Details for: FCGRT

Gene ID: 2217

Symbol: FCGRT

Ensembl ID: ENSG00000104870

Description: Fc gamma receptor and transporter

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.44
    Marker Score: 3934.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.42
    Marker Score: 191407
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.06
    Marker Score: 4435
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.04
    Marker Score: 5932
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.99
    Marker Score: 2990
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.94
    Marker Score: 14094
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.76
    Marker Score: 8661
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.74
    Marker Score: 70130
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.74
    Marker Score: 6956
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.64
    Marker Score: 2248
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.63
    Marker Score: 4047
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.63
    Marker Score: 1072
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.59
    Marker Score: 16861
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.57
    Marker Score: 6392
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.55
    Marker Score: 1829
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.45
    Marker Score: 6427
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.43
    Marker Score: 10477
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4
    Marker Score: 81692
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.39
    Marker Score: 4768
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.33
    Marker Score: 1319
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.33
    Marker Score: 6043.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.31
    Marker Score: 1272
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.28
    Marker Score: 2146
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.28
    Marker Score: 5496
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.27
    Marker Score: 846
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.27
    Marker Score: 5387
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.26
    Marker Score: 943
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.26
    Marker Score: 1944
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.21
    Marker Score: 5012
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.19
    Marker Score: 13316
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.18
    Marker Score: 2093
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.17
    Marker Score: 5471
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.16
    Marker Score: 28469
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.15
    Marker Score: 3644
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.15
    Marker Score: 24237
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.15
    Marker Score: 894
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.14
    Marker Score: 7611
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.12
    Marker Score: 2281
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.07
    Marker Score: 3436
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.07
    Marker Score: 587
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.06
    Marker Score: 777
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.05
    Marker Score: 3267
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.05
    Marker Score: 497
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.04
    Marker Score: 470
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.02
    Marker Score: 7807
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2
    Marker Score: 1414
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.99
    Marker Score: 727
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.98
    Marker Score: 12642
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.94
    Marker Score: 3188.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.93
    Marker Score: 423
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.92
    Marker Score: 2372
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.92
    Marker Score: 10099
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.92
    Marker Score: 14261
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.91
    Marker Score: 2032
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.91
    Marker Score: 552
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.89
    Marker Score: 2750
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.89
    Marker Score: 2911
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.88
    Marker Score: 6973
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.88
    Marker Score: 730
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.87
    Marker Score: 1896
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.86
    Marker Score: 396
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.85
    Marker Score: 21563
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.83
    Marker Score: 588
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.83
    Marker Score: 946
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.82
    Marker Score: 4965
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.82
    Marker Score: 1644
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.82
    Marker Score: 1002
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.82
    Marker Score: 4877
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.82
    Marker Score: 2574
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.81
    Marker Score: 4424
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.81
    Marker Score: 523
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.8
    Marker Score: 1614
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.75
    Marker Score: 1690
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.74
    Marker Score: 1868
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.74
    Marker Score: 1769.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.73
    Marker Score: 549
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.73
    Marker Score: 2090
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.73
    Marker Score: 853
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.72
    Marker Score: 429
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.71
    Marker Score: 1826
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.71
    Marker Score: 429
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7
    Marker Score: 17057
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.69
    Marker Score: 709
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.67
    Marker Score: 10888.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.66
    Marker Score: 1724
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.65
    Marker Score: 3766
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.65
    Marker Score: 1835
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.65
    Marker Score: 2263
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.63
    Marker Score: 380
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.63
    Marker Score: 652
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.63
    Marker Score: 1122
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.62
    Marker Score: 698
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.62
    Marker Score: 808
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.61
    Marker Score: 556
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.58
    Marker Score: 455
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.58
    Marker Score: 2536
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.57
    Marker Score: 6531
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.57
    Marker Score: 1565
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.56
    Marker Score: 2302
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.56
    Marker Score: 3667.5

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Other Information

**Key characteristics** * The FCGRT gene is located on chromosome 17q21.1. * It is a single-exon gene encoding a protein of 136 amino acids. * The protein is a glycoprotein that is expressed on the surface of immune cells. * It is a member of the immunoglobulin superfamily, which are a large family of cell surface receptors that are involved in the immune response. **Pathways and functions** The FCGRT gene is involved in a variety of immune pathways, including: * Beta-2-microglobulin binding: FCGRT is expressed on the surface of immune cells, and it binds to beta-2-microglobulin, a protein that is expressed on the surface of antigen-presenting cells. This binding is important for the activation of immune cells. * Endosome membrane: FCGRT is also expressed on the surface of endosomes, which are small organelles that are involved in the endocytosis of molecules. This binding is important for the internalization of ligands by immune cells. * Extracellular space: FCGRT is also expressed on the surface of the extracellular space, which is a fluid-filled space that surrounds cells. This binding is important for the interaction of immune cells with extracellular molecules. * Igg binding: FCGRT is also expressed on the surface of epithelial cells, where it binds to immunoglobulin G (Ig). This binding is important for the internalization of IgGs by epithelial cells. * Peptide antigen binding: FCGRT is also expressed on the surface of cells that are presenting peptides. This binding is important for the activation of immune cells that are presenting peptides. **Clinical significance** Mutations in the FCGRT gene have been linked to a number of human diseases, including: * Rheumatoid arthritis: Rheumatoid arthritis is a chronic inflammatory disease of the joints that is characterized by joint pain, swelling, and stiffness. Mutations in the FCGRT gene have been linked to the development of rheumatoid arthritis in some patients. * Crohn's disease: Crohn's disease is a chronic inflammatory disease of the digestive tract that is characterized by diarrhea, abdominal pain, and weight loss. Mutations in the FCGRT gene have been linked to the development of Crohn's disease in some patients. * Multiple sclerosis: Multiple sclerosis is a chronic inflammatory disease of the central nervous system that is characterized by muscle weakness, numbness, and vision problems. Mutations in the FCGRT gene have been linked to the development of multiple sclerosis in some patients.

Genular Protein ID: 1095494652

Symbol: FCGRN_HUMAN

Name: IgG receptor FcRn large subunit p51

UniProtKB Accession Codes:

P55899 Q5HYM5 Q9HBV7 Q9NZ19

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 EMDB 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 25 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7964511

Title: A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus.

PubMed ID: 7964511

DOI: 10.1084/jem.180.6.2377

PubMed ID: 10998088

Title: Cloning and analysis of the gene encoding the human neonatal Fc receptor.

PubMed ID: 10998088

DOI: 10.1046/j.1365-2370.2000.00225.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12578848

Title: Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans.

PubMed ID: 12578848

DOI: 10.1093/intimm/dxg018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30808762

Title: The neonatal Fc receptor is a pan-echovirus receptor.

PubMed ID: 30808762

DOI: 10.1073/pnas.1817341116

PubMed ID: 31104841

Title: Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.

PubMed ID: 31104841

DOI: 10.1016/j.cell.2019.04.035

PubMed ID: 10933786

Title: Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor.

PubMed ID: 10933786

DOI: 10.1021/bi000749m

PubMed ID: 24469444

Title: Structural insights into neonatal Fc receptor-based recycling mechanisms.

PubMed ID: 24469444

DOI: 10.1074/jbc.m113.537563

PubMed ID: 28330995

Title: Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.

PubMed ID: 28330995

DOI: 10.1073/pnas.1618291114

Sequence Information:

  • Length: 365
  • Mass: 39743
  • Checksum: C886C6A1F66A0D89
  • Sequence:
    • MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS 
YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE 
LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF 
SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL 
AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV 
VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA QDADLKDVNV 
IPATA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.