Details for: IFI6

Gene ID: 2537

Symbol: IFI6

Ensembl ID: ENSG00000126709

Description: interferon alpha inducible protein 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.07
    Marker Score: 3340
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.73
    Marker Score: 152396.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.68
    Marker Score: 7390
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.51
    Marker Score: 1798.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.38
    Marker Score: 3272
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.37
    Marker Score: 60767
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.33
    Marker Score: 9173.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.3
    Marker Score: 1981
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.27
    Marker Score: 784
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.23
    Marker Score: 25867
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.21
    Marker Score: 9541
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.2
    Marker Score: 917
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.17
    Marker Score: 5513
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.15
    Marker Score: 21324
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.1
    Marker Score: 783
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.09
    Marker Score: 1784
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.07
    Marker Score: 1501
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.06
    Marker Score: 2978
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.03
    Marker Score: 1414
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.02
    Marker Score: 3317.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.01
    Marker Score: 1109
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.01
    Marker Score: 2013
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.96
    Marker Score: 442
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.95
    Marker Score: 1525
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.9
    Marker Score: 766
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.86
    Marker Score: 4220.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.84
    Marker Score: 2220
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.74
    Marker Score: 903
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.74
    Marker Score: 9139
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.73
    Marker Score: 690
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.72
    Marker Score: 389.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.71
    Marker Score: 1529
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.68
    Marker Score: 3277
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.66
    Marker Score: 16733.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.66
    Marker Score: 5229
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.62
    Marker Score: 18287
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.62
    Marker Score: 705
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.62
    Marker Score: 3974
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.58
    Marker Score: 1056
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.57
    Marker Score: 3785
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.55
    Marker Score: 1579
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.53
    Marker Score: 715
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.53
    Marker Score: 2224
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.51
    Marker Score: 632
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.49
    Marker Score: 1308
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.47
    Marker Score: 471
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.45
    Marker Score: 76829
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.45
    Marker Score: 8823
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 165872
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.44
    Marker Score: 12546
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.44
    Marker Score: 9196.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.44
    Marker Score: 3763
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.43
    Marker Score: 738
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.41
    Marker Score: 1943
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.39
    Marker Score: 733
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.38
    Marker Score: 4753
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.37
    Marker Score: 377
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.36
    Marker Score: 474
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.35
    Marker Score: 987
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.35
    Marker Score: 524
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.35
    Marker Score: 761
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.34
    Marker Score: 353
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.34
    Marker Score: 341
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.34
    Marker Score: 1291
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.33
    Marker Score: 3632
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.32
    Marker Score: 307
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.32
    Marker Score: 2584
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.31
    Marker Score: 2612
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.31
    Marker Score: 377
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.3
    Marker Score: 1600.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.29
    Marker Score: 279.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.27
    Marker Score: 2155.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.24
    Marker Score: 7370.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.23
    Marker Score: 1243
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.22
    Marker Score: 506
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.22
    Marker Score: 1429
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.22
    Marker Score: 274
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.2
    Marker Score: 1019
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.19
    Marker Score: 1162
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.18
    Marker Score: 495
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.17
    Marker Score: 372
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.16
    Marker Score: 228
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.16
    Marker Score: 4754
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.14
    Marker Score: 658
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.14
    Marker Score: 1684
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.13
    Marker Score: 414
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.12
    Marker Score: 267.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.12
    Marker Score: 268.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.11
    Marker Score: 275.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.11
    Marker Score: 1448
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.11
    Marker Score: 782
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.11
    Marker Score: 9711
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.1
    Marker Score: 274.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.1
    Marker Score: 1527
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.1
    Marker Score: 311
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.09
    Marker Score: 279.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.09
    Marker Score: 1208
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.09
    Marker Score: 743
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.09
    Marker Score: 288.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.09
    Marker Score: 454

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Other Information

## Summary IFI6 is a protein that plays a crucial role in regulating the apoptotic process, immune response, and cellular health. This gene is highly expressed in various cell types, including syncytiotrophoblast cells, CD14-positive classical monocyte, decidual natural killer cell, and human cells. ## Key characteristics - IFI6 is a protein belonging to the interferon alpha/beta family. - It is a key regulator of the apoptotic process and plays a crucial role in the innate immune response. - It is involved in the regulation of cell growth, differentiation, and apoptosis. ## Pathways and functions - IFI6 is involved in the apoptotic process through various pathways. - It acts as a pro-apoptotic protein, promoting the activation of caspases and ultimately leading to cell death. - It also plays a role in the regulation of cell growth, differentiation, and apoptosis. - IFI6 is involved in the regulation of the immune response and is expressed in various immune cells. - It helps to control the inflammatory response and maintain immune homeostasis. ## Clinical significance - Mutations in IFI6 have been associated with various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - Targeting IFI6 has emerged as a potential therapeutic strategy for these diseases. - IFI6 inhibitors are being investigated as potential treatments for cancer and autoimmune disorders.

Genular Protein ID: 3443633415

Symbol: IFI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

P09912 Q13141 Q13142 Q5VVR2 Q5VVR3 Q6IE95 Q969M8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 4 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3017706

Title: Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells.

PubMed ID: 3017706

DOI: 10.1002/j.1460-2075.1986.tb04402.x

PubMed ID: 7596809

Title: Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript.

PubMed ID: 7596809

DOI: 10.1093/nar/23.11.1854

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14728724

Title: Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.

PubMed ID: 14728724

DOI: 10.1186/1471-2164-5-8

PubMed ID: 15685448

Title: G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell.

PubMed ID: 15685448

DOI: 10.1007/s00262-004-0645-2

PubMed ID: 17823654

Title: G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.

PubMed ID: 17823654

DOI: 10.1172/jci31122

PubMed ID: 26244642

Title: IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells.

PubMed ID: 26244642

DOI: 10.1371/journal.pone.0132743

PubMed ID: 25757571

Title: Interferon-alpha inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection.

PubMed ID: 25757571

DOI: 10.1038/srep09012

PubMed ID: 27673746

Title: Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.

PubMed ID: 27673746

DOI: 10.1111/boc.201600034

PubMed ID: 29899394

Title: G1P3 (IFI6), a mitochondrial localised antiapoptotic protein, promotes metastatic potential of breast cancer cells through mtROS.

PubMed ID: 29899394

DOI: 10.1038/s41416-018-0137-3

PubMed ID: 30224801

Title: A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication.

PubMed ID: 30224801

DOI: 10.1038/s41564-018-0244-1

PubMed ID: 31142663

Title: A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection.

PubMed ID: 31142663

DOI: 10.1128/jvi.00211-19

PubMed ID: 33868257

Title: The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression.

PubMed ID: 33868257

DOI: 10.3389/fimmu.2021.634937

PubMed ID: 36793726

Title: Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation.

PubMed ID: 36793726

DOI: 10.3389/fimmu.2023.1105309

Sequence Information:

  • Length: 130
  • Mass: 12927
  • Checksum: B1C2992A59203B38
  • Sequence:
    • MRQKAVSLFL CYLLLFTCSG VEAGKKKCSE SSDSGSGFWK ALTFMAVGGG LAVAGLPALG 
FTGAGIAANS VAASLMSWSA ILNGGGVPAG GLVATLQSLG AGGSSVVIGN IGALMGYATH 
KYLDSEEDEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.