Details for: EVI2B

Gene ID: 2124

Symbol: EVI2B

Ensembl ID: ENSG00000185862

Description: ecotropic viral integration site 2B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.95
    Marker Score: 164746
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.62
    Marker Score: 6316
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.52
    Marker Score: 1517
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.49
    Marker Score: 2448
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.45
    Marker Score: 62763
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.42
    Marker Score: 1209
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.33
    Marker Score: 823
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.31
    Marker Score: 5744.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.26
    Marker Score: 1929
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.19
    Marker Score: 21698
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.13
    Marker Score: 5970
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.12
    Marker Score: 2420
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.09
    Marker Score: 1969
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.06
    Marker Score: 4008
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.01
    Marker Score: 1883
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.01
    Marker Score: 700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.99
    Marker Score: 1167
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.91
    Marker Score: 591
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.86
    Marker Score: 1133
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.83
    Marker Score: 18496
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.68
    Marker Score: 725
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.65
    Marker Score: 1784
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.63
    Marker Score: 1373
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.59
    Marker Score: 517
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1138
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.55
    Marker Score: 1554.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.54
    Marker Score: 17890
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.51
    Marker Score: 3916
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.5
    Marker Score: 825.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.47
    Marker Score: 4063
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.45
    Marker Score: 1298
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.45
    Marker Score: 2524
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.44
    Marker Score: 1439
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.44
    Marker Score: 383
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.44
    Marker Score: 1044
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.43
    Marker Score: 8680
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.39
    Marker Score: 713
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.36
    Marker Score: 1512
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.28
    Marker Score: 882
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.28
    Marker Score: 445
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.26
    Marker Score: 1522
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.25
    Marker Score: 947
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.25
    Marker Score: 593
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.24
    Marker Score: 1261
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.23
    Marker Score: 5285
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.23
    Marker Score: 832
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.22
    Marker Score: 5065
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.22
    Marker Score: 783
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.21
    Marker Score: 2730
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.21
    Marker Score: 1308
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.2
    Marker Score: 63254
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.19
    Marker Score: 685
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.18
    Marker Score: 4847
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.18
    Marker Score: 3439
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.18
    Marker Score: 689
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.16
    Marker Score: 503
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.16
    Marker Score: 506
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4732.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.12
    Marker Score: 1131
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.12
    Marker Score: 809
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.11
    Marker Score: 541
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.1
    Marker Score: 750
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.08
    Marker Score: 271
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.08
    Marker Score: 373
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.08
    Marker Score: 530
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.05
    Marker Score: 515
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.04
    Marker Score: 2544
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.04
    Marker Score: 763
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.03
    Marker Score: 984
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.03
    Marker Score: 574
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.03
    Marker Score: 426
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.01
    Marker Score: 842
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.01
    Marker Score: 434
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71714
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47941
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.98
    Marker Score: 299
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.98
    Marker Score: 3096
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.98
    Marker Score: 1090
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.98
    Marker Score: 338
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.97
    Marker Score: 644
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.95
    Marker Score: 1034
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.95
    Marker Score: 436
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.95
    Marker Score: 1226
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.94
    Marker Score: 571
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.94
    Marker Score: 2776
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.92
    Marker Score: 928
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.92
    Marker Score: 807
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.92
    Marker Score: 1217
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5116
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.89
    Marker Score: 201
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.88
    Marker Score: 439
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.88
    Marker Score: 667
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.88
    Marker Score: 557

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Other Information

**Key characteristics:** * EVI2B is a transmembrane protein that is expressed in high levels in myeloid cells. * It is a key regulator of myeloid cell development and differentiation. * EVI2B is also involved in the regulation of apoptosis. * It is expressed in a variety of cell types, including myeloid cells, T cells, and B cells. * It plays an important role in the development of the immune system. **Pathways and functions:** * EVI2B is involved in the regulation of cell cycle. It is expressed in cells that are in G1 phase of the cell cycle. When EVI2B is deleted, cells enter apoptosis. * EVI2B is also involved in the regulation of apoptosis. It is expressed in cells that are undergoing apoptosis. When EVI2B is deleted, apoptosis is inhibited. * EVI2B plays an important role in the development of the immune system. It is expressed in myeloid cells, which are the first cells to develop during immune system development. EVI2B is required for the development of myeloid cell-derived dendritic cells, macrophages, and neutrophils. **Clinical significance:** * Mutations in EVI2B have been linked to a number of human diseases, including cancer and autoimmune disorders. * EVI2B is a potential target for cancer immunotherapy. * Inhibition of EVI2B has been shown to inhibit cancer growth in animal models.

Genular Protein ID: 23209564

Symbol: EVI2B_HUMAN

Name: Ecotropic viral integration site 2B protein homolog

UniProtKB Accession Codes:

P34910 B7Z4A7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 4 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1903357

Title: cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene.

PubMed ID: 1903357

DOI: 10.1016/0888-7543(91)90410-g

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28186500

Title: EVI2B is a C/EBPalpha target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.

PubMed ID: 28186500

DOI: 10.1038/cdd.2017.6

Sequence Information:

  • Length: 448
  • Mass: 48666
  • Checksum: 5BF2DC46798577E3
  • Sequence:
    • MDPKYFILIL FCGHLNNTFF SKTETITTEK QSQPTLFTSS MSQVLANSQN TTGNPLGQPT 
QFSDTFSGQS ISPAKVTAGQ PTPAVYTSSE KPEAHTSAGQ PLAYNTKQPT PIANTSSQQA 
VFTSARQLPS ARTSTTQPPK SFVYTFTQQS SSVQIPSRKQ ITVHNPSTQP TSTVKNSPRS 
TPGFILDTTS NKQTPQKNNY NSIAAILIGV LLTSMLVAII IIVLWKCLRK PVLNDQNWAG 
RSPFADGETP DICMDNIREN EISTKRTSII SLTPWKPSKS TLLADDLEIK LFESSENIED 
SNNPKTEKIK DQVNGTSEDS ADGSTVGTAV SSSDDADLPP PPPLLDLEGQ ESNQSDKPTM 
TIVSPLPNDS TSLPPSLDCL NQDCGDHKSE IIQSFPPLDS LNLPLPPVDF MKNQEDSNLE 
IQCQEFSIPP NSDQDLNESL PPPPAELL

Genular Protein ID: 1399445091

Symbol: Q9BRW1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BRW1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 448
  • Mass: 48608
  • Checksum: C2D4072BCF5C5370
  • Sequence:
    • MDPKYFILIL FCGHLNNTFF SKTETITTEK QSQPTLFTSS MSQVLANSQN TTGNPLGQPT 
QFSDTFSGQS ISPAKVTAGQ PTPAVYTSSE KPEAHTSAGQ PLAYNTKQPT PIANTSSQQA 
VFTSARQLPS ARTSTTQPPK SFVYTFTQQS SSVQIPSRKQ ITVHNPSTQP TSTVKNSPRS 
TPGFILDTTS NKQTPQKNNY NSIAAILIGV LLTSMLVAII IIVLWKCLRK PVLNDQNWAG 
RSPFADGETP DICMDNIREN EISTKRTSII SLTPWKPSKS TLLADDLEIK LFESSENIED 
SNNPKTEKIK DQVNGTSEDS ADGSTVGTAV SSSDDAGLPP PPPLLDLEGQ ESNQSDKPTM 
TIVSPLPNDS TSLPPSLDCL NQDCGDHKSE IIQSFPPLDS LNLPLPPVDF MKNQEDSNLE 
IQCQEFSIPP NSDQDLNESL PPPPAELL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.