Details for: FCGRT

Gene ID: 2217

Symbol: FCGRT

Ensembl ID: ENSG00000104870

Description: Fc gamma receptor and transporter

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 289.8192
    Cell Significance Index: -45.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 197.3243
    Cell Significance Index: -50.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 143.4163
    Cell Significance Index: -59.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 126.0054
    Cell Significance Index: -59.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 116.4108
    Cell Significance Index: -59.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 88.5366
    Cell Significance Index: -59.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.8969
    Cell Significance Index: -52.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.0757
    Cell Significance Index: -53.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.6626
    Cell Significance Index: -54.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.8784
    Cell Significance Index: -54.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6289
    Cell Significance Index: -18.8900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 7.7523
    Cell Significance Index: 45.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.2707
    Cell Significance Index: 115.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.3579
    Cell Significance Index: 77.0100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.5083
    Cell Significance Index: 44.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.2206
    Cell Significance Index: 412.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.9957
    Cell Significance Index: 411.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.8599
    Cell Significance Index: 32.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4039
    Cell Significance Index: 63.2100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.3817
    Cell Significance Index: 14.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.2297
    Cell Significance Index: 33.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.0420
    Cell Significance Index: 58.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.6894
    Cell Significance Index: 45.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5441
    Cell Significance Index: 115.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5037
    Cell Significance Index: 148.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5006
    Cell Significance Index: 43.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4928
    Cell Significance Index: 192.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4646
    Cell Significance Index: 290.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4040
    Cell Significance Index: 65.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2250
    Cell Significance Index: 26.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9720
    Cell Significance Index: 20.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9442
    Cell Significance Index: 515.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8587
    Cell Significance Index: 105.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8108
    Cell Significance Index: 22.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7444
    Cell Significance Index: 33.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7188
    Cell Significance Index: 129.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7092
    Cell Significance Index: 313.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7036
    Cell Significance Index: 33.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6148
    Cell Significance Index: 555.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4561
    Cell Significance Index: 77.8900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.4323
    Cell Significance Index: 3.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3669
    Cell Significance Index: 69.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2598
    Cell Significance Index: 5.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1932
    Cell Significance Index: 6.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1677
    Cell Significance Index: 5.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1225
    Cell Significance Index: 2.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0933
    Cell Significance Index: 2.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0890
    Cell Significance Index: 9.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0671
    Cell Significance Index: 49.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0340
    Cell Significance Index: 25.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0278
    Cell Significance Index: 52.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0058
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0171
    Cell Significance Index: -12.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0259
    Cell Significance Index: -47.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0315
    Cell Significance Index: -48.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0397
    Cell Significance Index: -25.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0471
    Cell Significance Index: -64.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0542
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0561
    Cell Significance Index: -35.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0666
    Cell Significance Index: -19.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0713
    Cell Significance Index: -40.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0813
    Cell Significance Index: -36.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0835
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1335
    Cell Significance Index: -15.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1440
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1569
    Cell Significance Index: -33.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1599
    Cell Significance Index: -57.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1760
    Cell Significance Index: -4.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2280
    Cell Significance Index: -14.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2469
    Cell Significance Index: -12.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2541
    Cell Significance Index: -36.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2566
    Cell Significance Index: -29.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2809
    Cell Significance Index: -56.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3177
    Cell Significance Index: -8.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4068
    Cell Significance Index: -47.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4214
    Cell Significance Index: -48.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4795
    Cell Significance Index: -36.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5175
    Cell Significance Index: -53.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6149
    Cell Significance Index: -48.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8930
    Cell Significance Index: -56.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8967
    Cell Significance Index: -31.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9054
    Cell Significance Index: -60.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.9080
    Cell Significance Index: -7.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9262
    Cell Significance Index: -56.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9415
    Cell Significance Index: -27.7300
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.9417
    Cell Significance Index: -5.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.9424
    Cell Significance Index: -7.6900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.9506
    Cell Significance Index: -9.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9687
    Cell Significance Index: -59.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9734
    Cell Significance Index: -54.6200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.9850
    Cell Significance Index: -15.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1004
    Cell Significance Index: -29.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1070
    Cell Significance Index: -11.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.1158
    Cell Significance Index: -45.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1190
    Cell Significance Index: -58.7500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -1.1950
    Cell Significance Index: -9.6800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -1.2266
    Cell Significance Index: -7.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.3211
    Cell Significance Index: -33.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.3688
    Cell Significance Index: -36.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3879
    Cell Significance Index: -61.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The FCGRT gene has several distinct characteristics that underscore its significance in the immune system: 1. **Structure:** The FcγRII is a heterodimeric receptor composed of two subunits, p51 and p55, which are encoded by the FCGRT gene. 2. **Function:** The FcγRII mediates the binding and internalization of IgG antibodies, facilitating their recycling and preventing their clearance. 3. **Expression:** The FcγRII is expressed on various cell types, including macrophages, monocytes, endothelial cells, and epithelial cells, highlighting its broad role in immune regulation. 4. **Cellular localization:** The FcγRII is primarily localized to the surface of immune cells, where it can interact with IgG antibodies. **Pathways and Functions:** The FcγRII is intricately involved in several key pathways that regulate immune responses: 1. **Antibody-mediated immunity:** The FcγRII plays a critical role in the regulation of IgG-mediated immune responses, including the clearance of immune complexes and the prevention of autoimmune damage. 2. **Immune complex clearance:** The FcγRII facilitates the internalization of IgG antibodies, allowing for their recycling and preventing their clearance. 3. **Immune cell activation:** The FcγRII can activate immune cells, such as macrophages and monocytes, in response to IgG antibodies. 4. **Endocytosis:** The FcγRII is involved in the endocytosis of IgG antibodies, allowing for their internalization and recycling. **Clinical Significance:** Dysregulation of the FcγRII has been implicated in various diseases, including: 1. **Autoimmune disorders:** Altered FcγRII expression and function have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Immunodeficiency disorders:** Deficiencies in FcγRII have been associated with impaired antibody-mediated immunity and increased susceptibility to infections. 3. **Cancer:** The FcγRII has been implicated in the progression and metastasis of certain cancers, such as breast and lung cancer. 4. **Vaccine development:** The FcγRII has been targeted in vaccine development, as it plays a critical role in the regulation of immune responses to vaccine antigens. In conclusion, the FCGRT gene and its encoded protein, FcγRII, play a vital role in the regulation of immune responses and are implicated in various diseases. Further research into the function and dysregulation of the FcγRII is essential for the development of novel therapeutic strategies and the improvement of immune-related disorders.

Genular Protein ID: 1095494652

Symbol: FCGRN_HUMAN

Name: IgG receptor FcRn large subunit p51

UniProtKB Accession Codes:

P55899 Q5HYM5 Q9HBV7 Q9NZ19

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 7 EMDB 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7964511

Title: A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus.

PubMed ID: 7964511

DOI: 10.1084/jem.180.6.2377

PubMed ID: 10998088

Title: Cloning and analysis of the gene encoding the human neonatal Fc receptor.

PubMed ID: 10998088

DOI: 10.1046/j.1365-2370.2000.00225.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12578848

Title: Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans.

PubMed ID: 12578848

DOI: 10.1093/intimm/dxg018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30808762

Title: The neonatal Fc receptor is a pan-echovirus receptor.

PubMed ID: 30808762

DOI: 10.1073/pnas.1817341116

PubMed ID: 31104841

Title: Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.

PubMed ID: 31104841

DOI: 10.1016/j.cell.2019.04.035

PubMed ID: 10933786

Title: Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor.

PubMed ID: 10933786

DOI: 10.1021/bi000749m

PubMed ID: 24469444

Title: Structural insights into neonatal Fc receptor-based recycling mechanisms.

PubMed ID: 24469444

DOI: 10.1074/jbc.m113.537563

PubMed ID: 28330995

Title: Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.

PubMed ID: 28330995

DOI: 10.1073/pnas.1618291114

Sequence Information:

  • Length: 365
  • Mass: 39743
  • Checksum: C886C6A1F66A0D89
  • Sequence:
    • MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS 
YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE 
LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF 
SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL 
AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV 
VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA QDADLKDVNV 
IPATA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.