Details for: EVI2B

Gene ID: 2124

Symbol: EVI2B

Ensembl ID: ENSG00000185862

Description: ecotropic viral integration site 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 165.9646
    Cell Significance Index: -25.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.8571
    Cell Significance Index: -31.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 63.7460
    Cell Significance Index: -32.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.6617
    Cell Significance Index: -12.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.9983
    Cell Significance Index: -25.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7789
    Cell Significance Index: -26.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.4060
    Cell Significance Index: -14.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.1241
    Cell Significance Index: -18.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0409
    Cell Significance Index: -10.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.8696
    Cell Significance Index: 71.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0443
    Cell Significance Index: 131.8900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.8034
    Cell Significance Index: 5.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6551
    Cell Significance Index: 29.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5789
    Cell Significance Index: 68.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5357
    Cell Significance Index: 101.9600
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.5322
    Cell Significance Index: 2.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3515
    Cell Significance Index: 317.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3001
    Cell Significance Index: 207.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2678
    Cell Significance Index: 26.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1912
    Cell Significance Index: 5.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1448
    Cell Significance Index: 7.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0771
    Cell Significance Index: 12.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0744
    Cell Significance Index: 14.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0052
    Cell Significance Index: 0.1300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0047
    Cell Significance Index: 0.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0034
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0138
    Cell Significance Index: -26.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0145
    Cell Significance Index: -0.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0206
    Cell Significance Index: -37.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0242
    Cell Significance Index: -37.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0281
    Cell Significance Index: -38.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0329
    Cell Significance Index: -11.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0330
    Cell Significance Index: -24.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0353
    Cell Significance Index: -26.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0415
    Cell Significance Index: -18.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0422
    Cell Significance Index: -30.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0480
    Cell Significance Index: -26.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0489
    Cell Significance Index: -27.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0684
    Cell Significance Index: -7.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0704
    Cell Significance Index: -31.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0782
    Cell Significance Index: -14.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0858
    Cell Significance Index: -1.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0889
    Cell Significance Index: -25.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0957
    Cell Significance Index: -16.3400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0981
    Cell Significance Index: -1.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1127
    Cell Significance Index: -2.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1384
    Cell Significance Index: -17.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1422
    Cell Significance Index: -17.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1431
    Cell Significance Index: -28.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1485
    Cell Significance Index: -31.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1508
    Cell Significance Index: -15.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1644
    Cell Significance Index: -7.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1751
    Cell Significance Index: -13.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1783
    Cell Significance Index: -7.3000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1839
    Cell Significance Index: -1.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1866
    Cell Significance Index: -25.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2098
    Cell Significance Index: -30.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2263
    Cell Significance Index: -15.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2434
    Cell Significance Index: -31.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2542
    Cell Significance Index: -26.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2557
    Cell Significance Index: -29.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2614
    Cell Significance Index: -18.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2644
    Cell Significance Index: -30.8100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2797
    Cell Significance Index: -1.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2848
    Cell Significance Index: -6.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2972
    Cell Significance Index: -16.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3063
    Cell Significance Index: -9.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3181
    Cell Significance Index: -14.9500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3820
    Cell Significance Index: -3.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4067
    Cell Significance Index: -17.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4238
    Cell Significance Index: -25.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4245
    Cell Significance Index: -31.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4263
    Cell Significance Index: -7.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4607
    Cell Significance Index: -13.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4994
    Cell Significance Index: -25.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5015
    Cell Significance Index: -18.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5047
    Cell Significance Index: -14.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5302
    Cell Significance Index: -27.8400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5521
    Cell Significance Index: -7.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5668
    Cell Significance Index: -14.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5723
    Cell Significance Index: -20.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5857
    Cell Significance Index: -27.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5951
    Cell Significance Index: -31.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6554
    Cell Significance Index: -12.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6674
    Cell Significance Index: -17.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6805
    Cell Significance Index: -22.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6807
    Cell Significance Index: -21.6800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.6893
    Cell Significance Index: -4.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7831
    Cell Significance Index: -16.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7854
    Cell Significance Index: -28.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8310
    Cell Significance Index: -22.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.8471
    Cell Significance Index: -20.5200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9137
    Cell Significance Index: -19.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9212
    Cell Significance Index: -22.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9397
    Cell Significance Index: -19.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9588
    Cell Significance Index: -20.3500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.9772
    Cell Significance Index: -8.6100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -1.0087
    Cell Significance Index: -17.3300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.0370
    Cell Significance Index: -21.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The EVI2B gene exhibits a wide range of expression profiles across different cell types, including CD14-positive classical monocytes, non-classical monocytes, IgG memory B cells, IgG-negative class-switched memory B cells, alveolar macrophages, DN3 thymocytes, transitional stage B cells, CD14-positive monocytes, IgA plasma cells, and mature T cells. The EVI2B protein is encoded by the ENSG00000185862 gene and is homologous to the ecotropic viral integration site 2. **Pathways and Functions:** The EVI2B gene is involved in multiple signaling pathways, including: 1. **Myeloid cell development:** EVI2B regulates the differentiation of granulocytes and neutrophils, crucial for the development of myeloid cells. 2. **Negative regulation of apoptotic process:** EVI2B inhibits apoptosis, ensuring the survival of cells and maintaining tissue homeostasis. 3. **Regulation of cell cycle:** EVI2B regulates cell cycle progression, ensuring proper cell division and proliferation. 4. **Regulation of stem cell division:** EVI2B regulates the division of stem cells, ensuring the maintenance of stem cell populations. **Clinical Significance:** The EVI2B gene has significant implications for various diseases, including: 1. **Immunodeficiency disorders:** Dysregulation of EVI2B expression has been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer:** EVI2B has been implicated in the development and progression of various cancers, including leukemia and lymphoma. 3. **Autoimmune diseases:** EVI2B may play a role in the regulation of immune responses and the development of autoimmune diseases. In conclusion, the EVI2B gene is a critical regulator of immunological processes, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the role of EVI2B in human health and disease.

Genular Protein ID: 23209564

Symbol: EVI2B_HUMAN

Name: Ecotropic viral integration site 2B protein homolog

UniProtKB Accession Codes:

P34910 B7Z4A7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 4 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1903357

Title: cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene.

PubMed ID: 1903357

DOI: 10.1016/0888-7543(91)90410-g

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28186500

Title: EVI2B is a C/EBPalpha target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.

PubMed ID: 28186500

DOI: 10.1038/cdd.2017.6

Sequence Information:

  • Length: 448
  • Mass: 48666
  • Checksum: 5BF2DC46798577E3
  • Sequence:
    • MDPKYFILIL FCGHLNNTFF SKTETITTEK QSQPTLFTSS MSQVLANSQN TTGNPLGQPT 
QFSDTFSGQS ISPAKVTAGQ PTPAVYTSSE KPEAHTSAGQ PLAYNTKQPT PIANTSSQQA 
VFTSARQLPS ARTSTTQPPK SFVYTFTQQS SSVQIPSRKQ ITVHNPSTQP TSTVKNSPRS 
TPGFILDTTS NKQTPQKNNY NSIAAILIGV LLTSMLVAII IIVLWKCLRK PVLNDQNWAG 
RSPFADGETP DICMDNIREN EISTKRTSII SLTPWKPSKS TLLADDLEIK LFESSENIED 
SNNPKTEKIK DQVNGTSEDS ADGSTVGTAV SSSDDADLPP PPPLLDLEGQ ESNQSDKPTM 
TIVSPLPNDS TSLPPSLDCL NQDCGDHKSE IIQSFPPLDS LNLPLPPVDF MKNQEDSNLE 
IQCQEFSIPP NSDQDLNESL PPPPAELL

Genular Protein ID: 1399445091

Symbol: Q9BRW1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BRW1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 IntAct 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 448
  • Mass: 48608
  • Checksum: C2D4072BCF5C5370
  • Sequence:
    • MDPKYFILIL FCGHLNNTFF SKTETITTEK QSQPTLFTSS MSQVLANSQN TTGNPLGQPT 
QFSDTFSGQS ISPAKVTAGQ PTPAVYTSSE KPEAHTSAGQ PLAYNTKQPT PIANTSSQQA 
VFTSARQLPS ARTSTTQPPK SFVYTFTQQS SSVQIPSRKQ ITVHNPSTQP TSTVKNSPRS 
TPGFILDTTS NKQTPQKNNY NSIAAILIGV LLTSMLVAII IIVLWKCLRK PVLNDQNWAG 
RSPFADGETP DICMDNIREN EISTKRTSII SLTPWKPSKS TLLADDLEIK LFESSENIED 
SNNPKTEKIK DQVNGTSEDS ADGSTVGTAV SSSDDAGLPP PPPLLDLEGQ ESNQSDKPTM 
TIVSPLPNDS TSLPPSLDCL NQDCGDHKSE IIQSFPPLDS LNLPLPPVDF MKNQEDSNLE 
IQCQEFSIPP NSDQDLNESL PPPPAELL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.