Details for: TYMP

Gene ID: 1890

Symbol: TYMP

Ensembl ID: ENSG00000025708

Description: thymidine phosphorylase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.15
    Marker Score: 232176
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.25
    Marker Score: 6341
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.18
    Marker Score: 3641
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.69
    Marker Score: 1123
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.69
    Marker Score: 6487
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.49
    Marker Score: 6459
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.41
    Marker Score: 10002
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.4
    Marker Score: 3481
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.39
    Marker Score: 61145
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.39
    Marker Score: 848
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.38
    Marker Score: 5934.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.32
    Marker Score: 7993
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.31
    Marker Score: 14059.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.16
    Marker Score: 7980
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.12
    Marker Score: 72024.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.07
    Marker Score: 1181
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.02
    Marker Score: 455
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.01
    Marker Score: 2011.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2
    Marker Score: 7707.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.99
    Marker Score: 17252
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.98
    Marker Score: 2717
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.96
    Marker Score: 1923
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.94
    Marker Score: 955
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.91
    Marker Score: 2038.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.8
    Marker Score: 4421
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.79
    Marker Score: 2936
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.77
    Marker Score: 13851
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.77
    Marker Score: 723.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.74
    Marker Score: 1201
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.68
    Marker Score: 5980
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.67
    Marker Score: 2968
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.67
    Marker Score: 8211
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.67
    Marker Score: 1145
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.65
    Marker Score: 7134
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.59
    Marker Score: 1351
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.58
    Marker Score: 10103
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.58
    Marker Score: 1607
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.57
    Marker Score: 1890
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.56
    Marker Score: 15441
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.55
    Marker Score: 8153
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.54
    Marker Score: 13236
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.53
    Marker Score: 1045
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.53
    Marker Score: 841
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.51
    Marker Score: 17512
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.49
    Marker Score: 2716
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.47
    Marker Score: 3726
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166339
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.43
    Marker Score: 1857
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.42
    Marker Score: 6792
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.41
    Marker Score: 2984
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.4
    Marker Score: 933
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.39
    Marker Score: 3643
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.39
    Marker Score: 660
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.39
    Marker Score: 354
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.36
    Marker Score: 781
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.36
    Marker Score: 1132
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.34
    Marker Score: 2070
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.34
    Marker Score: 2543.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.33
    Marker Score: 2531
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.33
    Marker Score: 580
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.33
    Marker Score: 1954.5
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.31
    Marker Score: 454
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.3
    Marker Score: 560.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.3
    Marker Score: 607
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.3
    Marker Score: 781.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.29
    Marker Score: 1436
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.29
    Marker Score: 9592
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.27
    Marker Score: 248
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.26
    Marker Score: 1327
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.25
    Marker Score: 330
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.24
    Marker Score: 2263.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.23
    Marker Score: 1486
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.21
    Marker Score: 2951
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.2
    Marker Score: 1398
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.19
    Marker Score: 3289
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.19
    Marker Score: 383
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.18
    Marker Score: 418.5
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.15
    Marker Score: 253
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.14
    Marker Score: 760
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.14
    Marker Score: 1158
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.14
    Marker Score: 247
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.14
    Marker Score: 490.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.13
    Marker Score: 279
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.13
    Marker Score: 958
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.12
    Marker Score: 324
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.12
    Marker Score: 656
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.11
    Marker Score: 638
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.11
    Marker Score: 250
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.1
    Marker Score: 460
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.1
    Marker Score: 867
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.1
    Marker Score: 7166
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1
    Marker Score: 12369
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.09
    Marker Score: 1735
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.09
    Marker Score: 270
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.08
    Marker Score: 259
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.08
    Marker Score: 1742
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 1.08
    Marker Score: 324
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.07
    Marker Score: 1385
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.07
    Marker Score: 265

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Other Information

**Key characteristics:** * The TYMP gene is located on chromosome 1q21.2. * It is a large gene, encoding a protein of 1,212 amino acids. * It contains 11 exons and 13 introns. * The protein is expressed in a variety of cell types, including immune cells, epithelial cells, and cancer cells. **Pathways and functions:** * TYMP is involved in several important cellular processes, including: * Angiogenesis * Chemotaxis * Growth factor activity * Metabolism * Pyrimidine catabolism * Signal transduction * It is a key regulator of angiogenesis, promoting the formation of new blood vessels to support immune cell migration and activity. * It is also involved in chemotaxis, guiding immune cells to sites of infection or injury. * TYMP also plays a role in growth factor activity, promoting cell proliferation and differentiation. **Clinical significance:** * Mutations in the TYMP gene have been linked to several human diseases, including: * Cancer * Cardiovascular disease * Diabetes * Rheumatoid arthritis **Conclusion:** TYMP is a critical gene for immune cell function. Its expression and activity are tightly regulated to ensure the appropriate immune response. Dysregulation of TYMP has been linked to various diseases, underscoring its importance in human health.

Genular Protein ID: 2998326775

Symbol: TYPH_HUMAN

Name: Gliostatin

UniProtKB Accession Codes:

P19971 A8MW15 H9KVA0 Q13390 Q8WVB7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 1 EMBL 5 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 2 SABIO-RK 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2467210

Title: Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.

PubMed ID: 2467210

DOI: 10.1038/338557a0

PubMed ID: 1580101

Title: Expression of recombinant platelet-derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae.

PubMed ID: 1580101

DOI: 10.1002/yea.320080106

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1570012

Title: Angiogenic factor.

PubMed ID: 1570012

DOI: 10.1038/356668a0

PubMed ID: 1400349

Title: Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor.

PubMed ID: 1400349

DOI: 10.1016/s0021-9258(19)88703-3

PubMed ID: 1590793

Title: Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.

PubMed ID: 1590793

DOI: 10.1016/s0006-291x(05)80025-7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 14725767

Title: Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor.

PubMed ID: 14725767

DOI: 10.1016/j.str.2003.11.018

PubMed ID: 16803458

Title: Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design.

PubMed ID: 16803458

DOI: 10.1042/bj20060513

PubMed ID: 19555658

Title: Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.

PubMed ID: 19555658

DOI: 10.1016/j.bbrc.2009.06.104

PubMed ID: 9924029

Title: Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder.

PubMed ID: 9924029

DOI: 10.1126/science.283.5402.689

PubMed ID: 12177387

Title: Phenotypic variability in a Spanish family with MNGIE.

PubMed ID: 12177387

DOI: 10.1212/wnl.59.3.455

Sequence Information:

  • Length: 482
  • Mass: 49955
  • Checksum: 0652FA0B8F3BDE28
  • Sequence:
    • MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA 
VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG 
VGDKVSLVLA PALAACGCKV PMISGRGLGH TGGTLDKLES IPGFNVIQSP EQMQVLLDQA 
GCCIVGQSEQ LVPADGILYA ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA 
VFPNQEQARE LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP 
DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ GVDPGLARAL 
CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV LHELGAGRSR AGEPLRLGVG 
AELLVDVGQR LRRGTPWLRV HRDGPALSGP QSRALQEALV LSDRAPFAAP SPFAELVLPP 
QQ

Genular Protein ID: 557288827

Symbol: B2RBL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RBL3

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 DNASU 1 EC 1 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 Rhea 1 SAM 1 SMART 2 SUPFAM 3 UniPathway 1

Sequence Information:

  • Length: 482
  • Mass: 49923
  • Checksum: 64397F697175206D
  • Sequence:
    • MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA 
VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG 
VGDKVSLVLA PALAACGCKV PVISGRGLGH TGGTLDKLES IPGFNVIQSP EQMQVLLDQA 
GCCIVGQSEQ LVPADGILYA ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA 
VFPNQEQARE LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP 
DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ GVDPGLARAL 
CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV LHELGAGRSR AGEPLRLGVG 
AELLVDVGQR LRRGTPWLRV HRDGPALSGP QSRALQEALV LSDRAPFAAP SPFAELVLPP 
QQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.