Details for: TYMP

Gene ID: 1890

Symbol: TYMP

Ensembl ID: ENSG00000025708

Description: thymidine phosphorylase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 245.5234
    Cell Significance Index: -38.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 149.2647
    Cell Significance Index: -37.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.0107
    Cell Significance Index: -37.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.0036
    Cell Significance Index: -39.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.3848
    Cell Significance Index: -40.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.2380
    Cell Significance Index: -39.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.1624
    Cell Significance Index: -37.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.1690
    Cell Significance Index: -38.4300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 20.0838
    Cell Significance Index: 172.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5278
    Cell Significance Index: -41.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 12.3483
    Cell Significance Index: 228.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9593
    Cell Significance Index: -39.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4107
    Cell Significance Index: -25.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8367
    Cell Significance Index: -19.3400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.5496
    Cell Significance Index: 21.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9411
    Cell Significance Index: 138.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6206
    Cell Significance Index: 75.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0941
    Cell Significance Index: 156.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5777
    Cell Significance Index: 46.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4535
    Cell Significance Index: 102.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3480
    Cell Significance Index: 1217.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2964
    Cell Significance Index: 167.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1636
    Cell Significance Index: 514.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1407
    Cell Significance Index: 31.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1312
    Cell Significance Index: 30.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0138
    Cell Significance Index: 60.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9577
    Cell Significance Index: 104.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8722
    Cell Significance Index: 101.6500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.4927
    Cell Significance Index: 4.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4091
    Cell Significance Index: 7.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4049
    Cell Significance Index: 4.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3903
    Cell Significance Index: 10.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3123
    Cell Significance Index: 40.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2941
    Cell Significance Index: 47.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2804
    Cell Significance Index: 153.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2663
    Cell Significance Index: 5.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2346
    Cell Significance Index: 42.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2298
    Cell Significance Index: 11.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2287
    Cell Significance Index: 28.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2286
    Cell Significance Index: 10.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1854
    Cell Significance Index: 9.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1755
    Cell Significance Index: 17.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1431
    Cell Significance Index: 28.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1078
    Cell Significance Index: 3.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1012
    Cell Significance Index: 19.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0617
    Cell Significance Index: 8.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0388
    Cell Significance Index: 4.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0315
    Cell Significance Index: 1.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0261
    Cell Significance Index: 2.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0194
    Cell Significance Index: 14.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0081
    Cell Significance Index: -12.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0145
    Cell Significance Index: -26.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0166
    Cell Significance Index: -31.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0289
    Cell Significance Index: -20.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0337
    Cell Significance Index: -45.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0421
    Cell Significance Index: -30.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0559
    Cell Significance Index: -41.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0560
    Cell Significance Index: -35.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0584
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0663
    Cell Significance Index: -41.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0765
    Cell Significance Index: -43.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0915
    Cell Significance Index: -41.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0976
    Cell Significance Index: -34.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1055
    Cell Significance Index: -6.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1178
    Cell Significance Index: -33.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1262
    Cell Significance Index: -25.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1295
    Cell Significance Index: -14.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1577
    Cell Significance Index: -26.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2189
    Cell Significance Index: -46.1000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2191
    Cell Significance Index: -1.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2268
    Cell Significance Index: -4.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2563
    Cell Significance Index: -37.2600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3631
    Cell Significance Index: -5.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3802
    Cell Significance Index: -39.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4180
    Cell Significance Index: -25.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4246
    Cell Significance Index: -13.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4267
    Cell Significance Index: -32.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4391
    Cell Significance Index: -8.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4554
    Cell Significance Index: -36.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4880
    Cell Significance Index: -25.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5289
    Cell Significance Index: -32.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5365
    Cell Significance Index: -7.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5770
    Cell Significance Index: -23.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5961
    Cell Significance Index: -37.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6088
    Cell Significance Index: -40.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7096
    Cell Significance Index: -39.8200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7733
    Cell Significance Index: -15.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8329
    Cell Significance Index: -43.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8333
    Cell Significance Index: -22.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8620
    Cell Significance Index: -38.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9018
    Cell Significance Index: -33.1100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.9068
    Cell Significance Index: -7.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9098
    Cell Significance Index: -21.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9406
    Cell Significance Index: -27.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0085
    Cell Significance Index: -38.1900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.0180
    Cell Significance Index: -13.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0370
    Cell Significance Index: -36.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0523
    Cell Significance Index: -18.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.0548
    Cell Significance Index: -25.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.1046
    Cell Significance Index: -17.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** TYMP exhibits a broad range of enzymatic activities, including thymidine phosphorylase activity, pyrimidine-nucleoside phosphorylase activity, and 1,4-alpha-oligoglucan phosphorylase activity. 2. **Cellular Expression:** TYMP is significantly expressed in immune cells, including CD14-positive, CD16-negative classical monocytes, CD14-positive, CD16-positive monocytes, lung macrophage, alternatively activated macrophage, non-classical monocyte, CD1c-positive myeloid dendritic cell, alveolar capillary type 2 endothelial cell, and alveolar macrophage. 3. **Regulation:** TYMP is regulated by various signaling pathways, including those involved in inflammation, immune response, and cell differentiation. **Pathways and Functions:** 1. **Immune Response:** TYMP plays a crucial role in regulating immune responses, particularly in the context of inflammation and immune cell activation. 2. **Angiogenesis:** TYMP has been implicated in angiogenesis, a process involved in tumor growth and metastasis. 3. **Nucleotide Metabolism:** TYMP enables the conversion of thymidine to thymine, a crucial step in DNA synthesis. 4. **Cancer:** TYMP has been associated with cancer, particularly in the context of tumor growth and metastasis. 5. **Neurological Disorders:** TYMP has been implicated in neurological disorders, including multiple sclerosis and Alzheimer's disease. **Clinical Significance:** TYMP has significant implications for various clinical conditions, including: 1. **Cancer:** TYMP expression has been associated with cancer progression and metastasis. 2. **Neurological Disorders:** TYMP has been implicated in the pathogenesis of neurological disorders, including multiple sclerosis and Alzheimer's disease. 3. **Infectious Diseases:** TYMP has been shown to play a role in the regulation of immune responses to infections. 4. **Vascular Diseases:** TYMP has been implicated in angiogenesis, a process involved in vascular diseases, including atherosclerosis and stroke. In conclusion, TYMP is a multifaceted enzyme that plays a crucial role in various biological processes, including immune regulation, angiogenesis, and nucleotide metabolism. Its significant expression in immune cells and its involvement in various clinical conditions make it an attractive target for therapeutic intervention. Further research is necessary to fully elucidate the functions and clinical significance of TYMP.

Genular Protein ID: 2998326775

Symbol: TYPH_HUMAN

Name: Gliostatin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2467210

Title: Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.

PubMed ID: 2467210

DOI: 10.1038/338557a0

PubMed ID: 1580101

Title: Expression of recombinant platelet-derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae.

PubMed ID: 1580101

DOI: 10.1002/yea.320080106

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1570012

Title: Angiogenic factor.

PubMed ID: 1570012

DOI: 10.1038/356668a0

PubMed ID: 1400349

Title: Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor.

PubMed ID: 1400349

DOI: 10.1016/s0021-9258(19)88703-3

PubMed ID: 1590793

Title: Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.

PubMed ID: 1590793

DOI: 10.1016/s0006-291x(05)80025-7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 14725767

Title: Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor.

PubMed ID: 14725767

DOI: 10.1016/j.str.2003.11.018

PubMed ID: 16803458

Title: Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design.

PubMed ID: 16803458

DOI: 10.1042/bj20060513

PubMed ID: 19555658

Title: Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.

PubMed ID: 19555658

DOI: 10.1016/j.bbrc.2009.06.104

PubMed ID: 9924029

Title: Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder.

PubMed ID: 9924029

DOI: 10.1126/science.283.5402.689

PubMed ID: 12177387

Title: Phenotypic variability in a Spanish family with MNGIE.

PubMed ID: 12177387

DOI: 10.1212/wnl.59.3.455

Sequence Information:

  • Length: 482
  • Mass: 49955
  • Checksum: 0652FA0B8F3BDE28
  • Sequence:
  • MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA 
    VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG 
    VGDKVSLVLA PALAACGCKV PMISGRGLGH TGGTLDKLES IPGFNVIQSP EQMQVLLDQA 
    GCCIVGQSEQ LVPADGILYA ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA 
    VFPNQEQARE LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP 
    DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ GVDPGLARAL 
    CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV LHELGAGRSR AGEPLRLGVG 
    AELLVDVGQR LRRGTPWLRV HRDGPALSGP QSRALQEALV LSDRAPFAAP SPFAELVLPP 
    QQ

Genular Protein ID: 557288827

Symbol: B2RBL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 482
  • Mass: 49923
  • Checksum: 64397F697175206D
  • Sequence:
  • MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA 
    VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG 
    VGDKVSLVLA PALAACGCKV PVISGRGLGH TGGTLDKLES IPGFNVIQSP EQMQVLLDQA 
    GCCIVGQSEQ LVPADGILYA ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA 
    VFPNQEQARE LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP 
    DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ GVDPGLARAL 
    CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV LHELGAGRSR AGEPLRLGVG 
    AELLVDVGQR LRRGTPWLRV HRDGPALSGP QSRALQEALV LSDRAPFAAP SPFAELVLPP 
    QQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.