Details for: CKLF

Gene ID: 51192

Symbol: CKLF

Ensembl ID: ENSG00000217555

Description: chemokine like factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.4714
    Cell Significance Index: -33.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.7139
    Cell Significance Index: -26.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 103.1806
    Cell Significance Index: -42.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.1839
    Cell Significance Index: -43.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 85.2863
    Cell Significance Index: -43.8700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.1857
    Cell Significance Index: -43.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.6962
    Cell Significance Index: -39.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3957
    Cell Significance Index: -31.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3319
    Cell Significance Index: -40.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.0859
    Cell Significance Index: 90.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2608
    Cell Significance Index: 41.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9036
    Cell Significance Index: 207.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6657
    Cell Significance Index: 100.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9539
    Cell Significance Index: 65.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9454
    Cell Significance Index: 116.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8711
    Cell Significance Index: 157.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8550
    Cell Significance Index: 55.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7263
    Cell Significance Index: 145.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6998
    Cell Significance Index: 382.1900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.6346
    Cell Significance Index: 1.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5391
    Cell Significance Index: 74.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4930
    Cell Significance Index: 11.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4669
    Cell Significance Index: 11.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4411
    Cell Significance Index: 20.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3885
    Cell Significance Index: 20.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3812
    Cell Significance Index: 21.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3521
    Cell Significance Index: 126.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3454
    Cell Significance Index: 9.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3172
    Cell Significance Index: 51.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3144
    Cell Significance Index: 15.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2970
    Cell Significance Index: 131.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2782
    Cell Significance Index: 35.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2569
    Cell Significance Index: 19.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2458
    Cell Significance Index: 46.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1983
    Cell Significance Index: 19.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1897
    Cell Significance Index: 22.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1561
    Cell Significance Index: 44.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1235
    Cell Significance Index: 77.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1012
    Cell Significance Index: 6.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0548
    Cell Significance Index: 2.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0517
    Cell Significance Index: 6.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0479
    Cell Significance Index: 3.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0360
    Cell Significance Index: 0.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0274
    Cell Significance Index: 3.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0178
    Cell Significance Index: 13.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0096
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0192
    Cell Significance Index: -36.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0228
    Cell Significance Index: -3.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0251
    Cell Significance Index: -46.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0294
    Cell Significance Index: -16.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0301
    Cell Significance Index: -46.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0314
    Cell Significance Index: -0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0341
    Cell Significance Index: -46.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0404
    Cell Significance Index: -1.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0474
    Cell Significance Index: -34.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0651
    Cell Significance Index: -41.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0748
    Cell Significance Index: -2.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0782
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0883
    Cell Significance Index: -18.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0938
    Cell Significance Index: -42.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1213
    Cell Significance Index: -3.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1258
    Cell Significance Index: -14.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1462
    Cell Significance Index: -4.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1655
    Cell Significance Index: -1.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1903
    Cell Significance Index: -37.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1989
    Cell Significance Index: -6.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2309
    Cell Significance Index: -26.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2847
    Cell Significance Index: -41.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3095
    Cell Significance Index: -14.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3849
    Cell Significance Index: -24.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3904
    Cell Significance Index: -17.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3915
    Cell Significance Index: -40.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4827
    Cell Significance Index: -37.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5000
    Cell Significance Index: -5.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5107
    Cell Significance Index: -19.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5277
    Cell Significance Index: -41.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5306
    Cell Significance Index: -11.3000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5559
    Cell Significance Index: -8.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5618
    Cell Significance Index: -11.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5807
    Cell Significance Index: -30.4900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.6001
    Cell Significance Index: -12.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6187
    Cell Significance Index: -9.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6237
    Cell Significance Index: -25.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6434
    Cell Significance Index: -43.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6769
    Cell Significance Index: -17.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6986
    Cell Significance Index: -42.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8425
    Cell Significance Index: -22.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8475
    Cell Significance Index: -14.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8804
    Cell Significance Index: -21.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9033
    Cell Significance Index: -26.6100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.9229
    Cell Significance Index: -9.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9585
    Cell Significance Index: -27.4800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.9732
    Cell Significance Index: -10.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0425
    Cell Significance Index: -34.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0433
    Cell Significance Index: -38.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0649
    Cell Significance Index: -29.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0727
    Cell Significance Index: -37.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1313
    Cell Significance Index: -36.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1468
    Cell Significance Index: -25.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CKLF is a small, secreted protein that belongs to the chemokine family. It is characterized by its ability to bind to specific receptors, leading to the activation of downstream signaling pathways. CKLF is highly expressed in various cell types, including hematopoietic cells, smooth muscle fibers, and immune cells such as T cells and macrophages. The protein is also secreted by cells, allowing it to exert its effects on surrounding tissues. **Pathways and Functions** CKLF's primary function is to regulate cell migration and chemotaxis, particularly in the context of immune responses. It binds to specific receptors, such as CXCR1 and CXCR2, which are expressed on the surface of various immune cells. This binding triggers the activation of signaling pathways, including the MAPK and PI3K/AKT pathways, leading to the regulation of cell migration, proliferation, and differentiation. CKLF has also been shown to regulate the function of T cells, macrophages, and dendritic cells, which are essential components of the immune system. In addition to its role in immune responses, CKLF has also been implicated in various other biological processes, including cell proliferation, differentiation, and survival. It has been shown to regulate the expression of genes involved in these processes, including genes involved in cell cycle regulation and apoptosis. **Clinical Significance** CKLF has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Its expression is altered in various types of cancer, including leukemia, lymphoma, and breast cancer. CKLF has also been shown to play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it regulates the function of immune cells and promotes inflammation. Furthermore, CKLF has been implicated in inflammatory conditions, such as atherosclerosis and inflammatory bowel disease. Its expression is increased in these conditions, where it promotes inflammation and tissue damage. In conclusion, CKLF is a multifunctional protein that plays a crucial role in various biological processes, including immune responses, cell migration, and proliferation. Its clinical significance is evident in its role in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Further research is needed to fully understand the mechanisms by which CKLF regulates these processes and to explore its potential as a therapeutic target. **Significantly expressed cells** - Polychromatophilic erythroblast - Hematopoietic oligopotent progenitor cell - Embryonic stem cell - Smooth muscle fiber of ileum - Peripheral blood mononuclear cell - Ileal goblet cell - Orthochromatic erythroblast - CD8-positive, alpha-beta regulatory T cell - Stromal cell of bone marrow - CD4-positive, alpha-beta memory T cell - CD45RO-positive **Proteins** - CKLF_HUMAN (Chemokine-like factor) - Q5BJH6_HUMAN **References** [Insert references to relevant research articles] Note: The provided information is based on the given data and is intended to provide an expert discussion on the gene CKLF.

Genular Protein ID: 1558708090

Symbol: CKLF_HUMAN

Name: Chemokine-like factor

UniProtKB Accession Codes:

Q9UBR5 C9JE38 Q9UHM7 Q9UHN8 Q9UI41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 5 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 5 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11415443

Title: Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity.

PubMed ID: 11415443

DOI: 10.1042/0264-6021:3570127

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16137713

Title: Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).

PubMed ID: 16137713

DOI: 10.1016/j.lfs.2005.05.070

Sequence Information:

  • Length: 152
  • Mass: 17170
  • Checksum: 6149D6D2B6AED9F3
  • Sequence:
    • MDNVQPKIKH RPFCFSVKGH VKMLRLALTV TSMTFFIIAQ APEPYIVITG FEVTVILFFI 
LLYVLRLDRL MKWLFWPLLD IINSLVTTVF MLIVSVLALI PETTTLTVGG GVFALVTAVC 
CLADGALIYR KLLFNPSGPY QKKPVHEKKE VL

Genular Protein ID: 2470312026

Symbol: Q5BJH6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5BJH6

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 ExpressionAtlas 1 GO 1 HOGENOM 1 NCBI Taxonomy 1 OrthoDB 1 PharmGKB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 99
  • Mass: 10923
  • Checksum: 1F5EBF5AA7A9479E
  • Sequence:
    • MDNVQPKIKH RPFCFSVKGH VKMLRLDIIN SLVTTVFMLI VSVLALIPET TTLTVGGGVF 
ALVTAVCCLA DGALIYRKLL FNPSGPYQKK PVHEKKEVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.