Details for: SCAND1

Gene ID: 51282

Symbol: SCAND1

Ensembl ID: ENSG00000171222

Description: SCAN domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 343.9514
    Cell Significance Index: -53.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 191.8047
    Cell Significance Index: -48.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 165.4337
    Cell Significance Index: -68.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.0035
    Cell Significance Index: -62.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 141.7640
    Cell Significance Index: -66.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 133.1104
    Cell Significance Index: -68.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 100.8163
    Cell Significance Index: -67.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.4158
    Cell Significance Index: -63.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.0862
    Cell Significance Index: -64.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.2839
    Cell Significance Index: -48.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.6430
    Cell Significance Index: -69.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.0250
    Cell Significance Index: -49.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.1238
    Cell Significance Index: 110.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 3.8708
    Cell Significance Index: 232.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1735
    Cell Significance Index: 219.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.9710
    Cell Significance Index: 138.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7490
    Cell Significance Index: 177.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7316
    Cell Significance Index: 21.8100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.7120
    Cell Significance Index: 22.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.5606
    Cell Significance Index: 23.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2615
    Cell Significance Index: 1235.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1061
    Cell Significance Index: 156.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0878
    Cell Significance Index: 376.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.0415
    Cell Significance Index: 47.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0283
    Cell Significance Index: 278.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0003
    Cell Significance Index: 245.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9299
    Cell Significance Index: 52.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.9252
    Cell Significance Index: 56.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6836
    Cell Significance Index: 44.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5678
    Cell Significance Index: 73.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5301
    Cell Significance Index: 180.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5289
    Cell Significance Index: 53.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3219
    Cell Significance Index: 584.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2966
    Cell Significance Index: 23.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1760
    Cell Significance Index: 13.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1181
    Cell Significance Index: 58.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0659
    Cell Significance Index: 137.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9985
    Cell Significance Index: 20.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9822
    Cell Significance Index: 44.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9423
    Cell Significance Index: 120.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8820
    Cell Significance Index: 46.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7894
    Cell Significance Index: 55.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7053
    Cell Significance Index: 36.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6796
    Cell Significance Index: 134.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6581
    Cell Significance Index: 41.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4236
    Cell Significance Index: 12.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4109
    Cell Significance Index: 11.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3329
    Cell Significance Index: 36.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2824
    Cell Significance Index: 3.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2690
    Cell Significance Index: 51.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1775
    Cell Significance Index: 2.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1105
    Cell Significance Index: 10.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0773
    Cell Significance Index: 56.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0730
    Cell Significance Index: 55.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0687
    Cell Significance Index: 13.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0536
    Cell Significance Index: 0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0371
    Cell Significance Index: 0.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0229
    Cell Significance Index: 3.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0243
    Cell Significance Index: -2.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0258
    Cell Significance Index: -48.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0438
    Cell Significance Index: -15.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0482
    Cell Significance Index: -88.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0569
    Cell Significance Index: -87.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0594
    Cell Significance Index: -44.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0621
    Cell Significance Index: -84.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0892
    Cell Significance Index: -56.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1040
    Cell Significance Index: -58.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1237
    Cell Significance Index: -77.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1382
    Cell Significance Index: -62.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1604
    Cell Significance Index: -2.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1794
    Cell Significance Index: -51.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2645
    Cell Significance Index: -30.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2724
    Cell Significance Index: -6.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3224
    Cell Significance Index: -37.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3260
    Cell Significance Index: -10.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3512
    Cell Significance Index: -73.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3528
    Cell Significance Index: -9.8600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3631
    Cell Significance Index: -4.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4067
    Cell Significance Index: -32.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4190
    Cell Significance Index: -60.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4629
    Cell Significance Index: -7.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4939
    Cell Significance Index: -10.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5678
    Cell Significance Index: -7.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6156
    Cell Significance Index: -34.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6655
    Cell Significance Index: -69.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7305
    Cell Significance Index: -44.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7453
    Cell Significance Index: -26.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7515
    Cell Significance Index: -57.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7891
    Cell Significance Index: -53.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7961
    Cell Significance Index: -23.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0395
    Cell Significance Index: -63.7300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1900
    Cell Significance Index: -7.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2466
    Cell Significance Index: -14.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.2555
    Cell Significance Index: -17.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4359
    Cell Significance Index: -38.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5854
    Cell Significance Index: -70.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6443
    Cell Significance Index: -60.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6573
    Cell Significance Index: -42.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.6696
    Cell Significance Index: -41.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SCAND1 belongs to the SCAN domain-containing family of proteins, which are characterized by the presence of a SCAN domain, a protein-protein interaction domain. The SCAN domain allows SCAND1 to interact with other proteins, modulating their activity and function. SCAND1's expression is widespread, with significant levels detected in hematopoietic cells, indicating its potential role in immune cell development and function. **Pathways and Functions:** SCAND1's involvement in various cellular pathways suggests its role as a modulator of immune responses. The protein is associated with: 1. **Nucleus**: SCAND1 is localized to the nucleus, where it may interact with transcription factors and other nuclear proteins to regulate gene expression. 2. **Positive regulation of DNA-templated transcription**: SCAND1 may facilitate the transcription of genes involved in immune responses, such as those encoding cytokines and chemokines. 3. **Protein binding**: The SCAN domain of SCAND1 allows it to interact with other proteins, modulating their activity and function. This interaction may be critical for regulating immune cell development and function. **Clinical Significance:** The clinical significance of SCAND1 lies in its potential role in immune-related disorders. Dysregulation of SCAND1 has been implicated in various diseases, including: 1. **Autoimmune disorders**: SCAND1's involvement in immune cell development and function may contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: Alterations in SCAND1 expression have been observed in certain types of cancer, suggesting its potential role as a tumor suppressor or oncogene. 3. **Immunodeficiency disorders**: SCAND1's involvement in immune cell development and function may contribute to the pathogenesis of immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, SCAND1 is a protein with significant implications for immune function and disease. Further research is needed to elucidate the mechanisms by which SCAND1 regulates immune responses and to explore its potential therapeutic applications.

Genular Protein ID: 82255863

Symbol: SCND1_HUMAN

Name: SCAN domain-containing protein 1

UniProtKB Accession Codes:

P57086 Q6IAG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10747874

Title: The SCAN domain mediates selective oligomerization.

PubMed ID: 10747874

DOI: 10.1074/jbc.m000119200

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 179
  • Mass: 19082
  • Checksum: 88AFEFC8E4DC9796
  • Sequence:
    • MAATEPILAA TGSPAAVPPE KLEGAGSSSA PERNCVGSSL PEASPPAPEP SSPNAAVPEA 
IPTPRAAASA ALELPLGPAP VSVAPQAEAE ARSTPGPAGS RLGPETFRQR FRQFRYQDAA 
GPREAFRQLR ELSRQWLRPD IRTKEQIVEM LVQEQLLAIL PEAARARRIR RRTDVRITG

Genular Protein ID: 2888625202

Symbol: Q9NZG6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NZG6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 10777584

Title: Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations.

PubMed ID: 10777584

DOI: 10.1074/jbc.275.17.12857

Sequence Information:

  • Length: 217
  • Mass: 23431
  • Checksum: E087141B54222401
  • Sequence:
    • GRREARDFRF RLPQALRWCR RSAEHTATGQ RVTPGAGVMA ATEPILAATG SPAAVPPEKL 
EGAGSSSAPE RNCVGSSLPE ASPPAPEPSS PNAAVPEAIP TPRAAASAAL ELPLGPAPVS 
VAPQAEAEAR STPGPAGSRL GPETFRQRFR QFRYQDAAGP REAFRQLREL SRQWLRPDIR 
TKEQIVEMLV QEQLLAILPE AARARRIRRR TDVRITG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.