Details for: NAIP
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 173.0686
Cell Significance Index: -26.9200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 104.8717
Cell Significance Index: -26.6000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 60.9466
Cell Significance Index: -24.7600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 60.0480
Cell Significance Index: -28.3500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 53.2869
Cell Significance Index: -27.4100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.9391
Cell Significance Index: -27.0500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.1909
Cell Significance Index: -27.3000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.7218
Cell Significance Index: -29.8600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.5306
Cell Significance Index: -18.6700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.9411
Cell Significance Index: -27.3900 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: 3.2150
Cell Significance Index: 51.7000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.1435
Cell Significance Index: 58.1000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7877
Cell Significance Index: 354.7800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.6602
Cell Significance Index: 24.5100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.5883
Cell Significance Index: 42.4900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.1105
Cell Significance Index: 49.1200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.0942
Cell Significance Index: 30.5800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.0600
Cell Significance Index: 40.1400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6965
Cell Significance Index: 113.2800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5952
Cell Significance Index: 64.7400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5093
Cell Significance Index: 102.1600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4499
Cell Significance Index: 406.2100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4109
Cell Significance Index: 23.0600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3546
Cell Significance Index: 21.2900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.3520
Cell Significance Index: 5.9300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2996
Cell Significance Index: 107.4500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2837
Cell Significance Index: 19.6200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.2376
Cell Significance Index: 3.5800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1837
Cell Significance Index: 34.9600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1681
Cell Significance Index: 30.3000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1387
Cell Significance Index: 10.6400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.1348
Cell Significance Index: 1.9900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1307
Cell Significance Index: 15.2300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1170
Cell Significance Index: 11.5700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1146
Cell Significance Index: 5.7900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1038
Cell Significance Index: 2.9900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0752
Cell Significance Index: 3.4100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0564
Cell Significance Index: 86.8100 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.0548
Cell Significance Index: 0.6900 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0544
Cell Significance Index: 1.3600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0491
Cell Significance Index: 66.7200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0466
Cell Significance Index: 87.6500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0450
Cell Significance Index: 83.0100 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.0439
Cell Significance Index: 1.3900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0222
Cell Significance Index: 0.7800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0220
Cell Significance Index: 3.0200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0162
Cell Significance Index: 0.3500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0144
Cell Significance Index: 9.1400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0023
Cell Significance Index: 1.0300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0075
Cell Significance Index: -5.4700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0098
Cell Significance Index: -6.1000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0148
Cell Significance Index: -8.1000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0169
Cell Significance Index: -12.5400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0177
Cell Significance Index: -1.8100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0186
Cell Significance Index: -1.2000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0271
Cell Significance Index: -12.2900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0293
Cell Significance Index: -16.5000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0311
Cell Significance Index: -1.9600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0332
Cell Significance Index: -4.8200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0332
Cell Significance Index: -25.1600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0590
Cell Significance Index: -7.2500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0696
Cell Significance Index: -11.8800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0765
Cell Significance Index: -9.0200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0769
Cell Significance Index: -16.1900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0977
Cell Significance Index: -28.1100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1180
Cell Significance Index: -3.1500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1219
Cell Significance Index: -13.9700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1272
Cell Significance Index: -5.9800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1495
Cell Significance Index: -19.1700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1539
Cell Significance Index: -2.2100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1671
Cell Significance Index: -19.0700 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1756
Cell Significance Index: -1.1900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1951
Cell Significance Index: -25.2100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2311
Cell Significance Index: -3.9600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2400
Cell Significance Index: -24.9900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2798
Cell Significance Index: -20.8500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2988
Cell Significance Index: -18.3200 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.3151
Cell Significance Index: -4.0400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3160
Cell Significance Index: -25.0300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3244
Cell Significance Index: -6.7300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3351
Cell Significance Index: -10.9700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3363
Cell Significance Index: -10.7100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3409
Cell Significance Index: -7.2600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3708
Cell Significance Index: -17.2900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3731
Cell Significance Index: -26.3900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4053
Cell Significance Index: -12.9800 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.4106
Cell Significance Index: -7.1000 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4160
Cell Significance Index: -10.1500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4168
Cell Significance Index: -21.6500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4302
Cell Significance Index: -9.4200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4354
Cell Significance Index: -9.2400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4443
Cell Significance Index: -23.3300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4466
Cell Significance Index: -11.1700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4489
Cell Significance Index: -15.7300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4573
Cell Significance Index: -9.1800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4675
Cell Significance Index: -24.3500 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4799
Cell Significance Index: -9.4900 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.5205
Cell Significance Index: -4.6200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5236
Cell Significance Index: -13.0600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5496
Cell Significance Index: -19.1000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 267624969
Symbol: BIRC1_HUMAN
Name: Baculoviral IAP repeat-containing protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7813013
Title: The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy.
PubMed ID: 7813013
PubMed ID: 9503025
Title: Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP.
PubMed ID: 9503025
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11955612
Title: Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes.
PubMed ID: 11955612
PubMed ID: 7552146
Title: A provisional transcript map of the spinal muscular atrophy (SMA) critical region.
PubMed ID: 7552146
DOI: 10.1159/000472281
PubMed ID: 8552191
Title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.
PubMed ID: 8552191
DOI: 10.1038/379349a0
PubMed ID: 11896143
Title: The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7.
PubMed ID: 11896143
PubMed ID: 18414036
Title: IAPs: more than just inhibitors of apoptosis proteins.
PubMed ID: 18414036
DOI: 10.4161/cc.7.8.5783
PubMed ID: 21371431
Title: Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP.
PubMed ID: 21371431
PubMed ID: 21918512
Title: The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
PubMed ID: 21918512
DOI: 10.1038/nature10510
PubMed ID: 22504023
Title: The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila.
PubMed ID: 22504023
PubMed ID: 19923725
Title: Structures of BIR domains from human NAIP and cIAP2.
PubMed ID: 19923725
Sequence Information:
- Length: 1403
- Mass: 159582
- Checksum: C1CE163D55900C6D
- Sequence:
MATQQKASDE RISQFDHNLL PELSALLGLD AVQLAKELEE EEQKERAKMQ KGYNSQMRSE AKRLKTFVTY EPYSSWIPQE MAAAGFYFTG VKSGIQCFCC SLILFGAGLT RLPIEDHKRF HPDCGFLLNK DVGNIAKYDI RVKNLKSRLR GGKMRYQEEE ARLASFRNWP FYVQGISPCV LSEAGFVFTG KQDTVQCFSC GGCLGNWEEG DDPWKEHAKW FPKCEFLRSK KSSEEITQYI QSYKGFVDIT GEHFVNSWVQ RELPMASAYC NDSIFAYEEL RLDSFKDWPR ESAVGVAALA KAGLFYTGIK DIVQCFSCGG CLEKWQEGDD PLDDHTRCFP NCPFLQNMKS SAEVTPDLQS RGELCELLET TSESNLEDSI AVGPIVPEMA QGEAQWFQEA KNLNEQLRAA YTSASFRHMS LLDISSDLAT DHLLGCDLSI ASKHISKPVQ EPLVLPEVFG NLNSVMCVEG EAGSGKTVLL KKIAFLWASG CCPLLNRFQL VFYLSLSSTR PDEGLASIIC DQLLEKEGSV TEMCVRNIIQ QLKNQVLFLL DDYKEICSIP QVIGKLIQKN HLSRTCLLIA VRTNRARDIR RYLETILEIK AFPFYNTVCI LRKLFSHNMT RLRKFMVYFG KNQSLQKIQK TPLFVAAICA HWFQYPFDPS FDDVAVFKSY MERLSLRNKA TAEILKATVS SCGELALKGF FSCCFEFNDD DLAEAGVDED EDLTMCLMSK FTAQRLRPFY RFLSPAFQEF LAGMRLIELL DSDRQEHQDL GLYHLKQINS PMMTVSAYNN FLNYVSSLPS TKAGPKIVSH LLHLVDNKES LENISENDDY LKHQPEISLQ MQLLRGLWQI CPQAYFSMVS EHLLVLALKT AYQSNTVAAC SPFVLQFLQG RTLTLGALNL QYFFDHPESL SLLRSIHFPI RGNKTSPRAH FSVLETCFDK SQVPTIDQDY ASAFEPMNEW ERNLAEKEDN VKSYMDMQRR ASPDLSTGYW KLSPKQYKIP CLEVDVNDID VVGQDMLEIL MTVFSASQRI ELHLNHSRGF IESIRPALEL SKASVTKCSI SKLELSAAEQ ELLLTLPSLE SLEVSGTIQS QDQIFPNLDK FLCLKELSVD LEGNINVFSV IPEEFPNFHH MEKLLIQISA EYDPSKLVKL IQNSPNLHVF HLKCNFFSDF GSLMTMLVSC KKLTEIKFSD SFFQAVPFVA SLPNFISLKI LNLEGQQFPD EETSEKFAYI LGSLSNLEEL ILPTGDGIYR VAKLIIQQCQ QLHCLRVLSF FKTLNDDSVV EIAKVAISGG FQKLENLKLS INHKITEEGY RNFFQALDNM PNLQELDISR HFTECIKAQA TTVKSLSQCV LRLPRLIRLN MLSWLLDADD IALLNVMKER HPQSKYLTIL QKWILPFSPI IQK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.