Details for: IFI6

Gene ID: 2537

Symbol: IFI6

Ensembl ID: ENSG00000126709

Description: interferon alpha inducible protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 319.5855
    Cell Significance Index: -49.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.8628
    Cell Significance Index: -42.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 133.5849
    Cell Significance Index: -55.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.2534
    Cell Significance Index: -46.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 110.3527
    Cell Significance Index: -52.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.8364
    Cell Significance Index: -50.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 78.0004
    Cell Significance Index: -52.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.5576
    Cell Significance Index: -46.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.7209
    Cell Significance Index: -51.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 19.9989
    Cell Significance Index: 534.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.0782
    Cell Significance Index: -45.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5017
    Cell Significance Index: -41.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.1397
    Cell Significance Index: -51.8500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 10.6817
    Cell Significance Index: 62.7600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.4569
    Cell Significance Index: 72.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.9334
    Cell Significance Index: 103.8900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.6956
    Cell Significance Index: 71.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.2366
    Cell Significance Index: 111.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.8160
    Cell Significance Index: 70.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.3496
    Cell Significance Index: 429.4000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.8825
    Cell Significance Index: 17.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0343
    Cell Significance Index: 279.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6539
    Cell Significance Index: 38.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1434
    Cell Significance Index: 12.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0934
    Cell Significance Index: 118.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8819
    Cell Significance Index: 15.5900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8506
    Cell Significance Index: 13.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7983
    Cell Significance Index: 41.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7011
    Cell Significance Index: 20.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6594
    Cell Significance Index: 65.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5038
    Cell Significance Index: 10.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3350
    Cell Significance Index: 20.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2934
    Cell Significance Index: 15.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2922
    Cell Significance Index: 18.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2629
    Cell Significance Index: 143.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2527
    Cell Significance Index: 28.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2318
    Cell Significance Index: 44.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1374
    Cell Significance Index: 49.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1219
    Cell Significance Index: 24.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1104
    Cell Significance Index: 5.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0968
    Cell Significance Index: 15.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0374
    Cell Significance Index: 16.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0172
    Cell Significance Index: 3.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0163
    Cell Significance Index: 2.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0149
    Cell Significance Index: 9.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0031
    Cell Significance Index: 0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0013
    Cell Significance Index: 0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0028
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0169
    Cell Significance Index: -31.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0182
    Cell Significance Index: -10.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0239
    Cell Significance Index: -17.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0368
    Cell Significance Index: -67.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0431
    Cell Significance Index: -66.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0483
    Cell Significance Index: -65.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0624
    Cell Significance Index: -39.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0710
    Cell Significance Index: -12.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0810
    Cell Significance Index: -17.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0871
    Cell Significance Index: -3.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1033
    Cell Significance Index: -20.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1115
    Cell Significance Index: -50.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1155
    Cell Significance Index: -3.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1226
    Cell Significance Index: -14.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1300
    Cell Significance Index: -2.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1466
    Cell Significance Index: -42.1900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1779
    Cell Significance Index: -1.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2049
    Cell Significance Index: -15.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2758
    Cell Significance Index: -35.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3083
    Cell Significance Index: -44.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3429
    Cell Significance Index: -40.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3601
    Cell Significance Index: -24.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3818
    Cell Significance Index: -12.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4192
    Cell Significance Index: -10.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4277
    Cell Significance Index: -30.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4336
    Cell Significance Index: -20.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4456
    Cell Significance Index: -50.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4929
    Cell Significance Index: -12.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5023
    Cell Significance Index: -52.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5241
    Cell Significance Index: -14.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5930
    Cell Significance Index: -27.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5943
    Cell Significance Index: -16.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6009
    Cell Significance Index: -47.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6416
    Cell Significance Index: -26.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6540
    Cell Significance Index: -22.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6710
    Cell Significance Index: -33.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6913
    Cell Significance Index: -53.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7402
    Cell Significance Index: -46.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7842
    Cell Significance Index: -48.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8018
    Cell Significance Index: -22.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8167
    Cell Significance Index: -28.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8252
    Cell Significance Index: -50.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8664
    Cell Significance Index: -48.6200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9782
    Cell Significance Index: -5.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.0179
    Cell Significance Index: -8.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0496
    Cell Significance Index: -21.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.1136
    Cell Significance Index: -30.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1437
    Cell Significance Index: -50.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1858
    Cell Significance Index: -41.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2253
    Cell Significance Index: -36.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFI6 is a member of the interferon alpha-inducible protein family, which is known for its involvement in immune responses and cellular regulation. The gene is significantly expressed in various cell types, including syncytiotrophoblast cells, monocytes, natural killer cells, and fibroblasts. IFI6 is characterized by its ability to modulate apoptotic processes, regulate mitochondrial function, and interact with various signaling pathways. **Pathways and Functions:** IFI6 is involved in several key pathways, including: 1. **Apoptotic process**: IFI6 regulates apoptosis by modulating the activity of cysteine-type endopeptidases, which are essential for the execution of programmed cell death. 2. **Interferon alpha/beta signaling**: IFI6 is induced by interferons alpha and beta, which are critical components of the innate immune response. 3. **Cytokine signaling in immune system**: IFI6 interacts with cytokines, such as TNF-alpha and IL-1beta, to regulate immune responses. 4. **Defense response to virus**: IFI6 plays a role in the defense against viral infections by regulating the expression of antiviral genes. 5. **Regulation of epidermal growth factor receptor signaling pathway**: IFI6 modulates the activity of the epidermal growth factor receptor, which is involved in cell proliferation and differentiation. IFI6 also interacts with various cellular components, including: 1. **Mitochondrial inner membrane**: IFI6 regulates mitochondrial function and morphology. 2. **Plasma membrane**: IFI6 interacts with the plasma membrane to regulate cell signaling and apoptosis. 3. **Reactive oxygen species metabolic process**: IFI6 modulates the production of reactive oxygen species, which are involved in cellular signaling and homeostasis. **Clinical Significance:** IFI6 has been implicated in various diseases, including: 1. **Viral infections**: IFI6 plays a role in the defense against viral infections, such as HIV and influenza. 2. **Cancer**: IFI6 has been shown to regulate apoptosis and proliferation in cancer cells. 3. **Autoimmune diseases**: IFI6 may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Reproductive disorders**: IFI6 is involved in the regulation of placental development and function, which is critical for pregnancy maintenance. In conclusion, IFI6 is a gene that plays a crucial role in the regulation of immune responses, cellular processes, and disease susceptibility. Further research is necessary to fully understand the mechanisms by which IFI6 functions and its clinical significance in various diseases. **References:** * [Insert relevant references] Note: This article is a summary of the provided gene information, and it is not an original research article. The references section is intentionally left blank, as it is not a requirement for this type of summary.

Genular Protein ID: 3443633415

Symbol: IFI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

P09912 Q13141 Q13142 Q5VVR2 Q5VVR3 Q6IE95 Q969M8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 4 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3017706

Title: Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells.

PubMed ID: 3017706

DOI: 10.1002/j.1460-2075.1986.tb04402.x

PubMed ID: 7596809

Title: Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript.

PubMed ID: 7596809

DOI: 10.1093/nar/23.11.1854

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14728724

Title: Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.

PubMed ID: 14728724

DOI: 10.1186/1471-2164-5-8

PubMed ID: 15685448

Title: G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell.

PubMed ID: 15685448

DOI: 10.1007/s00262-004-0645-2

PubMed ID: 17823654

Title: G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.

PubMed ID: 17823654

DOI: 10.1172/jci31122

PubMed ID: 26244642

Title: IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells.

PubMed ID: 26244642

DOI: 10.1371/journal.pone.0132743

PubMed ID: 25757571

Title: Interferon-alpha inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection.

PubMed ID: 25757571

DOI: 10.1038/srep09012

PubMed ID: 27673746

Title: Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.

PubMed ID: 27673746

DOI: 10.1111/boc.201600034

PubMed ID: 29899394

Title: G1P3 (IFI6), a mitochondrial localised antiapoptotic protein, promotes metastatic potential of breast cancer cells through mtROS.

PubMed ID: 29899394

DOI: 10.1038/s41416-018-0137-3

PubMed ID: 30224801

Title: A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication.

PubMed ID: 30224801

DOI: 10.1038/s41564-018-0244-1

PubMed ID: 31142663

Title: A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection.

PubMed ID: 31142663

DOI: 10.1128/jvi.00211-19

PubMed ID: 33868257

Title: The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression.

PubMed ID: 33868257

DOI: 10.3389/fimmu.2021.634937

PubMed ID: 36793726

Title: Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation.

PubMed ID: 36793726

DOI: 10.3389/fimmu.2023.1105309

Sequence Information:

  • Length: 130
  • Mass: 12927
  • Checksum: B1C2992A59203B38
  • Sequence:
    • MRQKAVSLFL CYLLLFTCSG VEAGKKKCSE SSDSGSGFWK ALTFMAVGGG LAVAGLPALG 
FTGAGIAANS VAASLMSWSA ILNGGGVPAG GLVATLQSLG AGGSSVVIGN IGALMGYATH 
KYLDSEEDEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.