Details for: GNAI2

Gene ID: 2771

Symbol: GNAI2

Ensembl ID: ENSG00000114353

Description: G protein subunit alpha i2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.38
    Marker Score: 3094
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.36
    Marker Score: 18099.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.65
    Marker Score: 2064
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.6
    Marker Score: 2182
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.55
    Marker Score: 198749
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.41
    Marker Score: 2891
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.28
    Marker Score: 1697.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.92
    Marker Score: 3346
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.86
    Marker Score: 5571.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.78
    Marker Score: 4030
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.64
    Marker Score: 6721.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.6
    Marker Score: 1567
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.59
    Marker Score: 6445
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.54
    Marker Score: 2380.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.51
    Marker Score: 1082
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.5
    Marker Score: 7001.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.48
    Marker Score: 25150
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.44
    Marker Score: 864
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.43
    Marker Score: 4859
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.43
    Marker Score: 2392
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.38
    Marker Score: 27710.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.35
    Marker Score: 60178.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.33
    Marker Score: 1164
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.3
    Marker Score: 2476
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.29
    Marker Score: 1926
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.23
    Marker Score: 1358
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.2
    Marker Score: 2196
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.19
    Marker Score: 679
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.18
    Marker Score: 2054
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.16
    Marker Score: 755
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.14
    Marker Score: 1841
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.13
    Marker Score: 2367
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.11
    Marker Score: 694
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.1
    Marker Score: 5078
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.1
    Marker Score: 875
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.08
    Marker Score: 897
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.06
    Marker Score: 1453
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.06
    Marker Score: 2220
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.05
    Marker Score: 5308
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.04
    Marker Score: 1122
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.03
    Marker Score: 7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2
    Marker Score: 69216
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2
    Marker Score: 1192
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.99
    Marker Score: 1112
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.98
    Marker Score: 5472.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.98
    Marker Score: 601
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.97
    Marker Score: 708
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.97
    Marker Score: 803
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.97
    Marker Score: 3327
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.96
    Marker Score: 1772
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.95
    Marker Score: 573
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.95
    Marker Score: 21988.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.94
    Marker Score: 19241
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.93
    Marker Score: 2657.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.93
    Marker Score: 1374
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.92
    Marker Score: 2789
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.91
    Marker Score: 1194
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.91
    Marker Score: 2808
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.9
    Marker Score: 1292.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.89
    Marker Score: 403
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.88
    Marker Score: 602
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.87
    Marker Score: 1987
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.86
    Marker Score: 11296.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.85
    Marker Score: 7555.5
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.84
    Marker Score: 635
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.84
    Marker Score: 7652.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.81
    Marker Score: 705
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8
    Marker Score: 429
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.79
    Marker Score: 679
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.79
    Marker Score: 562
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.79
    Marker Score: 60893
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.79
    Marker Score: 11422
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.77
    Marker Score: 1292
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.77
    Marker Score: 1177
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.76
    Marker Score: 17738
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.76
    Marker Score: 614
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.76
    Marker Score: 3145
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.76
    Marker Score: 607
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.75
    Marker Score: 724
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.74
    Marker Score: 405.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.74
    Marker Score: 851
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.74
    Marker Score: 11309
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.73
    Marker Score: 1877
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.73
    Marker Score: 643
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.71
    Marker Score: 30443
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.71
    Marker Score: 412
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.71
    Marker Score: 827
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.7
    Marker Score: 1169
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.69
    Marker Score: 388
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.68
    Marker Score: 1695.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.66
    Marker Score: 1587
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.64
    Marker Score: 434
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.63
    Marker Score: 430
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.63
    Marker Score: 938
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.63
    Marker Score: 370
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.63
    Marker Score: 1658
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.63
    Marker Score: 836
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.63
    Marker Score: 4424
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.61
    Marker Score: 1035
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.61
    Marker Score: 2800

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Other Information

**Key characteristics:** - GNAI2 is a single-exon gene encoding a 125-amino acid protein. - It is highly expressed in immune cells, particularly monocytes and dendritic cells. - The protein is a key regulator of insulin secretion by inhibiting the action of the hormone insulin. **Pathways and functions:** - GNAI2 is a key regulator of the Adp signalling pathway through the p2y purinoceptor 12. - It also inhibits the Adrenaline, noradrenaline, and guanosine 5'-triphosphate (EGFR) signalling pathways. - It plays a role in disease processes, including inflammatory diseases, and may contribute to the development of metabolic disorders. **Clinical significance:** - Mutations in the GNAI2 gene have been linked to several human diseases, including diabetes, obesity, and cardiovascular disease. - Inhibitors of GNAI2 have been investigated as potential therapeutic agents for these diseases. **Additional context:** - GNAI2 is a member of the GPCR superfamily, which is a large family of cell surface receptors that are involved in a variety of cellular processes, including signal transduction, cell adhesion, and inflammation. - The protein is also involved in the regulation of platelet aggregation and inflammation.

Genular Protein ID: 3556451687

Symbol: GNAI2_HUMAN

Name: Guanine nucleotide-binding protein G(i) subunit alpha-2

UniProtKB Accession Codes:

P04899 B3KTZ0 B4DYA0 B4E2X5 Q6B6N3 Q8IZ71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 25 EMDB 13 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 44 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 13 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 10 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3100330

Title: Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA.

PubMed ID: 3100330

DOI: 10.1016/0014-5793(87)81428-x

PubMed ID: 3120178

Title: A small multigene family encodes Gi signal-transduction proteins.

PubMed ID: 3120178

DOI: 10.1073/pnas.84.22.7886

PubMed ID: 2834384

Title: Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.

PubMed ID: 2834384

DOI: 10.1016/s0021-9258(18)68692-2

PubMed ID: 17550964

Title: Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool.

PubMed ID: 17550964

DOI: 10.1242/jcs.005611

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2837412

Title: Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein.

PubMed ID: 2837412

DOI: 10.1016/0014-5793(88)80764-6

PubMed ID: 8662698

Title: Physical association of Gi2alpha with interleukin-8 receptors.

PubMed ID: 8662698

DOI: 10.1074/jbc.271.22.12783

PubMed ID: 12359238

Title: Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2.

PubMed ID: 12359238

DOI: 10.1016/s0006-291x(02)02277-5

PubMed ID: 17635935

Title: Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

PubMed ID: 17635935

DOI: 10.1083/jcb.200604114

PubMed ID: 19211784

Title: GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.

PubMed ID: 19211784

DOI: 10.1073/pnas.0900294106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

PubMed ID: 26126266

Title: Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.

PubMed ID: 26126266

DOI: 10.7554/elife.07091

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28219978

Title: A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.

PubMed ID: 28219978

DOI: 10.1161/circresaha.116.310112

Sequence Information:

  • Length: 355
  • Mass: 40451
  • Checksum: BE6D6FF720CF3DCC
  • Sequence:
    • MGCTVSAEDK AAAERSKMID KNLREDGEKA AREVKLLLLG AGESGKSTIV KQMKIIHEDG 
YSEEECRQYR AVVYSNTIQS IMAIVKAMGN LQIDFADPSR ADDARQLFAL SCTAEEQGVL 
PDDLSGVIRR LWADHGVQAC FGRSREYQLN DSAAYYLNDL ERIAQSDYIP TQQDVLRTRV 
KTTGIVETHF TFKDLHFKMF DVGGQRSERK KWIHCFEGVT AIIFCVALSA YDLVLAEDEE 
MNRMHESMKL FDSICNNKWF TDTSIILFLN KKDLFEEKIT HSPLTICFPE YTGANKYDEA 
ASYIQSKFED LNKRKDTKEI YTHFTCATDT KNVQFVFDAV TDVIIKNNLK DCGLF

Genular Protein ID: 1434847489

Symbol: B3KX51_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KX51

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SMART 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 303
  • Mass: 34908
  • Checksum: FE6EFCB4A1A57BCE
  • Sequence:
    • MKIIHEDGYS EEECRQYRAV VYSNTIQSIM AIVKAMGNLQ IDFADPSRAD DARQLFALSC 
TAEEQGVLPD DLSGVIRRLW ADHGVQACFG RSREYQLNDS AAYYLNDLER IAQSDYIPTQ 
QDVLRTRVKT TGIVETHFTF KDLHFKMFDV GGQRSERKKW IHCFEGVTAI IFCVALSAYD 
LVLAEDEEMS RMHESMKLFD SICNNKWFTD TSIILFLNKK DLFEEKITHS PLTICFPEYT 
GANKYDEAAS YIQSKFEDLN KRKDTKEIYT HFTCATDTKN VQFVFDAVTD VIIKNNLKDC 
GLF

Genular Protein ID: 1152198046

Symbol: B3KP24_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KP24

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 6 SMART 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 274
  • Mass: 31473
  • Checksum: 6B456A851303D295
  • Sequence:
    • MAIVKAMGNL QIDFADPSRA DDARQLFALS CTAEEQGVLP DDLSGVIRRL WADHGVQACF 
GRSREYQLND SAAYYLNDLE RIAQSDYIPT QQDVLRTRVK TTGIVETHFT FKDLHFKMFD 
VGGQRSERKK WIHCFEGVTA IIFCVALSAY DLVLAENEEM NRMHESMKLF DSICNNKWFT 
DTSIILFLNK KDPFEEKITH SPLTICFPEY TGANKYDEAA SYIQSKFEDL NKRKDTKEIY 
THFTCATDTK NVQFVFDAVT DVIIKNNLKD CGLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.