Details for: NAIP

Gene ID: 4671

Symbol: NAIP

Ensembl ID: ENSG00000249437

Description: NLR family apoptosis inhibitory protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.0686
    Cell Significance Index: -26.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.8717
    Cell Significance Index: -26.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.9466
    Cell Significance Index: -24.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.0480
    Cell Significance Index: -28.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.2869
    Cell Significance Index: -27.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.9391
    Cell Significance Index: -27.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1909
    Cell Significance Index: -27.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.7218
    Cell Significance Index: -29.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5306
    Cell Significance Index: -18.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9411
    Cell Significance Index: -27.3900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 3.2150
    Cell Significance Index: 51.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.1435
    Cell Significance Index: 58.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7877
    Cell Significance Index: 354.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.6602
    Cell Significance Index: 24.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.5883
    Cell Significance Index: 42.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1105
    Cell Significance Index: 49.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0942
    Cell Significance Index: 30.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0600
    Cell Significance Index: 40.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6965
    Cell Significance Index: 113.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5952
    Cell Significance Index: 64.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5093
    Cell Significance Index: 102.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4499
    Cell Significance Index: 406.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4109
    Cell Significance Index: 23.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3546
    Cell Significance Index: 21.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3520
    Cell Significance Index: 5.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2996
    Cell Significance Index: 107.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2837
    Cell Significance Index: 19.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2376
    Cell Significance Index: 3.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1837
    Cell Significance Index: 34.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1681
    Cell Significance Index: 30.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1387
    Cell Significance Index: 10.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1348
    Cell Significance Index: 1.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1307
    Cell Significance Index: 15.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1170
    Cell Significance Index: 11.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1146
    Cell Significance Index: 5.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1038
    Cell Significance Index: 2.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0752
    Cell Significance Index: 3.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0564
    Cell Significance Index: 86.8100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0548
    Cell Significance Index: 0.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0544
    Cell Significance Index: 1.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0491
    Cell Significance Index: 66.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0466
    Cell Significance Index: 87.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0450
    Cell Significance Index: 83.0100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0439
    Cell Significance Index: 1.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0222
    Cell Significance Index: 0.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0220
    Cell Significance Index: 3.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0162
    Cell Significance Index: 0.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0144
    Cell Significance Index: 9.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0023
    Cell Significance Index: 1.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0075
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0098
    Cell Significance Index: -6.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0148
    Cell Significance Index: -8.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0177
    Cell Significance Index: -1.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0186
    Cell Significance Index: -1.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0271
    Cell Significance Index: -12.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0293
    Cell Significance Index: -16.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0311
    Cell Significance Index: -1.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0332
    Cell Significance Index: -4.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0332
    Cell Significance Index: -25.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0590
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0696
    Cell Significance Index: -11.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0765
    Cell Significance Index: -9.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0769
    Cell Significance Index: -16.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0977
    Cell Significance Index: -28.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1180
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1219
    Cell Significance Index: -13.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1272
    Cell Significance Index: -5.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1495
    Cell Significance Index: -19.1700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1539
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1671
    Cell Significance Index: -19.0700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1756
    Cell Significance Index: -1.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1951
    Cell Significance Index: -25.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2311
    Cell Significance Index: -3.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2400
    Cell Significance Index: -24.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2798
    Cell Significance Index: -20.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2988
    Cell Significance Index: -18.3200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3151
    Cell Significance Index: -4.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3160
    Cell Significance Index: -25.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3244
    Cell Significance Index: -6.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3351
    Cell Significance Index: -10.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3363
    Cell Significance Index: -10.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3409
    Cell Significance Index: -7.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3708
    Cell Significance Index: -17.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3731
    Cell Significance Index: -26.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4053
    Cell Significance Index: -12.9800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4106
    Cell Significance Index: -7.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4160
    Cell Significance Index: -10.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4168
    Cell Significance Index: -21.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4302
    Cell Significance Index: -9.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4354
    Cell Significance Index: -9.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4443
    Cell Significance Index: -23.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4466
    Cell Significance Index: -11.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4489
    Cell Significance Index: -15.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4573
    Cell Significance Index: -9.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4675
    Cell Significance Index: -24.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4799
    Cell Significance Index: -9.4900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5205
    Cell Significance Index: -4.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5236
    Cell Significance Index: -13.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5496
    Cell Significance Index: -19.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NAIP is a cytosolic protein that shares structural and functional similarities with other NLR family members, such as NLRP3 and NLRP4. It is primarily expressed in immune cells, including macrophages, dendritic cells, and microglia, as well as in certain epithelial cells, such as those in the kidney distal convoluted tubule. NAIP's expression is often restricted to cells that are involved in the recognition and processing of pathogens, highlighting its role in the innate immune response. **Pathways and Functions** NAIP's primary function is to regulate apoptosis by binding to and inhibiting the activity of caspases. This anti-apoptotic function is mediated through its interaction with the caspase-1 inhibitory protein, which prevents the activation of caspase-1, a key enzyme in the activation of the inflammasome complex. By inhibiting caspase-1, NAIP reduces the production of IL-1β, a potent pro-inflammatory cytokine that promotes inflammation and tissue damage. NAIP also plays a role in the regulation of the pyroptotic process, a form of cell death that is characterized by the release of pro-inflammatory cytokines and the activation of the inflammasome complex. By inhibiting pyroptosis, NAIP helps to prevent excessive inflammation and tissue damage in response to infection or injury. **Clinical Significance** Dysregulation of NAIP has been implicated in various human diseases, including autoimmune disorders, such as rheumatoid arthritis and lupus, as well as inflammatory bowel disease (IBD) and cancer. NAIP's role in regulating apoptosis and inflammation makes it a potential therapeutic target for the treatment of these diseases. In addition, NAIP has been shown to play a role in the regulation of the innate immune response to bacterial infections, such as Legionella pneumophila and Mycobacterium tuberculosis. Mutations in NAIP have been associated with an increased susceptibility to these infections, highlighting the importance of this gene in maintaining host defense against pathogens. In conclusion, NAIP is a critical component of the innate immune system, playing a key role in the regulation of apoptosis, inflammation, and immune response. Its dysregulation has been implicated in various human diseases, making it a potential therapeutic target for the treatment of these conditions. Further research is needed to fully understand the mechanisms of NAIP and its role in human disease.

Genular Protein ID: 267624969

Symbol: BIRC1_HUMAN

Name: Baculoviral IAP repeat-containing protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7813013

Title: The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy.

PubMed ID: 7813013

DOI: 10.1016/0092-8674(95)90461-1

PubMed ID: 9503025

Title: Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP.

PubMed ID: 9503025

DOI: 10.1006/geno.1997.5141

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11955612

Title: Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes.

PubMed ID: 11955612

DOI: 10.1016/s0167-4781(01)00343-8

PubMed ID: 7552146

Title: A provisional transcript map of the spinal muscular atrophy (SMA) critical region.

PubMed ID: 7552146

DOI: 10.1159/000472281

PubMed ID: 8552191

Title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

PubMed ID: 8552191

DOI: 10.1038/379349a0

PubMed ID: 11896143

Title: The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7.

PubMed ID: 11896143

DOI: 10.1523/jneurosci.22-06-02035.2002

PubMed ID: 18414036

Title: IAPs: more than just inhibitors of apoptosis proteins.

PubMed ID: 18414036

DOI: 10.4161/cc.7.8.5783

PubMed ID: 21371431

Title: Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP.

PubMed ID: 21371431

DOI: 10.1016/j.bbrc.2011.02.130

PubMed ID: 21918512

Title: The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

PubMed ID: 21918512

DOI: 10.1038/nature10510

PubMed ID: 22504023

Title: The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila.

PubMed ID: 22504023

DOI: 10.1016/j.micinf.2012.03.006

PubMed ID: 19923725

Title: Structures of BIR domains from human NAIP and cIAP2.

PubMed ID: 19923725

DOI: 10.1107/s1744309109038597

Sequence Information:

  • Length: 1403
  • Mass: 159582
  • Checksum: C1CE163D55900C6D
  • Sequence:
  • MATQQKASDE RISQFDHNLL PELSALLGLD AVQLAKELEE EEQKERAKMQ KGYNSQMRSE 
    AKRLKTFVTY EPYSSWIPQE MAAAGFYFTG VKSGIQCFCC SLILFGAGLT RLPIEDHKRF 
    HPDCGFLLNK DVGNIAKYDI RVKNLKSRLR GGKMRYQEEE ARLASFRNWP FYVQGISPCV 
    LSEAGFVFTG KQDTVQCFSC GGCLGNWEEG DDPWKEHAKW FPKCEFLRSK KSSEEITQYI 
    QSYKGFVDIT GEHFVNSWVQ RELPMASAYC NDSIFAYEEL RLDSFKDWPR ESAVGVAALA 
    KAGLFYTGIK DIVQCFSCGG CLEKWQEGDD PLDDHTRCFP NCPFLQNMKS SAEVTPDLQS 
    RGELCELLET TSESNLEDSI AVGPIVPEMA QGEAQWFQEA KNLNEQLRAA YTSASFRHMS 
    LLDISSDLAT DHLLGCDLSI ASKHISKPVQ EPLVLPEVFG NLNSVMCVEG EAGSGKTVLL 
    KKIAFLWASG CCPLLNRFQL VFYLSLSSTR PDEGLASIIC DQLLEKEGSV TEMCVRNIIQ 
    QLKNQVLFLL DDYKEICSIP QVIGKLIQKN HLSRTCLLIA VRTNRARDIR RYLETILEIK 
    AFPFYNTVCI LRKLFSHNMT RLRKFMVYFG KNQSLQKIQK TPLFVAAICA HWFQYPFDPS 
    FDDVAVFKSY MERLSLRNKA TAEILKATVS SCGELALKGF FSCCFEFNDD DLAEAGVDED 
    EDLTMCLMSK FTAQRLRPFY RFLSPAFQEF LAGMRLIELL DSDRQEHQDL GLYHLKQINS 
    PMMTVSAYNN FLNYVSSLPS TKAGPKIVSH LLHLVDNKES LENISENDDY LKHQPEISLQ 
    MQLLRGLWQI CPQAYFSMVS EHLLVLALKT AYQSNTVAAC SPFVLQFLQG RTLTLGALNL 
    QYFFDHPESL SLLRSIHFPI RGNKTSPRAH FSVLETCFDK SQVPTIDQDY ASAFEPMNEW 
    ERNLAEKEDN VKSYMDMQRR ASPDLSTGYW KLSPKQYKIP CLEVDVNDID VVGQDMLEIL 
    MTVFSASQRI ELHLNHSRGF IESIRPALEL SKASVTKCSI SKLELSAAEQ ELLLTLPSLE 
    SLEVSGTIQS QDQIFPNLDK FLCLKELSVD LEGNINVFSV IPEEFPNFHH MEKLLIQISA 
    EYDPSKLVKL IQNSPNLHVF HLKCNFFSDF GSLMTMLVSC KKLTEIKFSD SFFQAVPFVA 
    SLPNFISLKI LNLEGQQFPD EETSEKFAYI LGSLSNLEEL ILPTGDGIYR VAKLIIQQCQ 
    QLHCLRVLSF FKTLNDDSVV EIAKVAISGG FQKLENLKLS INHKITEEGY RNFFQALDNM 
    PNLQELDISR HFTECIKAQA TTVKSLSQCV LRLPRLIRLN MLSWLLDADD IALLNVMKER 
    HPQSKYLTIL QKWILPFSPI IQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.