergic signaling in leishmaniasis infection
    (R-HSA-9660826)
  • Sars-cov-1 activates/modulates innate immune responses
    (R-HSA-9692916)
  • Sars-cov-1 infection
    (R-HSA-9678108)
  • Sars-cov-1-host interactions
    (R-HSA-9692914)
  • Sars-cov infections
    (R-HSA-9679506)
  • The aim2 inflammasome
    (R-HSA-844615)
  • The nlrp3 inflammasome
    (R-HSA-844456)
  • Viral infection pathways
    (R-HSA-9824446)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Activation of innate immune response
    (GO:0002218)
  • Apoptotic process
    (GO:0006915)
  • Bmp receptor binding
    (GO:0070700)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cysteine-type endopeptidase activator activity
    (GO:0140608)
  • Cysteine-type endopeptidase activator activity involved in apoptotic process
    (GO:0008656)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Defense response to virus
    (GO:0051607)
  • Enzyme binding
    (GO:0019899)
  • Icosanoid biosynthetic process
    (GO:0046456)
  • Identical protein binding
    (GO:0042802)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Interleukin-6 receptor binding
    (GO:0005138)
  • Intrinsic apoptotic signaling pathway by p53 class mediator
    (GO:0072332)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Macropinocytosis
    (GO:0044351)
  • Myeloid dendritic cell activation
    (GO:0001773)
  • Myeloid dendritic cell activation involved in immune response
    (GO:0002277)
  • Myosin i binding
    (GO:0017024)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of interferon-beta production
    (GO:0032688)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of protein serine/threonine kinase activity
    (GO:0071901)
  • Nlrp3 inflammasome complex assembly
    (GO:0044546)
  • Osmosensory signaling pathway
    (GO:0007231)
  • Pattern recognition receptor activity
    (GO:0038187)
  • Pattern recognition receptor signaling pathway
    (GO:0002221)
  • Positive regulation of actin filament polymerization
    (GO:0030838)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of adaptive immune response
    (GO:0002821)
  • Positive regulation of antigen processing and presentation of peptide antigen via mhc class ii
    (GO:0002588)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Positive regulation of t cell activation
    (GO:0050870)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protease binding
    (GO:0002020)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein homooligomerization
    (GO:0051260)
  • Pyrin domain binding
    (GO:0032090)
  • Pyroptotic inflammatory response
    (GO:0070269)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of protein stability
    (GO:0031647)
  • Regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010803)
  • Signal transduction
    (GO:0007165)
  • Transmembrane transporter binding
    (GO:0044325)
  • Tropomyosin binding
    (GO:0005523)
  • Tumor necrosis factor-mediated signaling pathway
    (GO:0033209)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 183.3550
    Cell Significance Index: -28.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.3977
    Cell Significance Index: -31.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.3510
    Cell Significance Index: -34.1300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 47.3159
    Cell Significance Index: -31.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.2179
    Cell Significance Index: -6.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.0422
    Cell Significance Index: -28.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.4060
    Cell Significance Index: -28.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5595
    Cell Significance Index: -29.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.3909
    Cell Significance Index: 118.1200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 5.1856
    Cell Significance Index: 44.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3451
    Cell Significance Index: -11.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.6636
    Cell Significance Index: 107.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5902
    Cell Significance Index: 231.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.3278
    Cell Significance Index: 34.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9927
    Cell Significance Index: 1799.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6042
    Cell Significance Index: 174.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5051
    Cell Significance Index: 185.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2379
    Cell Significance Index: 87.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2003
    Cell Significance Index: 32.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1433
    Cell Significance Index: 59.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9684
    Cell Significance Index: 25.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8939
    Cell Significance Index: 395.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8686
    Cell Significance Index: 156.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7242
    Cell Significance Index: 32.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6637
    Cell Significance Index: 7.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6083
    Cell Significance Index: 28.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5638
    Cell Significance Index: 72.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5335
    Cell Significance Index: 73.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5099
    Cell Significance Index: 60.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4889
    Cell Significance Index: 266.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4865
    Cell Significance Index: 11.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3442
    Cell Significance Index: 65.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2322
    Cell Significance Index: 22.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2192
    Cell Significance Index: 10.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2086
    Cell Significance Index: 6.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1508
    Cell Significance Index: 11.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0807
    Cell Significance Index: 10.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0313
    Cell Significance Index: 1.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0304
    Cell Significance Index: 3.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0002
    Cell Significance Index: 0.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0125
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0140
    Cell Significance Index: -26.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0207
    Cell Significance Index: -31.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0236
    Cell Significance Index: -4.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0238
    Cell Significance Index: -32.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0272
    Cell Significance Index: -1.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0280
    Cell Significance Index: -1.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0421
    Cell Significance Index: -30.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0428
    Cell Significance Index: -31.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0517
    Cell Significance Index: -32.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0524
    Cell Significance Index: -32.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0531
    Cell Significance Index: -29.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0572
    Cell Significance Index: -1.4600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0678
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0713
    Cell Significance Index: -32.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0713
    Cell Significance Index: -20.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0868
    Cell Significance Index: -31.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0977
    Cell Significance Index: -11.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0987
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1213
    Cell Significance Index: -20.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1417
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1420
    Cell Significance Index: -16.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1469
    Cell Significance Index: -29.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1564
    Cell Significance Index: -32.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1803
    Cell Significance Index: -2.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1888
    Cell Significance Index: -3.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2124
    Cell Significance Index: -5.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2159
    Cell Significance Index: -31.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2258
    Cell Significance Index: -6.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2309
    Cell Significance Index: -2.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2747
    Cell Significance Index: -2.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2784
    Cell Significance Index: -28.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3932
    Cell Significance Index: -10.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4059
    Cell Significance Index: -6.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4170
    Cell Significance Index: -21.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4177
    Cell Significance Index: -33.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4231
    Cell Significance Index: -32.4700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.4244
    Cell Significance Index: -3.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4482
    Cell Significance Index: -27.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4897
    Cell Significance Index: -32.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4949
    Cell Significance Index: -31.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5148
    Cell Significance Index: -31.6400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.5293
    Cell Significance Index: -5.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5828
    Cell Significance Index: -14.9800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5899
    Cell Significance Index: -10.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5940
    Cell Significance Index: -33.3300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6005
    Cell Significance Index: -11.7400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6855
    Cell Significance Index: -5.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6943
    Cell Significance Index: -18.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6946
    Cell Significance Index: -25.5000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.7102
    Cell Significance Index: -4.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7229
    Cell Significance Index: -15.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7341
    Cell Significance Index: -25.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7800
    Cell Significance Index: -34.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8072
    Cell Significance Index: -23.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8084
    Cell Significance Index: -20.1900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.8172
    Cell Significance Index: -5.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.8240
    Cell Significance Index: -19.9600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.8478
    Cell Significance Index: -5.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8556
    Cell Significance Index: -17.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **PYD and CARD domains:** The presence of these domains in PYCARD is essential for its function, as they mediate interactions with other proteins and regulate its activity. 2. **Innate immune response:** PYCARD is involved in the regulation of the innate immune response, including the activation of cysteine-type endopeptidase activity and the production of pro-inflammatory cytokines. 3. **Apoptosis:** PYCARD plays a crucial role in regulating apoptosis, either promoting or inhibiting it, depending on the context. 4. **Multiple signaling pathways:** PYCARD is involved in various signaling pathways, including those regulated by tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). 5. **Cell type specificity:** PYCARD's expression in different cell types, including classical and non-classical monocytes, macrophages, and dendritic cells, highlights its role in immune cell function. **Pathways and Functions:** 1. **Activation of cysteine-type endopeptidase activity:** PYCARD activates cysteine-type endopeptidase activity, leading to the processing and activation of pro-inflammatory cytokines. 2. **Innate immune response:** PYCARD regulates the innate immune response by modulating the production of pro-inflammatory cytokines and the activation of immune cells. 3. **Apoptosis:** PYCARD promotes or inhibits apoptosis, depending on the context, and regulates the release of cytochrome c from mitochondria. 4. **Cytokine production:** PYCARD regulates the production of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-alpha. 5. **Immune cell activation:** PYCARD activates immune cells, including macrophages and dendritic cells, leading to the production of pro-inflammatory cytokines and the regulation of immune responses. **Clinical Significance:** 1. **Infectious diseases:** PYCARD's role in regulating the innate immune response and apoptosis makes it an important target for the treatment of infectious diseases, such as sepsis and tuberculosis. 2. **Autoimmune diseases:** PYCARD's involvement in the regulation of immune responses and apoptosis may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** PYCARD's role in regulating apoptosis and immune responses may contribute to the development of cancer, as dysregulation of its activity can lead to immune evasion and tumor progression. 4. **Neurological disorders:** PYCARD's involvement in the regulation of immune responses and apoptosis may contribute to the development of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, PYCARD is a complex protein that plays a crucial role in regulating the innate immune response, apoptosis, and immune cell function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 563241803

Symbol: ASC_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9ULZ3 Q96D12 Q9BSZ5 Q9HBD0 Q9NXJ8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 92 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10567338

Title: ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells.

PubMed ID: 10567338

DOI: 10.1074/jbc.274.48.33835

PubMed ID: 11103776

Title: TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers.

PubMed ID: 11103776

PubMed ID: 19759850

Title: A splice variant of ASC regulates IL-1beta release and aggregates differently from intact ASC.

PubMed ID: 19759850

DOI: 10.1155/2009/287387

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11103777

Title: Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1.

PubMed ID: 11103777

PubMed ID: 11374873

Title: Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis.

PubMed ID: 11374873

DOI: 10.1006/bbrc.2001.4928

PubMed ID: 11498534

Title: Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis.

PubMed ID: 11498534

DOI: 10.1074/jbc.m104730200

PubMed ID: 11786556

Title: PYPAF1: a PYRIN-containing APAF1-like protein that assembles with ASC and activates NF-kB.

PubMed ID: 11786556

DOI: 10.1074/jbc.m112208200

PubMed ID: 11967258

Title: The PYRIN-CARD protein ASC is an activating adaptor for caspase-1.

PubMed ID: 11967258

DOI: 10.1074/jbc.c200179200

PubMed ID: 12486103

Title: The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways.

PubMed ID: 12486103

DOI: 10.1084/jem.20021552

PubMed ID: 12191486

Title: The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

PubMed ID: 12191486

DOI: 10.1016/s1097-2765(02)00599-3

PubMed ID: 12646168

Title: ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.

PubMed ID: 12646168

DOI: 10.1016/s0006-291x(03)00309-7

PubMed ID: 12656673

Title: The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation.

PubMed ID: 12656673

DOI: 10.1042/bj20030304

PubMed ID: 14634131

Title: Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation.

PubMed ID: 14634131

DOI: 10.4049/jimmunol.171.11.6154

PubMed ID: 15030775

Title: NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.

PubMed ID: 15030775

DOI: 10.1016/s1074-7613(04)00046-9

PubMed ID: 15096476

Title: PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.

PubMed ID: 15096476

DOI: 10.1093/intimm/dxh081

PubMed ID: 15020601

Title: Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC.

PubMed ID: 15020601

DOI: 10.1074/jbc.m401178200

PubMed ID: 15456791

Title: PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.

PubMed ID: 15456791

DOI: 10.1074/jbc.m406741200

PubMed ID: 14730312

Title: ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.

PubMed ID: 14730312

DOI: 10.1038/ncb1087

PubMed ID: 15641782

Title: Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC.

PubMed ID: 15641782

DOI: 10.1021/bi048374i

PubMed ID: 16037825

Title: Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

PubMed ID: 16037825

DOI: 10.1038/sj.cdd.4401734

PubMed ID: 16585594

Title: ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions.

PubMed ID: 16585594

DOI: 10.4049/jimmunol.176.8.4979

PubMed ID: 16982856

Title: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways.

PubMed ID: 16982856

DOI: 10.4049/jimmunol.177.7.4252

PubMed ID: 17599095

Title: The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.

PubMed ID: 17599095

DOI: 10.1038/sj.cdd.4402194

PubMed ID: 17349957

Title: Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation.

PubMed ID: 17349957

DOI: 10.1016/j.molcel.2007.01.032

PubMed ID: 16964285

Title: Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells.

PubMed ID: 16964285

DOI: 10.1038/sj.onc.1209965

PubMed ID: 17178784

Title: Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.

PubMed ID: 17178784

DOI: 10.1128/iai.01315-06

PubMed ID: 17339483

Title: Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions.

PubMed ID: 17339483

DOI: 10.4049/jimmunol.178.6.3837

PubMed ID: 18362139

Title: Mapping of POP1-binding site on pyrin domain of ASC.

PubMed ID: 18362139

DOI: 10.1074/jbc.m801589200

PubMed ID: 19234215

Title: Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain.

PubMed ID: 19234215

DOI: 10.4049/jimmunol.0802367

PubMed ID: 19494289

Title: Mechanism and repertoire of ASC-mediated gene expression.

PubMed ID: 19494289

DOI: 10.4049/jimmunol.0800448

PubMed ID: 19158676

Title: AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.

PubMed ID: 19158676

DOI: 10.1038/nature07710

PubMed ID: 19158675

Title: AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.

PubMed ID: 19158675

DOI: 10.1038/nature07725

PubMed ID: 20482797

Title: Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes.

PubMed ID: 20482797

DOI: 10.1186/1476-9255-7-23

PubMed ID: 19915568

Title: Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.

PubMed ID: 19915568

DOI: 10.1038/ni.1824

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21575908

Title: IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.

PubMed ID: 21575908

DOI: 10.1016/j.chom.2011.04.008

PubMed ID: 21487011

Title: The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome.

PubMed ID: 21487011

DOI: 10.1074/jbc.m111.221077

PubMed ID: 22732093

Title: Central and overlapping role of cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells.

PubMed ID: 22732093

DOI: 10.1016/j.humimm.2012.06.008

PubMed ID: 21124315

Title: A role for mitochondria in NLRP3 inflammasome activation.

PubMed ID: 21124315

DOI: 10.1038/nature09663

PubMed ID: 23530044

Title: Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly.

PubMed ID: 23530044

DOI: 10.1074/jbc.m113.468033

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 23229815

Title: Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation.

PubMed ID: 23229815

DOI: 10.1136/thoraxjnl-2012-202182

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25847972

Title: MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3.

PubMed ID: 25847972

DOI: 10.4049/jimmunol.1402851

PubMed ID: 27432880

Title: ASC pyrin domain self-associates and binds NLRP3 protein using equivalent binding interfaces.

PubMed ID: 27432880

DOI: 10.1074/jbc.m116.741082

PubMed ID: 28094437

Title: The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.

PubMed ID: 28094437

DOI: 10.1002/1873-3468.12558

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 29440442

Title: Digital signaling network drives the assembly of the AIM2-ASC inflammasome.

PubMed ID: 29440442

DOI: 10.1073/pnas.1712860115

PubMed ID: 30674671

Title: Molecular mechanism for NLRP6 inflammasome assembly and activation.

PubMed ID: 30674671

DOI: 10.1073/pnas.1817221116

PubMed ID: 34678144

Title: Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.

PubMed ID: 34678144

DOI: 10.1016/j.cell.2021.09.032

PubMed ID: 35559676

Title: Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation.

PubMed ID: 35559676

DOI: 10.1126/sciadv.abn7583

PubMed ID: 33980849

Title: Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome.

PubMed ID: 33980849

DOI: 10.1038/s41467-021-23045-8

PubMed ID: 34341353

Title: SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation.

PubMed ID: 34341353

DOI: 10.1038/s41467-021-25015-6

PubMed ID: 34706239

Title: Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination.

PubMed ID: 34706239

DOI: 10.1016/j.celrep.2021.109904

PubMed ID: 36050480

Title: USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation.

PubMed ID: 36050480

DOI: 10.1038/s41423-022-00917-7

PubMed ID: 14499617

Title: The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition.

PubMed ID: 14499617

DOI: 10.1016/j.jmb.2003.07.007

PubMed ID: 19759015

Title: Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC).

PubMed ID: 19759015

DOI: 10.1074/jbc.m109.024273

PubMed ID: 24630722

Title: Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

PubMed ID: 24630722

DOI: 10.1016/j.cell.2014.02.008

PubMed ID: 33420028

Title: Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.

PubMed ID: 33420028

DOI: 10.1038/s41467-020-20319-5

PubMed ID: 33420033

Title: Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.

PubMed ID: 33420033

DOI: 10.1038/s41467-020-20320-y

Sequence Information:

  • Length: 195
  • Mass: 21627
  • Checksum: 455987286586F46A
  • Sequence:
    • MGRARDAILD ALENLTAEEL KKFKLKLLSV PLREGYGRIP RGALLSMDAL DLTDKLVSFY 
LETYGAELTA NVLRDMGLQE MAGQLQAATH QGSGAAPAGI QAPPQSAAKP GLHFIDQHRA 
ALIARVTNVE WLLDALYGKV LTDEQYQAVR AEPTNPSKMR KLFSFTPAWN WTCKDLLLQA 
LRESQSYLVE DLERS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.