Details for: STXBP2

Gene ID: 6813

Symbol: STXBP2

Ensembl ID: ENSG00000076944

Description: syntaxin binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 138.3520
    Cell Significance Index: -21.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.5639
    Cell Significance Index: -22.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.6605
    Cell Significance Index: -25.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.9465
    Cell Significance Index: -27.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.4230
    Cell Significance Index: -27.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 41.4889
    Cell Significance Index: -27.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.7192
    Cell Significance Index: -25.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.9034
    Cell Significance Index: -24.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.1756
    Cell Significance Index: 132.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0501
    Cell Significance Index: -27.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9320
    Cell Significance Index: -18.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2112
    Cell Significance Index: -13.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.8909
    Cell Significance Index: 453.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.2453
    Cell Significance Index: 224.4300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.8617
    Cell Significance Index: 21.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.1316
    Cell Significance Index: 57.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5636
    Cell Significance Index: 93.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4701
    Cell Significance Index: 43.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3861
    Cell Significance Index: 64.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3058
    Cell Significance Index: 129.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2086
    Cell Significance Index: 11.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9137
    Cell Significance Index: 24.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8455
    Cell Significance Index: 54.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7074
    Cell Significance Index: 52.7200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.6828
    Cell Significance Index: 4.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6748
    Cell Significance Index: 121.6400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.6742
    Cell Significance Index: 1.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6683
    Cell Significance Index: 31.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6518
    Cell Significance Index: 33.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6066
    Cell Significance Index: 9.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5720
    Cell Significance Index: 70.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5687
    Cell Significance Index: 310.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4344
    Cell Significance Index: 51.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4051
    Cell Significance Index: 11.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3825
    Cell Significance Index: 345.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3566
    Cell Significance Index: 46.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3498
    Cell Significance Index: 56.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3275
    Cell Significance Index: 2.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3205
    Cell Significance Index: 9.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3101
    Cell Significance Index: 8.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3091
    Cell Significance Index: 3.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2664
    Cell Significance Index: 6.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2292
    Cell Significance Index: 101.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2169
    Cell Significance Index: 4.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2133
    Cell Significance Index: 5.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1793
    Cell Significance Index: 34.1200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1625
    Cell Significance Index: 1.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0966
    Cell Significance Index: 6.8300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0579
    Cell Significance Index: 0.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0563
    Cell Significance Index: 1.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0452
    Cell Significance Index: 34.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0269
    Cell Significance Index: 4.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0011
    Cell Significance Index: 0.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0088
    Cell Significance Index: -0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0123
    Cell Significance Index: -23.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0160
    Cell Significance Index: -11.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0253
    Cell Significance Index: -46.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0313
    Cell Significance Index: -23.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0313
    Cell Significance Index: -48.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0336
    Cell Significance Index: -21.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0361
    Cell Significance Index: -49.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0405
    Cell Significance Index: -1.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0458
    Cell Significance Index: -25.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0492
    Cell Significance Index: -30.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0545
    Cell Significance Index: -15.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0547
    Cell Significance Index: -19.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0686
    Cell Significance Index: -31.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0712
    Cell Significance Index: -14.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0751
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1083
    Cell Significance Index: -12.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1127
    Cell Significance Index: -2.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1200
    Cell Significance Index: -4.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1536
    Cell Significance Index: -19.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1561
    Cell Significance Index: -32.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1582
    Cell Significance Index: -23.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1615
    Cell Significance Index: -22.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2047
    Cell Significance Index: -4.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2622
    Cell Significance Index: -27.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2622
    Cell Significance Index: -6.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2719
    Cell Significance Index: -8.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2938
    Cell Significance Index: -23.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3174
    Cell Significance Index: -4.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3477
    Cell Significance Index: -4.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3622
    Cell Significance Index: -18.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3688
    Cell Significance Index: -8.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3713
    Cell Significance Index: -10.9400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3872
    Cell Significance Index: -7.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3872
    Cell Significance Index: -29.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3938
    Cell Significance Index: -24.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4179
    Cell Significance Index: -28.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4294
    Cell Significance Index: -14.9200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4432
    Cell Significance Index: -7.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4513
    Cell Significance Index: -27.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4573
    Cell Significance Index: -28.1100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4600
    Cell Significance Index: -4.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5035
    Cell Significance Index: -5.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5268
    Cell Significance Index: -29.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5604
    Cell Significance Index: -4.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5790
    Cell Significance Index: -25.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** STXBP2 is a member of the syntaxin-binding protein family, which interacts with syntaxin-1 and syntaxin-3, two essential components of the SNARE complex involved in vesicle fusion and exocytosis. STXBP2 has been shown to regulate the activity of these syntaxins, modulating the release of various granule contents, including cytotoxins, chemokines, and cytokines. The protein's ability to bind to syntaxin-1 and syntaxin-3 also suggests its involvement in neurotransmitter secretion and platelet activation. **Pathways and Functions** STXBP2 is involved in several signaling pathways, including: 1. **Cytolytic granule formation and release**: STXBP2 regulates the release of cytotoxins from cytolytic granules, which are essential for the killing of pathogens and tumor cells. 2. **Immune cell regulation**: STXBP2 modulates the function of immune cells, including monocytes, macrophages, and neutrophils, influencing their ability to recognize and respond to pathogens. 3. **Neurotransmitter secretion**: STXBP2 is involved in the regulation of neurotransmitter release, which is essential for synaptic transmission and neural function. 4. **Platelet activation and aggregation**: STXBP2 regulates the release of platelet granules, which is crucial for platelet function and blood coagulation. **Clinical Significance** Dysregulation of STXBP2 has been implicated in various diseases, including: 1. **Autoimmune disorders**: Abnormalities in STXBP2 expression and function have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: STXBP2 has been shown to be overexpressed in certain types of cancer, including lung cancer and breast cancer, suggesting its potential role in tumorigenesis. 3. **Immunodeficiency disorders**: Mutations in the STXBP2 gene have been associated with immunodeficiency disorders, highlighting the protein's critical role in immune cell function. In conclusion, STXBP2 is a multifunctional protein that plays a crucial role in various cellular processes, including protein transport, vesicle-mediated transport, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of STXBP2 function and its potential therapeutic applications.

Genular Protein ID: 2460131438

Symbol: STXB2_HUMAN

Name: Syntaxin-binding protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8921365

Title: Molecular characterization of a nonneuronal human UNC18 homolog.

PubMed ID: 8921365

DOI: 10.1006/geno.1996.0515

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19804848

Title: Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11.

PubMed ID: 19804848

DOI: 10.1016/j.ajhg.2009.09.005

PubMed ID: 19884660

Title: Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells.

PubMed ID: 19884660

DOI: 10.1172/jci40732

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 593
  • Mass: 66453
  • Checksum: 98E27B55309168A9
  • Sequence:
  • MAPSGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED 
    INKRREPIPS LEAIYLLSPT EKSVQALIKD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR 
    SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAEERTRQLE VLAQQIATLC 
    ATLQEYPAIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV 
    SPLLHELTFQ AMAYDLLDIE QDTYRYETTG LSEAREKAVL LDEDDDLWVE LRHMHIADVS 
    KKVTELLRTF CESKRLTTDK ANIKDLSQIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS 
    VEKLCSVEQD LAMGSDAEGE KIKDSMKLIV PVLLDAAVPA YDKIRVLLLY ILLRNGVSEE 
    NLAKLIQHAN VQAHSSLIRN LEQLGGTVTN PGGSGTSSRL EPRERMEPTY QLSRWTPVIK 
    DVMEDAVEDR LDRNLWPFVS DPAPTASSQA AVSARFGHWH KNKAGIEARA GPRLIVYVMG 
    GVAMSEMRAA YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KALDKKLEDI ALP

Genular Protein ID: 1170956516

Symbol: Q53GF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 593
  • Mass: 66366
  • Checksum: 5BE27B47B2021A2B
  • Sequence:
  • MAPSGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED 
    INKRREPIPS LEAIYLLSPT EKSVQALIKD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR 
    SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAEERTRQLE VLAQQIATLC 
    ATLQEYPAIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV 
    SPLLHELTFQ AMAYDLLDIE QDTYRYETTG LSEAREKAVL LDEDDDLWVE LRHMHIADVS 
    KKVTELLRTF CESKRLTTDK ANIKDLSQIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS 
    VEKLCSVEQD LAMGSDAEGE KIKDSMKLIV PVLLDAAVPA YDKIRVLLLY ILLRNGVSEE 
    NLAKLIQHAN VQAHSSLIRN LEQLGGTVTN PGGSGTSSRL EPRERMEPTY QLSRWTPVIK 
    DVMEDAVEDR LDRNLWPFVS DPAPTASSQA AVSARFGHWH KNKAGVEARA GPRLIVYVMG 
    GVAMSEMRAA YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KALDKKLGDI ALP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.