Details for: NDUFA3
Gene ID: 4696
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NDUFA3
Ensembl ID: ENSG00000170906
Description: NADH:ubiquinone oxidoreductase subunit A3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 63.63rCSI 55.95%PRS 13.54
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CSI 59.24rCSI 62.05%PRS 17.39
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CSI 58.4rCSI 56.31%PRS 13.42
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CSI 52.36rCSI 61.5%PRS 21.62
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CSI 50.14rCSI 39.45%PRS 22.47
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CSI 47.42rCSI 49.56%PRS 19.5
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CSI 46.63rCSI 40.37%PRS 20.97
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CSI 43.84rCSI 35.44%PRS 18.65
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CSI 41rCSI 36.39%PRS 18.74
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CSI 40.36rCSI 42.89%PRS 32.05
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CSI 40.31rCSI 40.23%PRS 15.91
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CSI 38.07rCSI 51.87%PRS 16.56
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CSI 37.16rCSI 59.92%PRS 28.83
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CSI 36.31rCSI 52.05%PRS 25.4
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CSI 36.29rCSI 38.02%PRS 19.88
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CSI 36.29rCSI 32.77%PRS 16.77
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CSI 35.71rCSI 51.51%PRS 26.11
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CSI 34.35rCSI 58.84%PRS 25.31
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CSI 33.58rCSI 22.32%PRS 22.4
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CSI 31.96rCSI 30.77%PRS 19.31
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CSI 29.96rCSI 40.94%PRS 20.66
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CSI 28.07rCSI 25.77%PRS 21.79
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CSI 27.99rCSI 42.82%PRS 30.18
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CSI 26.28rCSI 42.3%PRS 14.31
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CSI 26.03rCSI 21.58%PRS 17.64
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CSI 24.82rCSI 35.77%PRS 29.47
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CSI 21.25rCSI 45.24%PRS 29.62
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CSI 21.21rCSI 50.43%PRS 27.92
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CSI 20.33rCSI 31.25%PRS 25.67
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CSI 19.42rCSI 22.23%PRS 37.67
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CSI 19.06rCSI 35.77%PRS 36.41
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CSI 18.56rCSI 16.3%PRS 21.42
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CSI 18.45rCSI 53.4%PRS 21.06
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CSI 18.38rCSI 14.53%PRS 12.78
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CSI 18.11rCSI 39.55%PRS 36.29
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CSI 17.82rCSI 16.44%PRS 19.29
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CSI 17.46rCSI 33.32%PRS 40.97
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CSI 16.87rCSI 16.6%PRS 20.23
-
CSI 16.51rCSI 19.1%PRS 13.69
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CSI 16.51rCSI 22.07%PRS 24.35
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CSI 15.81rCSI 31.39%PRS 19.65
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CSI 15.7rCSI 16%PRS 26.73
-
CSI 15.58rCSI 25.66%PRS 22.01
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CSI 15.41rCSI 14.56%PRS 19.53
-
CSI 15.15rCSI 34.54%PRS 19.24
-
CSI 14.58rCSI 22.27%PRS 32.72
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CSI 13.75rCSI 29.23%PRS 29.88
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CSI 13.33rCSI 47.34%PRS 30.26
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CSI 13.3rCSI 35.86%PRS 24.15
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CSI 12.94rCSI 28.65%PRS 17.25
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CSI 12.88rCSI 60.4%PRS 46.39
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CSI 12.7rCSI 28.06%PRS 13.35
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CSI 12.13rCSI 34.64%PRS 31.73
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CSI 12.11rCSI 53.17%PRS 34.42
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CSI 12.03rCSI 12.89%PRS 17.16
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CSI 11.94rCSI 15.65%PRS 65.29
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CSI 11.92rCSI 47.47%PRS 32.07
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CSI 11.92rCSI 29.49%PRS 17.21
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CSI 11.91rCSI 64.26%PRS 32.87
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CSI 11.86rCSI 17.37%PRS 21.5
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CSI 11.53rCSI 8.64%PRS 50.45
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CSI 11.22rCSI 15.33%PRS 21.09
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CSI 11.21rCSI 19.15%PRS 37.49
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CSI 11.09rCSI 7.39%PRS 45.04
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CSI 10.87rCSI 16.57%PRS 17.32
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CSI 10.4rCSI 33.36%PRS 26.89
-
CSI 10.31rCSI 7.2%PRS 19.8
-
CSI 10.24rCSI 14.23%PRS 19.12
-
CSI 10.09rCSI 34.12%PRS 29.97
-
CSI 9.98rCSI 15.25%PRS 21.37
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CSI 9.96rCSI 12.5%PRS 24.15
-
CSI 9.92rCSI 52.08%PRS 32.01
-
CSI 9.92rCSI 15.38%PRS 27.88
-
CSI 9.76rCSI 18.99%PRS 19.07
-
CSI 9.57rCSI 6.65%PRS 22.27
-
CSI 9.56rCSI 14.17%PRS 79.75
-
CSI 9.48rCSI 13.43%PRS 17.31
-
CSI 9.14rCSI 5.4%PRS 26.02
-
CSI 9.04rCSI 7.34%PRS 19.7
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CSI 8.95rCSI 6.9%PRS 17.24
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CSI 8.94rCSI 7.4%PRS 18.89
-
CSI 8.69rCSI 11.62%PRS 61.37
-
CSI 8.66rCSI 47.15%PRS 43.33
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CSI 8.57rCSI 6.65%PRS 17.85
-
CSI 8.35rCSI 11.42%PRS 18.54
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CSI 8.25rCSI 10.8%PRS 26.56
-
CSI 8.23rCSI 90.17%PRS 33.2
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CSI 8.22rCSI 10.33%PRS 66.09
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CSI 8.11rCSI 5.69%PRS 44.03
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CSI 7.98rCSI 9.58%PRS 18.25
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CSI 7.96rCSI 11.67%PRS 24.47
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CSI 7.94rCSI 19.39%PRS 18.35
-
CSI 7.9rCSI 5.5%PRS 26.46
-
CSI 7.84rCSI 11.66%PRS 22.34
-
CSI 7.81rCSI 5.84%PRS 29.63
-
CSI 7.77rCSI 58.36%PRS 33.93
-
CSI 7.64rCSI 26.81%PRS 32.55
-
CSI 7.22rCSI 6.03%PRS 48.38
-
CSI 7.15rCSI 9.14%PRS 62.73
-
CSI 7.04rCSI 22.66%PRS 19.54
-
CSI -5.0rCSI -7.7%PRS 18.8%
-
CSI -4.3rCSI -8.0%PRS 39.3%
-
CSI -2.9rCSI -12.1%PRS 22.6%
-
CSI -1.8rCSI -7.9%PRS 17.7%
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CSI -0.8rCSI -1.4%PRS 24.5%
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CSI -0.7rCSI -0.8%PRS 32.5%
-
CSI -0.7rCSI -12.1%PRS 63.7%
-
CSI 0.2rCSI 3.3%PRS 81.1%
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CSI 0.2rCSI 0.5%PRS 15.5%
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CSI 0.2rCSI 0.9%PRS 25.3%
-
CSI 0.2rCSI 0.3%PRS 15.8%
-
CSI 0.3rCSI 4.2%PRS 51.6%
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CSI 0.3rCSI 1.7%PRS 27.4%
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CSI 0.4rCSI 1.3%PRS 31.9%
-
CSI 0.4rCSI 0.9%PRS 50.1%
-
CSI 0.4rCSI 1.2%PRS 11.7%
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CSI 0.4rCSI 1.3%PRS 22.5%
-
CSI 0.4rCSI 0.6%PRS 29.1%
-
CSI 0.4rCSI 6.9%PRS 69.0%
-
CSI 0.5rCSI 12.3%PRS 80.6%
-
CSI 0.5rCSI 0.7%PRS 25.8%
-
CSI 0.5rCSI 2.4%PRS 38.5%
-
CSI 0.6rCSI 0.6%PRS 21.1%
-
CSI 0.6rCSI 14.5%PRS 67.3%
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CSI 0.6rCSI 3.1%PRS 61.3%
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CSI 0.6rCSI 5.0%PRS 18.9%
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CSI 0.6rCSI 1.6%PRS 24.5%
-
CSI 0.7rCSI 2.5%PRS 58.5%
-
CSI 0.7rCSI 6.9%PRS 65.6%
-
CSI 0.7rCSI 1.1%PRS 18.8%
-
CSI 0.8rCSI 1.4%PRS 29.5%
-
CSI 0.8rCSI 3.4%PRS 18.3%
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CSI 0.8rCSI 2.2%PRS 32.8%
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CSI 0.8rCSI 3.0%PRS 54.9%
-
CSI 0.8rCSI 2.0%PRS 73.0%
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CSI 0.9rCSI 1.4%PRS 20.4%
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CSI 0.9rCSI 0.9%PRS 37.7%
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CSI 0.9rCSI 4.5%PRS 24.7%
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CSI 0.9rCSI 2.0%PRS 25.0%
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CSI 0.9rCSI 1.8%PRS 45.2%
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CSI 0.9rCSI 2.5%PRS 63.6%
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CSI 1.0rCSI 25.3%PRS 70.0%
-
CSI 1.0rCSI 1.5%PRS 17.1%
-
CSI 1.0rCSI 5.7%PRS 54.6%
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CSI 1.1rCSI 5.6%PRS 61.6%
-
CSI 1.1rCSI 11.5%PRS 75.3%
-
CSI 1.2rCSI 3.0%PRS 46.9%
-
CSI 1.2rCSI 3.2%PRS 29.9%
-
CSI 1.2rCSI 13.4%PRS 35.5%
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CSI 1.3rCSI 1.4%PRS 29.7%
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CSI 1.3rCSI 6.1%PRS 22.9%
-
CSI 1.3rCSI 3.3%PRS 23.1%
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CSI 1.3rCSI 5.0%PRS 18.2%
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CSI 1.3rCSI 2.3%PRS 14.2%
-
CSI 1.4rCSI 1.7%PRS 23.4%
-
CSI 1.4rCSI 5.9%PRS 45.0%
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CSI 1.4rCSI 3.4%PRS 47.9%
-
CSI 1.5rCSI 3.7%PRS 29.6%
-
CSI 1.6rCSI 13.9%PRS 82.8%
-
CSI 1.6rCSI 18.4%PRS 62.6%
-
CSI 1.6rCSI 17.4%PRS 61.1%
-
CSI 1.7rCSI 4.8%PRS 14.3%
-
CSI 1.7rCSI 16.6%PRS 55.5%
-
CSI 1.7rCSI 2.1%PRS 16.3%
-
CSI 1.7rCSI 4.9%PRS 21.5%
-
CSI 1.7rCSI 40.1%PRS 34.7%
-
CSI 1.8rCSI 8.7%PRS 72.9%
-
CSI 1.8rCSI 2.3%PRS 11.5%
-
CSI 1.8rCSI 4.2%PRS 23.0%
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CSI 1.8rCSI 1.7%PRS 18.7%
-
CSI 1.9rCSI 8.4%PRS 56.5%
-
CSI 1.9rCSI 11.6%PRS 59.1%
-
CSI 1.9rCSI 2.4%PRS 10.2%
-
CSI 1.9rCSI 2.6%PRS 35.4%
-
CSI 1.9rCSI 8.6%PRS 69.1%
-
CSI 2.0rCSI 10.1%PRS 36.2%
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CSI 2.0rCSI 7.8%PRS 30.6%
-
CSI 2.0rCSI 8.9%PRS 32.6%
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CSI 2.1rCSI 4.3%PRS 18.5%
-
CSI 2.1rCSI 1.8%PRS 23.3%
-
CSI 2.2rCSI 1.7%PRS 33.0%
-
CSI 2.2rCSI 3.2%PRS 14.4%
-
CSI 2.3rCSI 6.6%PRS 27.6%
-
CSI 2.4rCSI 7.8%PRS 48.4%
-
CSI 2.4rCSI 10.5%PRS 34.4%
-
CSI 2.4rCSI 6.4%PRS 36.1%
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CSI 2.5rCSI 73.8%PRS 41.1%
-
CSI 2.5rCSI 17.7%PRS 35.3%
-
CSI 2.5rCSI 2.9%PRS 16.4%
-
CSI 2.5rCSI 2.6%PRS 21.9%
-
CSI 2.6rCSI 6.8%PRS 22.3%
-
CSI 2.6rCSI 3.8%PRS 28.0%
-
CSI 2.6rCSI 5.4%PRS 18.6%
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CSI 2.7rCSI 1.9%PRS 25.5%
-
CSI 2.7rCSI 35.0%PRS 54.1%
-
CSI 2.7rCSI 5.5%PRS 40.5%
-
CSI 2.7rCSI 3.7%PRS 37.1%
-
CSI 2.7rCSI 4.0%PRS 19.7%
-
CSI 2.8rCSI 8.0%PRS 39.8%
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CSI 2.8rCSI 8.2%PRS 42.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1239045564
Symbol: NDUA3_HUMAN
Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9878551
Title: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.
PubMed ID: 9878551
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12611891
Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
PubMed ID: 12611891
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 27626371
Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.
PubMed ID: 27626371
DOI: 10.1038/nature19754
Sequence Information:
- Length: 84
- Mass: 9279
- Checksum: 38B27A96D7A05D31
- Sequence:
MAARVGAFLK NAWDKEPVLV VSFVVGGLAV ILPPLSPYFK YSVMINKATP YNYPVPVRDD GNMPDVPSHP QDPQGPSLEW LKKL