Details for: TYMP
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 245.5234
Cell Significance Index: -38.1900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 149.2647
Cell Significance Index: -37.8600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 92.0107
Cell Significance Index: -37.3800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 84.0036
Cell Significance Index: -39.6600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 78.3848
Cell Significance Index: -40.3200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 59.2380
Cell Significance Index: -39.7500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 39.1624
Cell Significance Index: -37.3900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 31.1690
Cell Significance Index: -38.4300 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 20.0838
Cell Significance Index: 172.5800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.5278
Cell Significance Index: -41.5500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 12.3483
Cell Significance Index: 228.2300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.9593
Cell Significance Index: -39.3000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.4107
Cell Significance Index: -25.2100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.8367
Cell Significance Index: -19.3400 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 3.5496
Cell Significance Index: 21.8500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.9411
Cell Significance Index: 138.2300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.6206
Cell Significance Index: 75.1200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.0941
Cell Significance Index: 156.0700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.5777
Cell Significance Index: 46.3400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.4535
Cell Significance Index: 102.8000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.3480
Cell Significance Index: 1217.1800 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.2964
Cell Significance Index: 167.4900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.1636
Cell Significance Index: 514.4600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.1407
Cell Significance Index: 31.8800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1312
Cell Significance Index: 30.7900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0138
Cell Significance Index: 60.8600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9577
Cell Significance Index: 104.1700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.8722
Cell Significance Index: 101.6500 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.4927
Cell Significance Index: 4.0800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4091
Cell Significance Index: 7.2300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.4049
Cell Significance Index: 4.6000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3903
Cell Significance Index: 10.4400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3123
Cell Significance Index: 40.0300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2941
Cell Significance Index: 47.8300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2804
Cell Significance Index: 153.1400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2663
Cell Significance Index: 5.7700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2346
Cell Significance Index: 42.2900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2298
Cell Significance Index: 11.9400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2287
Cell Significance Index: 28.1300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2286
Cell Significance Index: 10.6600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1854
Cell Significance Index: 9.3700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1755
Cell Significance Index: 17.3600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1431
Cell Significance Index: 28.3900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1078
Cell Significance Index: 3.1100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1012
Cell Significance Index: 19.2600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0617
Cell Significance Index: 8.4700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0388
Cell Significance Index: 4.5800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0315
Cell Significance Index: 1.4300 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0261
Cell Significance Index: 2.6700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0194
Cell Significance Index: 14.6600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0081
Cell Significance Index: -12.4400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0145
Cell Significance Index: -26.6900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0166
Cell Significance Index: -31.2000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0289
Cell Significance Index: -20.0100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0337
Cell Significance Index: -45.8200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0421
Cell Significance Index: -30.8800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0559
Cell Significance Index: -41.4400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0560
Cell Significance Index: -35.5900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0584
Cell Significance Index: -1.4600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0663
Cell Significance Index: -41.4100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0765
Cell Significance Index: -43.1400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0915
Cell Significance Index: -41.5500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0976
Cell Significance Index: -34.9900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1055
Cell Significance Index: -6.8100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1178
Cell Significance Index: -33.9000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1262
Cell Significance Index: -25.3200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1295
Cell Significance Index: -14.8400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1577
Cell Significance Index: -26.9200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2189
Cell Significance Index: -46.1000 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2191
Cell Significance Index: -1.8400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2268
Cell Significance Index: -4.8300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2563
Cell Significance Index: -37.2600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3631
Cell Significance Index: -5.4400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3802
Cell Significance Index: -39.5900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4180
Cell Significance Index: -25.6300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4246
Cell Significance Index: -13.6000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4267
Cell Significance Index: -32.7500 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4391
Cell Significance Index: -8.5700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4554
Cell Significance Index: -36.0700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4880
Cell Significance Index: -25.4200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5289
Cell Significance Index: -32.5100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5365
Cell Significance Index: -7.3200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5770
Cell Significance Index: -23.6400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5961
Cell Significance Index: -37.5700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6088
Cell Significance Index: -40.9400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7096
Cell Significance Index: -39.8200 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.7733
Cell Significance Index: -15.1200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8329
Cell Significance Index: -43.7300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.8333
Cell Significance Index: -22.2500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8620
Cell Significance Index: -38.1300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.9018
Cell Significance Index: -33.1100 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.9068
Cell Significance Index: -7.3500 - Cell Name: peg cell (CL4033014)
Fold Change: -0.9098
Cell Significance Index: -21.0200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9406
Cell Significance Index: -27.7100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.0085
Cell Significance Index: -38.1900 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -1.0180
Cell Significance Index: -13.1100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.0370
Cell Significance Index: -36.0400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.0523
Cell Significance Index: -18.1400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.0548
Cell Significance Index: -25.5500 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.1046
Cell Significance Index: -17.0900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2998326775
Symbol: TYPH_HUMAN
Name: Gliostatin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2467210
Title: Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
PubMed ID: 2467210
DOI: 10.1038/338557a0
PubMed ID: 1580101
Title: Expression of recombinant platelet-derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae.
PubMed ID: 1580101
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1570012
PubMed ID: 1400349
Title: Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor.
PubMed ID: 1400349
PubMed ID: 1590793
Title: Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
PubMed ID: 1590793
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 14725767
Title: Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor.
PubMed ID: 14725767
PubMed ID: 16803458
Title: Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design.
PubMed ID: 16803458
DOI: 10.1042/bj20060513
PubMed ID: 19555658
Title: Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.
PubMed ID: 19555658
PubMed ID: 9924029
Title: Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder.
PubMed ID: 9924029
PubMed ID: 12177387
Title: Phenotypic variability in a Spanish family with MNGIE.
PubMed ID: 12177387
DOI: 10.1212/wnl.59.3.455
Sequence Information:
- Length: 482
- Mass: 49955
- Checksum: 0652FA0B8F3BDE28
- Sequence:
MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG VGDKVSLVLA PALAACGCKV PMISGRGLGH TGGTLDKLES IPGFNVIQSP EQMQVLLDQA GCCIVGQSEQ LVPADGILYA ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA VFPNQEQARE LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ GVDPGLARAL CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV LHELGAGRSR AGEPLRLGVG AELLVDVGQR LRRGTPWLRV HRDGPALSGP QSRALQEALV LSDRAPFAAP SPFAELVLPP QQ
Genular Protein ID: 557288827
Symbol: B2RBL3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 482
- Mass: 49923
- Checksum: 64397F697175206D
- Sequence:
MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG VGDKVSLVLA PALAACGCKV PVISGRGLGH TGGTLDKLES IPGFNVIQSP EQMQVLLDQA GCCIVGQSEQ LVPADGILYA ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA VFPNQEQARE LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ GVDPGLARAL CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV LHELGAGRSR AGEPLRLGVG AELLVDVGQR LRRGTPWLRV HRDGPALSGP QSRALQEALV LSDRAPFAAP SPFAELVLPP QQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.